Home Halogens 1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

CAS No.:
99592-32-2
Catalog Number:
AG0064WI
Molecular Formula:
C20H15Cl3N2OS
Molecular Weight:
437.7699
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG0064WI
Chemical Name:
1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
CAS Number:
99592-32-2
Molecular Formula:
C20H15Cl3N2OS
Molecular Weight:
437.7699
MDL Number:
MFCD00918063
IUPAC Name:
1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
InChI:
InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2
InChI Key:
JLGKQTAYUIMGRK-UHFFFAOYSA-N
SMILES:
Clc1ccc(c(c1)Cl)C(Cn1ccnc1)OCc1csc2c1cccc2Cl
Properties
Complexity:
488  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
435.997g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
437.763g/mol
Monoisotopic Mass:
435.997g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
55.3A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
6.3  
Literature
Title Journal
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Treatment of interdigital tinea pedis: once-daily therapy with sertaconazole nitrate. Journal of drugs in dermatology : JDD 20111001
An open-label study of the safety and efficacy of sertaconazole nitrate in the treatment of seborrheic dermatitis. Journal of drugs in dermatology : JDD 20110801
Efficacy and tolerability of sertaconazole nitrate 2% cream vs. miconazole in patients with cutaneous dermatophytosis. Mycoses 20110501
Induction of prostaglandin D2 through the p38 MAPK pathway is responsible for the antipruritic activity of sertaconazole nitrate. The Journal of investigative dermatology 20101001
Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea pedis interdigitalis: a subgroup analysis. Cutis 20100201
Sertaconazole 2% cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial. Clinical and experimental dermatology 20091201
A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091201
What is your diagnosis? Tinea nigra. Cutis 20091201
Observational evaluation of sertaconazole nitrate cream 2% in the treatment of pruritus related to tinea pedis. Cutis 20091101
Safe and effective treatment of seborrheic dermatitis. Cutis 20090601
Sertaconazole nitrate cream 2% for the treatment of tinea pedis. Cutis 20090501
Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs 20090101
Widespread, chronic, and fluconazole-resistant Trichophyton rubrum infection in an immunocompetent patient. Mycoses 20081101
In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents. Journal of chemotherapy (Florence, Italy) 20080801
Comprehensive management of patients with superficial fungal infections: the role of sertaconazole nitrate. Cutis 20080601
Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway. The Journal of investigative dermatology 20080201
Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis. American journal of clinical dermatology 20070101
Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections. Diagnostic microbiology and infectious disease 20061001
The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis. Cutis 20061001
Anti-inflammatory and anti-itch activity of sertaconazole nitrate. Archives of dermatological research 20060901
Sertaconazole/hydroxypropyl-beta-cyclodextrin complexation: isothermal titration calorimetry and solubility approaches. Journal of pharmaceutical sciences 20060801
Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis. Journal of the Chinese Medical Association : JCMA 20060601
Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation. American journal of clinical dermatology 20060101
Drug solubilization and delivery from cyclodextrin-Pluronic aggregates. Journal of nanoscience and nanotechnology 20060101
Sertaconazole: updated review of a topical antifungal agent. Expert review of anti-infective therapy 20050601
Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration. Arzneimittel-Forschung 20050101
In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis. Chemotherapy 20041201
Topical sertaconazole (ertaczo)--another azole for tinea pedis. The Medical letter on drugs and therapeutics 20040621
In vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates. Journal of chemotherapy (Florence, Italy) 20031201
In vitro activity of sertaconazole against dermatophyte isolates with reduced fluconazole susceptibility. Chemotherapy 20030901
Effect of cyclodextrins on the solubility and antimycotic activity of sertaconazole: experimental and computational studies. Journal of pharmaceutical sciences 20021101
Sertaconazole: in-vitro antifungal activity against vaginal and other superficial yeast isolates. Journal of chemotherapy (Florence, Italy) 20011001
In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates. Methods and findings in experimental and clinical pharmacology 20010301
Comparative study of antifungal activity of sertaconazole, terbinafine, and bifonazole against clinical isolates of Candida spp., Cryptococcus neoformans and dermatophytes. Chemotherapy 19970101
Antifungal activity of sertaconazole in vitro against clinical isolates of Candida spp. Chemotherapy 19960101
In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp. The Journal of antimicrobial chemotherapy 19951001
In vitro activity of sertaconazole. Arzneimittel-Forschung 19920501
In vitro antifungal activity of sertaconazole. Arzneimittel-Forschung 19920501
In vitro comparative study of the fungistatic and fungicidal activity of sertaconazole and other antifungals against Candida albicans. Arzneimittel-Forschung 19920501
Properties