Home Other Building Blocks (S,R,R,S)-Nebivolol

(S,R,R,S)-Nebivolol

CAS No.:
119365-23-0
Catalog Number:
AG008W78
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG008W78
Chemical Name:
(S,R,R,S)-Nebivolol
CAS Number:
119365-23-0
MDL Number:
MFCD31562471
IUPAC Name:
(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
InChI:
InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21+,22+/m1/s1
InChI Key:
KOHIRBRYDXPAMZ-UBBRYJJRSA-N
Properties
Complexity:
483  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
405.175g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
405.442g/mol
Monoisotopic Mass:
405.175g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
71A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
The use of beta blocker Nebivolol in patients with chronic obstructive pulmonary disease in association with arterial hypertension. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20120101
[Clinical-hemodynamic and anti-ischemic effects ivabradine and nebivolol ischemic heart disease with left ventricular dysfunction]. Georgian medical news 20101001
[Arterial hypertension in females engaged into penal system work]. Meditsina truda i promyshlennaia ekologiia 20100101
Nebivolol: a highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide. Cardiovascular therapeutics 20080101
Stability Indicating RP-HPLC Estimation of Nebivolol Hydrochloride in Pharmaceutical Formulations. Indian journal of pharmaceutical sciences 20080101
Influence of nebivolol on endothelial dysfunction in salt-sensitive hypertension. Georgian medical news 20060401
[Effect of nitrogen oxide donor and inhibitor on some biochemical indices of the brain of intact rats and rats with subarachnoidal hemorrages]. Likars'ka sprava 20060101
[Estimation of the protective effect of Nebilet for perioperative cardiac complications in patients underwent vascular surgery: results of prospective study]. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20060101
[Use of nebivolol in patients with mild and moderate hypertension]. Terapevticheskii arkhiv 20030101
[Dynamics of a 24-h profile of arterial pressure and function of the vascular endothelium in nebivolol treatment of hypertensive patients]. Klinicheskaia meditsina 20030101
[Effect of enape combined with nebilet in hypertension]. Likars'ka sprava 20020101
[Effect of nebivolol on the level of constitutional, inducible, and total NO-synthase in serum of patients with type II diabetes mellitus]. Likars'ka sprava 20020101
Properties