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Home Other Building Blocks L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-

L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-

CAS No.:
736992-21-5
Catalog Number:
AG005XXY
Molecular Formula:
C32H49N9O5
Molecular Weight:
639.7888
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Product Description
Catalog Number:
AG005XXY
Chemical Name:
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-
CAS Number:
736992-21-5
Molecular Formula:
C32H49N9O5
Molecular Weight:
639.7888
MDL Number:
MFCD20133791
IUPAC Name:
(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide
InChI:
InChI=1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1
InChI Key:
SFVLTCAESLKEHH-WKAQUBQDSA-N
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)[C@H](Cc1c(C)cc(cc1C)O)NC(=O)[C@@H](CCCNC(=N)N)N
UNII:
87GWG91S09
Properties
Complexity:
991  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
639.386g/mol
Formal Charge:
0
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
9  
Isotope Atom Count:
0
Molecular Weight:
639.802g/mol
Monoisotopic Mass:
639.386g/mol
Rotatable Bond Count:
19  
Topological Polar Surface Area:
267A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0
Literature
Title Journal
Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. Journal of molecular and cellular cardiology 20120501
Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells. Molecular medicine reports 20120401
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Human molecular genetics 20111201
Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance. International journal of molecular medicine 20111001
Mitochondria-targeted peptide MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. Investigative ophthalmology & visual science 20110901
Targeting mitochondrial oxidative stress in heart failure throttling the afterburner. Journal of the American College of Cardiology 20110628
Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy. Journal of the American College of Cardiology 20110628
Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. Journal of the American Society of Nephrology : JASN 20110601
Pores for thought: new strategies to re-energize stressed mitochondria in acute kidney injury. Journal of the American Society of Nephrology : JASN 20110601
Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells. Biochemical and biophysical research communications 20110107
Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. International journal of environmental research and public health 20110101
Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. The Journal of pharmacology and experimental therapeutics 20090401
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. The Journal of clinical investigation 20090302
A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction. American journal of physiology. Renal physiology 20081101
Potent mitochondria-targeted peptides reduce myocardial infarction in rats. Coronary artery disease 20070501
Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochemical pharmacology 20051205
Properties