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LY2183240

CAS No.:
874902-19-9
Catalog Number:
AG008C87
Molecular Formula:
C17H17N5O
Molecular Weight:
307.3498
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$168
- +
50mg
99%
1 week
United States
$515
- +
Product Description
Catalog Number:
AG008C87
Chemical Name:
LY2183240
CAS Number:
874902-19-9
Molecular Formula:
C17H17N5O
Molecular Weight:
307.3498
MDL Number:
MFCD08703123
IUPAC Name:
N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
InChI:
InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
InChI Key:
GZNIYOXWFCDBBJ-UHFFFAOYSA-N
SMILES:
CN(C(=O)n1nnnc1Cc1ccc(cc1)c1ccccc1)C
UNII:
2WBU91OKM7
Properties
Complexity:
388  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
307.143g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
307.357g/mol
Monoisotopic Mass:
307.143g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
63.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). Bioorganic & medicinal chemistry letters 20110815
Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Psychopharmacology 20101201
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. Journal of medicinal chemistry 20091210
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors. Journal of medicinal chemistry 20091126
Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. Journal of medicinal chemistry 20090108
The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. European journal of pharmacology 20090105
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. Journal of medicinal chemistry 20081211
Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. European journal of medicinal chemistry 20080101
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society 20060802
Properties