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Home Halogens (S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid

(S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid

CAS No.:
1110766-97-6
Catalog Number:
AG008ZUX
Molecular Formula:
C29H32Cl2N2O5S
Molecular Weight:
591.5458
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
2mg
99%
1 week
United States
$257
- +
5mg
99%
1 week
United States
$407
- +
10mg
99%
1 week
United States
$640
- +
25mg
99%
1 week
United States
$1307
- +
50mg
99%
1 week
United States
$1890
- +
100mg
99%
1 week
United States
$2640
- +
Product Description
Catalog Number:
AG008ZUX
Chemical Name:
(S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid
CAS Number:
1110766-97-6
Molecular Formula:
C29H32Cl2N2O5S
Molecular Weight:
591.5458
MDL Number:
MFCD28502075
IUPAC Name:
(E)-3-[2,6-dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
InChI:
InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1
InChI Key:
NOZIJMHMKORZBA-KJCUYJGMSA-N
SMILES:
CCCCCCO[C@H](c1cccc(c1OC)c1csc(n1)NC(=O)c1cc(Cl)c(c(c1)Cl)/C=C(/C(=O)O)\C)C
UNII:
6LL5JFU42F
Properties
Complexity:
822  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Exact Mass:
590.141g/mol
Formal Charge:
0
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
591.544g/mol
Monoisotopic Mass:
590.141g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
126A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
7.7  
Literature
Title Journal
Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl. Experimental hematology 20180301
Efficacy of Repeated Lusutrombopag Administration for Thrombocytopenia in a Patient Scheduled for Invasive Hepatocellular Carcinoma Treatment. Internal medicine (Tokyo, Japan) 20171101
Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient. Clinical journal of gastroenterology 20170101
[Avoidance of platelet transfusion with readministration of lusutrombopag before radiofrequency ablation in hepatocellular carcinoma:a case report]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20170101
Lusutrombopag: First Global Approval. Drugs 20160101
Properties