Home Other Building Blocks Thieno[3,2-d]pyrimidine

Thieno[3,2-d]pyrimidine

CAS No.:
272-68-4
Catalog Number:
AG007LBM
Molecular Formula:
C6H4N2S
Molecular Weight:
136.1744
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
95%
1 week
United States
$146
- +
Product Description
Catalog Number:
AG007LBM
Chemical Name:
Thieno[3,2-d]pyrimidine
CAS Number:
272-68-4
Molecular Formula:
C6H4N2S
Molecular Weight:
136.1744
MDL Number:
MFCD11110439
IUPAC Name:
thieno[3,2-d]pyrimidine
InChI:
InChI=1S/C6H4N2S/c1-2-9-6-3-7-4-8-5(1)6/h1-4H
InChI Key:
RBNBDIMXFJYDLQ-UHFFFAOYSA-N
SMILES:
c1ncc2c(n1)ccs2
Properties
Complexity:
107  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
136.01g/mol
Formal Charge:
0
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
136.172g/mol
Monoisotopic Mass:
136.01g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
54A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3  
Literature
Title Journal
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors. Bioorganic & medicinal chemistry letters 20130101
Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines. Bioorganic & medicinal chemistry 20121115
Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents. European journal of medicinal chemistry 20120901
Thieno analogues of RNA nucleosides: a detailed theoretical study. The journal of physical chemistry. B 20120705
Synthesis and antimicrobial activity of new substituted thienopyrimidines, their tetrazolyl and sugar derivatives. Acta poloniae pharmaceutica 20120101
Synthesis and anti-tumor activities of N'-benzylidene-2-(4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone derivatives. Bioorganic & medicinal chemistry letters 20111115
Thienopyrimidines as novel inhibitors of Mycobacterium tuberculosis: synthesis and in-vitro studies. Archiv der Pharmazie 20110701
Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. European journal of medicinal chemistry 20110301
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes. European journal of medicinal chemistry 20110101
Synthesis, antitrichinnellosis and antiprotozoal activity of some novel thieno[2,3-d]pyrimidin-4(3H)-ones containing benzimidazole ring. European journal of medicinal chemistry 20101201
Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity. European journal of medicinal chemistry 20101101
Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta pharmaceutica (Zagreb, Croatia) 20100901
Novel thiophenes, thienopyrimidines, and triazolothienopyrimidines for the evaluation of anticancer and augmentation effects of gamma-radiation. Archiv der Pharmazie 20100701
Recent advances in the development of selective, ATP-competitive inhibitors of mTOR. Current opinion in drug discovery & development 20100701
Synthesis and study of antiproliferative activity of novel thienopyrimidines on glioblastoma cells. European journal of medicinal chemistry 20100601
Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine receptor ligands. European journal of medicinal chemistry 20100501
Thieno[2,3-d]pyrimidines in the synthesis of antitumor and antioxidant agents. Archiv der Pharmazie 20100501
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorganic & medicinal chemistry letters 20100115
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorganic & medicinal chemistry letters 20100101
Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives. Organic & biomolecular chemistry 20091121
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity. Bioorganic & medicinal chemistry letters 20091101
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorganic & medicinal chemistry letters 20091015
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain. Bioorganic & medicinal chemistry letters 20090615
Enzymatic incorporation of emissive pyrimidine ribonucleotides. Chemistry, an Asian journal 20090302
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors. Bioorganic & medicinal chemistry letters 20090301
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors. Bioorganic & medicinal chemistry letters 20090201
Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine. Molecular and cellular endocrinology 20090127
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . Journal of medicinal chemistry 20080925
Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines. European journal of medicinal chemistry 20080301
Synthesis and antimicrobial evaluation of some new thienopyrimidine derivatives. Acta pharmaceutica (Zagreb, Croatia) 20061201
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. Bioorganic & medicinal chemistry 20061015
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR). The Journal of biological chemistry 20060414
Synthesis and antiviral screening of some thieno[2,3-d]pyrimidine nucleosides. Nucleosides, nucleotides & nucleic acids 20060101
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. Journal of medicinal chemistry 20050922
Synthesis of new iso-C-nucleoside analogues from 2-(methyl 2-O-benzyl-4,6-O-benzylidene-3-deoxy-alpha-D-altropyranosid-3-yl)ethanal. Carbohydrate research 20050321
Long-term benefits of an early invasive management in acute coronary syndromes depend on intracoronary stenting and aggressive antiplatelet treatment: a metaregression. American heart journal 20050301
Endothelial action of thienopyridines and thienopyrimidinones in the isolated guinea pig heart. Prostaglandins, leukotrienes, and essential fatty acids 20050201
Synthesis of novel acyclonucleosides analogs of pyridothienopyrimidine as antiviral agents. Nucleosides, nucleotides & nucleic acids 20050101
Synthesis and antimicrobial activity of novel tetrahydrobenzothienopyrimidines. Archives of pharmacal research 20040901
Focusing on inflammation in the treatment of atherosclerosis. Cardiology in review 20040101
Synthesis of substituted thienopyrimidine-4-ones. Journal of combinatorial chemistry 20040101
Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents. European journal of medicinal chemistry 20030101
Properties