Home Halogens 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide

4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide

CAS No.:
112885-41-3
Catalog Number:
AG007ROY
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.8929
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$25
- +
5g
98%
In Stock USA
United States
$82
- +
10g
98%
In Stock USA
United States
$138
- +
25g
98%
In Stock USA
United States
$282
- +
Product Description
Catalog Number:
AG007ROY
Chemical Name:
4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide
CAS Number:
112885-41-3
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.8929
MDL Number:
MFCD00867430
IUPAC Name:
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
InChI:
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
InChI Key:
YPELFRMCRYSPKZ-UHFFFAOYSA-N
SMILES:
CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl
EC Number:
601-210-0
Properties
Complexity:
521  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
421.157g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
421.897g/mol
Monoisotopic Mass:
421.157g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
76.8A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
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Effects of mosapride citrate on patients after vagal nerve preserving distal gastrectomy reconstructed by interposition of a jejunal J pouch with a jejunal conduit for early gastric cancer. World journal of surgery 20060201
Simultaneous quantification of cilostazol and its primary metabolite 3,4-dehydrocilostazol in human plasma by rapid liquid chromatography/tandem mass spectrometry. Analytical and bioanalytical chemistry 20060201
Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat. Journal of pharmacological and toxicological methods 20060101
Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying. Journal of diabetes and its complications 20060101
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Rapid, simple and highly sensitive LC-ESI-MS/MS method for the quantification of tamsulosin in human plasma. Biomedical chromatography : BMC 20051201
Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease. Parkinsonism & related disorders 20051201
Validation and application of a high-performance liquid chromatography--tandem mass spectrometry assay for mosapride in human plasma. Biomedical chromatography : BMC 20050901
The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression. Clinical pharmacology and therapeutics 20050901
A 5-HT4 agonist, mosapride, enhances intrinsic rectorectal and rectoanal reflexes after removal of extrinsic nerves in guinea pigs. American journal of physiology. Gastrointestinal and liver physiology 20050801
Effects of mosapride, a 5-hydroxytryptamine 4 receptor agonist, on electrical activity of the small intestine and cecum in horses. American journal of veterinary research 20050801
Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients. Movement disorders : official journal of the Movement Disorder Society 20050601
Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies. Alimentary pharmacology & therapeutics 20050601
Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia. Alimentary pharmacology & therapeutics 20050601
New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline. Alimentary pharmacology & therapeutics 20050601
[Comparative study on treatment of diabetic gastroparesis by acupuncture and Western medicine]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20050401
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. Therapeutics and clinical risk management 20050301
Persistent cough following pulmonary resection: observational and empiric study of possible causes. The Annals of thoracic surgery 20050101
Randomised, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia. Journal of the Indian Medical Association 20041201
Development and validation of a liquid chromatographic method for determination of related-substances of mosapride citrate in bulk drugs and pharmaceuticals. Journal of pharmaceutical and biomedical analysis 20041119
[The effect of mosapride on quality of life in functional dyspepsia]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20040301
[A randomized controlled Multi-center clinical trial on mosapride in the treatment of functional dyspepsia]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20040201
[New preparation method for barium enema: efficacy and administration of oral intestinal lavage solution with gastrointestinal prokinetic agent]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20040101
Comparison of efficacy of pantoprazole alone versus pantoprazole plus mosapride in therapy of gastroesophageal reflux disease: a randomized trial. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101
The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease. European journal of gastroenterology & hepatology 20031001
Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy. Diabetes research and clinical practice 20030901
Investigation into the effects of mosapride on motility of Guinea pig stomach, ileum, and colon. Yonsei medical journal 20030830
A 5-HT4 agonist mosapride enhances rectorectal and rectoanal reflexes in guinea pigs. American journal of physiology. Gastrointestinal and liver physiology 20030801
Stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo. The Journal of pharmacology and experimental therapeutics 20030801
Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug. Journal of pharmaceutical and biomedical analysis 20030601
A case of ACTH-independent macronodular adrenal hyperplasia: simultaneous expression of several aberrant hormone receptors in the adrenal gland. Endocrine journal 20030601
Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice. World journal of gastroenterology 20030415
5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20030401
Drug interaction between mosapride and erythromycin without electrocardiographic changes. Japanese heart journal 20030301
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity. Journal of medicinal chemistry 20030227
5-HT4 receptor ligands: applications and new prospects. Journal of medicinal chemistry 20030130
Effect of temperature on the reversal in the retention order of the enantiomers of mosapride on Chiral-AGP. Journal of biochemical and biophysical methods 20021231
Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs. Japanese journal of pharmacology 20021201
A validated RP-HPLC method for the determination of mosapride citrate in bulk drug samples and pharmaceutical formulations. Die Pharmazie 20021201
The determination of mosapride citrate in bulk drug samples and pharmaceutical dosage forms using HPLC. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021101
In vivo assessment of acceleration of motor activity associated with acetylcholine release via 5-hydroxytryptamine4 receptor in dog intestine. Japanese journal of pharmacology 20020901
[Reflux esophagitis]. Nihon rinsho. Japanese journal of clinical medicine 20020801
5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon. Autonomic neuroscience : basic & clinical 20020731
Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus. Diabetologia 20020601
Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study. Alimentary pharmacology & therapeutics 20020501
Drug-induced ventricular tachyarrhythmia in isolated rabbit hearts with atrioventricular block. Pharmacology & toxicology 20020501
Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents. Bioorganic & medicinal chemistry letters 20020325
[Prokinetics of gastrointestinal system; its newer aspects with regard to motillity stimulants]. Nihon rinsho. Japanese journal of clinical medicine 20020201
KDR-5169, a new gastrointestinal prokinetic agent, enhances gastric contractile and emptying activities in dogs and rats. European journal of pharmacology 20020111
5-HT4 receptors in the hippocampus modulate rat locomotor activity. Hippocampus 20020101
Teratogenicity of the I(Kr)-blocker cisapride: relation to embryonic cardiac arrhythmia. Reproductive toxicology (Elmsford, N.Y.) 20020101
Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. Journal of gastroenterology 20020101
Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel. The Journal of pharmacology and experimental therapeutics 20011201
Characteristics of fluvoxamine-induced nausea. Psychiatry research 20011130
Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin. Biological & pharmaceutical bulletin 20010901
Effects of 5-HT(4) receptor agonists, cisapride and mosapride citrate on electrocardiogram in anaesthetized rats and guinea-pigs and conscious cats. Pharmacology & toxicology 20010801
Pharmacological characterization of a novel 5-HT4 receptor agonist, TS-951, in vitro. Pharmacology 20010701
Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia. Pacing and clinical electrophysiology : PACE 20010101
The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug metabolism and disposition: the biological fate of chemicals 20001001
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. Journal of neurochemistry 20000201
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