JZL 184
| Title | Journal |
|---|---|
| Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model. | British journal of pharmacology 20160101 |
| Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20151001 |
| Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice. | The Journal of pharmacology and experimental therapeutics 20150801 |
| The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20150701 |
| Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | Nature communications 20140101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. | Biochemical pharmacology 20121101 |
| Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold. | Bioorganic & medicinal chemistry 20121101 |
| Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats. | European journal of pharmacology 20120915 |
| The temporal dynamics of the effects of monoacylglycerol lipase blockade on locomotion, anxiety, and body temperature. | Behavioural pharmacology 20120801 |
| Assay and inhibition of diacylglycerol lipase activity. | Bioorganic & medicinal chemistry letters 20120715 |
| Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. | Neuron 20120607 |
| Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | Chemistry & biology 20120525 |
| Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. | ACS chemical neuroscience 20120516 |
| Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120411 |
| Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. | British journal of pharmacology 20120401 |
| Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability. | British journal of pharmacology 20120401 |
| Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120214 |
| Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors. | Journal of medicinal chemistry 20120126 |
| Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111201 |
| The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors. | Bioorganic & medicinal chemistry letters 20111115 |
| Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. | Science (New York, N.Y.) 20111111 |
| Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. | The Journal of pharmacology and experimental therapeutics 20111001 |
| Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. | Pharmacological research 20110901 |
| Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | Biological psychiatry 20110901 |
| Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | British journal of pharmacology 20110801 |
| Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | British journal of pharmacology 20110801 |
| Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110801 |
| Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | Pharmacological research 20110701 |
| Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | Toxicological sciences : an official journal of the Society of Toxicology 20110701 |
| Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. | European journal of pharmacology 20110511 |
| Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. | Neuroscience 20110331 |
| Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. | Pharmacology, biochemistry, and behavior 20110301 |
| Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. | Chemical research in toxicology 20101220 |
| Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays. | British journal of pharmacology 20101201 |
| Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | Pharmacological research 20100901 |
| Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. | Nature neuroscience 20100901 |
| High-performance liquid chromatography assay with fluorescence detection for the evaluation of inhibitors against human recombinant monoacylglycerol lipase. | Analytical biochemistry 20100415 |
| Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors. | Journal of medicinal chemistry 20100311 |
| Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. | Journal of medicinal chemistry 20100225 |
| Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. | Journal of medicinal chemistry 20091210 |
| Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. | Molecular pharmacology 20091201 |
| Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | Proceedings of the National Academy of Sciences of the United States of America 20091201 |
| Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. | Chemistry & biology 20090731 |
| Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. | The AAPS journal 20090601 |
| Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | Nature chemical biology 20090101 |