D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.

Antiviral chemistry & chemotherapy 20120821

Crystal structure of dihydroorotate dehydrogenase from Leishmania major.

Biochimie 20120801

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.

Molecular and biochemical parasitology 20120801

Enhanced uridine 5'-monophosphate production by whole cell of Saccharomyces cerevisiae through rational redistribution of metabolic flux.

Bioprocess and biosystems engineering 20120601

Secondary processes in atmospheric pressure chemical ionization-ion trap mass spectrometry: a case study of orotic acid.

Journal of mass spectrometry : JMS 20120601

Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid.

Life sciences 20120409

Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.

Gene therapy 20120401

Reference intervals for orotic acid in urine, plasma and dried blood spot using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120201

Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.

Molecular genetics and metabolism 20120201

Conformational studies of hydantoin-5-acetic acid and orotic acid.

Acta crystallographica. Section C, Crystal structure communications 20120201

[The ileocoecal valve changes in chronic constipation in children].

Klinichna khirurhiia 20120201

Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.

Lipids in health and disease 20120101

[Correction of a connective tissue dysplasia in the treatment of postoperative abdominal hernias].

Klinichna khirurhiia 20120101

Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.

The Journal of toxicological sciences 20120101

Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis.

PloS one 20120101

Distinct fluctuations in nucleotide metabolism accompany the enhanced in vitro embryogenic capacity of Brassica cells over-expressing SHOOTMERISTEMLESS.

Planta 20111201

The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved.

PLoS genetics 20111201

Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension.

Biochemical and biophysical research communications 20111028

The function of oxalic acid in the human metabolism.

Clinical chemistry and laboratory medicine 20110901

Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.

Journal of lipid research 20110901

Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.

Journal of controlled release : official journal of the Controlled Release Society 20110810

Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.

The Plant cell 20110801

Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica.

Journal of genetics and genomics = Yi chuan xue bao 20110620

OAT2 catalyses efflux of glutamate and uptake of orotic acid.

The Biochemical journal 20110601

Study on possible mechanism of orotic acid-induced fatty liver in rats.

Nutrition (Burbank, Los Angeles County, Calif.) 20110501

Human urate transporter 1 (hURAT1) mediates the transport of orotate.

The journal of physiological sciences : JPS 20110501

Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.

Plant physiology 20110501

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.

Molecular therapy : the journal of the American Society of Gene Therapy 20110501

[Analysis of clinical features, biochemical analysis and gene mutations in one Chinese pedigree with neonatal-onset ornithine transcarbamylase deficiency].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20110501

Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase.

Biochemistry 20110412

A common telomeric gene silencing assay is affected by nucleotide metabolism.

Molecular cell 20110408

Molecular recognition of melamine by vesicles spontaneously formed from orotic acid derived bolaamphiphiles.

The journal of physical chemistry. B 20110303

New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant.

Journal of bioscience and bioengineering 20110201

Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.

Acta crystallographica. Section F, Structural biology and crystallization communications 20110201

[Adrenoreactivity in patients with arrhythmic syndrome associated with connective tissue dysplasia at the background of intake of the magnezium orotate].

Kardiologiia 20110101

Arginase I deficiency: severe infantile presentation with hyperammonemia: more common than reported?

Molecular genetics and metabolism 20110101

Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides.

Bioscience, biotechnology, and biochemistry 20110101

[Fifteen years experience of the use of magnesium preparations in patients with mitral valve prolapse].

Kardiologiia 20110101

Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.

Journal of the American Chemical Society 20101201

Use of the pyrG gene as a food-grade selection marker in Monascus.

Biotechnology letters 20101101

Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.

Analytical biochemistry 20100401

New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

Journal of biomolecular screening 20100401

The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae.

Applied microbiology and biotechnology 20100301

A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function.

The FEBS journal 20100301

Orotic acid quantification in dried blood spots and biological fluids by hydrophilic interaction liquid chromatography tandem mass spectrometry.

Journal of separation science 20100301

A trial of minimization of chromosome 7 in Aspergillus oryzae by multiple chromosomal deletions.

Molecular genetics and genomics : MGG 20100101

Quantitation of orotic acid in urine using isotope dilution-selected ion gas chromatography-mass spectrometry.

Methods in molecular biology (Clifton, N.J.) 20100101

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.

Lipids in health and disease 20100101

Early detection of steatohepatitis in fatty rat liver by using MR elastography.

Radiology 20091001

Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.

Brain research 20090929

Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.

Biochemistry 20090915

[Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901

Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.

Biochemistry 20090804

AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.

Molecular therapy : the journal of the American Society of Gene Therapy 20090801

Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.

Cardiovascular drugs and therapy 20090801

Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20090601

In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.

Gene therapy 20090601

Marker-disruptive gene integration and URA3 recycling for multiple gene manipulation in Saccharomyces cerevisiae.

Applied microbiology and biotechnology 20090601

Changes in noninfarcted myocardium explain benefits of on-pump beating-heart coronary artery bypass grafting for acute myocardial infarction.

The Journal of thoracic and cardiovascular surgery 20090601

Magnesium orotate in severe congestive heart failure (MACH).

International journal of cardiology 20090501

Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model.

Experimental parasitology 20090401

Babesia bovis: effect of Albumax II and orotic acid in a low-serum in vitro culture.

Experimental parasitology 20090301

Regulation of pyrimidine formation in Pseudomonas lundensis.

Canadian journal of microbiology 20090301

Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.

Biochemistry 20090203

Efficient generation of recessive traits in diploid sake yeast by targeted gene disruption and loss of heterozygosity.

Applied microbiology and biotechnology 20090201

Magnesium orotate in severe congestive heart failure (MACH).

International journal of cardiology 20090109

Mapping the landscape of potentially primordial informational oligomers: oligo-dipeptides tagged with orotic acid derivatives as recognition elements.

Angewandte Chemie (International ed. in English) 20090101

New amides of 5-(4-chlorobenzoyl)aminoorotic acid: their synthesis and biological activity.

Archiv der Pharmazie 20081101

Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.

Biochemistry 20081014

The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.

Drug metabolism and disposition: the biological fate of chemicals 20080901

Clinical applications of urinary organic acids. Part I: Detoxification markers.

Alternative medicine review : a journal of clinical therapeutic 20080901

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

Biochemistry 20080826

Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors.

The journal of gene medicine 20080801

Surprisingly low aqueous acidity at the alpha-positions of pyridiniums and pyrimidinium: the role of solvation.

Organic letters 20080703

Ghrelin and orotic acid increased in subclinical mastitis.

Archives of physiology and biochemistry 20080701

New lanthanide complexes with antioxidant activity.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.

Southern medical journal 20080501

Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.

Life sciences 20080409

Stochastic switching as a survival strategy in fluctuating environments.

Nature genetics 20080401

Control of 5-FOA and 5-FU resistance by Saccharomyces cerevisiae YJL055W.

Yeast (Chichester, England) 20080201

Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe.

Gene 20080115

Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.

Acta biochimica Polonica 20080101

Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids.

Molecular pharmaceutics 20080101

Differentiation of 2-alkylthioorotic acids, methyl and ethyl 2-alkylthioorotates and hydrazides of 2-alkylthioorotic acids by using electron ionization mass spectra.

European journal of mass spectrometry (Chichester, England) 20080101

QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.

The journal of physical chemistry. B 20071101

The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker.

Microbiology (Reading, England) 20071101

Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624.

Applied microbiology and biotechnology 20071001

Diversity of crystal structure with different lanthanide ions involving in situ oxidation-hydrolysis reaction.

Dalton transactions (Cambridge, England : 2003) 20070928

The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.

Molecular and biochemical parasitology 20070901

Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.

Bioorganic chemistry 20070801

Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process.

Applied microbiology and biotechnology 20070801

Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.

The Journal of pharmacology and experimental therapeutics 20070801

Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.

Microbiology (Reading, England) 20070801

Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.

Journal of molecular biology 20070727

The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

FEMS microbiology letters 20070501

Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.

Journal of plant physiology 20070401

Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.

FEMS microbiology letters 20070301

Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.

Acta crystallographica. Section F, Structural biology and crystallization communications 20070301

Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry.

The Journal of veterinary medical science 20070301

Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM.

Archives of pharmacal research 20070301

The clinical application of metabolic therapy for cardiovascular disease.

Heart, lung & circulation 20070101

Classical genetics.

Methods in molecular biology (Clifton, N.J.) 20070101

Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus.

BMC microbiology 20070101

Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.

Biochemistry 20061219

New lanthanum (III) complex--synthesis, characterization, and cytotoxic activity.

Archiv der Pharmazie 20061101

Effects of arginine treatment on nutrition, growth and urea cycle function in seven Japanese boys with late-onset ornithine transcarbamylase deficiency.

European journal of pediatrics 20060901

Control of ribosome turnover during growth of the haloalkaliphilic archaeon Natronococcus occultus.

Research in microbiology 20060901

Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.

Biochemistry 20060711

Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.

Molecular therapy : the journal of the American Society of Gene Therapy 20060701

Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice.

Molecular therapy : the journal of the American Society of Gene Therapy 20060701

Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.

The Journal of biological chemistry 20060630

13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.

Biochemistry 20060613

PCR-mediated seamless gene deletion and marker recycling in Saccharomyces cerevisiae.

Yeast (Chichester, England) 20060415

Stability of large segmental duplications in the yeast genome.

Genetics 20060401

Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid.

Bioorganic chemistry 20060401

Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.

Bioorganic & medicinal chemistry letters 20060315

Electronic structure of orotic acid III geometric feature and thermal properties of some transition metal orotic acid complexes.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301

Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.

Parasitology international 20060301

A new type of migrating zone boundary in electrophoresis: 3. The hybrid boundary and stacking criteria.

Electrophoresis 20060301

Pulsed electrochemical detection of orotic acid by an activated potential waveform at a gold working electrode following anion-exchange chromatography.

Journal of chromatography. A 20060224

Hazards associated with pregnancies and deliveries in lysinuric protein intolerance.

Metabolism: clinical and experimental 20060201

Influence of calcium and phosphorus, lactose, and salt-to-moisture ratio on Cheddar cheese quality: changes in residual sugars and water-soluble organic acids during ripening.

Journal of dairy science 20060201

Counter-selectable marker for bacterial-based interaction trap systems.

BioTechniques 20060201

An unusual clinical and biochemical presentation of ornithine transcarbamylase deficiency in a male patient.

Journal of inherited metabolic disease 20060201

An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiae.

Yeast (Chichester, England) 20060130

Integration of genomic and metabonomic data in systems biology--are we 'there' yet?

Current opinion in drug discovery & development 20060101

Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.

Arzneimittel-Forschung 20060101

A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

Journal of experimental botany 20060101

5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

Mycologia 20060101

Genomic reconstruction by serial mitotic recombination of yeast artificial chromosomes.

Methods in molecular biology (Clifton, N.J.) 20060101

[Use of orotic acid and orotates].

Journal de pharmacie de Belgique 20060101

[The results of application of magnesium-bearing medications and different load doses of vitamins B1 and B2 in volunteers].

Voprosy pitaniia 20060101

Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate.

Acta crystallographica. Section F, Structural biology and crystallization communications 20051001

A high-efficiency method to replace essential genes with mutant alleles in yeast.

Yeast (Chichester, England) 20050730

The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review.

Journal of inorganic biochemistry 20050701

Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.

The Plant cell 20050701

Urinary uracil in female patients with ornithine transcarbamylase deficiency.

Pediatrics international : official journal of the Japan Pediatric Society 20050601

Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.

Journal of molecular biology 20050506

Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid.

Biochemical pharmacology 20050215

5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.

Yeast (Chichester, England) 20050115

Regulation of pyrimidine biosynthesis in Acidovorax delafieldii.

Journal of basic microbiology 20050101

[Clinical value of the use of magnesium orotate in adolescents with syndrome of cardiac connective tissue dysplasia].

Kardiologiia 20050101

Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid.

Nutrition (Burbank, Los Angeles County, Calif.) 20050101

Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats.

JPEN. Journal of parenteral and enteral nutrition 20050101

Ornithine aminotransferase deficiency: diagnostic difficulties in neonatal presentation.

Journal of inherited metabolic disease 20050101

Synthesis and properties of PNA oligomers containing orotic acid derivatives.

Nucleosides, nucleotides & nucleic acids 20050101

Mechanism of the dihydroorotase reaction.

Biochemistry 20041228

Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.

Journal of experimental botany 20041201

Adsorption of bile acid by chitosan-orotic acid salt and its application as an oral preparation.

Chemical & pharmaceutical bulletin 20041001

Alleviation of fatty liver by alpha-linolenic acid.

Journal of nutritional science and vitaminology 20040801

Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.

Biochemistry 20040601

Improvement of culture conditions and evidence for nuclear transformation by homologous recombination in a red alga, Cyanidioschyzon merolae 10D.

Plant & cell physiology 20040601

A suspected case of ornithine transcarbamylase deficiency in a cat.

The Journal of veterinary medical science 20040601

Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.

Annals of the New York Academy of Sciences 20040601

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

Physiological genomics 20040413

Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine- 5' -monophosphate decarboxylase.

Bioorganic chemistry 20040401

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

Protein science : a publication of the Protein Society 20040401

pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.

Eukaryotic cell 20040401

Analytical derivatization-a tool for determination of orotic acid.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125

Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance.

Yeast (Chichester, England) 20040115

Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora.

Letters in applied microbiology 20040101

Determination of orotic acid, uric acid, and creatinine in milk by liquid chromatography.

Journal of AOAC International 20040101

Orotic aciduria and plasma urea cycle-related amino acid alterations in short bowel syndrome, evoked by an arginine-free diet.

JPEN. Journal of parenteral and enteral nutrition 20040101

Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.

Microbiology and immunology 20040101

Magnesium orotate--experimental and clinical evidence.

Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.

Carcinogenesis 20031201

High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue.

Magnetic resonance in medicine 20031101

Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris.

Yeast (Chichester, England) 20031101

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.

The Journal of biological chemistry 20030801

Concentration and purification of orotic acid directly from whey with an expanded bed adsorption system.

Journal of chromatography. A 20030718

Quantification of non-protein nitrogen components of infant formulae and follow-up milks: comparison with cows' and human milk.

The British journal of nutrition 20030701

Comprehensive study of the luminescent properties and lifetimes of Eu(3+) and Tb(3+) chelated with various ligands in aqueous solutions: influence of the synergic agent, the surfactant and the energy level of the ligand triplet.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

Influence of dietary arginine on sexual dimorphism of arginine metabolism in mice.

The Journal of nutritional biochemistry 20030601

Magnesium-orotate supplementation for idiopathic infertile male patients: a randomized, placebo-controlled clinical pilot study.

Magnesium research 20030601

Functions of a chitosan-orotic acid salt in the gastrointestinal tract.

Biological & pharmaceutical bulletin 20030501

Determination of orotic acid in urine by capillary zone electrophoresis in tandem-coupled columns with diode array detection.

Journal of chromatography. A 20030321

Rapid determination of orotic acid in urine by liquid chromatography-electrospray tandem mass spectrometry.

Clinical chemistry 20030301

Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet.

Clinical nutrition (Edinburgh, Scotland) 20030201

Rapid determination of orotic acid in urine by a fast liquid chromatography/tandem mass spectrometric method.

Rapid communications in mass spectrometry : RCM 20030101

[Mechanism of action of a novel antitumor preparation of chlofiden. Effect on RNA synthesis].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

Diagnostic value of urinary orotic acid levels: applicable separation methods.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021205

The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.

Protein science : a publication of the Protein Society 20021101

Urine amino and organic acids analysis in developmental delay or intellectual disability.

Journal of paediatrics and child health 20021001

An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mothers.

European journal of clinical nutrition 20021001

Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.

Mutation research 20020725

Unexpected toxicity induced by magnesium orotate treatment in congenital hypomagnesemia.

Journal of internal medicine 20020701

Variation in organic acids content during ripening of pickled white cheese.

Journal of dairy science 20020701

Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.

Bioscience, biotechnology, and biochemistry 20020601

Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.

Journal of hepatology 20020501

The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes.

Journal of inorganic biochemistry 20020428

Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap.

Journal of molecular biology 20020426

Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.

Journal of agricultural and food chemistry 20020327

Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301

Transcriptional cosuppression of yeast Ty1 retrotransposons.

Genes & development 20020215

The oral anti-volatile sulphur compound effects of zinc salts and their stability constants.

European journal of oral sciences 20020201

Dietary orotic acid increases 1 ,2-diacylglycerol level and lowers superoxide dismutase activity in rat liver.

Journal of nutritional science and vitaminology 20020201

Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.

Chemistry (Weinheim an der Bergstrasse, Germany) 20020104

A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.

Human gene therapy 20020101

[Orotic acid as a metabolic agent].

Vestnik Rossiiskoi akademii meditsinskikh nauk 20020101

Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.

BMC pediatrics 20020101

Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.

Journal of the American Chemical Society 20011205

Evolution: constantly avoiding mutation.

Current biology : CB 20011113

Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.

The Journal of pharmacology and experimental therapeutics 20011101

Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.

Parasitology international 20011101

Orotic acid added to casein, but not to egg protein, soy protein, or wheat gluten diets increases 1,2-diacylglycerol levels and lowers superoxide dismutase activities in rat liver.

Bioscience, biotechnology, and biochemistry 20011001

Pitfalls in the detection of heterozygosity by allopurinol in a variant form of ornithine carbamoyltransferase deficiency.

Journal of inherited metabolic disease 20010801

Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.

Archives of biochemistry and biophysics 20010715

Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.

The Journal of biological chemistry 20010629

Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

Biochemistry 20010619

Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.

Nature structural biology 20010601

Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.

Clinica chimica acta; international journal of clinical chemistry 20010601

Capillary zone electrophoresis of orotic acid in urine with on-line isotachophoresis sample pretreatment and diode array detection.

Journal of chromatography. A 20010504

Rapid selection against truncation mutants in yeast reverse two-hybrid screens.

BioTechniques 20010501

Extremely short small bowel induces focal tubulointerstitial fibrosis.

Journal of pediatric gastroenterology and nutrition 20010501

Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.

Biochemistry 20010410

Successful living-donor liver transplantation from an asymptomatic carrier mother in ornithine transcarbamylase deficiency.

The Journal of pediatrics 20010301

Large-scale production of the carbohydrate portion of the sialyl-Tn epitope, alpha-Neup5Ac-(2-->6)-D-GalpNAc, through bacterial coupling.

Carbohydrate research 20010227

Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.

Biochemistry 20010220

Ornithine carbamoyltransferase deficiency: improved sensitivity of testing for protein tolerance in the diagnosis of heterozygotes.

Journal of inherited metabolic disease 20010201

Laboratory evaluation of urea cycle disorders.

The Journal of pediatrics 20010101

[Passive orthostatic test in evaluation of efficiency of medical rehabilitation of flying personnel].

Voenno-meditsinskii zhurnal 20010101

[Effectiveness of treating periodontitis in patients with thyroid dysfunction].

Stomatologiia 20010101

Media formulations for various two-hybrid systems.

Methods in molecular biology (Clifton, N.J.) 20010101

[Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders].

Eksperimental'naia i klinicheskaia farmakologiia 20010101

Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

Plant foods for human nutrition (Dordrecht, Netherlands) 20010101

Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii.

Biochemical pharmacology 19991101

Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus.

Journal of biochemistry 19990101

Magnesium orotate in myocardial and neuronal protection.

Romanian journal of internal medicine = Revue roumaine de medecine interne 19990101

Metabolic supplementation with orotic acid and magnesium orotate.

Cardiovascular drugs and therapy 19980901

In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.

Carcinogenesis 19940901

Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase.

Biochimica et biophysica acta 19530101