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Home Other Building Blocks JZL 195

JZL 195

CAS No.:
1210004-12-8
Catalog Number:
AG008SS1
Molecular Formula:
C24H24ClN3O5
Molecular Weight:
469.9175
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$123
- +
10mg
≥98%
1 week
United States
$183
- +
50mg
≥98%
1 week
United States
$590
- +
100mg
≥98%
1 week
United States
$990
- +
Product Description
Catalog Number:
AG008SS1
Chemical Name:
JZL 195
CAS Number:
1210004-12-8
Molecular Formula:
C24H24ClN3O5
Molecular Weight:
469.9175
MDL Number:
MFCD18382122
IUPAC Name:
(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
InChI:
InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
InChI Key:
QNYRAEKLMNDRFY-UHFFFAOYSA-N
SMILES:
O=C(N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1)Oc1ccc(cc1)[N+](=O)[O-].Cl
Properties
Complexity:
605  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
433.164g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
433.464g/mol
Monoisotopic Mass:
433.164g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
87.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3  
Literature
Title Journal
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. British journal of pharmacology 20160101
Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice. The Journal of pharmacology and experimental therapeutics 20150801
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20150701
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nature chemical biology 20140801
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology 20140601
Assay and inhibition of diacylglycerol lipase activity. Bioorganic & medicinal chemistry letters 20120715
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. Journal of medicinal chemistry 20100225
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences of the United States of America 20091201
Properties