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Domoic acid

CAS No.:
14277-97-5
Catalog Number:
AG007Z9T
Molecular Formula:
C15H21NO6
Molecular Weight:
311.3303
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$276
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Product Description
Catalog Number:
AG007Z9T
Chemical Name:
Domoic acid
CAS Number:
14277-97-5
Molecular Formula:
C15H21NO6
Molecular Weight:
311.3303
MDL Number:
MFCD04221174
IUPAC Name:
(2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid
InChI:
InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1
InChI Key:
VZFRNCSOCOPNDB-AOKDLOFSSA-N
SMILES:
OC(=O)C[C@H]1[C@H](CN[C@@H]1C(=O)O)C(=CC=C[C@H](C(=O)O)C)C
UNII:
M02525818H
Properties
Complexity:
510  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
2  
Exact Mass:
311.137g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
311.334g/mol
Monoisotopic Mass:
311.137g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.3  
Literature
Title Journal
Fetal domoic acid exposure affects lateral amygdala neurons, diminishes social investigation and alters sensory-motor gating. Neurotoxicology 20160301
Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. Journal of biochemical and molecular toxicology 20150601
Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione. Toxicological sciences : an official journal of the Society of Toxicology 20130401
Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. BMC neuroscience 20130101
Algal toxins and reverse osmosis desalination operations: laboratory bench testing and field monitoring of domoic acid, saxitoxin, brevetoxin and okadaic acid. Water research 20121201
Chemical toxins that cause seizures. Neurotoxicology 20121201
Exposure to domoic acid through shellfish consumption in Belgium. Environment international 20121115
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Evaluation of circulating eosinophil count and adrenal gland function in California sea lions naturally exposed to domoic acid. Journal of the American Veterinary Medical Association 20121001
Molecular and pharmacological evidence for a facilitatory functional role of pre-synaptic GLUK2/3 kainate receptors on GABA release in rat trigeminal caudal nucleus. European journal of pain (London, England) 20120901
Impact of copper exposure on Pseudo-nitzschia spp. physiology and domoic acid production. Aquatic toxicology (Amsterdam, Netherlands) 20120815
Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice. Toxicological sciences : an official journal of the Society of Toxicology 20120701
Low-dose neonatal domoic acid causes persistent changes in behavioural and molecular indicators of stress response in rats. Behavioural brain research 20120501
Quantification of domoic acid in shellfish samples by capillary electrophoresis-based enzyme immunoassay with electrochemical detection. Toxicon : official journal of the International Society on Toxinology 20120501
Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid. Neuroscience 20120419
Toxicokinetics of domoic acid in the fetal rat. Toxicology 20120329
Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues. Analytica chimica acta 20120217
Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice. Free radical biology & medicine 20120201
[Development of direct competitive enzyme-linked immunosorbent assay for the determination of domoic acid]. Huan jing ke xue= Huanjing kexue 20120201
Domoic acid induced status epilepticus promotes aggressive behavior in rats. Physiology & behavior 20120118
Endangered North Atlantic right whales (Eubalaena glacialis) experience repeated, concurrent exposure to multiple environmental neurotoxins produced by marine algae. Environmental research 20120101
Condensation of the isoprenoid and amino precursors in the biosynthesis of domoic acid. Toxicon : official journal of the International Society on Toxinology 20120101
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. PloS one 20120101
A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. PloS one 20120101
Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA). PloS one 20120101
Cell-based measurements to assess physiological status of Pseudo-nitzschia multiseries, a toxic diatom. Research in microbiology 20111101
Modulation of neurite outgrowth by activation of calcium-permeable kainate receptors expressed by rat nociceptive-like dorsal root ganglion neurons. Developmental neurobiology 20111001
Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110901
Rapid behavioural diagnosis of domoic acid toxicosis in California sea lions. Biology letters 20110823
[Development of colloidal gold immunochromatographic strip for rapid detection of domoic acid]. Huan jing ke xue= Huanjing kexue 20110801
Ischemic cardiomyopathy following seizure induction by domoic Acid. The American journal of pathology 20110701
Nickel-catalyzed cyclizations of enoates and chiral allenes: an approach to domoic acid. Chemistry (Weinheim an der Bergstrasse, Germany) 20110527
Molecularly imprinted polymer for selective extraction of domoic acid from seafood coupled with high-performance liquid chromatographic determination. Talanta 20110515
A mussel tissue certified reference material for multiple phycotoxins. Part 3: homogeneity and stability. Analytical and bioanalytical chemistry 20110501
Altered social interaction in adult rats following neonatal treatment with domoic acid. Physiology & behavior 20110301
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid. Neuroscience letters 20110103
Domoic acid induced seizures progress to a chronic state of epilepsy in rats. Toxicon : official journal of the International Society on Toxinology 20110101
Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental toxicology and chemistry 20110101
Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons. Neurotoxicology 20110101
Concurrent exposure of bottlenose dolphins (Tursiops truncatus) to multiple algal toxins in Sarasota Bay, Florida, USA. PloS one 20110101
Analytical approaches for an important shellfish poisoning agent: domoic Acid. Journal of agricultural and food chemistry 20101124
Domoic acid--a new toxin in the Croatian Adriatic shellfish toxin profile. Molecules (Basel, Switzerland) 20101008
Domoic acid uptake and elimination kinetics in oysters and mussels in relation to body size and anatomical distribution of toxin. Aquatic toxicology (Amsterdam, Netherlands) 20101001
A protozoal-associated epizootic impacting marine wildlife: mass-mortality of southern sea otters (Enhydra lutris nereis) due to Sarcocystis neurona infection. Veterinary parasitology 20100920
Magnetic resonance imaging quality and volumes of brain structures from live and postmortem imaging of California sea lions with clinical signs of domoic acid toxicosis. Diseases of aquatic organisms 20100917
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats. Neuroscience 20100915
In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F. Neuropharmacology 20100901
Domoic acid as a developmental neurotoxin. Neurotoxicology 20100901
Domoic acid and human exposure risks: a review. Toxicon : official journal of the International Society on Toxinology 20100815
Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid. Hippocampus 20100801
Subclinical effects of saxitoxin and domoic acid on aggressive behaviour and monoaminergic turnover in rainbow trout (Oncorhynchus mykiss). Aquatic toxicology (Amsterdam, Netherlands) 20100801
Eosinophilia and biotoxin exposure in bottlenose dolphins (Tursiops truncatus) from a coastal area impacted by repeated mortality events. Environmental research 20100801
Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms. Journal of neurochemistry 20100701
Neurological disease rises from ocean to bring model for human epilepsy to life. Toxins 20100701
In situ passive solid-phase adsorption of micro-algal biotoxins as a monitoring tool. Current opinion in biotechnology 20100601
Development of ELISAs for detecting domoic acid, okadaic acid, and saxitoxin and their applicability for the detection of marine toxins in samples collected in Belgium. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100601
Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy. Brain research 20100517
Feeding mechanics as the basis for differential uptake of the neurotoxin domoic acid by oysters, Crassostrea virginica, and mussels, Mytilus edulis. Aquatic toxicology (Amsterdam, Netherlands) 20100415
Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid. Toxicon : official journal of the International Society on Toxinology 20100401
Enhancement of domoic acid neurotoxicity on Diptera larvae bioassay by marine fungal metabolites. Toxicon : official journal of the International Society on Toxinology 20100401
Zebrafish seizure model identifies p,p -DDE as the dominant contaminant of fetal California sea lions that accounts for synergistic activity with domoic acid. Environmental health perspectives 20100401
Immunomodulatory effects upon in vitro exposure of California sea lion and southern sea otter peripheral blood leukocytes to domoic acid. Journal of wildlife diseases 20100401
Environmental risk factors for temporal lobe epilepsy--is prenatal exposure to the marine algal neurotoxin domoic acid a potentially preventable cause? Medical hypotheses 20100301
Intracellular domoic acid production in Pseudo-nitzschia multistriata isolated from the Gulf of Naples (Tyrrhenian Sea, Italy). Toxicon : official journal of the International Society on Toxinology 20100101
Decrease of marine toxin content in bivalves by industrial processes. Toxicon : official journal of the International Society on Toxinology 20100101
Domoic acid: neurobehavioral consequences of exposure to a prevalent marine biotoxin. Neurotoxicology and teratology 20100101
Amnesic shellfish poisoning (ASP) toxins in plankton and molluscs from Luanda Bay, Angola. Toxicon : official journal of the International Society on Toxinology 20100101
Crassostrea virginica grazing on toxic and non-toxic diatoms. Toxicon : official journal of the International Society on Toxinology 20100101
Distribution and linkage of domoic acid (amnesic shellfish poisoning toxins) in subcellular fractions of the digestive gland of the scallop Pecten maximus. Toxicon : official journal of the International Society on Toxinology 20100101
Cloning and characterization of glutamate receptors in Californian sea lions (Zalophus californianus). Marine drugs 20100101
Toxic effects of domoic acid in the seabream Sparus aurata. Marine drugs 20100101
Reductions in paradoxical sleep time in adult rats treated neonatally with low dose domoic acid. Behavioural brain research 20091228
The occurrence of domoic acid linked to a toxic diatom bloom in a new potential vector: the tunicate Pyura chilensis (piure). Toxicon : official journal of the International Society on Toxinology 20091101
Amnesic shellfish poisoning toxin stimulates the transcription of CYP1A possibly through AHR and ARNT in the liver of red sea bream Pagrus major. Marine pollution bulletin 20091101
Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20091101
Domoic acid induces a long-lasting enhancement of CA1 field responses and impairs tetanus-induced long-term potentiation in rat hippocampal slices. Toxicological sciences : an official journal of the Society of Toxicology 20090901
Bimolecular rate constant determination for the reaction of hydroxyl radicals with domoic and kainic acid in aqueous solution. Environmental science & technology 20090901
[A indirect competitive ELISA to detect domoic acid in seawater and shellfish]. Wei sheng yan jiu = Journal of hygiene research 20090901
Analysis of trace levels of domoic acid in seawater and plankton by liquid chromatography without derivatization, using UV or mass spectrometry detection. Journal of chromatography. A 20090807
Effects of low dose neonatal domoic acid administration on behavioural and physiological response to mild stress in adult rats. Physiology & behavior 20090804
Effect of some habitual cooking processes on the domoic acid concentration in the cockle (Cerastoderma edule) and Manila clam (Ruditapes philippinarum). Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090701
Development of a novel antibody probe useful for domoic acid detection. Biosensors & bioelectronics 20090615
Quantification of domoic acid in shellfish tissues by pressurized capillary electrochromatography. Journal of separation science 20090601
Risk assessment of the amnesic shellfish poison, domoic acid, on animals and humans. Journal of environmental biology 20090501
Muscarinic receptors prevent oxidative stress-mediated apoptosis induced by domoic acid in mouse cerebellar granule cells. Journal of neurochemistry 20090401
Persistent changes in learning and memory in rats following neonatal treatment with domoic acid. Physiology & behavior 20090323
Photocatalytic properties of nanocrystalline titanium dioxide films in the degradation of domoic acid in aqueous solution: potential for use in molluscan shellfish biotoxin depuration facilities. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090201
Deaths in rockhopper penguins. The Veterinary record 20090124
Wildlife biology. Confused pelicans may have lingered too long up north. Science (New York, N.Y.) 20090123
Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicological sciences : an official journal of the Society of Toxicology 20090101
Characterization of a degenerative cardiomyopathy associated with domoic acid toxicity in California sea lions (Zalophus californianus). Veterinary pathology 20090101
DDT exposure of zebrafish embryos enhances seizure susceptibility: relationship to fetal p,p'-DDE burden and domoic acid exposure of California sea lions. Environmental health perspectives 20090101
The role of domoic acid in abortion and premature parturition of California sea lions (Zalophus californianus) on San Miguel Island, California. Journal of wildlife diseases 20090101
Association of an unusual marine mammal mortality event with Pseudo-nitzschia spp. Blooms along the southern California coastline. Journal of wildlife diseases 20090101
Intrauterine environment-genome interaction and children's development (2): Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams. The Journal of toxicological sciences 20090101
Determination of dissolved domoic acid in seawater with reversed-phase extraction disks and rapid resolution liquid chromatography tandem mass spectrometry with head-column trapping. Journal of chromatography. A 20081226
Comparative toxicity to mice of domoic acid and isodomoic acids A, B and C. Toxicon : official journal of the International Society on Toxinology 20081215
Determination of domoic acid in mussels by HPLC with post-column derivatization using 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215
Domoic acid induces direct DNA damage and apoptosis in Caco-2 cells: recent advances. Environmental toxicology 20081201
In vivo seizure induction and pharmacological preconditioning by domoic acid and isodomoic acids A, B and C. Neuropharmacology 20081201
Immunomodulatory effects of domoic acid differ between in vivo and in vitro exposure in mice. Marine drugs 20081201
[Effects of domoic acid on membrane function of primary cultured rat glial cells]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081201
In vivo genotoxicity testing of the amnesic shellfish poison (domoic acid) in piscine erythrocytes using the micronucleus test and the comet assay. Aquatic toxicology (Amsterdam, Netherlands) 20081111
Domoic acid impairment of cardiac energetics. Toxicological sciences : an official journal of the Society of Toxicology 20081001
Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding. Molecular pharmacology 20081001
Comparative study of the use of neuroblastoma cells (Neuro-2a) and neuroblastomaxglioma hybrid cells (NG108-15) for the toxic effect quantification of marine toxins. Toxicon : official journal of the International Society on Toxinology 20080915
Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. Journal of medicinal chemistry 20080724
Domoic acid excretion in dungeness crabs, razor clams and mussels. Marine environmental research 20080701
Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions. Neurotoxicology 20080701
[Aquatic biotoxins in relation to food poisonings]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20080701
Low dose domoic acid in neonatal rats abolishes nicotine induced conditioned place preference during late adolescence. Amino acids 20080601
Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid. Amino acids 20080601
Transcriptional responses of xenobiotic metabolizing enzymes, HSP70 and Na+/K+ -ATPase in the liver of rabbitfish (Siganus oramin) intracoelomically injected with amnesic shellfish poisoning toxin. Environmental toxicology 20080601
Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases. Neurochemistry international 20080501
Development of a high-affinity anti-domoic acid sheep scFv and its use in detection of the toxin in shellfish. Analytical chemistry 20080501
Inorganic carbon acquisition in potentially toxic and non-toxic diatoms: the effect of pH-induced changes in seawater carbonate chemistry. Physiologia plantarum 20080501
Extraction of domoic acid from seawater and urine using a resin based on 2-(trifluoromethyl)acrylic acid. Analytica chimica acta 20080303
Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus. Marine drugs 20080301
Domoic acid toxicologic pathology: a review. Marine drugs 20080301
In utero domoic acid toxicity: a fetal basis to adult disease in the California sea lion (Zalophus californianus). Marine drugs 20080301
Novel symptomatology and changing epidemiology of domoic acid toxicosis in California sea lions (Zalophus californianus): an increasing risk to marine mammal health. Proceedings. Biological sciences 20080207
Altered responses to novelty and drug reinforcement in adult rats treated neonatally with domoic acid. Physiology & behavior 20080128
Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells. Toxicological sciences : an official journal of the Society of Toxicology 20071201
Adsorption of domoic acid to marine sediments and clays. Journal of environmental monitoring : JEM 20071201
Maternal-fetal transfer of domoic acid in rats at two gestational time points. Environmental health perspectives 20071201
Effects of algal-produced neurotoxins on metabolic activity in telencephalon, optic tectum and cerebellum of Atlantic salmon (Salmo salar). Aquatic toxicology (Amsterdam, Netherlands) 20071130
Photostability of kainic acid in seawater. Journal of agricultural and food chemistry 20071128
Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer. Journal of the American Chemical Society 20071107
Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole. Environmental health perspectives 20071101
Occurrence and seasonal variations of algal toxins in water, phytoplankton and shellfish from North Stradbroke Island, Queensland, Australia. Marine environmental research 20071001
Isodomoic acids A and C exhibit low KA receptor affinity and reduced in vitro potency relative to domoic acid in region CA1 of rat hippocampus. Toxicon : official journal of the International Society on Toxinology 20071001
Determination of domoic acid in seawater and phytoplankton by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A 20070907
Domoic acid preconditioning and seizure induction in young and aged rats. Epilepsy research 20070901
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. The Journal of biological chemistry 20070831
Non-resonance micro-Raman spectroscopic studies on crystalline domoic acid and its aqueous solutions. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070801
Development of a monoclonal antibody against domoic acid and its application in enzyme-linked immunosorbent assay and colloidal gold immunostrip. Journal of agricultural and food chemistry 20070627
Development of a pressurised liquid extraction and liquid chromatography with electrospray ionization-tandem mass spectrometry method for the determination of domoic acid in shellfish. Journal of chromatography. A 20070622
Effect of addition of antibiotics and an antioxidant on the stability of tissue reference materials for domoic acid, the amnesic shellfish poison. Analytical and bioanalytical chemistry 20070401
Feasibility of gamma irradiation as a stabilisation technique in the preparation of tissue reference materials for a range of shellfish toxins. Analytical and bioanalytical chemistry 20070401
Freeze-drying for the stabilisation of shellfish toxins in mussel tissue (Mytilus edulis) reference materials. Analytical and bioanalytical chemistry 20070401
Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch). Aquatic toxicology (Amsterdam, Netherlands) 20070310
Optimisation of production of a domoic acid-binding scFv antibody fragment in Escherichia coli using molecular chaperones and functional immobilisation on a mesoporous silicate support. Protein expression and purification 20070301
Exposure to domoic acid affects larval development of king scallop Pecten maximus (Linnaeus, 1758). Aquatic toxicology (Amsterdam, Netherlands) 20070227
Solid-phase extraction-fluorimetric high performance liquid chromatographic determination of domoic acid in natural seawater mediated by an amorphous titania sorbent. Analytica chimica acta 20070130
Gender-based changes in cognition and emotionality in a new rat model of epilepsy. Amino acids 20070101
Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development. Hippocampus 20070101
Single-laboratory validation of the biosense direct competitive enzyme-linked immunosorbent assay (ELISA) for determination of domoic acid toxins in shellfish. Journal of AOAC International 20070101
Determination of domoic acid toxins in shellfish by biosense ASP ELISA--a direct competitive enzyme-linked immunosorbent assay: collaborative study. Journal of AOAC International 20070101
[Phycotoxins of ASP, PSP and DSP groups in aquaris organisms]. Voprosy pitaniia 20070101
Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Molecular pharmacology 20061201
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors. Neuropharmacology 20061101
Interface interactions modulating desensitization of the kainate-selective ionotropic glutamate receptor subunit GluR6. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060927
Adsorption and activity of a domoic acid binding antibody fragment on mesoporous silicates. The journal of physical chemistry. B 20060921
Role of the plasma membrane calcium adenosine triphosphatase on domoate-induced intracellular acidification in primary cultures of cerebelar granule cells. Journal of neuroscience research 20060801
Harmful algal bloom toxins alter c-Fos protein expression in the brain of killifish, Fundulus heteroclitus. Aquatic toxicology (Amsterdam, Netherlands) 20060720
Absence of neurotoxic effects in leopard sharks, Triakis semifasciata, following domoic acid exposure. Toxicon : official journal of the International Society on Toxinology 20060601
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience 20060512
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Determination of domoic acid by on-line coupled capillary isotachophoresis with capillary zone electrophoresis. Journal of chromatography. A 20060428
Role of Fe(III), phosphate, dissolved organic matter, and nitrate during the photodegradation of domoic acid in the marine environment. Environmental science & technology 20060401
Tissue distribution and effects of heat treatments on the content of domoic acid in blue mussels, Mytilus edulis. Toxicon : official journal of the International Society on Toxinology 20060315
Comparative study of Domoic Acid and Okadaic Acid induced-chromosomal abnormalities in the Caco-2 cell line. International journal of environmental research and public health 20060301
Marine toxin hinders cognitive development. Environmental health perspectives 20060201
Sequential involvement of distinct glutamate receptors in domoic acid-induced neurotoxicity in rat mixed cortical cultures: effect of multiple dose/duration paradigms, chronological age, and repeated exposure. Toxicological sciences : an official journal of the Society of Toxicology 20060101
Histopathological and molecular changes produced by hippocampal microinjection of domoic acid. Neurotoxicology and teratology 20060101
Comparative analysis of purified Pacific and Caribbean ciguatoxin congeners and related marine toxins using a modified ELISA technique. Journal of clinical laboratory analysis 20060101
Immunobiosensor detection of domoic acid as a screening test in bivalve molluscs: comparison with liquid chromatography-based analysis. Journal of AOAC International 20060101
Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats. Neurotoxicology and teratology 20060101
Amnesic shellfish poisoning toxins in bivalve molluscs in Ireland. Toxicon : official journal of the International Society on Toxinology 20051215
Production of isodomoic acids A and B as major toxin components of a pennate diatom Nitzschia navis-varingica. Toxicon : official journal of the International Society on Toxinology 20051215
Detection of domoic acid in rat serum and brain by direct competitive enzyme-linked immunosorbent assay (cELISA). Analytical and bioanalytical chemistry 20051101
Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli. Journal of biotechnology 20051017
Accumulation, transformation and tissue distribution of domoic acid, the amnesic shellfish poisoning toxin, in the common cuttlefish, Sepia officinalis. Aquatic toxicology (Amsterdam, Netherlands) 20050815
Quantitative 1H NMR with external standards: use in preparation of calibration solutions for algal toxins and other natural products. Analytical chemistry 20050515
[Domoic acid and human health]. Wei sheng yan jiu = Journal of hygiene research 20050501
Improved high-performance liquid chromatographic method for the determination of domoic acid and analogues in shellfish: effect of pH. Analytical and bioanalytical chemistry 20050401
Ultrasensitive detection of domoic acid in mouse blood by competitive ELISA using blood collection cards. Toxicon : official journal of the International Society on Toxinology 20050401
Domoic acid transfer to milk: evaluation of a potential route of neonatal exposure. Environmental health perspectives 20050401
The synthesis of (-)-isodomoic acid C. Journal of the American Chemical Society 20050302
NMDA receptor involvement in the effects of low dose domoic acid in neonatal rats. Amino acids 20050301
Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels. Amino acids 20050301
Pathology of domoic acid toxicity in California sea lions (Zalophus californianus). Veterinary pathology 20050301
Evaluation of cardiac lesions and risk factors associated with myocarditis and dilated cardiomyopathy in southern sea otters (Enhydra lutris nereis). American journal of veterinary research 20050201
Committee on Natural Toxins and Food Allergens. Marine and freshwater toxins. Journal of AOAC International 20050101
Hydrophilic interaction liquid chromatography/mass spectrometry for determination of domoic acid in Adriatic shellfish. Rapid communications in mass spectrometry : RCM 20050101
Behavioral and histopathological analysis of domoic Acid administration in marmosets. Epilepsia 20050101
Multiresidue method for determination of algal toxins in shellfish: single-laboratory validation and interlaboratory study. Journal of AOAC International 20050101
Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicology and teratology 20050101
Developmental toxicity of domoic acid in zebrafish (Danio rerio). Neurotoxicology and teratology 20050101
Mapping and reconstruction of domoic acid-induced neurodegeneration in the mouse brain. Neurotoxicology and teratology 20050101
Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid. Neurotoxicology and teratology 20050101
Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid. Neuroscience 20050101
Surface plasmon resonance sensor for domoic acid based on grafted imprinted polymer. Biosensors & bioelectronics 20040915
Disposable immunosensor for the determination of domoic acid in shellfish. Biosensors & bioelectronics 20040915
Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices. Neuropharmacology 20040901
Development of a sensitive enzyme-linked immunosorbent assay for the determination of domoic Acid in shellfish. Journal of agricultural and food chemistry 20040825
Characterization of a domoic acid binding site from Pacific razor clam. Aquatic toxicology (Amsterdam, Netherlands) 20040810
Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices. Brain research 20040716
Kainate receptor agonists and antagonists mediate tolerance to kainic acid and reduce high-affinity GTPase activity in young, but not aged, rat hippocampus. Journal of neurochemistry 20040701
Sensitive determination of domoic acid using high-performance liquid chromatography with electrogenerated tris(2,2'-bipyridine)ruthenium(III) chemiluminescence detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040701
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The neuroprotective effects of virally-derived caspase inhibitors p35 and crmA following a necrotic insult. Neurobiology of disease 20031001
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Novel electrochemical immunosensors for seafood toxin analysis. Toxicon : official journal of the International Society on Toxinology 20020901
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From sanddabs to blue whales: the pervasiveness of domoic acid. Toxicon : official journal of the International Society on Toxinology 20020701
Development of a protocol for determination of domoic acid in the sand crab (Emerita analoga): a possible new indicator species. Toxicon : official journal of the International Society on Toxinology 20020501
Evaluation of marine biotoxin's accumulation by Acanthocardia tuberculatum from Algarve, Portugal. Toxicon : official journal of the International Society on Toxinology 20020501
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Contributions of AMPA- and kainate-sensitive receptors to the photopic electroretinogram of the Xenopus retina. Visual neuroscience 20010101
Determination and confirmation of the amnesic shellfish poisoning toxin, domoic acid, in shellfish from Scotland by liquid chromatography and mass spectrometry. Journal of AOAC International 20010101
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Synthesis of a series of aryl kainic acid analogs and evaluation in cells stably expressing the kainate receptor humGluR6. Journal of medicinal chemistry 19960913
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