Propanedinitrile,2-[(3-hydroxy-4-nitrophenyl)methylene]-
| Title | Journal |
|---|---|
| Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study. | Biochemical pharmacology 20110901 |
| Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells. | PloS one 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. | Neurochemical research 20100401 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. | American journal of physiology. Heart and circulatory physiology 20090201 |
| Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma. | Neuropharmacology 20070601 |
| Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid. | The Journal of pharmacology and experimental therapeutics 20070201 |
| A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. | Molecular pharmacology 20060401 |
| Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. | Surgery 20051101 |
| Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. | Journal of leukocyte biology 20040901 |
| The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. | Journal of neurochemistry 20040801 |
| Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601 |
| The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis. | Experimental and molecular pathology 20040601 |
| Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. | American journal of physiology. Cell physiology 20040501 |
| Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status. | Cellular microbiology 20031201 |
| The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. | Kidney international 20031101 |
| Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. | Investigative ophthalmology & visual science 20030401 |
| Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | BMC ophthalmology 20030101 |
| The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. | Intensive care medicine 20020601 |
| Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice. | Journal of perinatal medicine 20020101 |
| The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. | Leukemia 20011101 |
| The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. | European journal of immunology 20010701 |
| ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. | The Journal of biological chemistry 20010209 |
| Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Journal of medicinal chemistry 19891001 |