3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
| Title | Journal |
|---|---|
| Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton. | Toxicology 20170815 |
| The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. | Journal of medicinal chemistry 20130808 |
| LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin. | Neurobiology of disease 20120901 |
| Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells. | Endocrinology 20120801 |
| The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine. | Die Pharmazie 20120801 |
| Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. | Science translational medicine 20120704 |
| Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ERK pathway. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20120701 |
| Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501 |
| Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2. | Molecular and biochemical parasitology 20120501 |
| Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptors. | PloS one 20120101 |
| Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. | Human molecular genetics 20111015 |
| Signaling cascades mediate astrocyte death induced by zinc. | Toxicology letters 20110728 |
| A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2. | Expert opinion on investigational drugs 20110401 |
| Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. | Nature chemical biology 20110201 |
| Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. | Biochimie 20101201 |
| Identification of specific inhibitors for a trypanosomatid RNA editing reaction. | RNA (New York, N.Y.) 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition. | Cell cycle (Georgetown, Tex.) 20100815 |
| Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. | Journal of vascular research 20100801 |
| Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways. | Endocrinology 20100701 |
| Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. | Endocrinology 20100201 |
| C-Raf is associated with disease progression and cell proliferation in a subset of melanomas. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090915 |
| Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. | The Journal of biological chemistry 20090821 |
| Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity. | Cellular signalling 20090501 |
| Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. | Experimental & molecular medicine 20090430 |
| Raf-1: a novel cardiac troponin T kinase. | Journal of muscle research and cell motility 20090101 |
| Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. | Toxicology and applied pharmacology 20081201 |
| Raf inhibition protects cortical cells against beta-amyloid toxicity. | Neuroscience letters 20081017 |
| Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity. | The Journal of general virology 20081001 |
| Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. | Journal of neurochemistry 20080501 |
| Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501 |
| Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner. | European journal of pharmacology 20080428 |
| The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice. | Respiratory research 20080101 |
| Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. | Journal of pharmacological sciences 20070901 |
| Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. | Neuroreport 20061106 |
| Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. | Journal of pharmacological sciences 20061101 |
| Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074. | European journal of pharmacology 20060701 |
| Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells. | Molecular cancer therapeutics 20060301 |
| Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | Journal of cellular biochemistry 20060201 |
| Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. | Reproductive biology and endocrinology : RB&E 20060101 |
| Structural model of the Plasmodium CDK, Pfmrk, a novel target for malaria therapeutics. | Journal of molecular graphics & modelling 20050901 |
| Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. | Frontiers in bioscience : a journal and virtual library 20050101 |
| The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | Journal of neurochemistry 20040801 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |