Name: Name:Anwulignan
Brand: Angene
SKU: AG008TMH
Rating: 90 (10 reviews)

Catalog Number:

AG008TMH

Chemical Name:

Anwulignan

CAS Number:

107534-93-0

Molecular Formula:

C20H24O4

Molecular Weight:

328.4022

MDL Number:

MFCD09953803

IUPAC Name:

4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol

InChI:

InChI=1S/C20H24O4/c1-13(8-15-4-6-17(21)19(10-15)22-3)14(2)9-16-5-7-18-20(11-16)24-12-23-18/h4-7,10-11,13-14,21H,8-9,12H2,1-3H3/t13-,14+/m0/s1

InChI Key:

QDDILOVMGWUNGD-UONOGXRCSA-N

SMILES:

COc1cc(ccc1O)C[C@@H]([C@@H](Cc1ccc2c(c1)OCO2)C)C

UNII:

8PP3614Z43

Complexity:

388

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

328.167g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

328.408g/mol

Monoisotopic Mass:

328.167g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

47.9A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

5.2

Title	Journal
Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.	Inflammation 20121001
Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts.	Biological & pharmaceutical bulletin 20120101
Macelignan inhibits melanosome transfer mediated by protease-activated receptor-2 in keratinocytes.	Biological & pharmaceutical bulletin 20110101
Determination of macelignan in rat plasma by high-performance liquid chromatography with ultraviolet detection.	Archives of pharmacal research 20080701
Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis.	Biological & pharmaceutical bulletin 20080501
Structure and estrogenic activity of new lignans from Iryanthera lancifolia.	Bioorganic & medicinal chemistry 20080315
In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria.	Phytotherapy research : PTR 20080301
Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.	Diabetes 20080301
Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation.	Biological & pharmaceutical bulletin 20080201
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.	Bioorganic & medicinal chemistry letters 20080101
Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage.	BioFactors (Oxford, England) 20070101
Microsphere-based protease assays and screening application for lethal factor and factor Xa.	Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301
Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells.	Biochemical and biophysical research communications 20050617