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UVI 3003

CAS No.:
847239-17-2
Catalog Number:
AG008GQ3
Molecular Formula:
C28H36O4
Molecular Weight:
436.5830
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥90%
1 week
United States
$166
- +
10mg
≥90%
1 week
United States
$254
- +
25mg
99%
1 week
United States
$487
- +
50mg
99%
1 week
United States
$890
- +
Product Description
Catalog Number:
AG008GQ3
Chemical Name:
UVI 3003
CAS Number:
847239-17-2
Molecular Formula:
C28H36O4
Molecular Weight:
436.5830
MDL Number:
MFCD18086862
IUPAC Name:
(E)-3-[4-hydroxy-3-(5,5,8,8-tetramethyl-3-pentoxy-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
InChI:
InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+
InChI Key:
APJSHECCIRQQDV-ZRDIBKRKSA-N
SMILES:
CCCCCOc1cc2c(cc1c1cc(/C=C/C(=O)O)ccc1O)C(C)(C)CCC2(C)C
Properties
Complexity:
652  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
436.261g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
436.592g/mol
Monoisotopic Mass:
436.261g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
66.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8  
Literature
Title Journal
The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicology and applied pharmacology 20170101
Quantitative toxicoproteomic analysis of zebrafish embryos exposed to a retinoid X receptor antagonist UVI3003. Journal of applied toxicology : JAT 20150901
A representative retinoid X receptor antagonist UVI3003 induced teratogenesis in zebrafish embryos. Journal of applied toxicology : JAT 20150301
Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling. Microbes and infection 20140201
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circulation research 20100305
Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles. European journal of medicinal chemistry 20090601
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. Journal of medicinal chemistry 20090528
Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. The Journal of biological chemistry 20050114
Properties