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Home Other Building Blocks GSK-2110183C

GSK-2110183C

CAS No.:
1047644-62-1
Catalog Number:
AG008TDA
Molecular Formula:
C18H17Cl2FN4OS
Molecular Weight:
427.3232
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
2mg
99+%
1 week
United States
$69
- +
5mg
99+%
1 week
United States
$112
- +
10mg
99+%
1 week
United States
$150
- +
50mg
99+%
1 week
United States
$450
- +
100mg
99%
1 week
United States
$840
- +
Product Description
Catalog Number:
AG008TDA
Chemical Name:
GSK-2110183C
CAS Number:
1047644-62-1
Molecular Formula:
C18H17Cl2FN4OS
Molecular Weight:
427.3232
MDL Number:
MFCD26961098
IUPAC Name:
N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
InChI:
InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1
InChI Key:
AFJRDFWMXUECEW-LBPRGKRZSA-N
SMILES:
NCC(NC(=O)c1sc(c(c1)c1c(Cl)cnn1C)Cl)Cc1cccc(c1)F
UNII:
8739X25QI3
Properties
Complexity:
520  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
426.048g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
427.319g/mol
Monoisotopic Mass:
426.048g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
101A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood 20141002
Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PloS one 20140101
Properties