Home Nitriles 4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile

4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile

CAS No.:
112809-51-5
Catalog Number:
AG0078V9
Molecular Formula:
C17H11N5
Molecular Weight:
285.3027
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
95%
In Stock USA
United States
$113
- +
1g
95%
In Stock USA
United States
$225
- +
5g
95%
In Stock USA
United States
$675
- +
Product Description
Catalog Number:
AG0078V9
Chemical Name:
4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile
CAS Number:
112809-51-5
Molecular Formula:
C17H11N5
Molecular Weight:
285.3027
MDL Number:
MFCD00866241
IUPAC Name:
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
InChI:
InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI Key:
HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)C(n1cncn1)c1ccc(cc1)C#N
UNII:
7LKK855W8I
Properties
Complexity:
420  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
285.101g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
285.31g/mol
Monoisotopic Mass:
285.101g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
78.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
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Randomized phase II trial of letrozole plus anti-MUC1 antibody AS1402 in hormone receptor-positive locally advanced or metastatic breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20111101
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Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age. Clinical pharmacology and therapeutics 20111101
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Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents. European journal of medicinal chemistry 20101201
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Phase II trial of combination of pegylated liposomal doxorubicin, cisplatin, and infusional 5-fluorouracil (CCF) plus trastuzumab as preoperative treatment for locally advanced and inflammatory breast cancer. Clinical breast cancer 20101201
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A randomized, placebo-controlled trial (NCIC CTG MAP1) examining the effects of letrozole on mammographic breast density and other end organs in postmenopausal women. Breast cancer research and treatment 20100401
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy. Breast (Edinburgh, Scotland) 20100401
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Feasibility trial of letrozole in combination with bevacizumab in patients with metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100201
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A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer. Breast cancer research and treatment 20100201
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A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. Fertility and sterility 20100101
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[A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy]. Gan to kagaku ryoho. Cancer & chemotherapy 20091201
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Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial. Fertility and sterility 20091001
Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis. Chirality 20091001
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer chemotherapy and pharmacology 20091001
Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC. Breast cancer research and treatment 20091001
Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism. The FEBS journal 20091001
Aromatase inhibitor letrozole in synergy with curcumin in the inhibition of xenografted endometrial carcinoma growth. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091001
Aromatase inhibitors for female infertility: a systematic review of the literature. Reproductive biomedicine online 20091001
Use of aromatase inhibitors in poor-responder patients receiving GnRH antagonist protocols. Reproductive biomedicine online 20091001
Update of the BIG 1-98 Trial: where do we stand? Breast (Edinburgh, Scotland) 20091001
Tamoxifen: the drug that came in from the cold. British journal of cancer 20090915
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood 20090910
Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial. Fertility and sterility 20090901
Letrozole versus clomiphene citrate: which is better for ovulation induction? Fertility and sterility 20090901
Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. Fertility and sterility 20090901
Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases? Annals of oncology : official journal of the European Society for Medical Oncology 20090901
Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial. Annals of oncology : official journal of the European Society for Medical Oncology 20090901
Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman. Fertility and sterility 20090901
Subdural collections arising from calvarial metastases following discontinuation of anti-angiogenic therapy. Annals of oncology : official journal of the European Society for Medical Oncology 20090901
Strategies for maximizing growth in puberty in children with short stature. Endocrinology and metabolism clinics of North America 20090901
The role of neoadjuvant (HER)2-targeted therapies in (HER)2-overexpressing breast cancers. Current oncology (Toronto, Ont.) 20090901
Effects of letrozole on bone biomarkers and femur fracture in female rats. Journal of physiology and biochemistry 20090901
Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826
Letrozole: a review of its use in the treatment of postmenopausal women with hormone-responsive early breast cancer. Drugs 20090820
Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. The New England journal of medicine 20090820
Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer? British journal of cancer 20090804
Endometrial and follicular development following letrozole intervention in unexplained infertile patients failed to get pregnant with clomiphene citrate. Archives of gynecology and obstetrics 20090801
Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. Hippocampus 20090801
Porcine hypothalamic aromatase cytochrome P450: isoform characterization, sex-dependent activity, regional expression, and regulation by enzyme inhibition in neonatal boars. Biology of reproduction 20090801
Estrogen promotes germ cell and seminiferous tubule development in the baboon fetal testis. Biology of reproduction 20090801
Alfacalcidol prevents aromatase inhibitor (Letrozole)-induced bone mineral loss in young growing female rats. The Journal of endocrinology 20090801
Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice. Hormones and behavior 20090801
Estrogens regulate humans and rabbit epididymal contractility through the RhoA/Rho-kinase pathway. The journal of sexual medicine 20090801
In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors. The Journal of clinical endocrinology and metabolism 20090801
Use of the aromatase inhibitor letrozole to treat male infertility. Fertility and sterility 20090801
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Annals of oncology : official journal of the European Society for Medical Oncology 20090801
Fulvestrant treatment is associated with cholesterol plasma level reduction in hormone-receptor-positive metastatic breast cancer patients. Cancer biology & therapy 20090801
The role of HER2-targeted therapies in women with HER2-overexpressing metastatic breast cancer. Current oncology (Toronto, Ont.) 20090801
Clinical perspectives on the utility of aromatase inhibitors for the adjuvant treatment of breast cancer. Breast (Edinburgh, Scotland) 20090801
De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 20090728
Antagonist/letrozole protocol in poor ovarian responders for intracytoplasmic sperm injection: a comparative study with the microdose flare-up protocol. Fertility and sterility 20090701
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol. Fertility and sterility 20090701
Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo-controlled trial. Fertility and sterility 20090701
Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial. Breast cancer research and treatment 20090701
Endocrine effects of adjuvant letrozole compared with tamoxifen in hormone-responsive postmenopausal patients with early breast cancer: the HOBOE trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090701
The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090701
Reassurance of safety of letrozole and suggested approaches in controlled ovarian hyperstimulation. Fertility and sterility 20090701
Promising effect of aromatase inhibitors on recurrent granulosa cell tumors. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20090701
Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome. The Annals of pharmacotherapy 20090701
Letrozole as a booster therapy in growth hormone deficiency. Indian pediatrics 20090701
An updated review on the efficacy of adjuvant endocrine therapies in hormone receptor-positive early breast cancer. Current oncology (Toronto, Ont.) 20090701
Safety of adjuvant endocrine therapies in hormone receptor-positive early breast cancer. Current oncology (Toronto, Ont.) 20090701
Preservation of fertility in patients with cancer. The New England journal of medicine 20090618
High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats. Talanta 20090615
Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes). Aquatic toxicology (Amsterdam, Netherlands) 20090604
Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertility and sterility 20090601
Digital image analysis of breast epithelial cells collected by random periareolar fine-needle aspirates (RPFNA) from women at high risk for breast cancer taking hormone replacement and the aromatase inhibitor, letrozole, for six months. Breast cancer research and treatment 20090601
Regulation of baboon fetal pituitary prolactin expression by estrogen. Biology of reproduction 20090601
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090601
History of aromatase: saga of an important biological mediator and therapeutic target. Endocrine reviews 20090601
Comparative review of anastrozole, letrozole and exemestane in the management of early breast cancer. Expert opinion on pharmacotherapy 20090601
Optimizing success with donor insemination. Frontiers in bioscience (Elite edition) 20090601
Design, conduct, and analyses of Breast International Group (BIG) 1-98: a randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer. Clinical trials (London, England) 20090601
Differential effects of aromatase inhibitors and antiestrogens on estrogen receptor expression in breast cancer cells. Anticancer research 20090601
Enhancing the efficacy of hormonal agents with selected targeted agents. Clinical breast cancer 20090601
A question of duration: do patients with early-stage breast cancer need more than five years of adjuvant endocrine therapy? Clinical breast cancer 20090601
Knowledge discovery processing and data mining in karyometry. Analytical and quantitative cytology and histology 20090601
Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. Journal of the National Cancer Institute 20090520
Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix. Fertility and sterility 20090501
A woman's heart: the impact of adjuvant endocrine therapy on cardiovascular health. Cancer 20090501
The efficacy of hormonal treatment for residual or recurrent low-grade endometrial stromal sarcoma. A retrospective study. European journal of obstetrics, gynecology, and reproductive biology 20090501
Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma. Current medical research and opinion 20090501
Zoledronic acid effectively prevents aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: Z-FAST study 36-month follow-up results. Clinical breast cancer 20090501
Accelerated cutaneous nodulosis associated with aromatase inhibitor therapy in a patient with rheumatoid arthritis. The Journal of rheumatology 20090501
Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial. Journal of the American College of Surgeons 20090501
2-Benzoylmethyl-4-[(2-benzylidene-ethylidene)amino]-5-(2-thienylmethyl)-2H-1,2,4-triazol-3(4H)-one. Acta crystallographica. Section E, Structure reports online 20090501
4-[(E)-4-Methoxy-benzyl-ideneamino]-3-{1-[4-(2-methyl-prop-yl)phen-yl]eth-yl}-1H-1,2,4-triazole-5(4H)-thione. Acta crystallographica. Section E, Structure reports online 20090501
A randomised study of the effects of letrozole and anastrozole on oestrogen receptor positive breast cancers in postmenopausal women. Breast cancer research and treatment 20090401
Regression of chronic lymphocytic leukemia with aromatase inhibitor-letrozole? Leukemia research 20090401
Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. Fertility and sterility 20090401
Developmental regulation of the expression of the transferrin receptor and Ki67 in oocytes of the baboon fetal ovary by estrogen. Endocrine 20090401
Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients. European journal of obstetrics, gynecology, and reproductive biology 20090401
Bone Quality Test (BQT) scores of fingernails in postmenopausal patients treated with adjuvant letrozole or tamoxifen for early breast cancer. Breast (Edinburgh, Scotland) 20090401
Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nuclear medicine and biology 20090401
Gene expression profiles differentiating between breast cancers clinically responsive or resistant to letrozole. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090320
Effectiveness of a letter notification program for women with early-stage breast cancer eligible for extended adjuvant letrozole. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090320
Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours. British journal of cancer 20090310
Long-term effectiveness of adjuvant goserelin in premenopausal women with early breast cancer. Journal of the National Cancer Institute 20090304
Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler. Archives of gynecology and obstetrics 20090301
Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men. European journal of endocrinology 20090301
Lack of complete cross-resistance between different aromatase inhibitors; a real finding in search for an explanation? European journal of cancer (Oxford, England : 1990) 20090301
Infusional fluorouracil, epirubicin, and cisplatin followed by weekly paclitaxel plus bevacizumab in locally advanced breast cancer with unfavorable prognostic features. Anti-cancer drugs 20090301
Future targets in endometriosis treatment: targeting the endometriotic implant. Mini reviews in medicinal chemistry 20090301
[Adjuvant breast cancer treatment with hormono-radiotherapy]. Bulletin du cancer 20090301
[Lipid metabolism disorders at the breast cancer patients receiving hormonotherapy]. Georgian medical news 20090301
Development of cell-cycle inhibitors for cancer therapy. Current oncology (Toronto, Ont.) 20090301
Controversies in the definition and treatment of idiopathic short stature (ISS). Journal of clinical research in pediatric endocrinology 20090301
3-[1-(4-Isobutyl-phen-yl)eth-yl]-1H-1,2,4-triazole-5(4H)-thione. Acta crystallographica. Section E, Structure reports online 20090301
[Ovulation induction by means of letrozole]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090226
Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen. Cancer research 20090215
Exemestane as primary treatment of oestrogen receptor-positive breast cancer in postmenopausal women: a phase II trial. British journal of cancer 20090210
Treating elderly patients with hormone sensitive breast cancer: what do the data show? Cancer treatment reviews 20090201
A case of prolonged disease-free survival in a patient with choroidal metastasis from breast cancer. Nature clinical practice. Oncology 20090201
Aromatase inhibitors and bone health. Current opinion in obstetrics & gynecology 20090201
Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC. Electrophoresis 20090201
Immunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20090201
Long-term inhibition of 5-alpha reductase and aromatase changes the cellular and extracellular compartments in gerbil ventral prostate at different postnatal ages. International journal of experimental pathology 20090201
Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug. Nuclear medicine and biology 20090201
Phase 3 trials of aromatase inhibitors for breast cancer prevention: following in the path of the selective estrogen receptor modulators. Annals of the New York Academy of Sciences 20090201
Aromatase inhibitors and breast cancer. Annals of the New York Academy of Sciences 20090201
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090110
Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. Journal of medicinal chemistry 20090108
Joint effects of body size, energy intake, and physical activity on breast cancer risk. Breast cancer research and treatment 20090101
Effects of letrozole and clomiphene citrate on the expression of HOXA10 and integrin alpha v beta 3 in uterine epithelium of rats. Fertility and sterility 20090101
Increase in response rate by prolonged treatment with neoadjuvant letrozole. Breast cancer research and treatment 20090101
Start strong or switch? Adjuvant endocrine strategies for postmenopausal women with hormone-sensitive breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090101
Letrozole in ovulation induction: time to make decisions. Human reproduction update 20090101
Prescribing adjuvant letrozole to patients well after the completion of tamoxifen: a good idea? Current oncology reports 20090101
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility. Acta obstetricia et gynecologica Scandinavica 20090101
The Coffey Lecture: steroidogenic enzyme inhibitors and hormone dependent cancer. Urologic oncology 20090101
San Antonio Breast Cancer Symposium. The Lancet. Oncology 20090101
Vitamin D insufficiency and musculoskeletal symptoms in breast cancer survivors on aromatase inhibitor therapy. Cancer nursing 20090101
Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial. Journal of assisted reproduction and genetics 20090101
Update on the role of aromatase inhibitors in growth disorders. Hormone research 20090101
A case of Meigs syndrome mimicking metastatic breast carcinoma. World journal of surgical oncology 20090101
An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer. Acta oncologica (Stockholm, Sweden) 20090101
Breast cancer in young women and its impact on reproductive function. Human reproduction update 20090101
Current indications for post-mastectomy radiation. International seminars in surgical oncology : ISSO 20090101
Are we HER-ting for innovation in neoadjuvant breast cancer trial design? Breast cancer research : BCR 20090101
Development and validation of RP-HPLC method to determine letrozole in different pharmaceutical formulations and its application to studies of drug release from nanoparticles. Acta poloniae pharmaceutica 20090101
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors. Breast cancer research : BCR 20090101
Diagnosis and treatment of early breast cancer, including locally advanced disease--summary of NICE guidance. BMJ (Clinical research ed.) 20090101
Risk reduction of distant metastasis in hormone-sensitive postmenopausal breast cancer. Breast cancer (Tokyo, Japan) 20090101
Enhancing the adjuvant treatment of hormone receptor positive breast cancer. The breast journal 20090101
Quantitative real-time RT-PCR and chromogenic in situ hybridization: precise methods to detect HER-2 status in breast carcinoma. BMC cancer 20090101
Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- and peripubertal boys with idiopathic short stature. Hormone research 20090101
Australian clinicians and chemoprevention for women at high familial risk for breast cancer. Hereditary cancer in clinical practice 20090101
A review of the use of exemestane in early breast cancer. Therapeutics and clinical risk management 20090101
Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy. Menopause (New York, N.Y.) 20090101
Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells. BMC cancer 20090101
In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer. BMC cancer 20090101
Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: final results of the ATENA lipid substudy. Breast cancer research : BCR 20090101
Current trends in the treatment of polycystic ovary syndrome with desire for children. Therapeutics and clinical risk management 20090101
The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial. BMC medical genomics 20090101
[Criteria for evaluating the effectiveness of aromatase inhibitors in the neoadjuvant treatment of patients with endometrial carcinoma]. Voprosy onkologii 20090101
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ. BMC cancer 20090101
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Reproduction, fertility, and development 20090101
HER2 breast cancer therapies: a review. Biologics : targets & therapy 20090101
'hCG priming' effect in controlled ovarian stimulation through a long protocol. Reproductive biology and endocrinology : RB&E 20090101
Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer. Breast cancer research : BCR 20090101
Tumor tissue levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and outcome following adjuvant chemotherapy in premenopausal lymph node-positive breast cancer patients: A retrospective study. BMC cancer 20090101
Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women. Therapeutics and clinical risk management 20090101
Long-term efficacy and safety of letrozole for the adjuvant treatment of early breast cancer in postmenopausal women: a review. Therapeutics and clinical risk management 20090101
A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. Reproductive biology and endocrinology : RB&E 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast cancer research : BCR 20090101
Abnormal 18F-FDG Uptake Detected with Positron Emission Tomography in a Patient with Breast Cancer: A Case of Sarcoidosis and Review of the Literature. Case reports in medicine 20090101
Can survival prediction be improved by merging gene expression data sets? PloS one 20090101
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. Journal of hematology & oncology 20090101
Pre-hCG 3D and 3D power Doppler assessment of the follicle for improving pregnancy rates in intrauterine insemination cycles. Journal of human reproductive sciences 20090101
Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network. BMC cancer 20090101
Update on the use of aromatase inhibitors in early-stage breast cancer. Breast cancer research : BCR 20090101
Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration. World journal of surgical oncology 20090101
Antiproliferative effect of exemestane in lung cancer cells. Molecular cancer 20090101
Idiopathic short stature: conundrums of definition and treatment. International journal of pediatric endocrinology 20090101
Drug-induced hematologic syndromes. Advances in hematology 20090101
The potential use of intrauterine insemination as a basic option for infertility: a review for technology-limited medical settings. Obstetrics and gynecology international 20090101
Who would have thought a single Ki67 measurement would predict long-term outcome? Breast cancer research : BCR 20090101
Introduction to sessions on guidelines and endocrine therapy, the influence of breast screening on number of mastectomies and the challenge between molecular science and traditional dogma in the treatment of breast cancer. Introduction to Session 6. Breast cancer research : BCR 20090101
Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy? Breast cancer research : BCR 20090101
Breast screening has increased the number of mastectomies. Breast cancer research : BCR 20090101
Are current drug development programmes realising the full potential of new agents? The scenario. Breast cancer research : BCR 20090101
Are current drug development programmes realising the full potential of new agents? Tyrosine kinase inhibitors. Breast cancer research : BCR 20090101
Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy. Breast cancer research : BCR 20090101
Tailored targeted therapy for all: a realistic and worthwhile objective? Breast cancer research : BCR 20090101
CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease. Breast cancer research : BCR 20090101
[Aromatase inhibitors in risk reduction of breast cancer: potential use in premenopausal women]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20090101
Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials. International journal of general medicine 20090101
The evolving role of zoledronic acid in early breast cancer. OncoTargets and therapy 20090101
Multiple roles and therapeutic implications of Akt signaling in cancer. OncoTargets and therapy 20090101
Acute uveitis following zoledronic acid infusion. Oman journal of ophthalmology 20090101
Recent advances in managing osteoporosis. F1000 medicine reports 20090101
Aromatase inhibitor strategies in metastatic breast cancer. International journal of women's health 20090101
Growth factor receptors and apoptosis regulators: signaling pathways, prognosis, chemosensitivity and treatment outcomes of breast cancer. Breast cancer : basic and clinical research 20090101
The evolution of treatment for early breast cancer: what's next? Ecancermedicalscience 20090101
Sonographic evaluation of endothelial function in letrozole and tamoxifen users. Maturitas 20081220
Economic evaluation of fulvestrant as an extra step in the treatment sequence for ER-positive advanced breast cancer. British journal of cancer 20081209
Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars. Animal reproduction science 20081201
Preoperative concurrent chemo- and endocrine therapies for women with large operable breast cancer expressing steroid hormone receptors. Breast (Edinburgh, Scotland) 20081201
Abnormal cervical smear: a sign of disseminated breast cancer. European journal of obstetrics, gynecology, and reproductive biology 20081201
Extending the benefits of adjuvant therapy in early HR+ breast cancer. Breast cancer research and treatment 20081201
Never too late: reducing late breast cancer relapse risk. Current medical research and opinion 20081201
Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081201
Overcoming recurrence risk: extended adjuvant endocrine therapy. Clinical breast cancer 20081201
Understanding the BIG results: Insights from the BIG 1-98 trial analyses. Advances in therapy 20081201
Are all aromatase inhibitors alike? Breast cancer research and treatment 20081201
Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer. Clinical interventions in aging 20081201
Exemestane in early breast cancer: a review. Therapeutics and clinical risk management 20081201
3-[1-(4-Isobutyl-phen-yl)eth-yl]-4-[(E)-4-methyl-benzyl-ideneamino]-1H-1,2,4-triazole-5(4H)-thione. Acta crystallographica. Section E, Structure reports online 20081201
Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and/or PgR-positive breast cancer: clinical and biological activity. British journal of cancer 20081104
Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination. Fertility and sterility 20081101
Aromatase inhibitors in the management of early breast cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20081101
Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis 20081101
Aromatase inhibition during adolescence reduces adult sexual and paternal behavior in the biparental dwarf hamster Phodopus campbelli. Hormones and behavior 20081101
[Effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20081101
[Problems and future direction of preoperative systemic therapy for patients with operable breast cancer]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20081101
A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research 20081015
A comparison of letrozole to gonadotropins for ovulation induction in subjects with advanced maternal age: a retrospective pilot study. Fertility and sterility 20081001
Antiestrogen therapies affect tissue homeostasis of the gerbil (Meriones unguiculatus) female prostate and ovaries. Biology of reproduction 20081001
Effects of testosterone undecanoate administered alone or in combination with letrozole or dutasteride in female to male transsexuals. The journal of sexual medicine 20081001
Cutaneous vasculitis in breast cancer treated with chemotherapy. Clinical immunology (Orlando, Fla.) 20081001
Focus on breast and ovarian cancer. Placenta 20081001
HER-2-positive metastatic breast cancer: trastuzumab and beyond. Expert opinion on pharmacotherapy 20081001
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics. Journal of the National Cancer Institute 20081001
Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels. Clinical cancer research : an official journal of the American Association for Cancer Research 20081001
Treatment of symptomatic uterine leiomyoma with letrozole. Reproductive biomedicine online 20081001
Safety profiles of aromatase inhibitors and selective estrogen-receptor modulators in the treatment of early breast cancer. International journal of clinical oncology 20081001
Extended adjuvant endocrine therapy in breast cancer: current status and future directions. Clinical breast cancer 20081001
Breast cancer survivors. Australian family physician 20081001
Survival from breast cancer in England and Wales up to 2001. British journal of cancer 20080923
Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential? British journal of cancer 20080902
Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Breast cancer research and treatment 20080901
Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination. Fertility and sterility 20080901
Screening and management of osteoporosis in breast cancer patients on aromatase inhibitors. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20080901
Luteal phase oestradiol suppression by letrozole: a pilot study in oocyte donors. Reproductive biomedicine online 20080901
Hormone therapy for epithelial ovarian cancer. Current opinion in oncology 20080901
Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors. Bioorganic & medicinal chemistry letters 20080815
Target and reality of adjuvant endocrine therapy in postmenopausal patients with invasive breast cancer. British journal of cancer 20080805
Safely promoting breast-conserving surgery and preventing early relapses with an aromatase inhibitor. Surgical oncology 20080801
Tolerance of adjuvant letrozole outside of clinical trials. Breast (Edinburgh, Scotland) 20080801
Effects of the aromatase inhibitor letrozole on in utero development in rats. Human reproduction (Oxford, England) 20080801
Reducing early recurrence with adjuvant aromatase inhibitors: what is the evidence? Breast (Edinburgh, Scotland) 20080801
The endocrine prevention of breast cancer. Best practice & research. Clinical endocrinology & metabolism 20080801
[Clinical analysis of assistant treatment proposals for infertile women with polycystic ovary syndrome]. Zhonghua fu chan ke za zhi 20080801
4-[(E)-2-Furylmethyl-eneamino]-3-phenyl-1H-1,2,4-triazole-5(4H)-thione. Acta crystallographica. Section E, Structure reports online 20080801
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. Journal of medicinal chemistry 20080724
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands. Biochemical pharmacology 20080715
A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20080715
The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands. Breast cancer research and treatment 20080701
A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy. Breast cancer research and treatment 20080701
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. Fertility and sterility 20080701
Choosing early adjuvant therapy for postmenopausal women with hormone-sensitive breast cancer: aromatase inhibitors versus tamoxifen. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20080701
The role of endocrine therapies in reducing risk of recurrence in postmenopausal women with hormone receptor-positive breast cancer. European journal of oncology nursing : the official journal of European Oncology Nursing Society 20080701
Efficacy of letrozole in the treatment of recurrent platinum- and taxane-resistant high-grade cancer of the ovary or peritoneum. Gynecologic oncology 20080701
Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer. The Journal of steroid biochemistry and molecular biology 20080701
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. Journal of natural products 20080701
Method to test whether late extended letrozole, rather than self- selection, improves the outcome in patients with breast cancer who have completed 5 years of tamoxifen. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080701
Experience with exemestane in the treatment of early and advanced breast cancer. Expert opinion on drug metabolism & toxicology 20080701
Stopping treatment can reverse acquired resistance to letrozole. Cancer research 20080615
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer research 20080615
Factors that predict early treatment failure for patients with locally advanced (T4) breast cancer. British journal of cancer 20080603
Increased intrafollicular androgen levels affect human granulosa cell secretion of anti-Müllerian hormone and inhibin-B. Fertility and sterility 20080601
Pre-clinical validation of early molecular markers of sensitivity to aromatase inhibitors in a mouse model of post-menopausal hormone-sensitive breast cancer. Breast cancer research and treatment 20080601
Intravenous leiomyomatosis treated with aromatase inhibitor therapy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20080601
Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080601
Excellent response to letrozole in brain metastases from breast cancer. Acta neurochirurgica 20080601
Fertility preservation: a vital survivorship issue for young women with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080601
Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080601
Drugs in infertility and fetal safety. Fertility and sterility 20080601
Estrogen receptor (ER) and epidermal growth factor receptor (EGFR) as targets for dual lung cancer therapy: not just a case? Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080601
Aromatase inhibitors: a new reality for the adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women. Mini reviews in medicinal chemistry 20080601
Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. The Journal of steroid biochemistry and molecular biology 20080601
Reducing the risk of distant metastases: a better end point in adjuvant aromatase inhibitor breast cancer trials? Cancer investigation 20080601
[Adjuvant endocrine therapy in postmenopausal hormone-sensitive breast cancer: to start, to switch or to extend?]. Magyar onkologia 20080601
Switching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women. British journal of cancer 20080506
Cost utility analysis of early adjuvant letrozole or anastrozole versus tamoxifen in postmenopausal women with early invasive breast cancer: the UK perspective. The European journal of health economics : HEPAC : health economics in prevention and care 20080501
Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial. Fertility and sterility 20080501
Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2). European journal of obstetrics, gynecology, and reproductive biology 20080501
CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma. Drug metabolism and disposition: the biological fate of chemicals 20080501
Sex steroids and leptin regulate the 'first Kiss' (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. The journal of sexual medicine 20080501
Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17. Annals of oncology : official journal of the European Society for Medical Oncology 20080501
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. European journal of endocrinology 20080501
Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphen citrate gonadotropins in controlled ovarian hyperstimulation: a prospective, simply randomized, clinical trial. Journal of assisted reproduction and genetics 20080501
Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20080501
Targeting breast cancer with hormonal treatment options. The Nurse practitioner 20080501
Controlling for the EFFECTS related to the underlying pathology of infertility. Fertility and sterility 20080501
Integrated analysis of zoledronic acid for prevention of aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole. The oncologist 20080501
Development, physical characterization, micromeritics and in vitro release kinetics of letrozole loaded biodegradable nanoparticles. Die Pharmazie 20080501
Role of ErbB2 in selection for adjuvant tamoxifen or aromatase inhibitors. Women's health (London, England) 20080501
Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080420
Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080420
Efficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080420
Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080420
Evaluation of neoadjuvant inhibition of aromatase activity and signal transduction in breast cancer. Cancer letters 20080418
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in postmenopausal women with hormone-receptor positive early breast cancer from a Canadian perspective. Breast cancer research and treatment 20080401
Beyond tamoxifen: extended and late extended endocrine therapy in postmenopausal early breast cancer. Cancer treatment reviews 20080401
Aromatase inhibitors in adjuvant therapy for hormone receptor positive breast cancer: a systematic review. Cancer treatment reviews 20080401
Aromatase inhibitors in early breast-cancer treatment: The story so far. Breast (Edinburgh, Scotland) 20080401
Letrozole suppresses plasma estradiol and estrone sulphate more completely than anastrozole in postmenopausal women with breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080401
Impact of estrogen deprivation on gene expression profiles of normal postmenopausal breast tissue in vivo. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080401
[A case of elderly breast cancer achieving partial response by letrozole with stable disease to anastrozole as neoadjuvant endocrine therapy]. Gan to kagaku ryoho. Cancer & chemotherapy 20080401
Neoadjuvant endocrine therapy for breast cancer: past, present and future. Anti-cancer drugs 20080401
Micellar electrokinetic chromatographic method for the determination of letrozole, citalopram and their metabolites in human urine. Journal of chromatography. A 20080328
Decision making in adjuvant trials in breast cancer: the NCIC CTG MA.17 trial as an example. Breast cancer research and treatment 20080301
Facilitating breast-conserving surgery and preventing recurrence: aromatase inhibitors in the neoadjuvant and adjuvant settings. Annals of surgical oncology 20080301
Effective inhibition of aromatase inhibitor-associated bone loss by zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: ZO-FAST Study results. Cancer 20080301
Aromatase inhibitors for breast cancer: different structures, same effects? Endocrine-related cancer 20080301
Menopausal symptoms and adjuvant therapy-associated adverse events. Endocrine-related cancer 20080301
Anticancer therapy in patients with porphyrias: evidence today. Expert opinion on drug safety 20080301
A comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on superovulation in Asian women with normal ovulatory cycles. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080301
Is the use of letrozole to induce ovulation teratogenic? Canadian family physician Medecin de famille canadien 20080301
Controversies in endocrine treatment: effective utilization of steroidal and nonsteroidal aromatase inhibitors: now and in the future. Forward. Anti-cancer drugs 20080301
[The effect of hormone therapy on cognitive function in patients with breast cancer]. Nederlands tijdschrift voor geneeskunde 20080301
Lapatinib in combination with capecitabine in the management of ErbB2-positive (HER2-positive) advanced breast cancer. Biologics : targets & therapy 20080301
Time to remove the subspecialty blinders: breast cancer does not exist in isolation. Journal of the National Cancer Institute 20080220
Competing causes of death from a randomized trial of extended adjuvant endocrine therapy for breast cancer. Journal of the National Cancer Institute 20080220
Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition. Neuroscience 20080206
Expression of lactoferrin in the boar epididymis: effects of reduced estrogen. Domestic animal endocrinology 20080201
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects. Endocrinology 20080201
New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorganic & medicinal chemistry 20080201
Predicting response and resistance to endocrine therapy: profiling patients on aromatase inhibitors. Cancer 20080201
Preclinical modeling of endocrine response and resistance: focus on aromatase inhibitors. Cancer 20080201
Current NCI-sponsored Cooperative Group trials of endocrine therapies in breast cancer. Cancer 20080201
Micellar electrokinetic chromatographic screening of letrozole and its metabolite in human urine: validation and robustness/ruggedness evaluation. Electrophoresis 20080201
A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20080201
Ovulation induction in polycystic ovary syndrome. Minerva ginecologica 20080201
Aromatase inhibitors for breast cancer: proven efficacy across the spectrum of disease. Clinical breast cancer 20080201
Letrozole versus letrozole plus Lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: a double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB). Clinical breast cancer 20080201
Long-term safety of aromatase inhibitors in the treatment of breast cancer. Therapeutics and clinical risk management 20080201
Endocrine effects of adjuvant letrozole + triptorelin compared with tamoxifen + triptorelin in premenopausal patients with early breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080110
Pharmacokinetics of raloxifene in male Wistar-Hannover rats: influence of complexation with hydroxybutenyl-beta-cyclodextrin. International journal of pharmaceutics 20080104
Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats. Neuroscience 20080102
Reducing endogenous estrogen during development alters hormone production by porcine Leydig cells and seminiferous tubules. Domestic animal endocrinology 20080101
Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol? Fertility and sterility 20080101
In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation. Fertility and sterility 20080101
The breast cancer continuum in hormone-receptor-positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors. Annals of oncology : official journal of the European Society for Medical Oncology 20080101
Letrozole as primary therapy for endometrial hyperplasia in young women. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20080101
Increasing protection after tamoxifen: insights from the extended adjuvant aromatase inhibitor trials. Journal of cancer research and clinical oncology 20080101
Aromatase inhibitors: past, present and future in breast cancer therapy. Medical oncology (Northwood, London, England) 20080101
The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics. European journal of cancer (Oxford, England : 1990) 20080101
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. The Lancet. Oncology 20080101
San Antonio Breast Cancer Symposium. The Lancet. Oncology 20080101
Preventive effects of letrozole in the model of premenopausal mammary carcinogenesis. Neoplasma 20080101
Aromatase inhibitors: from bench to bedside and back. Breast cancer (Tokyo, Japan) 20080101
Matters of the heart: cardiac toxicity of adjuvant systemic therapy for early-stage breast cancer. Current oncology (Toronto, Ont.) 20080101
Cancer treatment-related bone loss: a review and synthesis of the literature. Current oncology (Toronto, Ont.) 20080101
Training community resource center and clinic personnel to prompt patients in listing questions for doctors: follow-up interviews about barriers and facilitators to the implementation of consultation planning. Implementation science : IS 20080101
Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB. Vascular pharmacology 20080101
The impact of adjuvant endocrine therapy on reducing the risk of distant metastases in hormone-responsive breast cancer. Breast (Edinburgh, Scotland) 20080101
A review of the BIG results: the Breast International Group 1-98 trial analyses. Breast (Edinburgh, Scotland) 20080101
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. BMC cancer 20080101
Joint one-sided and two-sided simultaneous confidence intervals. Journal of biopharmaceutical statistics 20080101
[Adjuvant treatment of operable breast cancer]. Anales de medicina interna (Madrid, Spain : 1984) 20080101
Breast conserving surgery with preservation of the nipple-areola complex as a feasible and safe approach in male breast cancer: a case report. Journal of medical case reports 20080101
Aromatase inhibitors and mammographic breast density in postmenopausal women receiving hormone therapy. Menopause (New York, N.Y.) 20080101
McCune-Albright syndrome. Orphanet journal of rare diseases 20080101
Cancer and fertility preservation: fertility preservation in breast cancer patients. Breast cancer research : BCR 20080101
Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutrition journal 20080101
Evaluation of the quality and accuracy of information regarding aromatase inhibitors available on the internet. The breast journal 20080101
Effects of maternal exposure to an aromatase inhibitor on sexual behaviour and neurochemical and endocrine aspects of adult male rat. Reproduction, fertility, and development 20080101
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer. Breast cancer research : BCR 20080101
Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosalpinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimenopausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer. Gynecologic and obstetric investigation 20080101
New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death. BMC cell biology 20080101
Molecular targeted therapies for breast cancer treatment. Breast cancer research : BCR 20080101
Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients. Breast cancer research : BCR 20080101
Factors predictive of response to hormone therapy in breast cancer. Tumori 20080101
Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. Journal of experimental & clinical cancer research : CR 20080101
ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patients. Breast cancer research : BCR 20080101
Bioequivalence study of two letrozole tablet formulations. Single dose, randomized, open-label, two-way crossover bioequivalence study of letrozole 2.5 mg tablets in healthy volunteers under fasting conditions. Arzneimittel-Forschung 20080101
Current topics and perspectives on the use of aromatase inhibitors in the treatment of breast cancer. Breast cancer (Tokyo, Japan) 20080101
Use of letrozole in assisted reproduction: a systematic review and meta-analysis. Human reproduction update 20080101
Infertility and the provision of infertility medical services in developing countries. Human reproduction update 20080101
Role of endocrine responsiveness and HER2/neu overexpression in inflammatory breast cancer treated with multimodality preoperative therapy. The breast journal 20080101
Presentation and course of brain metastases from breast cancer in a paranoid-schizophrenic patient: A case report. Cases journal 20080101
Novel therapies in breast cancer: what is new from ASCO 2008. Journal of hematology & oncology 20080101
Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes. Breast cancer research : BCR 20080101
Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer. Breast cancer research : BCR 20080101
Breast cancer in men: should aromatase inhibitors become first-line hormonal treatment? The breast journal 20080101
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature. BMC cancer 20080101
Breast carcinoma metastatic to the orbit: an unusually late presentation. Ophthalmic plastic and reconstructive surgery 20080101
Anti-oestrogens but not oestrogen deprivation promote cellular invasion in intercellular adhesion-deficient breast cancer cells. Breast cancer research : BCR 20080101
Putative growth characteristics of micrometastatic breast cancer. Breast cancer research : BCR 20080101
Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda. Breast cancer research : BCR 20080101
Pharmacogenetics and pharmacogenomics of endocrine agents for breast cancer. Breast cancer research : BCR 20080101
Markers of endocrine sensitivity. Breast cancer research : BCR 20080101
Identification and mechanisms of endocrine resistance. Breast cancer research : BCR 20080101
Integration of endocrine therapy with targeted agents. Breast cancer research : BCR 20080101
Who should participate in clinical trials and who not? Can clinical trials be made more efficient and effective? Breast cancer research : BCR 20080101
Neoadjuvant/presurgical treatments. Breast cancer research : BCR 20080101
Polycystic ovaries and infertility: Our experience. Journal of human reproductive sciences 20080101
Micellar electrokinetic chromatographic study of the separation of an aromatase inhibitor and a tryciclic antidepressant in the breast cancer treatment. Analytical chemistry insights 20080101
Reverse phase high performance liquid chromatographic method for the analysis of letrozole in pharmaceutical dosage forms. Indian journal of pharmaceutical sciences 20080101
The epidermal growth factor receptor family in breast cancer. OncoTargets and therapy 20080101
Targeted treatment of advanced and metastaticbreast cancer with lapatinib. OncoTargets and therapy 20080101
Cancer care in Singapore. Biomedical imaging and intervention journal 20080101
Response of cutaneous metastases from breast cancer to capecitabine. Clinical medicine. Oncology 20080101
Psychological Distress among Prostate Cancer Patients: Fact Or Fiction? Clinical medicine. Oncology 20080101
Cardiovascular adverse events during adjuvant endocrine therapy for early breast cancer using letrozole or tamoxifen: safety analysis of BIG 1-98 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071220
Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a. Journal of the National Cancer Institute 20071219
Ontogeny of androgen and estrogen receptor expression in porcine testis: effect of reducing testicular estrogen synthesis. Animal reproduction science 20071201
Treatment strategies that effectively reduce early recurrence risk in postmenopausal women with endocrine-sensitive breast cancer: AIs upfront vs. switching. Journal of cancer research and clinical oncology 20071201
Effect of letrozole on urinary bladder function in the female rabbit. BJU international 20071201
Reducing the risk of distant metastases in breast cancer patients: role of aromatase inhibitors. Cancer treatment reviews 20071201
The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer. International journal of clinical practice 20071201
Erythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literature. Breast cancer research and treatment 20071201
Adjuvant and extended adjuvant use of aromatase inhibitors: reducing the risk of recurrence and distant metastasis. Breast (Edinburgh, Scotland) 20071201
Reducing the risk of cancer treatment-associated bone loss in patients with breast cancer. Seminars in oncology 20071201
Management of arthralgias associated with aromatase inhibitor therapy. Current oncology (Toronto, Ont.) 20071201
Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Current oncology (Toronto, Ont.) 20071201
Cancer therapy disparity: unequal access to breast cancer therapeutics and drug funding in Canada. Current oncology (Toronto, Ont.) 20071201
Managing bone loss in women with early-stage breast cancer receiving aromatase inhibitors. Clinical breast cancer 20071201
Alteration of glyoxalase genes expression in response to testosterone in LNCaP and PC3 human prostate cancer cells. Cancer biology & therapy 20071201
High circulating HER2 extracellular domain levels correlate with reduced efficacy of an aromatase inhibitor in hormone receptor-positive metastatic breast cancer: a confirmatory prospective study. Cancer 20071115
Reduction in proliferation with six months of letrozole in women on hormone replacement therapy. Breast cancer research and treatment 20071101
Management of cancer treatment-induced bone loss in early breast and prostate cancer -- a consensus paper of the Belgian Bone Club. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20071101
Novel therapeutic strategies combining antihormonal and biological targeted therapies in breast cancer: focus on clinical trials and perspectives. Critical reviews in oncology/hematology 20071101
The use of third-generation aromatase inhibitors and tamoxifen in the adjuvant treatment of postmenopausal patients with hormone-dependent breast cancer: evidence based review. Current opinion in oncology 20071101
Phase III, double-blind, controlled trial of atamestane plus toremifene compared with letrozole in postmenopausal women with advanced receptor-positive breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071101
Progression of endocrine therapies for breast cancer: where are we headed? Expert review of anticancer therapy 20071101
Effects of third generation aromatase inhibitors on bone health and other safety parameters: results of an open, randomised, multi-centre study of letrozole, exemestane and anastrozole in healthy postmenopausal women. European journal of cancer (Oxford, England : 1990) 20071101
Letrozole in advanced breast cancer: the PO25 trial. Breast cancer research and treatment 20071001
Progesterone, but not luteal estrogen, is required for the establishment of pregnancy in the new world monkey Cebus apella. American journal of primatology 20071001
Patients' knowledge and experience of adjuvant endocrine therapy for early breast cancer: a European study. Breast (Edinburgh, Scotland) 20071001
Limiting access to letrozole--is it justified? Fertility and sterility 20071001
Prescribing extended adjuvant letrozole. Breast (Edinburgh, Scotland) 20071001
Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model. Endocrinology 20071001
Role of aromatase inhibitor in patients with poor response to clomiphene citrate needs further evaluation. The journal of obstetrics and gynaecology research 20071001
Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole. Pharmacogenetics and genomics 20071001
Reduced endogenous estrogen delays epididymal development but has no effect on efferent duct morphology in boars. Reproduction (Cambridge, England) 20071001
Aromatase inhibitor and bone. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20071001
The early days of letrozole. Breast cancer research and treatment 20071001
The discovery and mechanism of action of letrozole. Breast cancer research and treatment 20071001
Letrozole in the neoadjuvant setting: the P024 trial. Breast cancer research and treatment 20071001
Letrozole in the extended adjuvant setting: MA.17. Breast cancer research and treatment 20071001
Letrozole as upfront endocrine therapy for postmenopausal women with hormone-sensitive breast cancer: BIG 1-98. Breast cancer research and treatment 20071001
A decade of letrozole: FACE. Breast cancer research and treatment 20071001
Safety of aromatase inhibitors in the adjuvant setting. Breast cancer research and treatment 20071001
The patient experience. Breast cancer research and treatment 20071001
Femara and the future: tailoring treatment and combination therapies with Femara. Breast cancer research and treatment 20071001
A comparison of letrozole to gonadotropins for ovulation induction, in subjects who failed to conceive with clomiphene citrate. Fertility and sterility 20071001
Update on the use of letrozole in breast cancer. Expert opinion on pharmacotherapy 20071001
Effects of aromatase inhibitors letrozole and anastrazole on bone metabolism and steroid hormone levels in intact female rats. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20071001
Antitumour and biological effects of letrozole and GnRH analogue as primary therapy in premenopausal women with ER and PgR positive locally advanced operable breast cancer. British journal of cancer 20070911
[Antiestrogen treatment in postmenopausal patients with metastatic breast cancer]. Ugeskrift for laeger 20070910
Letrozole and norethisterone acetate in rectovaginal endometriosis. Fertility and sterility 20070901
Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma. Fertility and sterility 20070901
Developmental changes in testicular sensitivity to estrogens throughout fetal and neonatal life. Toxicological sciences : an official journal of the Society of Toxicology 20070901
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Gynecologic oncology 20070901
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070901
Oestrogen receptors and linear bone growth. Acta paediatrica (Oslo, Norway : 1992) 20070901
Reducing the risk of late recurrence in hormone-responsive breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20070901
Reducing the risk of early recurrence in hormone-responsive breast cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20070901
Effect of estrogens on skin aging and the potential role of SERMs. Clinical interventions in aging 20070901
Letrozole as adjuvant therapy for postmenopausal women with early breast cancer. Managed care interface 20070901
Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer. Biologics : targets & therapy 20070901
The molecular genetics of breast cancer and targeted therapy. Biologics : targets & therapy 20070901
Nonsurgical treatment of male infertility: specific and empiric therapy. Biologics : targets & therapy 20070901
Hope for axed cancer-prevention trial. Nature 20070823
Health care costs for the treatment of breast cancer recurrent events: estimates from a UK-based patient-level analysis. British journal of cancer 20070820
Role of gonadotropin-releasing hormone analog in the management of male metastatic breast cancer is uncertain. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070820
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology 20070801
Histopathology of breast carcinoma following neoadjuvant systemic therapy: a common association between letrozole therapy and central scarring. Histopathology 20070801
Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling. Annals of oncology : official journal of the European Society for Medical Oncology 20070801
Letrozole: present and future role in the treatment of breast cancer. Expert opinion on pharmacotherapy 20070801
Clomiphene citrate: an old favourite lives on. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20070801
Fetal safety of letrozole and clomiphene citrate for ovulation induction. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20070801
Letrozole effective in ovarian cancer. The Lancet. Oncology 20070801
Development and validation of a spectrophotometric method for estimation of letrozole in bulk and pharmaceutical formulation. Die Pharmazie 20070801
Reducing the risk for breast cancer recurrence after completion of tamoxifen treatment in postmenopausal women. Clinical therapeutics 20070801
Effects of hormonal therapy on cognitive functioning in breast cancer patients: a review of the literature. Minerva ginecologica 20070801
Assisted reproduction and breast cancer. Minerva ginecologica 20070801
A review of lapatinib ditosylate in the treatment of refractory or advanced breast cancer. Therapeutics and clinical risk management 20070801
Dual aromatase-steroid sulfatase inhibitors. Journal of medicinal chemistry 20070726
Debilitating musculoskeletal pain and stiffness with letrozole and exemestane: associated tenosynovial changes on magnetic resonance imaging. Breast cancer research and treatment 20070701
The effects of atamestane and toremifene alone and in combination compared with letrozole on bone, serum lipids and the uterus in an ovariectomized rat model. Breast cancer research and treatment 20070701
Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta). Placenta 20070701
Continuing with letrozole offers greater benefits. Journal of cancer research and clinical oncology 20070701
Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation? Endocrinology 20070701
Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats. Neuroscience research 20070701
Superiority of gas chromatography/tandem mass spectrometry assay (GC/MS/MS) for estradiol for monitoring of aromatase inhibitor therapy. Steroids 20070701
Hormonal therapies for early breast cancer: systematic review and economic evaluation. Health technology assessment (Winchester, England) 20070701
Regression of choroidal metastasis from breast carcinoma following Letrozole therapy. Clinical & experimental ophthalmology 20070701
NCI and the STELLAR trial. Lancet (London, England) 20070630
Clinical research. No lifeline for proposed breast cancer prevention trial. Science (New York, N.Y.) 20070622
Adjuvant endocrine therapy for early breast cancer. Cancer letters 20070618
Meta-analysis of clodronate and breast cancer survival. British journal of cancer 20070618
Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20070615
Cost-utility of adjuvant hormone therapies with aromatase inhibitors in post-menopausal women with breast cancer: upfront anastrozole, sequential tamoxifen-exemestane and extended tamoxifen-letrozole. Breast (Edinburgh, Scotland) 20070601
Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate. Cell and tissue research 20070601
Relative potencies of anastrozole and letrozole to suppress estradiol in breast cancer patients undergoing ovarian stimulation before in vitro fertilization. The Journal of clinical endocrinology and metabolism 20070601
Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study. The Journal of clinical endocrinology and metabolism 20070601
New advances in ovulation induction. Current opinion in obstetrics & gynecology 20070601
Aromatase inhibitors in the treatment of severe endometriosis. Obstetrics and gynecology 20070601
Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis. The Australian & New Zealand journal of obstetrics & gynaecology 20070601
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in hormone receptor-positive postmenopausal women with early-stage breast cancer. Clinical breast cancer 20070601
The National Cancer Institute of Canada Clinical Trials Group MAP.3 trial: an international breast cancer prevention trial. Current oncology (Toronto, Ont.) 20070601
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A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. British journal of cancer 20060327
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The effects of testosterone and oestrogen on gonadectomised and intact male rat anterior pituitary mitotic and apoptotic activity. The Journal of endocrinology 20060301
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Serum endostatin and bFGF as predictive factors in advanced breast cancer patients treated with letrozole. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20060301
Should aromatase inhibitors be used as initial adjuvant treatment or sequenced after tamoxifen? British journal of cancer 20060227
Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. Journal of medicinal chemistry 20060223
Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation. Toxicology 20060215
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Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents. Annals of oncology : official journal of the European Society for Medical Oncology 20060201
Dehydroepiandrosterone sulfate is neuroprotective when administered either before or after injury in a focal cortical cold lesion model. Endocrinology 20060201
Toxic epidermal necrolysis in patient with breast cancer receiving letrozole. The Lancet. Oncology 20060201
Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis. The Journal of endocrinology 20060201
ErbB receptor signaling and therapeutic resistance to aromatase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research 20060201
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Anastrozole as an adjuvant endocrine treatment for postmenopausal patients with breast cancer: emerging data. Clinical cancer research : an official journal of the American Association for Cancer Research 20060201
Effectiveness of letrozole in the breast cancer treatment continuum. Breast (Edinburgh, Scotland) 20060201
Review of the development of letrozole and its use in advanced breast cancer and in the neoadjuvant setting. Breast (Edinburgh, Scotland) 20060201
The extended adjuvant NCIC CTG MA.17 trials: initial and rerandomization studies. Breast (Edinburgh, Scotland) 20060201
The evolving role of letrozole in the adjuvant setting: first results from the large, phase III, randomized trial BIG 1-98. Breast (Edinburgh, Scotland) 20060201
Improving bone health in patients with early breast cancer by adding bisphosphonates to letrozole: the Z-ZO-E-ZO-FAST program. Breast (Edinburgh, Scotland) 20060201
Emerging data on optimal adjuvant endocrine therapy: Breast International Group trial 1-98/MA.17. Clinical breast cancer 20060201
A new era in ovulation induction. Fertility and sterility 20060201
Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio. Fertility and sterility 20060201
Synaptic plasticity in the hippocampus: effects of estrogen from the gonads or hippocampus? Neurochemical research 20060201
Does HER2/neu overexpression in breast cancer influence adjuvant chemotherapy and hormonal therapy choices by Ontario physicians? A physician survey. Current oncology (Toronto, Ont.) 20060201
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Current management of treatment-induced bone loss in women with breast cancer treated in the United Kingdom. British journal of cancer 20060116
Reducing estrogen synthesis does not affect gonadotropin secretion in the developing boar. Biology of reproduction 20060101
Direct and indirect effects of estrogen on rat hippocampus. Neuroscience 20060101
Letrozole as adjuvant endocrine therapy in postmenopausal women with breast cancer. Expert review of anticancer therapy 20060101
Hormonal therapy in epithelial ovarian cancer. Expert review of anticancer therapy 20060101
A randomized trial of superovulation with two different doses of letrozole. Fertility and sterility 20060101
Reverting estrogen-receptor-negative phenotype in HER-2-overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy. Breast cancer research : BCR 20060101
Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons. Hippocampus 20060101
Estrogen receptors as therapeutic targets in breast cancer. Current topics in medicinal chemistry 20060101
Aromatase inhibitors in breast cancer: a review of cost considerations and cost effectiveness. PharmacoEconomics 20060101
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Reducing estrogen synthesis in developing boars increases testis size and total sperm production. Journal of andrology 20060101
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Disease-free survival was greater with letrozole than tamoxifen in postmenopausal women with early breast cancer. ACP journal club 20060101
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A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti-oestrogen drugs and synthetic anabolic steroids. Rapid communications in mass spectrometry : RCM 20060101
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An integrated view of aromatase and its inhibition. The Journal of steroid biochemistry and molecular biology 20030901
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Examining quality of life issues in relation to endocrine therapy for breast cancer. American journal of clinical oncology 20030801
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25th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 10-14 December 2002 Update on clinical research. Breast cancer research : BCR 20030101
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Advances in endocrine treatments for postmenopausal women with metastatic and early breast cancer. The oncologist 20030101
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[Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis]. Zentralblatt fur Gynakologie 20030101
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Neoadjuvant therapy of endometrial cancer with the aromatase inhibitor letrozole: endocrine and clinical effects. European journal of obstetrics, gynecology, and reproductive biology 20021115
Expression and purification of a recombinant form of human aromatase from Escherichia coli. Biochemical pharmacology 20021101
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Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis. Endocrinology 20021101
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Neoadjuvant endocrine therapy of breast cancer: a surgical perspective. European journal of cancer (Oxford, England : 1990) 20021101
Anastrozole ('Arimidex') blocks oestrogen synthesis both peripherally and within the breast in postmenopausal women with large operable breast cancer. British journal of cancer 20021021
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New generation aromatase inhibitors--from the advanced to the adjuvant setting. Breast cancer research and treatment 20021001
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Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021001
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A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women. Fertility and sterility 20020801
American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for women with hormone receptor-positive breast cancer: status report 2002. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801
Signaling through estrogen receptors modulates telomerase activity in human prostate cancer. The Journal of clinical investigation 20020715
Endocrine effects of nonsteroidal aromatase inhibitors and their clinical impact. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020701
Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020701
Human ejaculated spermatozoa contain active P450 aromatase. The Journal of clinical endocrinology and metabolism 20020701
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. The Journal of clinical endocrinology and metabolism 20020701
CA125 response is associated with estrogen receptor expression in a phase II trial of letrozole in ovarian cancer: identification of an endocrine-sensitive subgroup. Clinical cancer research : an official journal of the American Association for Cancer Research 20020701
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clinical cancer research : an official journal of the American Association for Cancer Research 20020701
Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue. Endocrine 20020701
[Antiestrogen therapy in the treatment of breast neoplasms]. Minerva ginecologica 20020601
Letrozole for the management of breast cancer. Expert review of anticancer therapy 20020601
Exemestane: a potent irreversible aromatase inactivator and a promising advance in breast cancer treatment. Expert review of anticancer therapy 20020601
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Recent advances in aromatase inhibitor therapy for breast cancer. Seminars in oncology 20020601
Letrozole in the treatment of breast cancer. Expert opinion on pharmacotherapy 20020501
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Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertility and sterility 20020401
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[CGS 20267 (Letrozole), a new aromatase inhibitor: early phase II study for postmenopausal women with advanced breast cancer]. Gan to kagaku ryoho. Cancer & chemotherapy 20020401
Short-term effects of anastrozole treatment on insulin-like growth factor system in postmenopausal advanced breast cancer patients. The Journal of steroid biochemistry and molecular biology 20020401
Antiaromatase agents: evolving role in adjuvant therapy. Clinical breast cancer 20020401
[The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile]. Minerva ginecologica 20020401
Aromatase inhibitors in breast cancer therapy. Expert review of anticancer therapy 20020401
Detection of aromatase inhibitors in vitro using rat ovary microsomes. Toxicology letters 20020324
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The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor. European journal of endocrinology 20020301
Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer. Current opinion in obstetrics & gynecology 20020201
Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020201
Superior efficacy of letrozole versus tamoxifen as first-line therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020201
[Superiority of letrozole compared with tamoxifen as first line therapy of postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20020201
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Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020101
Reproductive changes in male rats treated perinatally with an aromatase inhibitor. Pharmacology, biochemistry, and behavior 20020101
Tamoxifen resistant and refractory breast cancer: the value of aromatase inhibitors. Drugs 20020101
Anti-aromatase agents in the treatment and prevention of breast cancer. Cancer control : journal of the Moffitt Cancer Center 20020101
Endocrine and clinical endpoints of exemestane as neoadjuvant therapy. Cancer control : journal of the Moffitt Cancer Center 20020101
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Novel treatment of delayed male puberty with aromatase inhibitors. Hormone research 20020101
Estrogen as therapy for breast cancer. Breast cancer research : BCR 20020101
Defining the galaxy of gene expression in breast cancer. Breast cancer research : BCR 20020101
The impact of hormonal treatments on quality of life of patients with metastatic breast cancer. Clinical therapeutics 20020101
Evolving uses of hormonal agents for breast cancer therapy. Clinical therapeutics 20020101
Sequencing of hormonal therapy in postmenopausal women with metastatic breast cancer. Clinical therapeutics 20020101
Efficacy and economics of hormonal therapies for advanced breast cancer. Drugs & aging 20020101
Tumour Fas ligand:Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer. Breast cancer research : BCR 20020101
Anti-tumor effects of letrozole. Cancer investigation 20020101
Current role of endocrine therapy in the management of breast cancer. Breast cancer (Tokyo, Japan) 20020101
Aromatase inhibitors in breast cancer: an update. Cancer control : journal of the Moffitt Cancer Center 20020101
New breast cancer drug. U.S. news & world report 20011224
Letrozole in second-line therapy of advanced breast cancer: more questions than answers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011201
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High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery 20011201
Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology. The Journal of steroid biochemistry and molecular biology 20011201
Aromatase and COX-2 expression in human breast cancers. The Journal of steroid biochemistry and molecular biology 20011201
Comparative clinical pharmacology and pharmacokinetic interactions of aromatase inhibitors. The Journal of steroid biochemistry and molecular biology 20011201
Local endocrine effects of aromatase inhibitors within the breast. The Journal of steroid biochemistry and molecular biology 20011201
Biological and clinical effects of aromatase inhibitors in neoadjuvant therapy. The Journal of steroid biochemistry and molecular biology 20011201
A summary of second-line randomized studies of aromatase inhibitors. The Journal of steroid biochemistry and molecular biology 20011201
Adjuvant trials of aromatase inhibitors: determining the future landscape of adjuvant endocrine therapy. The Journal of steroid biochemistry and molecular biology 20011201
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17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture. The Journal of steroid biochemistry and molecular biology 20011201
The role of tamoxifen and aromatase inhibitors/inactivators in postmenopausal patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Are differences in the available aromatase inhibitors and inactivators significant? Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Neoadjuvant endocrine therapy for breast cancer: medical perspectives. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Preliminary data from ongoing adjuvant aromatase inhibitor trials. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Future use of selective estrogen receptor modulators and aromatase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Promising results for Arimidex and Femara. Expert review of anticancer therapy 20011201
Pre-operative endocrine therapy for postmenopausal women: when and why? Annals of oncology : official journal of the European Society for Medical Oncology 20011101
Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study. Annals of oncology : official journal of the European Society for Medical Oncology 20011101
Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable? Annals of oncology : official journal of the European Society for Medical Oncology 20011101
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Aromatase inhibitors and inactivators in breast cancer. BMJ (Clinical research ed.) 20011020
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Sex reversal and aromatase in the European pond turtle: treatment with letrozole after the thermosensitive period for sex determination. The Journal of experimental zoology 20010915
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A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet (London, England) 20010602
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Metastatic breast cancer: understanding current management options. Oncology nursing forum 20010401
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