Home Carbonyls 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide

1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide

CAS No.:
90779-69-4
Catalog Number:
AG006AH8
Molecular Formula:
C43H67N11O12S2
Molecular Weight:
994.1886
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$98
- +
5mg
99%
1 week
United States
$173
- +
10mg
99%
1 week
United States
$257
- +
50mg
99%
1 week
United States
$423
- +
Product Description
Catalog Number:
AG006AH8
Chemical Name:
1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
CAS Number:
90779-69-4
Molecular Formula:
C43H67N11O12S2
Molecular Weight:
994.1886
MDL Number:
MFCD00672436
IUPAC Name:
(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
InChI:
InChI=1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1
InChI Key:
VWXRQYYUEIYXCZ-OBIMUBPZSA-N
SMILES:
NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C
UNII:
081D12SI0Z
Properties
Complexity:
1770  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0
Exact Mass:
993.441g/mol
Formal Charge:
0
Heavy Atom Count:
68  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
11  
Isotope Atom Count:
0
Molecular Weight:
994.194g/mol
Monoisotopic Mass:
993.441g/mol
Rotatable Bond Count:
18  
Topological Polar Surface Area:
416A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.9  
Literature
Title Journal
Oxytocin is involved in the proconvulsant effects of Sildenafil: Possible role of CREB. Toxicology letters 20160810
Therapeutic efficiency of Atosiban, an oxytocin receptor blocking agent in the treatment of experimental endometriosis. Archives of gynecology and obstetrics 20120901
Atosiban improves implantation and pregnancy rates in patients with repeated implantation failure. Reproductive biomedicine online 20120901
Expression of selected genes in preterm premature rupture of fetal membranes. Acta obstetricia et gynecologica Scandinavica 20120801
The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin. Stress (Amsterdam, Netherlands) 20120701
Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain. Addiction biology 20120701
Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart? Life sciences 20120522
Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway. Journal of neurochemistry 20120501
Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat. Journal of psychopharmacology (Oxford, England) 20120401
Elevated cardiac oxidative stress in newborn rats from mothers treated with atosiban. Archives of gynecology and obstetrics 20120301
Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes. The Journal of biological chemistry 20120203
Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesthesia and analgesia 20120201
Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency. Journal of medicinal chemistry 20120126
Three Dimensional Power Doppler evaluation of human endometrium after administration of oxytocine receptor antagonist (OTRa) in an IVF program. Archives of gynecology and obstetrics 20120101
Atosiban and non-cardiogenic pulmonary oedema. International journal of obstetric anesthesia 20120101
Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization. Cellular signalling 20120101
Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia. BMC research notes 20120101
Who plays the strings in newborn analgesia at birth, vasopressin or oxytocin? Frontiers in neuroscience 20120101
The effects of benzoylecgonine, oxytocin, ritodrine and atosiban on the contractility of myometrium. An experimental study. Clinical and experimental obstetrics & gynecology 20120101
Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. BMJ (Clinical research ed.) 20120101
Using atosiban in uterine contractions of early pregnancies after assisted reproduction. Journal of the Formosan Medical Association = Taiwan yi zhi 20111201
Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. Journal of medicinal chemistry 20110908
Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects. European journal of obstetrics, gynecology, and reproductive biology 20110801
The design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor. Medicinal research reviews 20110701
Oxytocin antagonists for the management of preterm birth: a review. American journal of perinatology 20110601
The influence of tocolytic drugs on cardiac function, large arteries, and resistance vessels. European journal of clinical pharmacology 20110601
Use of an oxytocin antagonist in in vitro fertilization-embryo transfer for women with repeated implantation failure: a retrospective study. Taiwanese journal of obstetrics & gynecology 20110601
Oxytocin antagonist successfully prevents from threatened abortion in 15 weeks' gestation. Taiwanese journal of obstetrics & gynecology 20110601
[Atosiban treatment for preterm labor--financial considerations and savings by implementing clinical guidelines]. Harefuah 20110601
Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') using a drug discrimination paradigm in the rat. Addiction biology 20110401
Severe non-cardiogenic pulmonary oedema secondary to atosiban and steroids. International journal of obstetric anesthesia 20110401
Role of endogenous oxytocin in cardiac ischemic preconditioning. Regulatory peptides 20110225
Different effects of tocolytic medication on blood pressure and blood pressure amplification. European journal of clinical pharmacology 20110101
Possible involvement of oxytocin and its receptor in the local regulation of prostaglandin secretion in the cat endometrium. Animal reproduction science 20110101
Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction. Reproductive biomedicine online 20110101
Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia. Journal of biomedicine & biotechnology 20110101
Maternal thyroid function and the outcome of external cephalic version: a prospective cohort study. BMC pregnancy and childbirth 20110101
Preterm birth. BMJ clinical evidence 20110101
Newborn Analgesia Mediated by Oxytocin during Delivery. Frontiers in cellular neuroscience 20110101
The effect of combined tocolysis on in vitro uterine contractility in preterm labour. Advances in medical sciences 20110101
Prevention of preterm labour: 2011 update on tocolysis. Journal of pregnancy 20110101
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. International journal of endocrinology 20110101
Use of atosiban in a twin pregnancy with extremely preterm premature rupture in the membrane of one twin: a case report and literature review. Taiwanese journal of obstetrics & gynecology 20101201
CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats. Pflugers Archiv : European journal of physiology 20101101
Oxytocin mediates the antidepressant effects of mating behavior in male mice. Neuroscience research 20101001
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS neuroscience & therapeutics 20101001
Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF. Reproductive biomedicine online 20100901
Oxytocin protects rat heart against ischemia-reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel. Peptides 20100701
Oxytocin is neuroprotective against oxygen-glucose deprivation and reoxygenation in immature hippocampal cultures. Neuroscience letters 20100614
Comparison between atosiban and nicardipine in inducing hypotension during in-utero transfers for threatening premature delivery. European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100601
[Effects of abdominal breathing on state anxiety, stress, and tocolytic dosage for pregnant women in preterm labor]. Journal of Korean Academy of Nursing 20100601
Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology 20100501
Quantitative determination of oxytocin receptor antagonist atosiban in rat plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501
[Parturient at full term with inferior vena cava thrombosis: anesthesia during surgical delivery]. Revista espanola de anestesiologia y reanimacion 20100501
Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism. Regulatory peptides 20100225
Atosiban vs. ritodrine as a tocolytic in external cephalic version at term: a prospective cohort study. Journal of perinatal medicine 20100101
Critical appraisal and clinical utility of atosiban in the management of preterm labor. Therapeutics and clinical risk management 20100101
Meconium pseudocyst secondary to ileum volvulus perforation without peritoneal calcification: a case report. Journal of medical case reports 20100101
Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor. PloS one 20100101
Management of preterm labor: atosiban or nifedipine? International journal of women's health 20100101
Indirect comparisons: a review of reporting and methodological quality. PloS one 20100101
Management of foetal asphyxia by intrauterine foetal resuscitation. Indian journal of anaesthesia 20100101
Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats. Peptides 20091201
Once-daily milking effects in high-yielding Alpine dairy goats. Journal of dairy science 20091101
[Effectiveness and safety of atosiban vs. pulsatile administration of fenoterol in the treatment of preterm labour]. Zeitschrift fur Geburtshilfe und Neonatologie 20091001
Oxytocin antagonist for repeated implantation failure and delay of delivery. Taiwanese journal of obstetrics & gynecology 20090901
Healthcare evaluation of the use of atosiban and fibronectin for the management of pre-term labour. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090801
[Management of preterm labor]. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20090801
Effect of an OT antagonist on the control of the midcycle LH surge in women. Clinical endocrinology 20090701
Anaesthesiological considerations on tocolytic and uterotonic therapy in obstetrics. Acta anaesthesiologica Scandinavica 20090701
The effects of the tocolytics atosiban and nifedipine on fetal movements, heart rate and blood flow. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20090601
Randomized trial of oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of spontaneous preterm labor in Taiwanese women. Journal of the Formosan Medical Association = Taiwan yi zhi 20090601
Estradiol upregulates the expression of oxytocin receptor in colon in rats. American journal of physiology. Endocrinology and metabolism 20090501
Adverse reactions to tocolytics. Atosiban v nifedipine. BMJ (Clinical research ed.) 20090414
Computerized evaluation of fetal heart rate during tocolytic treatment: comparison between atosiban and ritodrine. American journal of perinatology 20090401
Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090401
Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology 20090401
[Twin gestation in a single horn of a bicornuate uterus]. Ugeskrift for laeger 20090309
Tocolytics and preterm labour. BMJ (Clinical research ed.) 20090305
[Acute pulmonary edema occurred during tocolytic treatment using nicardipine in a twin pregnancy. Report of three cases]. Journal de gynecologie, obstetrique et biologie de la reproduction 20090201
Discovery and optimization of highly ligand-efficient oxytocin receptor antagonists using structure-based drug design. Bioorganic & medicinal chemistry letters 20090201
Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour. The Cochrane database of systematic reviews 20090121
Bidirectional communication between neural and cardiac cells in human amniotic fluid. Fetal diagnosis and therapy 20090101
Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia, and autonomic neuropathy with hypergastrinemia. BMC gastroenterology 20090101
Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study. BMJ (Clinical research ed.) 20090101
Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation. BMC pregnancy and childbirth 20090101
Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial). BMC pregnancy and childbirth 20090101
Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists. Neuro endocrinology letters 20090101
Medical therapy in the management of preterm birth. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20090101
Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms. BMC gastroenterology 20090101
Prolonged use of atosiban and grade IV intraventricular haemorrhage in an infant born at 29 weeks and 4 days. BMJ case reports 20090101
Evaluation of udder cisterns and effects on milk yield of dairy ewes. Journal of dairy science 20081201
Management of threatened preterm delivery in France: a national practice survey (the EVAPRIMA study). BJOG : an international journal of obstetrics and gynaecology 20081101
[Non-invasive ventilation for pulmonary edema associated with tocolytic agents during labour for a twin pregnancy]. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20081101
A prospective randomized trial of acute tocolysis in term labour with atosiban or ritodrine. European journal of obstetrics, gynecology, and reproductive biology 20080801
Preterm birth. BMJ clinical evidence 20080602
Acute tocolysis for uterine activity reduction in term labor: a review. Obstetrical & gynecological survey 20080601
Developments in the pharmacotherapeutic management of spontaneous preterm labor. Expert opinion on pharmacotherapy 20080501
Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats. European journal of pharmacology 20080212
Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn-Schmiedeberg's archives of pharmacology 20080201
[Clinical experience of using oxytocin antagonist atosiban in the rescue therapy of preterm labour]. Zhonghua fu chan ke za zhi 20080201
[Atosiban as a tocolytic agent: a new proposal of a therapeutic approach]. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20080201
The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorganic & medicinal chemistry letters 20080101
Market failure and the poverty of new drugs in maternal health. PLoS medicine 20080101
Non-cardiogenic lung edema in a woman treated with atosiban for preterm labor. Journal of perinatal medicine 20080101
Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Progress in brain research 20080101
Expression profiles of the pluripotency marker gene POU5F1 and validation of reference genes in rabbit oocytes and preimplantation stage embryos. BMC molecular biology 20080101
Commentary: a case of non-cardiogenic lung edema in a woman treated with atosiban for preterm labor. Journal of perinatal medicine 20080101
Prevention of preterm delivery. The New England journal of medicine 20071108
Preterm labour. The present and future of tocolysis. Best practice & research. Clinical obstetrics & gynaecology 20071001
No effect of tocolytic therapy with atosiban on maternal serum interleukin-6 and tumor necrosis factor-alpha in threatened preterm labor. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20071001
Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20071001
Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor. Minerva ginecologica 20071001
The effects of atosiban on abnormal fetal heart rate patterns. European journal of obstetrics, gynecology, and reproductive biology 20070801
Clinical practice evaluation of atosiban in preterm labour management in six European countries. BJOG : an international journal of obstetrics and gynaecology 20070801
Secretory and cytosolic phospholipase A2 activities and expression are regulated by oxytocin and estradiol during labor. Reproduction (Cambridge, England) 20070801
Oxytocin antagonists may improve infertility treatment. Fertility and sterility 20070701
Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. European journal of medicinal chemistry 20070601
In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor. The Journal of pharmacology and experimental therapeutics 20070601
Oxytocin is not important for the control of gonadotrophin secretion in the late follicular phase of the cycle. Clinical endocrinology 20070601
The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban. Expert opinion on investigational drugs 20070601
Effect of atosiban on rabbit embryo development and human sperm motility. Fertility and sterility 20070501
Novel in vitro system for functional assessment of oxytocin action. American journal of physiology. Endocrinology and metabolism 20070101
Oxytocin--a stimulator of directed sperm transport in humans. Reproductive biomedicine online 20070101
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? BMC pregnancy and childbirth 20070101
Barusiban suppresses oxytocin-induced preterm labour in non-human primates. BMC pregnancy and childbirth 20070101
Overview. Preterm labour: mechanisms and management. BMC pregnancy and childbirth 20070101
New research models and novel signal analysis in studies on preterm labor: a key to progress? BMC pregnancy and childbirth 20070101
Atosiban versus usual care for the management of preterm labor. Journal of perinatal medicine 20070101
The use of atosiban and ritodrine in external cephalic version. Acta obstetricia et gynecologica Scandinavica 20070101
New insights into the understanding of gastrointestinal dysmotility. Drug target insights 20070101
Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science (New York, N.Y.) 20061215
Use of tocolytics: what is the benefit of gaining 48 hours for the fetus? BJOG : an international journal of obstetrics and gynaecology 20061201
Use of tocolytics: what is the benefit of gaining even more time? BJOG : an international journal of obstetrics and gynaecology 20061201
A quality assessment tool to evaluate tocolytic studies. BJOG : an international journal of obstetrics and gynaecology 20061201
Clinical practice evaluation of atosiban in preterm labour management in six European countries. BJOG : an international journal of obstetrics and gynaecology 20061201
Emerging tocolytics for maintenance therapy of preterm labour: oxytocin antagonists and calcium channel blockers. BJOG : an international journal of obstetrics and gynaecology 20061201
'Normal' pregnancy with adverse events on initial tocolytic treatment. BJOG : an international journal of obstetrics and gynaecology 20061201
Multicentre, parallel group, randomised, single-blind study of the safety and efficacy of atosiban versus ritodrine in the treatment of acute preterm labour in Korean women. BJOG : an international journal of obstetrics and gynaecology 20061101
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency. Journal of medicinal chemistry 20060713
Atosiban vs ritodrine used prophylactically with cerclage in ICSI pregnancies to prevent pre-term birth in women identified as being at high risk on the basis of transvaginal ultrasound scan. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060701
Atosiban for prophylactic tocolysis following transabdominal cervico-isthmic cerclage. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060701
Targeting the oxytocin receptor to relax the myometrium. Expert opinion on therapeutic targets 20060601
Preterm birth. Clinical evidence 20060601
The extracorporeal perfusion of the swine uterus as an experimental model: The effect of tocolytic drugs. European journal of obstetrics, gynecology, and reproductive biology 20060501
Tocolytic treatment for the management of preterm labour: a systematic review. Singapore medical journal 20060501
Role of intraluteal prostaglandin F(2alpha), progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum. Prostaglandins & other lipid mediators 20060501
Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorganic & medicinal chemistry letters 20060215
The inhibitory effects of oxytocin on distal colonic contractile activity in rabbits are enhanced by ovarian steroids. Acta physiologica (Oxford, England) 20060201
Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells. The Journal of physiology 20060101
Atosiban and nifedipine in acute tocolysis: a comparative study. European journal of obstetrics, gynecology, and reproductive biology 20060101
Pragmatic comparison of beta2-agonist side effects within the Worldwide Atosiban versus Beta Agonists study. European journal of obstetrics, gynecology, and reproductive biology 20060101
Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea. Acta obstetricia et gynecologica Scandinavica 20060101
The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human. BMC gastroenterology 20060101
A case report on a patient suffering from recurrent vomiting episodes, whose condition improved markedly during pregnancy and breast feeding. BMC gastroenterology 20060101
Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. Journal of medicinal chemistry 20051201
Visual compatibility of atosiban acetate with four drugs. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051201
Social and sexual motivation in the mouse. Behavioral neuroscience 20051201
Does insulin release kinins in rats? European journal of pharmacology 20051121
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics. Journal of medicinal chemistry 20051103
Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers. BJOG : an international journal of obstetrics and gynaecology 20051101
Design of peptide oxytocin antagonists with strikingly higher affinities and selectivities for the human oxytocin receptor than atosiban. Journal of peptide science : an official publication of the European Peptide Society 20051001
Atosiban and nifedipin for the treatment of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20051001
Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability. The Journal of organic chemistry 20050930
Possible neural mediation of the central effects of oxytocin on uterine motility. American journal of physiology. Regulatory, integrative and comparative physiology 20050901
Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis. Endocrinology 20050801
Oxytocin receptor antagonists for inhibiting preterm labour. The Cochrane database of systematic reviews 20050720
Tocolysis with atosiban: experience in the management of premature labor before 24 weeks of pregnancy. Archives of gynecology and obstetrics 20050601
The oxytocin receptor antagonist atosiban inhibits cell growth via a 'biased agonist' mechanism. The Journal of biological chemistry 20050422
Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. The Journal of clinical endocrinology and metabolism 20050401
Acute tocolysis. Current opinion in obstetrics & gynecology 20050401
[Licensed or non-licensed tocolysis?]. Gynecologie, obstetrique & fertilite 20050401
[Tocolysis by first intention with atosiban]. Gynecologie, obstetrique & fertilite 20050401
Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. European journal of pharmacology 20050307
Adverse effects of tocolytic therapy. BJOG : an international journal of obstetrics and gynaecology 20050301
Tocolytic therapy and clinical experience. Combination therapy. BJOG : an international journal of obstetrics and gynaecology 20050301
Maintenance tocolysis. BJOG : an international journal of obstetrics and gynaecology 20050301
Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis. The Journal of endocrinology 20050301
Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by mu and kappa opioid receptors. Brain research 20050221
Oxytocin microinjected into dorsal motor nucleus of the vagus excites gallbladder motility via NMDA receptor-NO-cGMP pathway. Brain research 20050125
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network. Journal of neuroimmunology 20050101
[Pharmacoeconomic assessment of two tocolysis protocols for the inhibition of premature delivery]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101
Tocolysis and preterm labour. Current opinion in obstetrics & gynecology 20041201
Current medical therapy in the prevention and treatment of preterm labour. Seminars in fetal & neonatal medicine 20041201
Evaluation of the maternal and neonatal effects of the oxytocin antagonist, atosiban, in a cross-fostering study in rats. Reproductive toxicology (Elmsford, N.Y.) 20041101
Recent pharmacological advances in the treatment of preterm membrane rupture, labour and delivery. Expert opinion on pharmacotherapy 20040901
The Gordian knot of developing tocolytics. Journal of the Society for Gynecologic Investigation 20040901
Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women. Journal of the Society for Gynecologic Investigation 20040901
Roles of oxytocin in spatial learning and memory in the nucleus basalis of Meynert in rats. Regulatory peptides 20040815
Spinal effects of oxytocin on uterine motility in anesthetized rats. American journal of physiology. Regulatory, integrative and comparative physiology 20040801
Delaying preterm delivery at the threshold of viability. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040601
Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice. Pharmacology, biochemistry, and behavior 20040601
Preterm birth. Clinical evidence 20040601
SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, hydrochloride): a new selective and orally active oxytocin receptor antagonist for the prevention of preterm labor. The Journal of pharmacology and experimental therapeutics 20040401
A prospective randomised trial of atosiban versus hexoprenaline for acute tocolysis and intrauterine resuscitation. BJOG : an international journal of obstetrics and gynaecology 20040401
The drugs we deserve. BJOG : an international journal of obstetrics and gynaecology 20040401
Management options for preterm labour in Canada. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20040401
Tocolysis: current controversies, future directions. Current opinion in investigational drugs (London, England : 2000) 20040401
Emerging issues over the choice of nifedipine, beta-agonists and atosiban for tocolysis in spontaneous preterm labour--a proposed systematic review by the International Preterm Labour Council. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20040401
Sex differences and developmental effects of manipulations of oxytocin on alloparenting and anxiety in prairie voles. Developmental psychobiology 20040301
[Comparison of the cost of treatment of premature labor with atosiban or beta-sympathomimetics from the perspective of the health care payer--a pharmacoeconomic model]. Ceska gynekologie 20040301
Atosiban for preterm labour. Drugs 20040101
Atosiban treatment for uterine hyperactivity during active labor: a pilot study. Journal of perinatal medicine 20040101
Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. BJOG : an international journal of obstetrics and gynaecology 20031201
FE 200 440: a selective oxytocin antagonist on the term-pregnant human uterus. BJOG : an international journal of obstetrics and gynaecology 20031101
Endogenous oxytocin excites phasic contraction of gallbladder in rabbits through oxytocin receptor. The Chinese journal of physiology 20030930
Involvement of oxytocin in spinal antinociception in rats with inflammation. Brain research 20030905
Preterm delivery: an overview. Acta obstetricia et gynecologica Scandinavica 20030801
Preterm labour: an overview of current and emerging therapeutics. Current medicinal chemistry 20030801
The in vitro effect of dual combinations of ritodrine, nicardipine and atosiban on contractility of pregnant rat myometrium. BJOG : an international journal of obstetrics and gynaecology 20030801
Effects of alpha- and beta-adrenergic receptor stimulation and oxytocin receptor blockade on milking characteristics in dairy cows before and after removal of the teat sphincter. The Journal of dairy research 20030801
The oxytocin receptor. Trends in endocrinology and metabolism: TEM 20030701
Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women. Human reproduction (Oxford, England) 20030701
Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology 20030601
The effects of a progesterone metabolite, 5 beta-dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes. BJOG : an international journal of obstetrics and gynaecology 20030601
Oxytocin and fetal membranes in preterm labor: current concepts and clinical implication. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20030601
Molecular modeling of the neurohypophyseal receptor/atosiban complexes. Protein and peptide letters 20030601
Significant delay of birth in advanced preterm labour at 23 gestational weeks with an oxytocin antagonist. European journal of obstetrics, gynecology, and reproductive biology 20030501
Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn-Schmiedeberg's archives of pharmacology 20030401
[In utero medicalized transfers: medical regulation and transport process]. Journal de gynecologie, obstetrique et biologie de la reproduction 20030401
The development and introduction of anti-oxytocic tocolytics. BJOG : an international journal of obstetrics and gynaecology 20030401
Exploring the role of Tractocile in everyday clinical practice. BJOG : an international journal of obstetrics and gynaecology 20030401
Review of clinical experience with atosiban and the Tractocile Efficacy Assessment Survey in Europe (TREASURE) study protocol. International journal of clinical practice 20030301
Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. BJOG : an international journal of obstetrics and gynaecology 20030101
An update on the controversies of tocolytic therapy for the prevention of preterm birth. Acta obstetricia et gynecologica Scandinavica 20030101
Oxytocin antagonists for tocolysis in preterm labour -- a systematic review. Medical science monitor : international medical journal of experimental and clinical research 20021101
[Tocolysis: indications and contraindications. When to start and when to stop]. Journal de gynecologie, obstetrique et biologie de la reproduction 20021101
[Which tocolytic drugs in case of preterm labor?]. Journal de gynecologie, obstetrique et biologie de la reproduction 20021101
[Special management for threatened preterm delivery in multiple pregnancies]. Journal de gynecologie, obstetrique et biologie de la reproduction 20021101
Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats. Pflugers Archiv : European journal of physiology 20021101
Effect of weaning system on milk composition and distribution of milk fat within the udder of East Friesian dairy ewes. Journal of dairy science 20021001
In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents. BJOG : an international journal of obstetrics and gynaecology 20020901
Development and clinical experience with the new evidence-based tocolytic atosiban. Acta obstetricia et gynecologica Scandinavica 20020701
Effects of mating stimuli and oxytocin on plasma cortisol concentration in gilts. Reproductive biology 20020301
Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea. Progress in brain research 20020101
Review on prostaglandin and oxytocin activity in preterm labor. Collegium antropologicum 20011201
Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life sciences 20011121
Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. European journal of obstetrics, gynecology, and reproductive biology 20011001
Adverse and beneficial effects of tocolytic therapy. Seminars in perinatology 20011001
Oxytocin decreases carrageenan induced inflammation in rats. Peptides 20010901
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP. British journal of pharmacology 20010901
Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro. BJOG : an international journal of obstetrics and gynaecology 20010901
Design of oxytocin antagonists, which are more selective than atosiban. Journal of peptide science : an official publication of the European Peptide Society 20010901
Atosiban for the primary prevention of preterm labour. BJOG : an international journal of obstetrics and gynaecology 20010801
Tocolysis with beta-adrenergic receptor agonists. Seminars in perinatology 20010801
Effects of oxytocin receptor antagonist atosiban on pregnant myometrium in vitro. Obstetrics and gynecology 20010701
Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats. Acta pharmacologica Sinica 20010601
The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor. A randomized, double-blind, controlled study. Acta obstetricia et gynecologica Scandinavica 20010501
[Tocolysis. Atosiban, an ocytcin-receptor antagonist]. Journal de gynecologie, obstetrique et biologie de la reproduction 20010501
The oxytocin receptor system: structure, function, and regulation. Physiological reviews 20010401
Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. American journal of physiology. Regulatory, integrative and comparative physiology 20010301
Oxytocin antagonists: clinical and scientific considerations. Experimental physiology 20010301
Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. The Worldwide Atosiban versus Beta-agonists Study Group. BJOG : an international journal of obstetrics and gynaecology 20010201
Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep. Journal of the Society for Gynecologic Investigation 20010101
Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. American journal of obstetrics and gynecology 20000501
Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. British journal of obstetrics and gynaecology 19991001
Oxytocin and vasopressin constrict rat isolated uterine resistance arteries by activating vasopressin V1A receptors. European journal of pharmacology 19990702
Intrathecal injection of an oxytocin-receptor antagonist attenuated postnephrectomy natriuresis in the male rat. Neuroscience letters 19950728
Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life sciences 19950101
Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells. Molecular endocrinology (Baltimore, Md.)
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