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Home Other Building Blocks 2'-HYDROXY-3,4,4'-TRIMETHOXYCHALCONE

2'-HYDROXY-3,4,4'-TRIMETHOXYCHALCONE

CAS No.:
10493-06-8
Catalog Number:
AG008RR5
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG008RR5
Chemical Name:
2'-HYDROXY-3,4,4'-TRIMETHOXYCHALCONE
CAS Number:
10493-06-8
MDL Number:
MFCD00205556
IUPAC Name:
(E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
InChI:
InChI=1S/C18H18O5/c1-21-13-6-7-14(16(20)11-13)15(19)8-4-12-5-9-17(22-2)18(10-12)23-3/h4-11,20H,1-3H3/b8-4+
InChI Key:
SKTAHPCCLORHHM-XBXARRHUSA-N
NSC Number:
91849
Properties
Complexity:
408  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
314.115g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
314.337g/mol
Monoisotopic Mass:
314.115g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
65A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8  
Literature
Title Journal
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. Bioorganic & medicinal chemistry letters 20120715
Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. Journal of medicinal chemistry 20120412
Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorganic & medicinal chemistry 20120101
Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. Bioorganic & medicinal chemistry 20091115
Properties