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norcisapride

CAS No.:
102671-04-5
Catalog Number:
AG008WAQ
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG008WAQ
Chemical Name:
norcisapride
CAS Number:
102671-04-5
MDL Number:
MFCD28898457
IUPAC Name:
4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-hydroxybenzamide
InChI:
InChI=1S/C22H27ClFN3O4/c1-30-21-13-27(8-2-10-31-15-5-3-14(24)4-6-15)9-7-19(21)26-22(29)16-11-17(23)18(25)12-20(16)28/h3-6,11-12,19,21,28H,2,7-10,13,25H2,1H3,(H,26,29)/t19-,21+/m1/s1
InChI Key:
WUYNAGSDZADZCE-CTNGQTDRSA-N
Properties
Complexity:
567  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
451.167g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
451.923g/mol
Monoisotopic Mass:
451.167g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
97A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6  
Literature
Title Journal
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). Bioorganic & medicinal chemistry letters 20091001
Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny. Clinical pharmacology and therapeutics 20031001
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo. Clinical pharmacology and therapeutics 20030301
Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug metabolism and disposition: the biological fate of chemicals 20011201
Red wine-cisapride interaction: comparison with grapefruit juice. Clinical pharmacology and therapeutics 20010701
Properties