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Dalfopristin

CAS No.:
112362-50-2
Catalog Number:
AG008T3Q
Molecular Formula:
C34H50N4O9S
Molecular Weight:
690.8472
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%
1 week
United States
$490
- +
5mg
98%
1 week
United States
$1490
- +
10mg
98%
1 week
United States
$2557
- +
Product Description
Catalog Number:
AG008T3Q
Chemical Name:
Dalfopristin
CAS Number:
112362-50-2
Molecular Formula:
C34H50N4O9S
Molecular Weight:
690.8472
MDL Number:
MFCD00895414
IUPAC Name:
(6R,7S,10R,11R,12E,17E,19E,21S)-6-[2-(diethylamino)ethylsulfonyl]-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone
InChI:
InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1
InChI Key:
SUYRLXYYZQTJHF-VMBLUXKRSA-N
SMILES:
CCN(CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H](C(C)C)[C@H](C)/C=C/C(=O)NC/C=C\C(=C\[C@H](CC(=O)Cc1nc(C2=O)co1)O)\C)CC
UNII:
R9M4FJE48E
Properties
Complexity:
1340  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
3  
Exact Mass:
690.33g/mol
Formal Charge:
0
Heavy Atom Count:
48  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
690.853g/mol
Monoisotopic Mass:
690.33g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
185A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
[In vitro activities of quinupristin/dalfopristin in combination with vancomycin and gatifloxacin against Staphylococcus aureus and Enterococcus faecium clinical isolates]. Mikrobiyoloji bulteni 20090101
New treatment options and protocols for peritoneal dialysis-related peritonitis. Contributions to nephrology 20090101
[Persistent bacteremia caused by methicillin-resistant Staphylococcus aureus]. Enfermedades infecciosas y microbiologia clinica 20081101
A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080601
Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids. The Journal of antimicrobial chemotherapy 20070801
[Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens]. Recenti progressi in medicina 20070301
In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus. Indian journal of medical microbiology 20070101
Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061201
Prevalence of macrolide resistance genes among staphylococci in Cyprus. Journal of chemotherapy (Florence, Italy) 20061001
Emergence of Enterococcus faecalis susceptible to quinupristin/dalfopristin in Greece. International journal of antimicrobial agents 20060801
Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis originating from endodontic infections in Finland and Lithuania. Oral microbiology and immunology 20060601
In vitro activity of quinupristin and dalfopristin in combination and alone against coryneform bacteria. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051101
In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) from Malaysian hospitals. The Medical journal of Malaysia 20051001
Emergence of Staphylococcus hominis strains expressing low-level resistance to quinupristin/dalfopristin in Greece. The Journal of antimicrobial chemotherapy 20050501
In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections. The Journal of antimicrobial chemotherapy 20050201
In vitro activity of linezolid & quinupristin/dalfopristin against Gram-positive cocci. The Indian journal of medical research 20041201
In vitro activity of telithromycin, quinupristin/dalfopristin, linezolid and comparator antimicrobial agents against Staphylococcus aureus clinical isolates. Journal of chemotherapy (Florence, Italy) 20040601
Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. BMC biology 20040101
Sequence and genetic organization of the 19.3-kb erythromycin- and dalfopristin-resistance plasmid pLME300 from Lactobacillus fermentum ROT1. Plasmid 20031101
What is the role of streptogramins in intensive care? Journal of chemotherapy (Florence, Italy) 20031101
Role of quinupristin/dalfopristin in the treatment of Gram-positive nosocomial infections in haematological or oncological patients. Cancer treatment reviews 20031001
Quinupristin/dalfopristin-induced Sweet's syndrome. The Korean journal of internal medicine 20030901
Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. The Journal of biological chemistry 20030808
Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin. Southern medical journal 20030801
Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. The Journal of parasitology 20030801
Treatment of central nervous system infection by vancomycin-resistant enterococcus faecium. Diagnostic microbiology and infectious disease 20030301
[Other antimicrobial agents (linezolid, quinupristin/dalfopristin, glycylcycline etc)]. Nihon rinsho. Japanese journal of clinical medicine 20030301
[Other antimicrobials (linezolid, quinupristin/dalfopristin)]. Nihon rinsho. Japanese journal of clinical medicine 20030201
Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report. Infection 20021001
Comparative in vitro activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, pristinamycin, quinupristin-dalfopristin and linezolid against ofloxacin-intermediate and -resistant Streptococcus pneumoniae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021001
Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients. The Pediatric infectious disease journal 20021001
Quinupristin/dalfopristin. Expert opinion on pharmacotherapy 20020901
Clinical experience with quinupristin-dalfopristin as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci. Intensive care medicine 20020801
Combination of quinupristin/dalfopristin and glycopeptide in severe methicillin-resistant staphylococcal infections failing previous glycopeptide regimens. Infection 20020601
[symbol: see text]Quinupristin + dalfopristin for infections. Drug and therapeutics bulletin 20020201
Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections. American family physician 20011201
Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens. The New England journal of medicine 20011018
Antibiotic resistance rates and macrolide resistance phenotypes of viridans group streptococci from the oropharynx of healthy Greek children. International journal of antimicrobial agents 20010301
Antistaphylococcal (MSSA, MRSA, MSSE, MRSE) antibiotics. The Medical clinics of North America 20010101
Quinupristin/dalfopristin: a therapeutic review. Clinical therapeutics 20010101
Macrolide resistance in Streptococcus pyogenes isolates from throat infections in the region of Aachen, Germany. Microbial drug resistance (Larchmont, N.Y.) 20010101
Quinupristin/dalfopristin and linezolid: spectrum of activity and potential roles in therapy--a status report. Current clinical topics in infectious diseases 20010101
[Quinupristin/dalfopristin]. Revista de medicina de la Universidad de Navarra 20010101
Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs 19991201
Quinupristin-dalfopristin is active against Toxoplasma gondii. Antimicrobial agents and chemotherapy 19990801
Properties