Home Sulfos 5'-(4-Fluorosulfonylbenzoyl)adenosine hydrochloride

5'-(4-Fluorosulfonylbenzoyl)adenosine hydrochloride

CAS No.:
78859-42-4
Catalog Number:
AG008NLF
Molecular Formula:
C17H17ClFN5O7S
Molecular Weight:
489.8626
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG008NLF
Chemical Name:
5'-(4-Fluorosulfonylbenzoyl)adenosine hydrochloride
CAS Number:
78859-42-4
Molecular Formula:
C17H17ClFN5O7S
Molecular Weight:
489.8626
MDL Number:
MFCD00043258
IUPAC Name:
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 4-fluorosulfonylbenzoate;hydrochloride
InChI:
InChI=1S/C17H16FN5O7S.ClH/c18-31(27,28)9-3-1-8(2-4-9)17(26)29-5-10-12(24)13(25)16(30-10)23-7-22-11-14(19)20-6-21-15(11)23;/h1-4,6-7,10,12-13,16,24-25H,5H2,(H2,19,20,21);1H/t10-,12-,13-,16-;/m1./s1
InChI Key:
ZUHVYHQVJYIHPN-KHXPSBENSA-N
SMILES:
O[C@@H]1[C@@H](COC(=O)c2ccc(cc2)S(=O)(=O)F)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N.Cl
Properties
Complexity:
763  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
489.052g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
489.859g/mol
Monoisotopic Mass:
489.052g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
188A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites. Biochemistry 20110510
Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. The Biochemical journal 20081201
5'-p-Fluorosulfonyl benzoyl adenosine inhibits an ecto-ATP-diphosphohydrolase in the tegument surface of Taenia crassiceps cysticerci. Molecular and biochemical parasitology 20081201
A 5'-fluorosulfonylbenzoyladenosine-based method to identify physiological substrates of a Drosophila p21-activated kinase. Analytical biochemistry 20070915
Structural characterization of the functional regions in the archaeal protein Sso7d. Proteins 20070401
Synthesis and characterization of 5'-p-fluorosulfonylbenzoyl-2' (or 3')-(biotinyl)adenosine as an activity-based probe for protein kinases. Journal of biomolecular screening 20070201
A new functional, chemical proteomics technology to identify purine nucleotide binding sites in complex proteomes. Journal of proteome research 20061201
A liquid chromatography/mass spectrometry-based method for the selection of ATP competitive kinase inhibitors. Journal of biomolecular screening 20050801
A mechanism-based cross-linker for the identification of kinase-substrate pairs. Journal of the American Chemical Society 20040804
Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding. Platelets 20040801
Triatoma infestans apyrases belong to the 5'-nucleotidase family. The Journal of biological chemistry 20040507
Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. Journal of immunology (Baltimore, Md. : 1950) 20030315
The nucleotide-binding site of human sphingosine kinase 1. The Journal of biological chemistry 20021220
5'-p-Fluorosulfonylbenzoyl adenosine inhibits progesterone synthesis in human placental mitochondria. Biochimica et biophysica acta 20021108
The ATP-binding site of brain phosphatidylinositol 4-kinase PI4K230 as revealed by 5'-p-fluorosulfonylbenzoyladenosine. The international journal of biochemistry & cell biology 20010301
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. The Journal of biological chemistry 19970502
Carboxylases in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme. Biochemistry 19941004
Chemical modification of Salmonella typhimurium phosphoribosylpyrophosphate synthetase with 5'-(p-fluorosulfonylbenzoyl)adenosine. Identification of an active site histidine. The Journal of biological chemistry 19900405
Identification of the AMP binding sites of rabbit phosphofructo-1-kinase isozymes B and C. Biochimica et biophysica acta 19881012
Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. European journal of biochemistry 19860715
Properties