Home Other Building Blocks N-Desmethyl-cis-tramadol HCl

N-Desmethyl-cis-tramadol HCl

CAS No.:
1018989-94-0
Catalog Number:
AG008T2B
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG008T2B
Chemical Name:
N-Desmethyl-cis-tramadol HCl
CAS Number:
1018989-94-0
MDL Number:
MFCD03788593
IUPAC Name:
(1R,2R)-1-(3-methoxyphenyl)-2-(methylaminomethyl)cyclohexan-1-ol;hydrochloride
InChI:
InChI=1S/C15H23NO2.ClH/c1-16-11-13-6-3-4-9-15(13,17)12-7-5-8-14(10-12)18-2;/h5,7-8,10,13,16-17H,3-4,6,9,11H2,1-2H3;1H/t13-,15+;/m1./s1
InChI Key:
NOZLWRHUQJHIRG-PBCQUBLHSA-N
Properties
Complexity:
259  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
285.15g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
285.812g/mol
Monoisotopic Mass:
285.15g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
41.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients. British journal of clinical pharmacology 20121101
False-positive urine phencyclidine immunoassay screen result caused by interference by tramadol and its metabolites. Annals of emergency medicine 20120601
Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101
Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. Clinical pharmacology and therapeutics 20110701
Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses. American journal of veterinary research 20110701
Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics. Chirality 20110401
Quantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication. Journal of analytical toxicology 20101101
Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study. Veterinary journal (London, England : 1997) 20090501
Enantioselective determination of tramadol and its main phase I metabolites in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315
Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers. Biopharmaceutics & drug disposition 20071201
Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods and findings in experimental and clinical pharmacology 20070501
Stereoselective pharmacokinetic analysis of tramadol and its main phase I metabolites in healthy subjects after intravenous and oral administration of racemic tramadol. Biopharmaceutics & drug disposition 20070101
Maturational changes in the in vivo activity of CYP3A4 in the first months of life. International journal of clinical pharmacology and therapeutics 20060701
Properties