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HO-3867

CAS No.:
1172133-28-6
Catalog Number:
AG008TP1
Molecular Formula:
C28H30F2N2O2
Molecular Weight:
464.5468
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$119
- +
5mg
99%
1 week
United States
$237
- +
10mg
99%
1 week
United States
$335
- +
25mg
99%
1 week
United States
$473
- +
50mg
99%
1 week
United States
$821
- +
Product Description
Catalog Number:
AG008TP1
Chemical Name:
HO-3867
CAS Number:
1172133-28-6
Molecular Formula:
C28H30F2N2O2
Molecular Weight:
464.5468
MDL Number:
MFCD28143913
IUPAC Name:
(3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one
InChI:
InChI=1S/C28H30F2N2O2/c1-27(2)15-23(28(3,4)32(27)34)18-31-16-21(13-19-5-9-24(29)10-6-19)26(33)22(17-31)14-20-7-11-25(30)12-8-20/h5-15,34H,16-18H2,1-4H3/b21-13+,22-14+
InChI Key:
PWZQFTQMMAIRRM-JFMUQQRKSA-N
SMILES:
Fc1ccc(cc1)/C=C/1\CN(C/C(=C\c2ccc(cc2)F)/C1=O)CC1=CC(N(C1(C)C)O)(C)C
Properties
Complexity:
816  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
2  
Exact Mass:
464.228g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
464.557g/mol
Monoisotopic Mass:
464.228g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
43.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1  
Literature
Title Journal
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy 20120701
Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867. The Journal of pharmacology and experimental therapeutics 20111101
HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer biology & therapy 20111101
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer biology & therapy 20101115
HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. Molecular cancer research : MCR 20100901
Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts. Molecular cancer therapeutics 20100501
Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression. The Journal of pharmacology and experimental therapeutics 20090601
Properties