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Gadoteridol

CAS No.:
120066-54-8
Catalog Number:
AG008TM1
Molecular Formula:
C17H28GdN4O7
Molecular Weight:
557.6768
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Product Description
Catalog Number:
AG008TM1
Chemical Name:
Gadoteridol
CAS Number:
120066-54-8
Molecular Formula:
C17H28GdN4O7
Molecular Weight:
557.6768
MDL Number:
MFCD01725526
IUPAC Name:
2-[4,7-bis(carboxylatomethyl)-10-(2-hydroxypropyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+)
InChI:
InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3
InChI Key:
DPNNNPAKRZOSMO-UHFFFAOYSA-K
SMILES:
CC1C[N]23[Gd+3]45678(O1)[O-]C(=O)C[N]8(CC[N]7(CC2)CC(=O)[O-]4)CC[N]6(CC3)CC(=O)[O-]5
Properties
Complexity:
471  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
559.128g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
558.69g/mol
Monoisotopic Mass:
559.128g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
154A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Preoperative imaging of anterior shoulder instability: diagnostic effectiveness of MDCT arthrography and comparison with MR arthrography and arthroscopy. AJR. American journal of roentgenology 20120301
Ocular pharmacokinetic study using T₁ mapping and Gd-chelate- labeled polymers. Pharmaceutical research 20111201
Contrast visibility for indirect MR arthrography with different protein contents and agent relaxivities at different field strengths: an in vitro model. European journal of radiology 20111101
Spectral presaturation inversion recovery MR imaging sequence after gadolinium injection to differentiate fibrotic scar tissue and neoplastic strands in the mesorectal fat in patients undergoing restaging of rectal carcinoma after neoadjuvant chemo- and radiation therapy. Academic radiology 20111101
Diamagnetically trapped arrays of living cells above micromagnets. Lab on a chip 20110921
Improved paramagnetic liposomes for MRI visualization of pH triggered release. Journal of controlled release : official journal of the Controlled Release Society 20110905
Perfusion imaging with a freely diffusible hyperpolarized contrast agent. Magnetic resonance in medicine 20110901
MR evaluation of retroperitoneal fibrosis. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20110801
Magnetic resonance evaluation of brain metastases from systemic malignances with two doses of gadobutrol 1.0 m compared with gadoteridol: a multicenter, phase ii/iii study in patients with known or suspected brain metastases. Investigative radiology 20110701
Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy. Radiology 20110501
Imaging patients with kidney disease: how do we approach contrast-related toxicity? The American journal of the medical sciences 20110301
Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes. Bioorganic & medicinal chemistry 20110201
Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101
Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101
Effect of different classes of gadolinium-based contrast agents on control and nephrogenic systemic fibrosis-derived fibroblast proliferation. Radiology 20100901
Dual-energy CT for the assessment of chronic myocardial infarction in patients with chronic coronary artery disease: comparison with 3-T MRI. AJR. American journal of roentgenology 20100901
In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes. Journal of controlled release : official journal of the Controlled Release Society 20100615
Crystallization of the pneumococcal autolysin LytC: in-house phasing using novel lanthanide complexes. Acta crystallographica. Section F, Structural biology and crystallization communications 20100401
Gadoteridol-induced anaphylaxis - not a class allergy. Allergy 20100101
Three-dimensional multiphase time-resolved low-dose contrast-enhanced magnetic resonance angiography using TWIST on a 32-channel coil at 3 T: a quantitative and qualitative comparison of a conventional gadolinium chelate with a high-relaxivity agent. Journal of computer assisted tomography 20100101
Detection of bone metastases in non-small cell lung cancer patients: comparison of whole-body diffusion-weighted imaging (DWI), whole-body MR imaging without and with DWI, whole-body FDG-PET/CT, and bone scintigraphy. Journal of magnetic resonance imaging : JMRI 20090801
MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema. Microvascular research 20090501
Effects of radiation on the NMR relaxation effects of aqueous solutions of gadolinium contrast agents. Contrast media & molecular imaging 20090101
Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model. Molecular pharmaceutics 20090101
Non-small cell lung cancer: whole-body MR examination for M-stage assessment--utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT. Radiology 20080801
Nephrogenic systemic fibrosis in Japan: advisability of keeping the administered dose as low as possible. Radiology 20080601
Risk for nephrogenic systemic fibrosis with gadoteridol (ProHance) in patients who are on long-term hemodialysis. Clinical journal of the American Society of Nephrology : CJASN 20080501
How should nephrologists approach gadolinium-based contrast imaging in patients with kidney disease? Clinical journal of the American Society of Nephrology : CJASN 20080501
MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels. Microvascular research 20080501
Comparison between gadolinium and iodine contrast for percutaneous intervention in atherosclerotic renal artery stenosis: clinical outcomes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080401
Stability of gadolinium chelates and their biological consequences: new data and some comments. The British journal of radiology 20080301
Response to the FDA's May 23, 2007, nephrogenic systemic fibrosis update. Radiology 20080101
Determination of water permeability of paramagnetic liposomes of interest in MRI field. Journal of inorganic biochemistry 20080101
[The Grenelle of MR contrast agents?]. Journal de radiologie 20071101
Contrast enhanced cartilage imaging: Comparison of ionic and non-ionic contrast agents. European journal of radiology 20070701
Gain in signal-to-noise for first-pass contrast-enhanced abdominal MR angiography at 3 Tesla over standard 1.5 Tesla: prediction with a computer model. Academic radiology 20070701
[Acute renal failure after gadolinium-containing contrast medium in preexisting chronic renal failure stage II]. Medizinische Klinik (Munich, Germany : 1983) 20070615
Ab initio simulation of a gadolinium-based magnetic resonance imaging contrast agent in aqueous solution. The Journal of chemical physics 20070514
Quantitative assessment of regional left ventricular function with cardiac MRI: three-dimensional centersurface method. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20070401
Indirect MR lymphangiography of the head and neck using conventional gadolinium contrast: a pilot study in humans. International journal of radiation oncology, biology, physics 20061001
Pharmacokinetic parameters as a potential predictor of response to pharmacotherapy in benign prostatic hyperplasia: a preclinical trial using dynamic contrast-enhanced MRI. Magnetic resonance imaging 20060701
Gadolinium-enhanced MR images of the growing piglet skeleton: ionic versus nonionic contrast agent. Radiology 20060501
Quantitative imaging of proteoglycan in cartilage using a gadolinium probe and microCT. Osteoarthritis and cartilage 20060301
Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications. Investigative radiology 20060301
Gd-enhanced MR images of substrates other than water. Contrast media & molecular imaging 20060101
Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents. Contrast media & molecular imaging 20060101
Synthesis and relaxivity studies of a tetranuclear gadolinium(III) complex of DO3A as a contrast-enhancing agent for MRI. Inorganic chemistry 20051212
Effect of tamoxifen in an experimental model of breast tumor studied by dynamic contrast-enhanced magnetic resonance imaging and different contrast agents. Investigative radiology 20050701
Effect of the transmural extent of myocardial scar on left ventricular systolic wall thickening during intravenous dobutamine administration. The American journal of cardiology 20050215
Measurement of serum calcium concentration after administration of gadoversetamide in dogs. Radiology 20041001
Benign prostate hyperplasia: evaluation of treatment response with DCE MRI. Magma (New York, N.Y.) 20040901
Heavy-atom derivatives in lipidic cubic phases: results on hen egg-white lysozyme tetragonal derivative crystals with Gd-HPDO3A complex. Acta crystallographica. Section D, Biological crystallography 20040801
Flow-injection EPR investigation on OH radical scavenging activity of Gd(III) containing MRI contrast media. Journal of medicine 20040101
Contrast use at low field: a review. Topics in magnetic resonance imaging : TMRI 20031001
Noninvasive measurement of absolute renal perfusion by contrast medium-enhanced magnetic resonance imaging. Investigative radiology 20030901
[Gadolinium in arteriography and interventional radiology: 39 patients]. Journal de radiologie 20021101
Electrocardiographic effects of diagnostic imaging agents. Academic radiology 20020801
Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. Psychiatry research 20020615
Gd-HPDO3A, a complex to obtain high-phasing-power heavy-atom derivatives for SAD and MAD experiments: results with tetragonal hen egg-white lysozyme. Acta crystallographica. Section D, Biological crystallography 20020101
Phase III, randomized, double-blind, cross-over comparison of gadoteridol and gadopentetate dimeglumine in magnetic resonance imaging of patients with intracranial lesions. Australasian radiology 20011101
Vascular response to gadolinium-containing contrast media in an ex vivo rabbit arterial model. Investigative radiology 20011001
Comparison of aerosolized gadoteridol and gadopentetate dimeglumine for magnetic resonance ventilation imaging of the lung. Magnetic resonance in medicine 20011001
Central nervous system: review of clinical use of contrast media. Topics in magnetic resonance imaging : TMRI 20010801
Cocaine-induced cerebral vasoconstriction differs as a function of sex and menstrual cycle phase. Biological psychiatry 20010501
Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. Magma (New York, N.Y.) 20010501
Cardiovascular effects caused by rapid administration of gadoversetamide injection in anesthetized dogs. Investigative radiology 20010501
Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet (London, England) 20010106
Acute cardiotoxicity of gadolinium-based contrast media: findings in the isolated rat heart. Academic radiology 19970401
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