Home Other Building Blocks SB 290157 trifluoroacetate salt

SB 290157 trifluoroacetate salt

CAS No.:
1140525-25-2
Catalog Number:
AG00924D
Molecular Formula:
C24H29F3N4O6
Molecular Weight:
526.5055
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$105
- +
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$190
- +
25mg
99%
1 week
United States
$340
- +
50mg
99%
1 week
United States
$540
- +
100mg
99%
1 week
United States
$907
- +
Product Description
Catalog Number:
AG00924D
Chemical Name:
SB 290157 trifluoroacetate salt
CAS Number:
1140525-25-2
Molecular Formula:
C24H29F3N4O6
Molecular Weight:
526.5055
MDL Number:
MFCD04974198
IUPAC Name:
(2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid;2,2,2-trifluoroacetic acid
InChI:
InChI=1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
InChI Key:
ZJRMPPVJAQWGEG-FYZYNONXSA-N
SMILES:
OC(=O)C(F)(F)F.NC(=N)NCCC[C@@H](C(=O)O)NC(=O)COCC(c1ccccc1)c1ccccc1
Properties
Complexity:
619  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
526.204g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
526.513g/mol
Monoisotopic Mass:
526.204g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
177A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Potent heterocyclic ligands for human complement c3a receptor. Journal of medicinal chemistry 20141023
Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice. Toxicology letters 20140817
Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats. American journal of hypertension 20120301
Establishment and characterization of a murine model for allergic asthma using allergen-specific IgE monoclonal antibody to study pathological roles of IgE. Immunology letters 20120130
Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis. Journal of pharmacological sciences 20100101
Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage. Brain research 20091028
Complement factors C3a and C5a have distinct hemodynamic effects in the rat. International immunopharmacology 20090601
C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy. Journal of the American Society of Nephrology : JASN 20090301
C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080501
Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. International immunopharmacology 20060801
The C3a receptor antagonist SB 290157 has agonist activity. Immunology letters 20050915
Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. Journal of immunology (Baltimore, Md. : 1950) 20050801
Agonist activity of the small molecule C3aR ligand SB 290157. Journal of immunology (Baltimore, Md. : 1950) 20050615
Innovative strategies for PBPC mobilization. Cytotherapy 20050101
Synthetic small-molecule complement inhibitors. Current opinion in investigational drugs (London, England : 2000) 20041101
Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British journal of pharmacology 20040601
Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 20040315
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. Journal of immunology (Baltimore, Md. : 1950) 20010515
Properties