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ML-9 HYDROCHLORIDE

CAS No.:
105637-50-1
Catalog Number:
AG008RE3
Molecular Formula:
C15H18Cl2N2O2S
Molecular Weight:
361.2866
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Product Description
Catalog Number:
AG008RE3
Chemical Name:
ML-9 HYDROCHLORIDE
CAS Number:
105637-50-1
Molecular Formula:
C15H18Cl2N2O2S
Molecular Weight:
361.2866
MDL Number:
MFCD00065525
IUPAC Name:
1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride
InChI:
InChI=1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI Key:
ZNRYCIVTNLZOGI-UHFFFAOYSA-N
SMILES:
Clc1cccc2c1cccc2S(=O)(=O)N1CCNCCC1.Cl
UNII:
BZ2L6JK93I
NSC Number:
734549
Properties
Complexity:
451  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
360.047g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
361.281g/mol
Monoisotopic Mass:
360.047g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
57.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium. American journal of physiology. Heart and circulatory physiology 20061001
Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain. Journal of cardiovascular pharmacology 20060701
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Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. The Biochemical journal 20060515
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Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. American journal of physiology. Lung cellular and molecular physiology 20060201
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. The Journal of physiology 20060115
Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B. The Journal of biological chemistry 20050923
Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Molecular pharmacology 20050701
Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer. The Journal of pharmacy and pharmacology 20050301
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Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways. Brain research. Molecular brain research 20040823
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Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice. European journal of pharmacology 20030319
Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae. The Journal of physiology 20030201
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Myosin phosphatase and myosin phosphorylation in differentiating C2C12 cells. Journal of muscle research and cell motility 20030101
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway. The Journal of biological chemistry 20021115
Alpha(1)-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation. American journal of physiology. Heart and circulatory physiology 20021001
Role of Ca2+-activated Cl- channels and MLCK in slow IJP in opossum esophageal smooth muscle. American journal of physiology. Gastrointestinal and liver physiology 20020701
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Macrophage binding and the uptake of oxidized low density lipoprotein are regulated by intracellular protein phosphorylation. Journal of biochemistry 20020401
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Dynamics of integrin clustering at focal contacts of endothelial cells studied by multimode imaging microscopy. Journal of cell science 20010901
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Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. FEBS letters 20010413
Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways. Atherosclerosis 20010401
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle. Journal of muscle research and cell motility 20010101
An essential role of myosin light-chain kinase in the regulation of agonist- and fluid flow-stimulated Ca2+ influx in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19980301
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