NSC 23766 trihydrochloride
| Title | Journal |
|---|---|
| Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. | Clinical science (London, England : 1979) 20121001 |
| Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury. | Urological research 20120801 |
| A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. | Journal of molecular and cellular cardiology 20120801 |
| ROCK1 feedback regulation of the upstream small GTPase RhoA. | Cellular signalling 20120701 |
| Maladaptive dendritic spine remodeling contributes to diabetic neuropathic pain. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120516 |
| Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. | The Journal of biological chemistry 20120413 |
| NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus. | American journal of physiology. Endocrinology and metabolism 20120215 |
| Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling. | American journal of physiology. Lung cellular and molecular physiology 20120215 |
| Enucleation of human erythroblasts involves non-muscle myosin IIB. | Blood 20120126 |
| Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. | Blood 20111110 |
| Mediation of Rac1 activation by kindlin-2: an essential function in osteoblast adhesion, spreading, and proliferation. | Journal of cellular biochemistry 20110901 |
| Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. | Nature cell biology 20110901 |
| Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1. | Journal of neuro-oncology 20110801 |
| Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology. | Brain research 20110705 |
| Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice. | Biochimica et biophysica acta 20110701 |
| Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110209 |
| Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1. | American journal of physiology. Regulatory, integrative and comparative physiology 20110101 |
| Novel inhibitors of Rac1 in metastatic breast cancer. | Puerto Rico health sciences journal 20101201 |
| Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium. | American journal of physiology. Lung cellular and molecular physiology 20100401 |
| Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque. | Journal of translational medicine 20100101 |
| Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown. | Journal of cellular physiology 20090901 |
| Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells. | Cancer science 20090901 |
| Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. | Journal of neuroscience research 20090701 |
| Rac1 activates HIF-1 in retinal pigment epithelium cells under hypoxia. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090501 |
| Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells. | Biochemical pharmacology 20090101 |
| Signaling through Rho GTPase pathway as viable drug target. | Current medicinal chemistry 20090101 |
| Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. | Nature medicine 20081201 |
| Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling. | American journal of physiology. Cell physiology 20081101 |
| Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice. | Experimental physiology 20081001 |
| Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. | Circulation research 20080815 |
| Prostaglandin E2-mediated migration of human trophoblast requires RAC1 and CDC42. | Biology of reproduction 20080601 |
| Impact of the FcgammaII-receptor on quartz uptake and inflammatory response by alveolar macrophages. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| Involvement of Rac in fenretinide-induced apoptosis. | Cancer research 20080601 |
| The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. | Planta 20080401 |
| TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species. | American journal of physiology. Gastrointestinal and liver physiology 20080401 |
| The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression. | American journal of physiology. Renal physiology 20080201 |
| Yersinia controls type III effector delivery into host cells by modulating Rho activity. | PLoS pathogens 20080101 |
| Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. | Journal of muscle research and cell motility 20080101 |
| Ultrastructural analysis of the interaction between F-actin and respiratory syncytial virus during virus assembly. | Virology 20071220 |
| Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. | Journal of thrombosis and haemostasis : JTH 20070801 |
| Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction. | Biochemical pharmacology 20070630 |
| Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20070401 |
| Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. | Nature cell biology 20070301 |
| Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. | American journal of nephrology 20070101 |
| RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. | The Journal of biological chemistry 20051111 |
| Observations on the distribution of visual pigments in Amphibia. | Comparative biochemistry and physiology. A, Comparative physiology 19751201 |