Home Other Building Blocks 8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-

8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-

CAS No.:
38966-21-1
Catalog Number:
AG007732
Molecular Formula:
C20H34O4
Molecular Weight:
338.4816
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$151
- +
5mg
≥98%
1 week
United States
$362
- +
25mg
≥98%
1 week
United States
$1119
- +
Product Description
Catalog Number:
AG007732
Chemical Name:
8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
CAS Number:
38966-21-1
Molecular Formula:
C20H34O4
Molecular Weight:
338.4816
MDL Number:
MFCD00083214
IUPAC Name:
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
InChI:
InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI Key:
NOFOAYPPHIUXJR-APNQCZIXSA-N
SMILES:
OCC1(O)CCC23CC1CC2CCC1C3(C)CCC(C1(C)CO)O
UNII:
192TJ6PP19
Properties
Complexity:
524  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
338.246g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
338.488g/mol
Monoisotopic Mass:
338.246g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
80.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5  
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Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation. Molecular cytogenetics 20100101
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ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. The EMBO journal 20091104
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Single-nucleotide and long-patch base excision repair of DNA damage in plants. The Plant journal : for cell and molecular biology 20091101
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Chromosomal instability at common fragile sites in Seckel syndrome. American journal of human genetics 20041001
Crosstalk between elicitor-induced cell death and cell cycle regulation in tobacco BY-2 cells. The Plant journal : for cell and molecular biology 20041001
Cell-cycle dependence of foamy virus vectors. The Journal of general virology 20041001
A hypophosphorylated form of RPA34 is a specific component of pre-replication centers. Journal of cell science 20041001
Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis. Nucleosides, nucleotides & nucleic acids 20041001
Stimulation of deoxycytidine kinase results in prolonged maintenance of the enzyme activity. Nucleosides, nucleotides & nucleic acids 20041001
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Purification of Drosophila DNA polymerase zeta by REV1 protein-affinity chromatography. The Biochemical journal 20040901
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening. Journal of immunological methods 20040901
Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. British journal of cancer 20040816
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Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint. The Journal of biological chemistry 20040702
Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cells. DNA repair 20040702
Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. American journal of respiratory cell and molecular biology 20040701
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Two breakpoint clusters at fragile site FRA3B form phased nucleosomes. Genome research 20040701
Synchronized generation of reactive oxygen species with the cell cycle. Life sciences 20040604
Bromodeoxyuridine DNA fiber technology in plants: replication origins and DNA synthesis in tobacco BY-2 cells under prolonged treatment with aphidicolin. Protoplasma 20040601
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The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). British journal of cancer 20040517
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Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage. The Journal of biological chemistry 20040402
[Detecting DNA repair capacity of human lymphocytes exposed to ultraviolet C with comet assay]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040401
An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation. Journal of biomolecular screening 20040401
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Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study. Mutation research 20040226
The role of baculovirus apoptotic suppressors in AcMNPV-mediated translation arrest in Ld652Y cells. Virology 20040220
Characterization of DNA demethylation in normal and cancerous cell lines and the regulatory role of cell cycle proteins in human DNA demethylase activity. Journal of cellular biochemistry 20040215
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer research 20040215
Rb regulates C/EBPbeta-DNA-binding activity during 3T3-L1 adipogenesis. American journal of physiology. Cell physiology 20040201
RXRalpha mRNA expression is associated with cell proliferation and cell cycle regulation in Hep3B cell. Experimental and molecular pathology 20040201
PPARgamma1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion. Journal of cellular biochemistry 20040201
Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system. The journal of gene medicine 20040201
The Yin Yang-1 (YY1) protein undergoes a DNA-replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase. Journal of cell science 20040126
The role of late/slow replication of the FRA16D in common fragile site induction. Genes, chromosomes & cancer 20040101
In vivo analysis of cell division, cell growth, and differentiation at the shoot apical meristem in Arabidopsis. The Plant cell 20040101
Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha. Bioscience, biotechnology, and biochemistry 20040101
[A comparative level of expression of some proteins in XL2 cell synchronized on different phases of cell cycle]. Tsitologiia 20040101
Functional analysis of APC-Cdh1. Methods in molecular biology (Clifton, N.J.) 20040101
Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA repair 20040101
Halofuginone inhibits serum-stimulated pericardial tissue retraction in vitro. Tissue engineering 20040101
Control and maintenance of mammalian cell size. BMC cell biology 20040101
Control and maintenance of mammalian cell size: response. BMC cell biology 20040101
Conservation of aphidicolin-induced fragile sites in Papionini (Primates) species and humans. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20040101
[Special function of deoxycytidine kinase (dCK) in the activation of chemotherapeutic nucleoside analogs and in the inhibition of cell proliferation]. Magyar onkologia 20040101
Size control in growing yeast and mammalian cells. Theoretical biology & medical modelling 20040101
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells. BMC pharmacology 20040101
Nick-dependent and -independent processing of large DNA loops in human cells. The Journal of biological chemistry 20031212
Investigations on the effect of cigarette smoking in the comet assay. Mutation research 20031209
Hypo-osmotic or Ca2+-rich external conditions trigger extra contractile vacuole complex generation in Paramecium multimicronucleatum. The Journal of experimental biology 20031201
Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation research 20031127
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents. Mutation research 20031127
Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells. Oncogene 20031127
Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells. American journal of human genetics 20031101
Genome-wide gene expression in an Arabidopsis cell suspension. Plant molecular biology 20031101
8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways. Mutation research 20031029
Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. The Journal of biological chemistry 20031017
The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. The Journal of biological chemistry 20031017
The role of DNA synthesis inhibition in the cytotoxicity of 2',2'-difluoro-2'-deoxycytidine. Cancer chemotherapy and pharmacology 20031001
Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction. Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene 20030904
Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Oncogene 20030904
XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus. Molecular biology of the cell 20030901
Origin of cortical microtubules organized at M/G1 interface: recruitment of tubulin from phragmoplast to nascent microtubules. European journal of cell biology 20030901
Characterization of all the subunits of replication factor C from a higher plant, rice (Oryza sativa L.), and their relation to development. Plant molecular biology 20030901
Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases. Biochemical pharmacology 20030815
Evidence that DNA replication is not regulated by ubiquitin-dependent proteolysis in Xenopus egg extract. Experimental cell research 20030815
Flow cytometric analysis of the cell cycle in different coconut palm (Cocos nucifera L.) tissues cultured in vitro. Plant cell reports 20030801
Different cell cycle regulation of vascular smooth muscle in genetic hypertension. Hypertension (Dallas, Tex. : 1979) 20030801
Activation of a p53-mediated apoptotic pathway in quiescent lymphocytes after the inhibition of DNA repair by fludarabine. Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
BY-2 cells: culture and transformation for live cell imaging. Current protocols in cell biology 20030801
ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. British journal of cancer 20030707
Measuring the mitotic index in chemically-treated human lymphocyte cultures by flow cytometry. Mutation research 20030606
Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants. Hearing research 20030601
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. The Journal of biological chemistry 20030530
Tracking the cell cycle origins for escape from topotecan action by breast cancer cells. British journal of cancer 20030422
Diastereoselective formal total synthesis of the DNA polymerase alpha inhibitor, aphidicolin, using palladium-catalyzed cycloalkenylation and intramolecular Diels-Alder reactions. Organic letters 20030417
Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer research 20030415
bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary. Development (Cambridge, England) 20030401
Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation. Archives of biochemistry and biophysics 20030401
Hypotonic buffer induces meiosis and formation of anucleate cytoplasmic islands in the egg of the two-spotted cricket Gryllus bimaculatus. Development, growth & differentiation 20030401
Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells. The Journal of biological chemistry 20030328
Cell cycle independent infection and gene transfer by recombinant Sendai viruses. Journal of virological methods 20030301
E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin. Cancer gene therapy 20030301
Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors. Cell death and differentiation 20030301
Nuclear phosphoinositide 3-kinase C2beta activation during G2/M phase of the cell cycle in HL-60 cells. Biochimica et biophysica acta 20030220
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. The EMBO journal 20030203
MuERV-L is one of the earliest transcribed genes in mouse one-cell embryos. Biology of reproduction 20030201
A genome-wide identification of E2F-regulated genes in Arabidopsis. The Plant journal : for cell and molecular biology 20030201
Inhibition of replication induces non-apoptotic cell death in fibroblast cell lines derived from LEC rats. The Journal of veterinary medical science 20030201
Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB/ATF sites in the LTR. AIDS (London, England) 20030124
Fragile sites and bladder cancer. Cancer genetics and cytogenetics 20030115
An in vitro model of pericardial tissue healing. Biomaterials 20030101
The use of the MTT assay to study drug resistance in fresh tumour samples. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20030101
Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks. Molecular cancer therapeutics 20030101
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Molecular cell 20030101
Cell growth arrest by nucleotides, nucleosides and bases as a tool for improved production of recombinant proteins. Biotechnology progress 20030101
Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients. Teratogenesis, carcinogenesis, and mutagenesis 20030101
Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression. Journal of biology 20030101
Entamoeba invadens: inhibition of excystation and metacystic development by aphidicolin. Experimental parasitology 20030101
Common fragile sites. Cytogenetic and genome research 20030101
Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia. Oncology reports 20030101
How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites. Cytogenetic and genome research 20030101
Behavior and differentiation process of pigment cells in a tropical sea urchin Echinometra mathaei. Development, growth & differentiation 20030101
Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells. Mutation research 20021229
ATR regulates fragile site stability. Cell 20021213
An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nature genetics 20021201
Xath5 regulates neurogenesis in the Xenopus olfactory placode. Developmental dynamics : an official publication of the American Association of Anatomists 20021201
Host DNA replication is induced by geminivirus infection of differentiated plant cells. The Plant cell 20021201
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint. Oncogene 20021121
HL60 cells halted in G1 or S phase differentiate normally. Experimental cell research 20021115
Cell cycle-regulated gene expression in Arabidopsis. The Journal of biological chemistry 20021101
Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein. The Plant cell 20021101
Apoptosis of Spodoptera litura cells induced by AcMNPV ie-1 gene. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20021101
Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements. Oncogene 20021031
Stabilization of p53 and transactivation of its target genes in response to replication blockade. Oncogene 20021017
Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells. Experimental cell research 20021015
Regulation of epithelial cell migration and tumor formation by beta-catenin signaling. Experimental cell research 20021015
ATF is important to late S phase-dependent regulation of DNA topoisomerase IIalpha gene expression in HeLa cells. Cancer letters 20021008
Mutant alleles of Arabidopsis RADIALLY SWOLLEN 4 and 7 reduce growth anisotropy without altering the transverse orientation of cortical microtubules or cellulose microfibrils. Development (Cambridge, England) 20021001
Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20021001
Cell cycle-dependent expression of an essential SMC-like protein and dynamic chromosome localization in the archaeon Halobacterium salinarum. Molecular microbiology 20021001
Dynamic organization of vacuolar and microtubule structures during cell cycle progression in synchronized tobacco BY-2 cells. Plant & cell physiology 20020901
Expression of folate sensitive and aphidicolin induced chromosomal fragile sites in familial neuroblastoma. Journal of experimental & clinical cancer research : CR 20020901
Wild-type p53 inhibits replication-associated homologous recombination. Oncogene 20020829
Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts. Oncogene 20020808
Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells. Aquatic toxicology (Amsterdam, Netherlands) 20020801
Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy. Gene therapy 20020801
Dependence of DNA synthesis and in vitro development of bovine nuclear transfer embryos on the stage of the cell cycle of donor cells and recipient cytoplasts. Biology of reproduction 20020801
Studies on fertilization in the teleost IV. Effects of aphidicolin and camptothecin on chromosome formation in fertilized medaka eggs. Development, growth & differentiation 20020801
Mismatch repair in human nuclear extracts. Time courses and ATP requirements for kinetically distinguishable steps leading to tightly controlled 5' to 3' and aphidicolin-sensitive 3' to 5' mispair-provoked excision. The Journal of biological chemistry 20020719
Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis. Journal of cell science 20020715
The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer research 20020715
Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme. Genes to cells : devoted to molecular & cellular mechanisms 20020701
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones. Bone 20020701
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors. Cancer research 20020615
Cell synchronization effect on mammalian cell permeabilization and gene delivery by electric field. Biochimica et biophysica acta 20020613
Matrix association of early- and late-replicating chromatin studied by single-cell electrophoresis. Biochimica et biophysica acta 20020612
Pyrido[2, 3-d]pyrimidines and pyrimido[5',4':5, 6]pyrido[2, 3-d]pyrimidines as new antiviral agents: synthesis and biological activity. Archiv der Pharmazie 20020601
DNA polymerase theta purified from human cells is a high-fidelity enzyme. Journal of molecular biology 20020531
Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells. Cell 20020503
Inhibition of nucleotide excision repair by fludarabine in normal lymphocytes in vitro, measured by the alkaline single cell gel electrophoresis (Comet) assay. Japanese journal of cancer research : Gann 20020501
Cell cycle specific plasmid DNA replication in the nuclear extract of Saccharomyces cerevisiae: modulation by replication protein A and proliferating cell nuclear antigen. Biochemistry 20020423
Segment-specific expression of alkaline phosphatase in the Tubifex embryo requires DNA replication and mRNA synthesis. The Journal of experimental zoology 20020415
The role of the cell cycle on the efficiency of photochemical gene transfection. Biochimica et biophysica acta 20020415
Endoreduplication is not inhibited but induced by aphidicolin in cultured cells of tobacco. Journal of experimental botany 20020401
Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin. Molecular pharmacology 20020401
Process of pigment cell specification in the sand dollar, Scaphechinus mirabilis. Development, growth & differentiation 20020401
Synchronous Arabidopsis suspension cultures for analysis of cell-cycle gene activity. The Plant journal : for cell and molecular biology 20020401
The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants. The Journal of biological chemistry 20020322
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects. Cancer research 20020315
Organophosphate-based pesticides and genetic damage implicated in bladder cancer. Cancer genetics and cytogenetics 20020301
Role of cell contact in the specification process of pigment founder cells in the sea urchin embryo. Zoological science 20020301
Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts. Mutation research 20020220
Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells. Biochimica et biophysica acta 20020130
Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53. Oncogene 20020117
Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response. Molecular pharmacology 20020101
Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer. Teratogenesis, carcinogenesis, and mutagenesis 20020101
Repair of damaged DNA by Arabidopsis cell extract. The Plant cell 20020101
Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolution. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 20020101
Investigation of genetic susceptibility to non-small cell lung cancer by fragile site expression. Teratogenesis, carcinogenesis, and mutagenesis 20020101
Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncology reports 20020101
In vitro antiviral activity of aphidicolin and its derivates. Synergistic effects of aphidicolin with other antiviral drugs. Arzneimittel-Forschung 20020101
Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL. Cell cycle (Georgetown, Tex.) 20020101
Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding. Genetics, selection, evolution : GSE 20020101
Genetic modification of human trabecular meshwork with lentiviral vectors. Human gene therapy 20011120
Characterization of the DNA polymerase gene of varicella-zoster viruses resistant to acyclovir. The Journal of general virology 20011101
A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines. Experimental cell research 20011101
Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. The Biochemical journal 20011101
Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote. Development (Cambridge, England) 20011101
Total synthesis of (+/-)-stemodinone via an efficient ring-exchange strategy. The Journal of organic chemistry 20011019
Extracellular control of cell size. Nature cell biology 20011001
A new flow cytometric method to follow DNA gap filling during nucleotide excision repair of UVc-induced damage. Cytometry 20011001
Quiescence, cell viability, apoptosis and necrosis of smooth muscle cells using different growth inhibitors. Cell proliferation 20011001
'Caged cytoskeletons': a rapid method for the isolation of microtubule-associated proteins from synchronized plant suspension cells. The Plant journal : for cell and molecular biology 20011001
Post-mitotic, differentiated myotubes efficiently produce retroviral vector from hybrid adeno-retrovirus templates. Gene therapy 20011001
p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication. American journal of physiology. Renal physiology 20010901
Transfection of large plasmids in primary human myoblasts. Gene therapy 20010901
Arsenic trioxide induces G2/M growth arrest and apoptosis after caspase-3 activation and bcl-2 phosphorylation in promonocytic U937 cells. Biochemical and biophysical research communications 20010831
Reduced store-operated Ca(2+) currents in rat basophilic leukaemia cells cultured under serum-free conditions. Cell calcium 20010801
Ethylene induces cell death at particular phases of the cell cycle in the tobacco TBY-2 cell line. Journal of experimental botany 20010801
Characterization of homologous recombination induced by replication inhibition in mammalian cells. The EMBO journal 20010716
Expression, purification and characterization of the Spodoptera littoralis nucleopolyhedrovirus (SpliNPV) DNA polymerase and interaction with the SpliNPV non-hr origin of DNA replication. The Journal of general virology 20010701
Initial amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of embryonic duck hepatocytes is increased by cell cycle progression. Hepatology (Baltimore, Md.) 20010701
Cell cycle regulation of cyclin-dependent kinases in tobacco cultivar Bright Yellow-2 cells. Plant physiology 20010701
Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle. Molecular therapy : the journal of the American Society of Gene Therapy 20010701
Fate of nascent microtubules organized at the M/G1 interface, as visualized by synchronized tobacco BY-2 cells stably expressing GFP-tubulin: time-sequence observations of the reorganization of cortical microtubules in living plant cells. Plant & cell physiology 20010701
Maintenance of the DNA puff expanded state is independent of active replication and transcription. Chromosoma 20010701
Incomplete RNA polymerase II phosphorylation in Xenopus laevis early embryos. Journal of cell science 20010701
Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst. Developmental biology 20010615
Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. Biology of reproduction 20010601
Treatment of drug-resistant human neuroblastoma cells with cyclodextrin inclusion complexes of aphidicolin. Anti-cancer drugs 20010601
Differentiation between inducers of apoptosis and nonspecific cytotoxic drugs by means of cell analyzer and immunoassay. Die Pharmazie 20010601
Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene 20010531
Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin. Journal of the American Chemical Society 20010530
Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts. The Journal of biological chemistry 20010518
Delaying S-phase progression rescues cells from heat-induced S-phase hypertoxicity. Journal of cellular physiology 20010501
Analysis of repair and PCNA complex formation induced by ionizing radiation in human fibroblast cell lines. Mutagenesis 20010501
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51. Genes to cells : devoted to molecular & cellular mechanisms 20010501
Methods for synchronizing cells at specific stages of the cell cycle. Current protocols in cell biology 20010501
The cellular response to DNA damage induced by the enediynes C-1027 and neocarzinostatin includes hyperphosphorylation and increased nuclear retention of replication protein a (RPA) and trans inhibition of DNA replication. Biochemistry 20010417
Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts. Journal of cellular physiology 20010401
Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. Cardiovascular research 20010401
p53 is dispensable for UV-induced cell cycle arrest at late G(1) in mammalian cells. Carcinogenesis 20010401
DNA replication and daughter cell budding are not tightly linked in the protozoan parasite Toxoplasma gondii. Microbes and infection 20010401
Induction of the common fragile site FRA3B does not affect FHIT expression. Oncogene 20010329
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA. The EMBO journal 20010315
Circumvention of ara-C resistance by aphidicolin in blast cells from patients with AML. British journal of cancer 20010301
Swelling-activated taurine and K+ transport in human cervical cancer cells: association with cell cycle progression. Pflugers Archiv : European journal of physiology 20010301
The efficiency of simian foamy virus vector type-1 (SFV-1) in nondividing cells and in human PBLs. Virology 20010215
Differences in DNA synthesis in vitro using isolated nuclei from regenerating livers of young and aged rats. Mechanisms of ageing and development 20010201
Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. Cancer research 20010201
Identification of DNA polymerase delta in eggs of a teleost fish (loach). Biochemistry. Biokhimiia 20010201
Early stages of p53-induced apoptosis are reversible. Cell death and differentiation 20010201
De novo activation of the beta-phaseolin promoter by phosphatase or protein synthesis inhibitors. The Journal of biological chemistry 20010119
Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes. Biochemical pharmacology 20010115
The nuclear death domain protein p84N5 activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. The Journal of biological chemistry 20010112
Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene. The Journal of biological chemistry 20010105
Cell division activity during apical hook development. Plant physiology 20010101
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer. The journal of gene medicine 20010101
Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. Endothelium : journal of endothelial cell research 20010101
Towards a virtual Arabidopsis plant. Genome biology 20010101
Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts. Progress in nucleic acid research and molecular biology 20010101
Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis. Intervirology 20010101
Transcription and temporal cascade in Chilo iridescent virus infected cells. Archives of virology 20010101
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorganic & medicinal chemistry letters 20000918
Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. Journal of medicinal chemistry 20000727
Herpes simplex type1:lacZ recombinant viruses. II. Microtiter plate-based colorimetric assays for the discovery of new antiherpes agents and the points at which such agents disrupt the viral replication cycle. Antiviral research 19951101
Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. Leukemia research 19950801
Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochemical pharmacology 19931117
Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses. Journal of medicinal chemistry 19931112
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure. Environmental health perspectives 19930701
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. The Journal of biological chemistry 19930415
Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. Cellular immunology 19910701
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. The Journal of biological chemistry 19910105
Antiviral agents of plant origin. II. Antiviral activity of scopadulcic acid B derivatives. Chemical & pharmaceutical bulletin 19900101
Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes. Journal of virology 19801101
Effect of aphidicolin on viral and human DNA polymerases. Biochemical and biophysical research communications 19790627
Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrobial agents and chemotherapy 19730901
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