7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine,7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (8R)-
| Title | Journal |
|---|---|
| Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives. | ACS chemical neuroscience 20130417 |
| Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. | Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20110901 |
| Glutamate and the biology of gliomas. | Glia 20110801 |
| alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. | Journal of medicinal chemistry 20100812 |
| A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20100503 |
| Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100415 |
| Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. | Cancer 20100401 |
| Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090901 |
| [New roles of glutamate receptors in glias and gliomas]. | Brain and nerve = Shinkei kenkyu no shinpo 20090701 |
| Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model. | Epilepsia 20090401 |
| Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080806 |
| Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent. | Bioorganic & medicinal chemistry 20080301 |
| Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models. | British journal of pharmacology 20070901 |
| Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism. | Brain research bulletin 20070315 |
| [A new aspect in the research on antiepileptic drugs]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070201 |
| Talampanel. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101 |
| Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton. | Journal of medicinal chemistry 20060907 |
| Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia. | Brain research bulletin 20060731 |
| 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents. | Archiv der Pharmazie 20060701 |
| Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants. | Die Pharmazie 20060201 |
| Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study. | Brain research bulletin 20060115 |
| Potential metabolites of a condensed 2,3-benzodiazepine derivative. | Bioorganic & medicinal chemistry letters 20051101 |
| The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. | European journal of pharmacology 20050905 |
| New features in synthesis of talampanel related 2,3-benzodiazepines. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20050901 |
| Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans. | Journal of pharmacokinetics and pharmacodynamics 20050801 |
| The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia. | Brain research bulletin 20050715 |
| Influence of the combined treatment of LY 300164 (an AMPA/kainate receptor antagonist) with adenosine receptor agonists on the electroconvulsive threshold in mice. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001 |
| Effect of two noncompetitive AMPA receptor antagonists GYKI 52466 and GYKI 53405 on vigilance, behavior and spike-wave discharges in a genetic rat model of absence epilepsy. | Brain research 20040522 |
| Omeprazole and talampanel as two examples of retrometabolic drug design. | Die Pharmazie 20040501 |
| Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives. | Farmaco (Societa chimica italiana : 1989) 20040101 |
| AMPA receptor blockade potentiates the stimulatory effect of L-DOPA on dopamine release in dopamine-deficient corticostriatal slice preparation. | Critical reviews in neurobiology 20040101 |
| Is a hypothermic effect of LY300164, valproate and phenobarbital evident in mice? | Roczniki Akademii Medycznej w Bialymstoku (1995) 20040101 |
| Influence of LY 300164 alone or in combination with carbamazepine or diphenylhydantoin on the body temperature in mice. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives. | Journal of medicinal chemistry 20030814 |
| Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist. | Journal of medicinal chemistry 20030102 |
| Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. | Epilepsia 20030101 |
| Influence of LY 300164, an AMPA/kainate receptor antagonist upon the anticonvulsant action of antiepileptic drugs against aminophylline-induced seizures in mice. | Polish journal of pharmacology 20030101 |
| Influence of several convulsants on the protective activity of a non-competitive AMPA/kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201 |
| Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats. | Brain research bulletin 20021015 |
| Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801 |
| Na(+) entry through AMPA receptors results in voltage-gated k(+) channel blockade in cultured rat spinal cord motoneurons. | Journal of neurophysiology 20020801 |
| A crossover, add-on trial of talampanel in patients with refractory partial seizures. | Neurology 20020611 |
| AMPA and GABA(B) receptor antagonists and their interaction in rats with a genetic form of absence epilepsy. | European journal of pharmacology 20011102 |
| Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. | Journal of neurotrauma 20011001 |
| Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. | Brain research bulletin 20010601 |
| A kainate receptor increases the efficacy of GABAergic synapses. | Neuron 20010501 |
| AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. | Neurology 20000425 |
| Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. | European journal of pharmacology 19990910 |