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LOXIGLUMIDE

CAS No.:
107097-80-3
Catalog Number:
AG008S1Q
Molecular Formula:
C21H30Cl2N2O5
Molecular Weight:
461.3793
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$118
- +
10mg
≥98%
1 week
United States
$154
- +
25mg
≥98%
1 week
United States
$286
- +
50mg
≥98%
1 week
United States
$454
- +
100mg
98%
1 week
United States
$757
- +
Product Description
Catalog Number:
AG008S1Q
Chemical Name:
LOXIGLUMIDE
CAS Number:
107097-80-3
Molecular Formula:
C21H30Cl2N2O5
Molecular Weight:
461.3793
MDL Number:
MFCD00866772
IUPAC Name:
4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
InChI:
InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)
InChI Key:
QNQZBKQEIFTHFZ-UHFFFAOYSA-N
SMILES:
CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC
Properties
Complexity:
550  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
460.153g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
461.38g/mol
Monoisotopic Mass:
460.153g/mol
Rotatable Bond Count:
14  
Topological Polar Surface Area:
95.9A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
Literature
Title Journal
Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats. Alcoholism, clinical and experimental research 20100201
The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy. International journal of surgery (London, England) 20090401
Cholecystokinin hyperresponsiveness in functional dyspepsia. World journal of gastroenterology 20060507
Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their 'receptor desmodynamic processes'. Journal of medicinal chemistry 20060420
Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 20060301
Role of cholecystokinin in appetite control and body weight regulation. Obesity reviews : an official journal of the International Association for the Study of Obesity 20051101
[New aspects of pharmaco-therapy for acute pancreatitis]. Nihon rinsho. Japanese journal of clinical medicine 20041101
Use of a hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography. Journal of chromatography. A 20041008
Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide. The Journal of pharmacology and experimental therapeutics 20040701
Long-term bile diversion enhances basal and duodenal oleate-stimulated pancreatic exocrine secretion in dogs. The Tohoku journal of experimental medicine 20040601
Sensitive SPE-HPLC method to determine a novel angiotensin-AT1 antagonist in biological samples. Journal of pharmaceutical and biomedical analysis 20040416
The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits. Nutritional neuroscience 20040401
Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats. American journal of physiology. Gastrointestinal and liver physiology 20031001
CCK-1 receptor blockade for treatment of biliary colic: a pilot study. Alimentary pharmacology & therapeutics 20030801
Effect of cholecystokinin1 receptor antagonist loxiglumide (CR1505) on basal pancreatic exocrine secretion in conscious rats. Pancreas 20030101
Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Digestive diseases and sciences 20021101
Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20021001
Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan. Pancreas 20020701
Inhibitory effect of loxiglumide (CR 1505), a cholecystokinin receptor antagonist, on N-nitrosobis(2-oxopropyl) amine-induced biliary carcinogenesis in Syrian hamsters. World journal of surgery 20020301
Transient lower oesophageal sphincter relaxations--a pharmacological target for gastro-oesophageal reflux disease? Alimentary pharmacology & therapeutics 20020101
The effect of cholecystokinin antagonism on postprandial lower oesophageal sphincter function in asymptomatic volunteers and patients with reflux disease. Alimentary pharmacology & therapeutics 20010901
Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. American journal of physiology. Regulatory, integrative and comparative physiology 20010401
Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs. American journal of physiology. Gastrointestinal and liver physiology 20010401
Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients. Scandinavian journal of gastroenterology 20010301
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Regulatory peptides 19990630
Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat. Journal of clinical gastroenterology 19980101
Pharmacological profile of T-0632, a novel potent and selective CCKA receptor antagonist, in vitro. European journal of pharmacology 19960523
Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist. British journal of pharmacology 19960401
Pharmacological profile of FK480, a novel cholecystokinin type-A receptor antagonist: comparison to loxiglumide. The Journal of pharmacology and experimental therapeutics 19940201
Pharmacological characterisation of a new potent and specific nonpolypeptidic cholecystokinin antagonist. Arzneimittel-Forschung 19870601
Properties