Home Other Building Blocks Gabazine Hydrobromide

Gabazine Hydrobromide

CAS No.:
104104-50-9
Catalog Number:
AG008SG4
Molecular Formula:
C15H18BrN3O3
Molecular Weight:
368.2257
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$139
- +
10mg
98%
1 week
United States
$182
- +
25mg
≥98%
1 week
United States
$344
- +
50mg
98%
1 week
United States
$515
- +
100mg
98%
1 week
United States
$876
- +
Product Description
Catalog Number:
AG008SG4
Chemical Name:
Gabazine Hydrobromide
CAS Number:
104104-50-9
Molecular Formula:
C15H18BrN3O3
Molecular Weight:
368.2257
MDL Number:
MFCD09055424
IUPAC Name:
4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
InChI:
InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
InChI Key:
GFZHNFOGCMEYTA-UHFFFAOYSA-N
SMILES:
COc1ccc(cc1)c1ccc(=[NH2+])n(n1)CCCC(=O)O.[Br-]
UNII:
99460MG420
Properties
Complexity:
451  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
367.053g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
368.231g/mol
Monoisotopic Mass:
367.053g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
86A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation. Brain research 20150807
Interaction of NMDA receptors and L-type calcium channels during early odor preference learning in rats. The European journal of neuroscience 20121001
Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition. Journal of neurophysiology 20121001
Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120808
D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120801
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes. Diabetologia 20120701
Multiple novel modes of action involved in the in vitro neurotoxic effects of tetrabromobisphenol-A. Toxicological sciences : an official journal of the Society of Toxicology 20120701
Period coding of Bmal1 oscillators in the suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120627
Segregation of axonal and somatic activity during fast network oscillations. Science (New York, N.Y.) 20120615
Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. Neuron 20120607
Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120530
Phasic GABAA -receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus. Epilepsia 20120501
[Inhibitory regulation of glutamate receptors in the frog motoneuron]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20120501
Distinct cortical circuit mechanisms for complex forelimb movement and motor map topography. Neuron 20120426
Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418
Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid. American journal of physiology. Regulatory, integrative and comparative physiology 20120401
Activation of VTA GABA neurons disrupts reward consumption. Neuron 20120322
Interneurons provide circuit-specific depolarization and hyperpolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321
Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation. The Journal of biological chemistry 20120224
Spatially distinct actions of metabotropic glutamate receptor activation in dorsal lateral geniculate nucleus. Journal of neurophysiology 20120215
Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors. Journal of neurophysiology 20120201
Cellular mechanisms underlying spatiotemporal features of cholinergic retinal waves. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120118
Regulation of neuronal input transformations by tunable dendritic inhibition. Nature neuroscience 20120115
Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron 20120112
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area. Neuroscience 20120110
GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus. PloS one 20120101
Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb. PloS one 20120101
Gap junctions synchronize action potentials and Ca2+ transients in Caenorhabditis elegans body wall muscle. The Journal of biological chemistry 20111223
Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. American journal of physiology. Regulatory, integrative and comparative physiology 20111201
Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits. The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102
Differential roles of GABAergic and glycinergic input on FM selectivity in the inferior colliculus of the pallid bat. Journal of neurophysiology 20111101
GABA(B) restrains release from singly-evoked GABA terminals. Neuroscience 20111013
A diversity of synaptic filters are created by temporal summation of excitation and inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012
Effect of depolarizing GABA(A)-mediated membrane responses on excitability of Cajal-Retzius cells in the immature rat neocortex. Journal of neurophysiology 20111001
Cannabinoids modulate spontaneous synaptic activity in retinal ganglion cells. Visual neuroscience 20110901
Visual-induced excitation leads to firing pauses in striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803
Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727
The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720
Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531). Bioorganic & medicinal chemistry letters 20110715
Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615
Biphasic action of axonal GABA-A receptors on presynaptic calcium influx. Journal of neurophysiology 20110601
Control of programmed cell death by distinct electrical activity patterns. Cerebral cortex (New York, N.Y. : 1991) 20110501
GABAA inhibition controls response gain in visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110420
NMDA currents modulate the synaptic input-output functions of neurons in the dorsal nucleus of the lateral lemniscus in Mongolian gerbils. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110323
Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex. The Journal of physiology 20110301
Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110216
A circuit model for saccadic suppression in the superior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110209
Network oscillations in rod-degenerated mouse retinas. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110209
Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110201
Direct and indirect control of orexin/hypocretin neurons by glycine receptors. The Journal of physiology 20110201
Propofol alters vesicular transport in rat cortical neuronal cultures. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110201
Development of asymmetric inhibition underlying direction selectivity in the retina. Nature 20110120
Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105
Inhibitory plasticity underlies visual deprivation-induced loss of receptive field refinement in the adult superior colliculus. The European journal of neuroscience 20110101
The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum. Molecular brain 20110101
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience 20101229
Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208
Neuromodulatory effect of GnRH on the synaptic transmission of the olfactory bulbar neural circuit in goldfish, Carassius auratus. Journal of neurophysiology 20101201
Histamine regulates activities of neurons in the ventrolateral preoptic nucleus. The Journal of physiology 20101101
Electrophysiological effects of melatonin on mouse Per1 and non-Per1 suprachiasmatic nuclei neurones in vitro. Journal of neuroendocrinology 20101101
Histamine: from flop to flip-flop. The Journal of physiology 20101101
Local GABAergic modulation of the activity of serotoninergic neurons in the nucleus raphe magnus. Neuroscience and behavioral physiology 20101001
Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci. Nature neuroscience 20101001
Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). Organic & biomolecular chemistry 20100921
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition. Neuron 20100909
Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity. Experimental physiology 20100901
Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain research 20100806
Temporal patterns of inputs to cerebellum necessary and sufficient for trace eyelid conditioning. Journal of neurophysiology 20100801
The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate. Journal of neurophysiology 20100801
Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice. Epilepsia 20100801
Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of synchronized oscillations in the olfactory bulb. Journal of neurophysiology 20100801
Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit. Brain research 20100716
Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. The Journal of physiology 20100715
GABA shapes a systematic map of binaural sensitivity in the auditory cortex. Journal of neurophysiology 20100701
Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616
Dendritic Kv3.3 potassium channels in cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes. Journal of neurophysiology 20100601
Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria). Epilepsy research 20100601
Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526
Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100519
Excitation-transcription coupling via calcium/calmodulin-dependent protein kinase/ERK1/2 signaling mediates the coordinate induction of VGLUT2 and Narp triggered by a prolonged increase in glutamatergic synaptic activity. The Journal of biological chemistry 20100507
Munc13-2 differentially affects hippocampal synaptic transmission and plasticity. Cerebral cortex (New York, N.Y. : 1991) 20100501
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nature neuroscience 20100501
GABA(A) and GABA(B) receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca(2+). FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100401
alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation. Neuropharmacology 20100301
Sequential steps underlying neuronal plasticity induced by a transient exposure to gabazine. Journal of cellular physiology 20100301
Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217
Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217
Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. Neuroscience 20100120
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120
Feedforward inhibition determines the angular tuning of vibrissal responses in the principal trigeminal nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120
A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex. Proceedings of the National Academy of Sciences of the United States of America 20100105
Long-range effects of GABAergic inhibition in gerbil primary auditory cortex. The European journal of neuroscience 20100101
The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20100101
GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses. Neuroscience letters 20091218
Inactivating the middle cerebellar peduncle abolishes the expression of short-latency conditioned eyeblinks. Brain research 20091215
Effects of sciatic nerve axotomy on excitatory synaptic transmission in rat substantia gelatinosa. Journal of neurophysiology 20091201
Blocking GABAA neurotransmission in the interposed nuclei: effects on conditioned and unconditioned eyeblinks. Brain research 20091006
Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Autonomic neuroscience : basic & clinical 20091005
The timing of external input controls the sign of plasticity at local synapses. Nature neuroscience 20091001
Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo. Neuroscience 20090901
GABA shapes selectivity for the rate and direction of frequency-modulated sweeps in the auditory cortex. Journal of neurophysiology 20090901
Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons. Brain research 20090825
Short-latency cross- and autocorrelation identify clusters of interacting cortical neurons recorded from multi-electrode array. Journal of neuroscience methods 20090730
Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090715
Extrasynaptic release of GABA by retinal dopaminergic neurons. Journal of neurophysiology 20090701
Effects of sevoflurane on primary neuronal cultures of embryonic rats. European journal of anaesthesiology 20090701
Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701
Potentiating effect of eszopiclone on GABA(A) receptor-mediated responses in pedunculopontine neurons. Sleep 20090701
[Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090701
Synaptic properties of the mammillary and cortical afferents to the anterodorsal thalamic nucleus in the mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090617
Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics. Neuron 20090611
Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090610
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. Journal of applied physiology (Bethesda, Md. : 1985) 20090601
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission. Neuropharmacology 20090601
Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation. American journal of physiology. Cell physiology 20090601
Subthreshold glutamate release from mitral cell dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527
Synaptic and extrasynaptic factors governing glutamatergic retinal waves. Neuron 20090430
Mapping and identification of GABAergic neurons in transgenic mice projecting to cardiac vagal neurons in the nucleus ambiguus using photo-uncaging. Journal of neurophysiology 20090401
Distinct roles of metabotropic glutamate receptor activation on inhibitory signaling in the ventral lateral geniculate nucleus. Journal of neurophysiology 20090401
The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. Journal of applied physiology (Bethesda, Md. : 1985) 20090401
GABAAergic and glycinergic inhibition in the phrenic nucleus organizes and couples fast oscillations in motor output. Journal of neurophysiology 20090401
Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity. Nature neuroscience 20090401
Transformation of odor representations in target areas of the olfactory bulb. Nature neuroscience 20090401
Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation. Anesthesiology 20090401
Subcellular topography of visually driven dendritic activity in the vertebrate visual system. Neuron 20090326
GABAergic/glutamatergic-glial/neuronal interaction contributes to rapid adaptation in pacinian corpuscles. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090304
Slow glycinergic transmission mediated by transmitter pooling. Nature neuroscience 20090301
Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges. The European journal of neuroscience 20090301
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology 20090201
GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. Journal of neurophysiology 20090201
Anesthetics discriminate between tonic and phasic gamma-aminobutyric acid receptors on hippocampal CA1 neurons. Anesthesia and analgesia 20090201
Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology 20090201
Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats. The Journal of physiology 20090115
Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090114
Differential cAMP signaling at hippocampal output synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20081231
Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation. American journal of physiology. Lung cellular and molecular physiology 20081201
GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum. The Journal of physiology 20081201
Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse. Journal of neurophysiology 20081201
Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex. Journal of neurophysiology 20081101
D1-like dopamine receptors regulate GABAA receptor function to modulate hippocampal neural progenitor cell proliferation. Journal of neurochemistry 20081101
Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors. Molecular pharmacology 20081001
The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924
Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system. Neuroscience 20080922
Blockade of prostaglandin E2-induced thermogenesis by unilateral microinjection of GABAA receptor antagonist into the preoptic area. Brain research 20080916
Diencephalic locomotor region in the lamprey--afferents and efferent control. Journal of neurophysiology 20080901
SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons. The European journal of neuroscience 20080901
Dissociation constants for GABA(A) receptor antagonists determined with neuronal networks on microelectrode arrays. Journal of neuroscience methods 20080830
Recurrent inhibitory network among striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080827
Prostaglandin E(2) fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis. Pflugers Archiv : European journal of physiology 20080801
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat. The journal of pain : official journal of the American Pain Society 20080801
Pre- and postsynaptic serotoninergic excitation of globus pallidus neurons. Journal of neurophysiology 20080801
Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. Brain cell biology 20080801
Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesia. Brain research 20080718
The time course of transmitter at glycinergic synapses onto motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080716
Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces. Molecular pharmacology 20080701
Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific. Journal of neurophysiology 20080701
Pathway-dependent modulation by P2-purinoceptors in the mouse retina. The European journal of neuroscience 20080701
Multiple functions of GABA A and GABA B receptors during pattern processing in the zebrafish olfactory bulb. The European journal of neuroscience 20080701
High-frequency network oscillations in cerebellar cortex. Neuron 20080612
Developmental changes in the fidelity and short-term plasticity of GABAergic synapses in the neonatal rat dorsal horn. Journal of neurophysiology 20080601
Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats. The European journal of neuroscience 20080601
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks. The European journal of neuroscience 20080601
Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. The Journal of biological chemistry 20080530
Activation of A-type gamma-amino butyric acid receptors excites gonadotrophin-releasing hormone neurones isolated from adult rats. Journal of neuroendocrinology 20080501
Glycinergic synaptic currents in the deep cerebellar nuclei. Neuropharmacology 20080401
Single-photon absorptions evoke synaptic depression in the retina to extend the operational range of rod vision. Neuron 20080327
Imaging of glutamate in brain slices using FRET sensors. Journal of neuroscience methods 20080315
Influence of inhibitory inputs on rate and timing of responses in the anteroventral cochlear nucleus. Journal of neurophysiology 20080301
Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys. Journal of neurophysiology 20080301
GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments. Journal of neurophysiology 20080301
SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses. Nature neuroscience 20080201
Rhythm generation by the pre-Bötzinger complex in medullary slice and island preparations: effects of adenosine A(1) receptor activation. BMC neuroscience 20080101
Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats. American journal of physiology. Heart and circulatory physiology 20071201
Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20071128
Unilateral microdialysis of gabazine in the dorsal medulla reverses thermal prolongation of the laryngeal chemoreflex in decerebrate piglets. Journal of applied physiology (Bethesda, Md. : 1985) 20071101
Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). Journal of neurophysiology 20070901
Voltage imaging reveals the CA1 region at the CA2 border as a focus for epileptiform discharges and long-term potentiation in hippocampal slices. Journal of neurophysiology 20070901
Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells. Journal of neurophysiology 20070801
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons. The Journal of physiology 20070715
Role of ventrolateral medulla in generating the 10-Hz rhythm in sympathetic nerve discharge. American journal of physiology. Regulatory, integrative and comparative physiology 20070701
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. The Journal of physiology 20070615
In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. The Journal of physiology 20070601
Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats. Neuropharmacology 20070601
Differences in spike train variability in rat vasopressin and oxytocin neurons and their relationship to synaptic activity. The Journal of physiology 20070515
Modulation of inhibitory activity by nitric oxide in the thalamus. Journal of neurophysiology 20070501
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors. Naunyn-Schmiedeberg's archives of pharmacology 20070501
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. Journal of medicinal chemistry 20070419
The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531. The Journal of physiology 20070401
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension. Hypertension (Dallas, Tex. : 1979) 20070401
Effects of the GABA(A) receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitro. The European journal of neuroscience 20070401
Descending GABAergic projections to the mesencephalic locomotor region in the lamprey Petromyzon marinus. The Journal of comparative neurology 20070310
Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia. Journal of neurophysiology 20070301
Role of GABA A inhibition in modulation of pyramidal tract neuron activity during postural corrections. The European journal of neuroscience 20070301
Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro. Biochemical and biophysical research communications 20070216
Inhibiting the inhibition: a neuronal network for sound localization in reverberant environments. The Journal of neuroscience : the official journal of the Society for Neuroscience 20070214
GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207
GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury. Experimental neurology 20070201
Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating. Molecular pharmacology 20070201
Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 20070201
Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus. The Journal of physiology 20070115
Propagation of postsynaptic currents and potentials via gap junctions in GABAergic networks of the rat hippocampus. The Journal of physiology 20070115
Early functional development of interneurons in the zebrafish olfactory bulb. The European journal of neuroscience 20070101
Glycine receptors of A-type ganglion cells of the mouse retina. Visual neuroscience 20070101
Glycine receptor subunit composition alters the action of GABA antagonists. Visual neuroscience 20070101
Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus. Journal of neurophysiology 20061201
A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons. Brain research 20061106
Mapping of the functional interconnections between thalamic reticular neurons using photostimulation. Journal of neurophysiology 20061101
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology 20061001
The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells. Neuron 20060921
A new probe to monitor the effects of drugs on local field potentials. Journal of neuroscience methods 20060915
Medullary lateral tegmental field neurons influence the timing and pattern of phrenic nerve activity in cats. Journal of applied physiology (Bethesda, Md. : 1985) 20060801
Tonic GABA(A) receptor-mediated currents in human brain. The European journal of neuroscience 20060801
The adult rat hippocampal slice revisited with multi-electrode arrays. Brain research 20060622
Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060614
Functional GABA(A)-receptor-mediated inhibition in the neonatal dorsal horn. Journal of neurophysiology 20060601
The neurosteroid 3alphaDIOL modulates place preference when infused in the basolateral amygdala according to sex. Behavioral neuroscience 20060601
Central effects of the anabolic steroid 17alpha methyltestosterone in female anxiety. Pharmacology, biochemistry, and behavior 20060601
An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503
Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells. Journal of neurophysiology 20060501
Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb. Neuron 20060316
Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron 20060302
Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301
GABAA receptor antagonists prevent abnormalities in leptin, insulin and amylin actions on paraventricular hypothalamic neurons of overweight rats. The European journal of neuroscience 20060301
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex. Hearing research 20060201
Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. European journal of pharmacology 20060113
A postnatal switch in GABAergic control of spinal cutaneous reflexes. The European journal of neuroscience 20060101
Characterization of the glycinergic input to bipolar cells of the mouse retina. The European journal of neuroscience 20060101
Depression of retinogeniculate synaptic transmission by presynaptic D(2)-like dopamine receptors in rat lateral geniculate nucleus. The European journal of neuroscience 20060101
Slow oscillatory activity of rat globus pallidus neurons in vitro. The European journal of neuroscience 20060101
An ionotropic GABA receptor with novel pharmacology at bullfrog cone photoreceptor terminals. Neuro-Signals 20060101
Dissociated GABAergic retinal interneurons exhibit spontaneous increases in intracellular calcium. Visual neuroscience 20060101
GABAA receptor-mediated tonic inhibition in thalamic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20051214
GABAergic signaling to newborn neurons in dentate gyrus. Journal of neurophysiology 20051201
SK channel regulation of dendritic excitability and dendrodendritic inhibition in the olfactory bulb. Journal of neurophysiology 20051201
Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus. Journal of neurophysiology 20051201
Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex. Journal of neurophysiology 20051201
SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. The European journal of neuroscience 20051201
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro. Journal of neurophysiology 20051001
Mapping by laser photostimulation of connections between the thalamic reticular and ventral posterior lateral nuclei in the rat. Journal of neurophysiology 20051001
Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050914
Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050907
Millisecond-timescale, genetically targeted optical control of neural activity. Nature neuroscience 20050901
GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters. Journal of neurophysiology 20050801
Regulation of hippocampal synapse remodeling by epileptiform activity. Molecular and cellular neurosciences 20050801
Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus. Journal of neurophysiology 20050801
Mono- and dual-frequency fast cerebellar oscillation in mice lacking parvalbumin and/or calbindin D-28k. The European journal of neuroscience 20050801
Target-dependent use of co-released inhibitory transmitters at central synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713
Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706
Nanomolar allopregnanolone potentiates rat cerebellar GABAA receptors. Neuroscience letters 20050701
The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors. Journal of neurochemistry 20050701
Effects of chronic infusion of a GABAA receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig. The Journal of pharmacology and experimental therapeutics 20050601
Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked. Journal of neurophysiology 20050501
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323
Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices. The Journal of physiology 20050315
Dendritic sodium spikelets and low-threshold calcium spikes in turtle olfactory bulb granule cells. Journal of neurophysiology 20050301
Local calcium transients regulate the spontaneous motility of dendritic filopodia. Nature neuroscience 20050301
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050105
Movement-related discharge in the cerebellar nuclei persists after local injections of GABA(A) antagonists. Journal of neurophysiology 20050101
Factors accounting for perinatal occurrence of pulsatile gonadotropin-releasing hormone secretion in vitro in rats. Biology of reproduction 20050101
Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex. Hippocampus 20050101
Fast cerebellar oscillation associated with ataxia in a mouse model of Angelman syndrome. Neuroscience 20050101
GABA-mediated component in the feedback response of turtle retinal cones. Visual neuroscience 20050101
Feed-forward facilitation of glutamate release by presynaptic GABA(A) receptors. Neuroscience 20050101
Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica). Brain research 20041217
Pentobarbital induces thalamic oscillations in brain slices, modulated by GABA and glycine receptors. Neuropharmacology 20041201
Role of ionotropic glutamatergic and GABAergic inputs on the firing activity of neurons in the external pallidum in awake monkeys. Journal of neurophysiology 20041101
Cell type-specific synaptic dynamics of synchronized bursting in the juvenile CA3 rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20041027
The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network. Journal of neurophysiology 20041001
Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801
Slow actions of neuroactive steroids at GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728
GABA( A) synapses shape neuronal responses to sound intensity in the inferior colliculus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040526
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes 20040401
Mechanisms and significance of reduced activity and responsiveness in resting frog tadpoles. The Journal of experimental biology 20040301
Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices. Journal of neurophysiology 20040101
A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex. The Journal of biological chemistry 20031107
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe. The European journal of neuroscience 20031001
Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices. The Journal of physiology 20030801
Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons. Journal of neurophysiology 20030501
Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. Journal of neurophysiology 20030501
Temporal modulation of scotopic visual signals by A17 amacrine cells in mammalian retina in vivo. Journal of neurophysiology 20030401
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists. European journal of medicinal chemistry 20030401
Identified sources and targets of slow inhibition in the neocortex. Science (New York, N.Y.) 20030321
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner. Anesthesia and analgesia 20030301
Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide. Anesthesia and analgesia 20030301
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 20030201
Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201
Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei. Brain research 20030124
Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Molecular pharmacology 20030101
Competitive GABA(A) receptor antagonists increase the proportion of functional high-affinity alpha6 subunit-containing receptors in granule cells of adult rat cerebellum. Neuropharmacology 20030101
Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus. Neuroscience 20030101
The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. The European journal of neuroscience 20021101
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. The Journal of pharmacology and experimental therapeutics 20020901
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms. Neuropharmacology 20020901
Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature 20020822
Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions. The Journal of biological chemistry 20020524
Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020515
Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. Journal of neurophysiology 20020501
Functional independence of layer IV barrels. Journal of neurophysiology 20020201
GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions. The Journal of biological chemistry 20020125
Pallidal administrations of gabazine and 5-AVA affect pressure-induced behavioral disorders in rats. Pharmacology, biochemistry, and behavior 20020101
Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists. Biophysical journal 20011101
Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system. Journal of neurophysiology 20011001
Compartmental models of rat cerebellar Purkinje cells based on simultaneous somatic and dendritic patch-clamp recordings. The Journal of physiology 20010901
Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats. British journal of pharmacology 20010901
Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science (New York, N.Y.) 20010810
Paradoxical reduction of synaptic inhibition by vigabatrin. Journal of neurophysiology 20010801
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. British journal of pharmacology 20010601
Pharmacological study on recombinant human GABA-A receptor complex containing alpha5 (leucine155 to valine) combined with beta3gamma2s subunits. Acta pharmacologica Sinica 20010601
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs. The Journal of physiology 20010501
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Molecular pharmacology 20010401
Comparison of N2O- and chlordiazepoxide-induced behaviors in the light/dark exploration test. Pharmacology, biochemistry, and behavior 20010401
Glycine receptor mediated responses in rat histaminergic neurons. Neuroscience letters 20010302
Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors. European journal of pharmacology 20010105
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 20010104
Multireceptor GABAergic regulation of synaptic communication in amphibian retina. The Journal of physiology 20010101
Clozapine inhibits synaptic transmission at GABAergic synapses established by ventral tegmental area neurones in culture. Neuropharmacology 20000710
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Molecular pharmacology 19970901
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