2,5-diamino-2-(difluoromethyl)pentanoic acid
| Title | Journal |
|---|---|
| Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20150415 |
| Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine. | Medical oncology (Northwood, London, England) 20121201 |
| Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation. | Bioorganic & medicinal chemistry letters 20121101 |
| HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation. | The Journal of nutritional biochemistry 20121001 |
| Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial. | Journal of the American Academy of Dermatology 20121001 |
| Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas. | Cancer causes & control : CCC 20121001 |
| Pharmacotherapy of actinic keratosis: an update. | Expert opinion on pharmacotherapy 20120901 |
| Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. | Journal of medicinal chemistry 20120726 |
| In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum). | Journal of natural medicines 20120701 |
| Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. | American journal of physiology. Cell physiology 20120701 |
| The investigation and management of hirsutism. | The journal of family planning and reproductive health care 20120701 |
| Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. | Parasitology 20120601 |
| Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. | PLoS neglected tropical diseases 20120601 |
| Early prediction of treatment efficacy in second-stage gambiense human African trypanosomiasis. | PLoS neglected tropical diseases 20120601 |
| Combination chemoprevention: future direction of colorectal cancer prevention. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120501 |
| Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. | PLoS neglected tropical diseases 20120501 |
| Human African trypanosomiasis in South Sudan: how can we prevent a new epidemic? | PLoS neglected tropical diseases 20120501 |
| In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei. | Journal of natural medicines 20120401 |
| The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. | British journal of pharmacology 20120401 |
| Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts. | Biochimica et biophysica acta 20120401 |
| Ribonuclease activity of p53 in cytoplasm in response to various stress signals. | Cell cycle (Georgetown, Tex.) 20120401 |
| Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. | The Biochemical journal 20120315 |
| Multiple infections of Trypanosoma brucei gambiense in blood and cerebrospinal fluid of human African trypanosomosis patients from Angola: consequences on clinical course and treatment outcome. | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20120301 |
| Hirsutism in women. | American family physician 20120215 |
| The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. | Brain research 20120203 |
| High-throughput decoding of antitrypanosomal drug efficacy and resistance. | Nature 20120125 |
| Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors. | ChemMedChem 20120102 |
| Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. | Pharmacology, biochemistry, and behavior 20120101 |
| Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20120101 |
| Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma. | BMC research notes 20120101 |
| The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries. | PloS one 20120101 |
| Arsenic and antimony transporters in eukaryotes. | International journal of molecular sciences 20120101 |
| Late stage infection in sleeping sickness. | PloS one 20120101 |
| Towards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis. | Journal of tropical medicine 20120101 |
| New insights in staging and chemotherapy of African trypanosomiasis and possible contribution of medicinal plants. | TheScientificWorldJournal 20120101 |
| [Analysis of oncogenic signaling pathway induced by a myeloproliferative neoplasm-associated Janus kinase 2 (JAK2) V617F mutant]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101 |
| Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels. | Investigative ophthalmology & visual science 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Parasitic infections in HIV infected individuals: diagnostic & therapeutic challenges. | The Indian journal of medical research 20111201 |
| In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. | Phytochemistry 20111101 |
| Nonmelanoma skin cancer chemoprevention. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20111101 |
| Sleeping sickness in travelers - do they really sleep? | PLoS neglected tropical diseases 20111101 |
| Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488. | ChemMedChem 20111004 |
| [Congenital human African trypanosomiasis: an observation at the University Hospital of Brazzaville (Congo)]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20111001 |
| Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities. | The Biochemical journal 20110901 |
| Drug resistance in human African trypanosomiasis. | Future microbiology 20110901 |
| Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design. | Journal of medicinal chemistry 20110811 |
| Role of peripheral polyamines in the development of inflammatory pain. | Biochemical pharmacology 20110801 |
| Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801 |
| Target repurposing for neglected diseases. | Future medicinal chemistry 20110801 |
| DFMO: targeted risk reduction therapy for colorectal neoplasia. | Best practice & research. Clinical gastroenterology 20110801 |
| Reversal of difluoromethylornithine effects by the administration of putrescine in rats. | JPMA. The Journal of the Pakistan Medical Association 20110801 |
| The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism. | Journal of medicinal chemistry 20110714 |
| Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. | Cancer prevention research (Philadelphia, Pa.) 20110701 |
| Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. | American journal of physiology. Gastrointestinal and liver physiology 20110701 |
| Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei. | Eukaryotic cell 20110701 |
| Drug delivery systems in the treatment of African trypanosomiasis infections. | Expert opinion on drug delivery 20110601 |
| Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett's esophagus. | Cancer prevention research (Philadelphia, Pa.) 20110601 |
| Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia. | Cancer prevention research (Philadelphia, Pa.) 20110601 |
| SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. | PLoS neglected tropical diseases 20110601 |
| Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma? | European journal of clinical pharmacology 20110501 |
| 1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. | European journal of medicinal chemistry 20110501 |
| Target validation: linking target and chemical properties to desired product profile. | Current topics in medicinal chemistry 20110501 |
| Studies on cell migration model in intestinal epithelial restitution for pharmacological research. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501 |
| A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes. | Amino acids 20110401 |
| Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice. | Molecular and biochemical parasitology 20110401 |
| Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. | PLoS neglected tropical diseases 20110401 |
| Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice. | PLoS neglected tropical diseases 20110401 |
| [Nifurtimox, a bright future for treatment of Chagas disease]. | Medecine tropicale : revue du Corps de sante colonial 20110401 |
| Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. | The Journal of biological chemistry 20110311 |
| Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. | Molecular and biochemical parasitology 20110301 |
| Clinical presentation of T.b. rhodesiense sleeping sickness in second stage patients from Tanzania and Uganda. | PLoS neglected tropical diseases 20110301 |
| New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. | Seminars in cutaneous medicine and surgery 20110301 |
| Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. | The American journal of tropical medicine and hygiene 20110204 |
| The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers. | The Journal of pharmacology and experimental therapeutics 20110201 |
| 2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. | PLoS neglected tropical diseases 20110201 |
| Diagnostic accuracy of PCR in gambiense sleeping sickness diagnosis, staging and post-treatment follow-up: a 2-year longitudinal study. | PLoS neglected tropical diseases 20110201 |
| The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward. | PLoS neglected tropical diseases 20110201 |
| Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters. | Molecular and biochemical parasitology 20110101 |
| Treatment options for polycystic ovary syndrome. | International journal of women's health 20110101 |
| Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. | PloS one 20110101 |
| State of the art in African trypanosome drug discovery. | Current topics in medicinal chemistry 20110101 |
| Risk of second primary colorectal cancer among colorectal cancer cases: a population-based analysis. | Journal of carcinogenesis 20110101 |
| Clinical trials update: Tertiary prevention of colorectal cancer. | Journal of carcinogenesis 20110101 |
| Drug discovery and development for neglected diseases: the DNDi model. | Drug design, development and therapy 20110101 |
| Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo. | Conflict and health 20110101 |
| Trypanosoma cruzi Coexpressing Ornithine Decarboxylase and Green Fluorescence Proteins as a Tool to Study the Role of Polyamines in Chagas Disease Pathology. | Enzyme research 20110101 |
| Perspective: Chemoprevention of colorectal neoplasia: Translating scientific promise into clinical practice. | Journal of carcinogenesis 20110101 |
| Trypanosome prereplication machinery: a potential new target for an old problem. | Enzyme research 20110101 |
| Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma. | Arzneimittel-Forschung 20110101 |
| Evaluation of the effect of formic acid and sodium formate on hair reduction in rat. | Clinical, cosmetic and investigational dermatology 20110101 |
| Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. | PloS one 20110101 |
| Neglected disease - african sleeping sickness: recent synthetic and modeling advances. | Scientia pharmaceutica 20110101 |
| Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi. | Parasites & vectors 20110101 |
| Prevalence and types of coinfections in sleeping sickness patients in kenya (2000/2009). | Journal of tropical medicine 20110101 |
| Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. | Molecular biology international 20110101 |
| Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors. | Behavioural brain research 20101201 |
| Potential new drugs for human African trypanosomiasis: some progress at last. | Current opinion in infectious diseases 20101201 |
| Chemotherapy against human African trypanosomiasis: is there a road to success? | Parasitology 20101201 |
| Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. | PLoS neglected tropical diseases 20101201 |
| Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. | Biochemical pharmacology 20101115 |
| Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. | Carcinogenesis 20101101 |
| Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. | Anti-cancer drugs 20101101 |
| [Pseudofolliculitis barbae]. | Actas dermo-sifiliograficas 20101101 |
| A molecular mechanism for eflornithine resistance in African trypanosomes. | PLoS pathogens 20101101 |
| Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. | Journal of the National Cancer Institute 20101006 |
| Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells. | Experimental cell research 20101001 |
| Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. | Gastroenterology 20101001 |
| Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. | The European journal of neuroscience 20101001 |
| New discoveries in the transmission biology of sleeping sickness parasites: applying the basics. | Journal of molecular medicine (Berlin, Germany) 20100901 |
| Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. | Gastroenterology 20100901 |
| Polyamines and hair: a couple in search of perfection. | Experimental dermatology 20100901 |
| Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds. | Journal of medicinal chemistry 20100826 |
| Smoothened antagonists for hair inhibition. | Bioorganic & medicinal chemistry letters 20100815 |
| Chemotherapy for second-stage Human African trypanosomiasis. | The Cochrane database of systematic reviews 20100804 |
| Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. | American journal of physiology. Gastrointestinal and liver physiology 20100801 |
| Best practice options for hair removal in patients with unwanted facial hair using combination therapy with laser: guidelines drawn up by an expert working group. | Dermatology (Basel, Switzerland) 20100801 |
| Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1. | PLoS neglected tropical diseases 20100801 |
| Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. | European journal of pharmacology 20100710 |
| Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. | Journal of medicinal chemistry 20100708 |
| Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection. | Biomedical chromatography : BMC 20100701 |
| Trypanosoma brucei: trypanosome-specific endoplasmic reticulum proteins involved in variant surface glycoprotein expression. | Experimental parasitology 20100701 |
| Comprehensive clinical management of hirsutism. | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100701 |
| Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain. | European journal of medicinal chemistry 20100701 |
| Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. | Journal of cellular and molecular medicine 20100601 |
| Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer. | Anticancer research 20100601 |
| Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei. | The Journal of biological chemistry 20100514 |
| 'Manifesto' for advancing the control and elimination of neglected tropical diseases. | PLoS neglected tropical diseases 20100501 |
| Controlling sleeping sickness--'when will they ever learn?'. | PLoS neglected tropical diseases 20100501 |
| NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness. | PLoS neglected tropical diseases 20100501 |
| The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. | The Journal of biological chemistry 20100423 |
| Late-stage human African trypanosomiasis in a Sudanese refugee. | The Medical journal of Australia 20100405 |
| The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis. | PLoS neglected tropical diseases 20100401 |
| A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. | PLoS neglected tropical diseases 20100401 |
| Hirsutism: Diagnosis and management. | Gender medicine 20100401 |
| Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. | Journal of medicinal chemistry 20100311 |
| Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture. | Experimental dermatology 20100301 |
| Anticancer agents against malaria: time to revisit? | Trends in parasitology 20100301 |
| Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells. | Amino acids 20100201 |
| Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002-2008). | Journal of the American Veterinary Medical Association 20100201 |
| [Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon]. | Medecine tropicale : revue du Corps de sante colonial 20100201 |
| Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase. | Analytical biochemistry 20100115 |
| Human African trypanosomiasis. | Lancet (London, England) 20100109 |
| Killer coma: the evolving story of sleeping sickness treatment. | Lancet (London, England) 20100109 |
| Fever of unknown origin in an infant with an unexpected blood film report: a case report. | Rural and remote health 20100101 |
| Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans. | Cancer prevention research (Philadelphia, Pa.) 20100101 |
| A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. | Cancer prevention research (Philadelphia, Pa.) 20100101 |
| A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology. | PLoS computational biology 20100101 |
| A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. | PLoS neglected tropical diseases 20100101 |
| Trypanosomatid parasites causing neglected diseases. | Current medicinal chemistry 20100101 |
| The development of drugs for treatment of sleeping sickness: a historical review. | Parasites & vectors 20100101 |
| Hirsutism: evaluation and treatment. | Indian journal of dermatology 20100101 |
| Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. | BMC medicine 20100101 |
| Management of the adult with congenital adrenal hyperplasia. | International journal of pediatric endocrinology 20100101 |
| Effects of oral administration of synthesized delta-amides of eflornithine in the rat. | Arzneimittel-Forschung 20100101 |
| A comparative analysis of the Libyan national essential medicines list and the WHO model list of essential medicines. | The Libyan journal of medicine 20100101 |
| Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue. | World journal of urology 20091201 |
| S-Nitrosylation of secreted recombinant human glypican-1. | Glycoconjugate journal 20091201 |
| Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome. | American journal of physiology. Cell physiology 20091201 |
| Pharmacotherapy of actinic keratosis. | Expert opinion on pharmacotherapy 20091201 |
| Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry. | Analytical and quantitative cytology and histology 20091201 |
| Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. | Organic & biomolecular chemistry 20091121 |
| Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention. | Essays in biochemistry 20091104 |
| Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells. | The international journal of biochemistry & cell biology 20091101 |
| Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods. | Molecular microbiology 20091101 |
| East African trypanosomiasis in a pregnant traveler. | Emerging infectious diseases 20091101 |
| Inner ear protection and regeneration: a 'historical' perspective. | Current opinion in otolaryngology & head and neck surgery 20091001 |
| Role of polyamines and cAMP-dependent mechanisms on 5alpha-dihydrotestosterone-elicited functional effects in isolated right atria of rat. | Journal of cardiovascular pharmacology 20091001 |
| On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. | Journal of medicinal chemistry 20090924 |
| Nutrition and colon cancer prevention. | Current opinion in clinical nutrition and metabolic care 20090901 |
| Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. | PLoS neglected tropical diseases 20090901 |
| Hirsutism. | BMJ (Clinical research ed.) 20090828 |
| Recent advances in the development of polyamine analogues as antitumor agents. | Journal of medicinal chemistry 20090813 |
| The change of antizyme inhibitor expression and its possible role during mammalian cell cycle. | Experimental cell research 20090801 |
| Advancing drug innovation for neglected diseases-criteria for lead progression. | PLoS neglected tropical diseases 20090801 |
| Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. | PLoS neglected tropical diseases 20090801 |
| Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. | Neuroscience 20090707 |
| Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. | Lancet (London, England) 20090704 |
| NECT trial: more than a small victory over sleeping sickness. | Lancet (London, England) 20090704 |
| Green tea extract: a novel addition to the antihirsutism armamentarium? | Journal of alternative and complementary medicine (New York, N.Y.) 20090701 |
| Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Magnetic resonance imaging findings in human African trypanosomiasis: a four-year follow-up study in a patient and review of the literature. | The American journal of tropical medicine and hygiene 20090601 |
| A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients. | PLoS neglected tropical diseases 20090601 |
| Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration. | The Journal of physiology 20090515 |
| Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. | Brain : a journal of neurology 20090501 |
| Drug treatments for polycystic ovary syndrome. | American family physician 20090415 |
| Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor. | Journal of medicinal chemistry 20090409 |
| Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function. | American journal of physiology. Cell physiology 20090401 |
| Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome. | Oncology reports 20090401 |
| Off-label use of approved drugs. | Nature reviews. Clinical oncology 20090401 |
| Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. | Bioorganic & medicinal chemistry 20090315 |
| Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20090301 |
| Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats. | Pharmacology, biochemistry, and behavior 20090301 |
| Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas. | Cancer prevention research (Philadelphia, Pa.) 20090301 |
| Cardiac alterations in human African trypanosomiasis (T.b. gambiense) with respect to the disease stage and antiparasitic treatment. | PLoS neglected tropical diseases 20090201 |
| Effect ofalpha-difluormethylornithine on Anastrepha fraterculus (Diptera, Tephritidae) ovary size. | Brazilian journal of biology = Revista brasleira de biologia 20090201 |
| Reducing the risk of recurrent colon polyps. | Clinical advances in hematology & oncology : H&O 20090201 |
| Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma. | Cancer research 20090115 |
| Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. | The Journal of biological chemistry 20090109 |
| Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate. | Cancer letters 20090108 |
| Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol. | Journal of plant physiology 20090101 |
| The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. | British journal of pharmacology 20090101 |
| Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib. | Parasites & vectors 20090101 |
| Ethics of conducting research in conflict settings. | Conflict and health 20090101 |
| Chemotherapy of human african trypanosomiasis. | Interdisciplinary perspectives on infectious diseases 20090101 |
| [Agents for the treatment of African sleeping sickness. Those developed in the last century]. | Pharmazie in unserer Zeit 20090101 |
| A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. | Parasites & vectors 20090101 |
| Brucellosis presenting as pyrexia of unknown origin in an international traveller: a case report. | Cases journal 20090101 |
| [Molecular functions of polyamines in neoplastic growth and their role in control of the NF-kappaB transcription factor in experimental tumors cells]. | Likars'ka sprava 20090101 |
| Hirsutism in Kashmir: an etiological study. | Indian journal of dermatology 20090101 |
| Effect of difluoromethylornithine on thyroid function in rats. | Journal of Ayub Medical College, Abbottabad : JAMC 20090101 |
| New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives. | Bioorganic & medicinal chemistry 20081215 |
| Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana. | Applied biochemistry and biotechnology 20081201 |
| Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review. | Clinical endocrinology 20081201 |
| ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma. | Cancer research 20081201 |
| Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma. | Cancer research 20081201 |
| The natural progression of Gambiense sleeping sickness: what is the evidence? | PLoS neglected tropical diseases 20081201 |
| Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas. | Cancer prevention research (Philadelphia, Pa.) 20081201 |
| Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat. | European journal of pharmacology 20081119 |
| Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. | Cancer research 20081115 |
| Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells. | Breast cancer research and treatment 20081101 |
| The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain. | Journal of neurochemistry 20081101 |
| TDR thirty years on: taking stock and envisioning the future for the Special Programme for Research and Training in Tropical Diseases. | PLoS neglected tropical diseases 20081101 |
| Chemoprevention of bladder cancer. | BJU international 20081101 |
| A parasite cysteine protease is key to host protein degradation and iron acquisition. | The Journal of biological chemistry 20081024 |
| Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. | Journal of medicinal chemistry 20081009 |
| Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. | American journal of physiology. Renal physiology 20081001 |
| Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. | Endocrinology 20081001 |
| Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes. | PLoS pathogens 20081001 |
| Kinetoplastida: new therapeutic strategies. | Parasite (Paris, France) 20080901 |
| Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice. | Carcinogenesis 20080801 |
| Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats. | Journal of cardiovascular pharmacology 20080801 |
| The continuing problem of human African trypanosomiasis (sleeping sickness). | Annals of neurology 20080801 |
| Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes. | Journal of cellular physiology 20080701 |
| Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target. | Molecular and biochemical parasitology 20080701 |
| Drugs to prevent colon cancer show promise, but hurdles remain for chemoprevention. | Journal of the National Cancer Institute 20080604 |
| High-frequency ultrasonic atomization for drug delivery to rodent animal models - optimal particle size for lung inhalation of difluoromethyl ornithine. | Experimental lung research 20080601 |
| High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo. | Emerging infectious diseases 20080601 |
| Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. | Cancer prevention research (Philadelphia, Pa.) 20080601 |
| Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone. | Cancer prevention research (Philadelphia, Pa.) 20080601 |
| Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period. | Endocrinology 20080501 |
| Making a difference: 30 years of TDR. | Nature reviews. Microbiology 20080501 |
| Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation. | International journal of oncology 20080401 |
| African sleeping sickness. | BMJ (Clinical research ed.) 20080329 |
| Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study. | BMJ (Clinical research ed.) 20080329 |
| Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20080301 |
| Hirsutism. | International journal of clinical practice 20080301 |
| Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes. | Journal of cellular biochemistry 20080301 |
| Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum. | Mycological research 20080301 |
| Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips. | Acta biologica Hungarica 20080301 |
| Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and alpha-keto acid homeostasis? | Amino acids 20080201 |
| Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion. | Biological chemistry 20080201 |
| The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080201 |
| Eliminating human African trypanosomiasis: where do we stand and what comes next? | PLoS medicine 20080201 |
| Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola. | Tropical medicine & international health : TM & IH 20080201 |
| Idiopathic hirsutism: excessive bodily and facial hair in women. | British journal of nursing (Mark Allen Publishing) 20080201 |
| In search of novel agents for therapy of tropical diseases and human immunodeficiency virus. | Journal of medicinal chemistry 20080124 |
| Validation of spermidine synthase as a drug target in African trypanosomes. | The Biochemical journal 20080115 |
| Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells. | Breast cancer research and treatment 20080101 |
| Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. | Breast cancer research and treatment 20080101 |
| Chemoprevention with special reference to inherited colorectal cancer. | Familial cancer 20080101 |
| A 4-month, open-label study evaluating the efficacy of eflornithine 11.5% cream in the treatment of unwanted facial hair in women using TrichoScan. | European journal of dermatology : EJD 20080101 |
| Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme. | PLoS neglected tropical diseases 20080101 |
| The history of African trypanosomiasis. | Parasites & vectors 20080101 |
| Hypothesis: the potential utility of topical eflornithine against cutaneous leishmaniasis. | Indian journal of dermatology, venereology and leprology 20080101 |
| Medical treatment of hirsutism. | Dermatologic therapy 20080101 |
| Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis. | Nutrition and cancer 20080101 |
| EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. | Cellular signalling 20071201 |
| Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites. | Biochimica et biophysica acta 20071201 |
| Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201 |
| Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201 |
| Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis). | Tropical medicine & international health : TM & IH 20071201 |
| Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. | The Journal of biological chemistry 20071130 |
| Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy. | International journal of cancer 20071115 |
| Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells. | International journal of oncology 20071101 |
| Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series. | PLoS neglected tropical diseases 20071101 |
| Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases. | The Journal of biological chemistry 20070914 |
| Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and alpha-keto acid homeostasis or immunocompetence. | Amino acids 20070901 |
| Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. | Breast cancer research and treatment 20070901 |
| Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity. | American journal of physiology. Gastrointestinal and liver physiology 20070901 |
| The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism. | International journal of dermatology 20070901 |
| Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase. | ChemMedChem 20070813 |
| Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention. | Amino acids 20070801 |
| Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. | Amino acids 20070801 |
| Polyamines and mRNA stability in regulation of intestinal mucosal growth. | Amino acids 20070801 |
| Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential. | Amino acids 20070801 |
| Kidney growth, hypertrophy and the unifying mechanism of diabetic complications. | Amino acids 20070801 |
| Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells. | American journal of physiology. Cell physiology 20070801 |
| Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells. | Amino acids 20070801 |
| Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. | Amino acids 20070801 |
| Does eflornithine help women face hirsutism? | Drug and therapeutics bulletin 20070801 |
| A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women. | Journal of the American Academy of Dermatology 20070701 |
| p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion. | American journal of physiology. Cell physiology 20070701 |
| Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination. | International journal of oncology 20070701 |
| Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion. | The Biochemical journal 20070501 |
| Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats. | Alcoholism, clinical and experimental research 20070501 |
| Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts. | International journal of molecular medicine 20070501 |
| Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. | American journal of physiology. Endocrinology and metabolism 20070401 |
| Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. | Biochemical Society transactions 20070401 |
| Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent. | Biochemical Society transactions 20070401 |
| Astroglia growth retardation and increased microglia proliferation by lithium and ornithine decarboxylase inhibitor in rat cerebellar cultures: Cytotoxicity by combined lithium and polyamine inhibition. | Journal of neuroscience research 20070215 |
| Determination of eflornithine enantiomers in plasma, by solid-phase extraction and liquid chromatography with evaporative light-scattering detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201 |
| HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells. | Molecular cancer therapeutics 20070201 |
| Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair. | International journal of dermatology 20070101 |
| Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas. | BMC cancer 20070101 |
| [Characteristics of polyamine biosynthesis regulation and tumor growth rate in hormone-dependant grafted breast tumors of mice and rats]. | Likars'ka sprava 20070101 |
| Eflornithine. | Indian journal of dermatology, venereology and leprology 20070101 |
| Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201 |
| Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. | PLoS clinical trials 20061201 |
| Polyamines, PI(4,5)P2, and actin polymerization. | Journal of cellular physiology 20061101 |
| Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. | Molecular cancer therapeutics 20061101 |
| Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20061001 |
| Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo. | Bulletin of the World Health Organization 20061001 |
| Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo. | Bulletin of the World Health Organization 20061001 |
| The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. | Biochemical pharmacology 20060928 |
| New dimensions in Hirsutism. | Lasers in medical science 20060901 |
| A Gambian infant with fever and an unexpected blood film. | PLoS medicine 20060901 |
| Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene. | Life sciences 20060822 |
| Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. | The Biochemical journal 20060801 |
| Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer. | The Journal of urology 20060801 |
| Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. | The Journal of biological chemistry 20060714 |
| Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and alpha-keto acid profiles or host defense capability. | Amino acids 20060701 |
| In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition. | International journal of cancer 20060601 |
| Treatment of hirsutism and acne in hyperandrogenism. | Best practice & research. Clinical endocrinology & metabolism 20060601 |
| Excess salt and pepper hair treated with a combination of laser hair removal and topical eflornithine HCl. | Journal of drugs in dermatology : JDD 20060601 |
| Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. | Bioorganic & medicinal chemistry letters 20060515 |
| Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. | International journal of cancer 20060501 |
| The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea. | Tropical medicine & international health : TM & IH 20060501 |
| The rise and fall of sleeping sickness. | Lancet (London, England) 20060429 |
| Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401 |
| Human African trypanosomiasis-neurological aspects. | Journal of neurology 20060401 |
| alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention. | International journal of dermatology 20060401 |
| Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture. | The Journal of parasitology 20060401 |
| Role of polyamines derived from arginine in differentiation and proliferation of human blood cells. | Biological & pharmaceutical bulletin 20060201 |
| Understanding the causes and management of hirsutism. | Nursing times 20060201 |
| Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines. | Journal of medicinal chemistry 20060112 |
| Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha. | Journal of cellular physiology 20060101 |
| Induction of apoptotic cell death by putrescine. | The international journal of biochemistry & cell biology 20060101 |
| Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. | Oncology 20060101 |
| STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. | The Biochemical journal 20051201 |
| Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells. | Cancer research 20051201 |
| Treatments for unwanted facial hair. | Skin therapy letter 20051201 |
| [Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life expectancy of animals with cancer]. | Likars'ka sprava 20051201 |
| Chemotherapy of trypanosomiases and leishmaniasis. | Trends in parasitology 20051101 |
| Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101 |
| African trypanosomiasis gambiense, Italy. | Emerging infectious diseases 20051101 |
| A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. | Annals of the New York Academy of Sciences 20051101 |
| [Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral ischemia reperfusion]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20051001 |
| Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells. | The Journal of biological chemistry 20050902 |
| Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia. | American journal of physiology. Gastrointestinal and liver physiology 20050901 |
| Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050901 |
| Karyometry in the early detection and chemoprevention of intraepithelial lesions. | European journal of cancer (Oxford, England : 1990) 20050901 |
| Suppression and regression of choroidal neovascularization by polyamine analogues. | Investigative ophthalmology & visual science 20050901 |
| Trypanosomiasis control, Democratic Republic of Congo, 1993-2003. | Emerging infectious diseases 20050901 |
| Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells. | Stem cells (Dayton, Ohio) 20050801 |
| Guidance for the management of hirsutism. | Current medical research and opinion 20050801 |
| Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity. | Apoptosis : an international journal on programmed cell death 20050801 |
| Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes. | Differentiation; research in biological diversity 20050701 |
| Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20050601 |
| Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001. | Emerging infectious diseases 20050601 |
| Polyamines protect against radiation-induced oxidative stress. | Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 20050601 |
| B23 is a downstream target of polyamine-modulated CK2. | Molecular and cellular biochemistry 20050601 |
| Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors. | World journal of gastroenterology 20050528 |
| Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons. | Journal of neurophysiology 20050501 |
| Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. | Journal of hypertension 20050501 |
| Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells. | Kidney international 20050501 |
| Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. | Cancer cell 20050501 |
| Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501 |
| Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity. | The Journal of biological chemistry 20050415 |
| Molecular mechanisms of polyamine analogs in cancer cells. | Anti-cancer drugs 20050301 |
| Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts. | Journal of periodontology 20050301 |
| Independent roles of eIF5A and polyamines in cell proliferation. | The Biochemical journal 20050201 |
| Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization. | Endocrinology 20050201 |
| Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? | Seminars in oncology 20050201 |
| Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis. | Cancer research 20050115 |
| Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050101 |
| New agents in intravesical chemotherapy of superficial bladder cancer. | Scandinavian journal of urology and nephrology 20050101 |
| Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells. | Clinical & experimental metastasis 20050101 |
| Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. | Breast cancer research : BCR 20050101 |
| Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. | Clinical & experimental metastasis 20050101 |
| [Key aspects of excessive hair in 2005]. | Annales de dermatologie et de venereologie 20050101 |
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| [Vaniqa in daily practice]. | Annales de dermatologie et de venereologie 20050101 |
| [Vaniqa and laser depilation in practice]. | Annales de dermatologie et de venereologie 20050101 |
| Polycystic ovary syndrome (PCOS) in the adolescent patient: recommendations for practice. | Pediatric nursing 20050101 |
| Lung distribution of the chemopreventive agent difluoromethylornithine (DFMO) following oral and inhalation delivery. | Experimental lung research 20041201 |
| The role of polyamines in human cancer: prospects for drug combination therapies. | Hawaii medical journal 20041201 |
| Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20041101 |
| Polyamines regulate eukaryotic initiation factor 4E-binding protein 1 gene transcription. | Biochemical and biophysical research communications 20041008 |
| Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors. | Carcinogenesis 20041001 |
| Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts. | Amino acids 20041001 |
| Polyamines and cancer: old molecules, new understanding. | Nature reviews. Cancer 20041001 |
| New drugs for neglected diseases: from pipeline to patients. | PLoS medicine 20041001 |
| Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells. | Experimental oncology 20040901 |
| Protective role of arginase in a mouse model of colitis. | Journal of immunology (Baltimore, Md. : 1950) 20040801 |
| Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells. | The international journal of biochemistry & cell biology 20040701 |
| A novel role for polyamines in adult neurogenesis in rodent brain. | The European journal of neuroscience 20040701 |
| Irreversible ototoxicity associated with difluoromethylornithine. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701 |
| Inhibitors of polyamine metabolism: review article. | Amino acids 20040701 |
| Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells. | The Journal of biological chemistry 20040625 |
| The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness. | European journal of clinical pharmacology 20040601 |
| Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies. | European journal of cancer (Oxford, England : 1990) 20040601 |
| Difluoromethylornithine-induced reversible hearing loss across a wide frequency range. | The Laryngoscope 20040601 |
| Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. | The Journal of biological chemistry 20040521 |
| Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia. | Chest 20040501 |
| [Clinical reasoning and decision making in practice. A depressive foreign woman with symptoms of malaise]. | Nederlands tijdschrift voor geneeskunde 20040417 |
| The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells. | Molecular carcinogenesis 20040401 |
| Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. | Cancer research 20040401 |
| Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. | The Journal of clinical investigation 20040315 |
| The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas. | American journal of obstetrics and gynecology 20040301 |
| Possible cases of sexual and congenital transmission of sleeping sickness. | Lancet (London, England) 20040117 |
| Review article: chemoprevention of colorectal cancer. | Alimentary pharmacology & therapeutics 20040101 |
| Retaking sleeping sickness control in Angola. | Tropical medicine & international health : TM & IH 20040101 |
| Developmental treatment with difluoromethylornithine has few effects on behavior or body weight in Sprague-Dawley rats. | Neurotoxicology and teratology 20040101 |
| Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. | Environmental and molecular mutagenesis 20040101 |
| Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells. | Clinical & experimental metastasis 20040101 |
| Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201 |
| Hexachlorobenzene-induced early changes in ornithine decarboxylase and protein tyrosine kinase activities, polyamines and c-Myc, c-Fos and c-Jun proto-oncogenes in rat liver. | Toxicological sciences : an official journal of the Society of Toxicology 20031201 |
| [Apoptotic induction of human lung carcinoma A549 cells by DFMO through Fas/FasL pathway]. | Ai zheng = Aizheng = Chinese journal of cancer 20031201 |
| A perspective of polyamine metabolism. | The Biochemical journal 20031115 |
| Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20031101 |
| Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells. | American journal of physiology. Gastrointestinal and liver physiology 20031101 |
| Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation. | Experimental cell research 20031101 |
| Alpha-difluoromethylornithine, ornithine decarboxylase inhibitor, antagonizes H2O2-induced cytotoxicity in HL-60 leukemia cells: regulation of iron-dependent lysosomal damage. | Cell biology and toxicology 20031101 |
| Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. | The Biochemical journal 20031015 |
| Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance. | European journal of pharmacology 20031008 |
| RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity. | American journal of physiology. Gastrointestinal and liver physiology 20031001 |
| Antimalarial effect of agmatine on Plasmodium berghei K173 strain. | Acta pharmacologica Sinica 20030901 |
| Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. | Brain research 20030815 |
| Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO. | Virus research 20030801 |
| The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes. | European journal of pharmacology 20030801 |
| Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. | Cancer research 20030715 |
| In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. | Cancer research 20030701 |
| Pseudofolliculitis barbae: review and update on new treatment modalities. | Military medicine 20030701 |
| Barrett's esophagus: chemoprevention. | Gastrointestinal endoscopy clinics of North America 20030701 |
| Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. | Cancer research 20030615 |
| Polyamines in cultured rabbit corneal cells. | Investigative ophthalmology & visual science 20030601 |
| Current chemotherapy of human African trypanosomiasis. | Parasitology research 20030601 |
| Eflornithine for the treatment of human African trypanosomiasis. | Parasitology research 20030601 |
| High-performance liquid chromatographic method for determination of 2-difluoromethyl-DL-ornithine in plasma and cerebrospinal fluid. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525 |
| Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity. | Oncogene 20030501 |
| The evaluation and management of hirsutism. | Obstetrics and gynecology 20030501 |
| Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. | Carcinogenesis 20030501 |
| The requirement for polyamines for intestinal epithelial cell migration is mediated through Rac1. | The Journal of biological chemistry 20030411 |
| Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells. | International journal of cancer 20030410 |
| Treatment perspectives for human African trypanosomiasis. | Fundamental & clinical pharmacology 20030401 |
| Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030301 |
| Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate. | Gut 20030201 |
| Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture. | Biochimica et biophysica acta 20030120 |
| Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line. | BMC cancer 20030101 |
| Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries. | Plant physiology 20030101 |
| Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates. | Journal of medical virology 20030101 |
| Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines. | Anticancer research 20030101 |
| Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. | Clinical & experimental metastasis 20030101 |
| [Eflornithine in the treatment of African trypanosomiasis]. | Medecine tropicale : revue du Corps de sante colonial 20030101 |
| [The return of sleeping sickness in an epidemic form: international action for drugs]. | Nederlands tijdschrift voor geneeskunde 20021228 |
| Polyamine metabolism as chemotherapeutic target in protozoan parasites. | Mini reviews in medicinal chemistry 20021201 |
| Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. | Carcinogenesis 20021201 |
| Removal of unwanted facial hair. | American family physician 20021115 |
| Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine. | Journal of medicinal chemistry 20021107 |
| A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021001 |
| Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion. | FEBS letters 20020911 |
| Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration. | American journal of physiology. Cell physiology 20020901 |
| Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. | Carcinogenesis 20020901 |
| Effect of polyamine depletion on cone photoreceptors of the developing rabbit retina. | Investigative ophthalmology & visual science 20020901 |
| Resurrecting the resurrection drug. | Nature medicine 20020901 |
| Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis. | Tropical medicine & international health : TM & IH 20020901 |
| Polyamine-mediated post-transcriptional regulation of COX-2. | Biochimie 20020801 |
| [Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020801 |
| Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity. | Brain research 20020705 |
| Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205. | Molecular endocrinology (Baltimore, Md.) 20020701 |
| RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion. | Gastroenterology 20020701 |
| Treatment of human African trypanosomiasis--present situation and needs for research and development. | The Lancet. Infectious diseases 20020701 |
| Polyamine uptake is necessary for a normal biochemical maturation of astrocytes in culture. | Neuroreport 20020612 |
| Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c. | American journal of physiology. Cell physiology 20020601 |
| Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica. | Journal of experimental botany 20020601 |
| Are polyamines involved in olfaction? An EAG and biochemical study in Periplaneta americana antennae. | Chemical senses 20020601 |
| Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. | Oncogene 20020516 |
| Effects of difluoromethylornithine on growth inhibition and apoptosis in human cervical epithelial and cancerous cell lines. | Gynecologic oncology 20020501 |
| Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020501 |
| [Hypertrichosis and hirsutism]. | Therapeutische Umschau. Revue therapeutique 20020501 |
| The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum. | Biochemical and biophysical research communications 20020426 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats. | Neuroscience letters 20020419 |
| Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding. | American journal of physiology. Cell physiology 20020401 |
| Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats. | Experimental biology and medicine (Maywood, N.J.) 20020401 |
| Polyamine-dependent migration of retinal pigment epithelial cells. | Investigative ophthalmology & visual science 20020401 |
| Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells. | Chinese medical journal 20020401 |
| Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines. | Clinical science (London, England : 1979) 20020301 |
| Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice. | Cancer research 20020301 |
| Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat. | Life sciences 20020208 |
| Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition. | Biochimica et biophysica acta 20020130 |
| [Chemoprevention of colorectal cancer]. | Presse medicale (Paris, France : 1983) 20020126 |
| Activities of arginase I and II are limiting for endothelial cell proliferation. | American journal of physiology. Regulatory, integrative and comparative physiology 20020101 |
| African trypanosomiasis in travelers returning to the United Kingdom. | Emerging infectious diseases 20020101 |
| Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020101 |
| Chemoprevention of colorectal cancer. | The American journal of gastroenterology 20020101 |
| Chemotherapy of human African trypanosomiasis. | Current pharmaceutical design 20020101 |
| The ornithine decarboxylase inhibitor, difluoromethylornithine, inhibits casein kinase II activity, c-Myc expression and normal human keratinocyte proliferation. | Archives of dermatological research 20020101 |
| Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells. | Neoplasia (New York, N.Y.) 20020101 |
| Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. | Clinical & experimental metastasis 20020101 |
| Winterbottom's sign and hypertrophic cardiomyopathy. | Scandinavian journal of infectious diseases 20020101 |
| Causes and management of hypertrichosis. | American journal of clinical dermatology 20020101 |
| Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats. | Tumori 20020101 |
| Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells. | The Journal of biological chemistry 20011207 |
| Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. | Journal of immunology (Baltimore, Md. : 1950) 20011201 |
| Eflornithine. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011201 |
| Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse. | Annals of the New York Academy of Sciences 20011201 |
| Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. | Annals of the New York Academy of Sciences 20011201 |
| The future of colon cancer prevention. | Annals of the New York Academy of Sciences 20011201 |
| The effect of polyamine biosynthesis inhibition on growth and differentiation of the phytopathogenic fungus Sclerotinia sclerotiorum. | Antonie van Leeuwenhoek 20011201 |
| No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting. | Behavioural brain research 20011129 |
| Spermidine is essential for normal proliferation of trypanosomatid protozoa. | FEBS letters 20011123 |
| The eflornithine story. | Journal of the American Academy of Dermatology 20011101 |
| Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype. | Cancer research 20011101 |
| Availability and affordability of treatment for Human African Trypanosomiasis. | Tropical medicine & international health : TM & IH 20011101 |
| Cell culture analysis of the regulatory frameshift event required for the expression of mammalian antizymes. | Genes to cells : devoted to molecular & cellular mechanisms 20011101 |
| [Current treatment of hypertrichosis]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20011101 |
| The effect of DFMO induced uptake of [3H] putrescine on human glioma cells. | Journal of neuro-oncology 20011101 |
| Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors. | Journal of medicinal chemistry 20011025 |
| 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. | Cancer research 20011015 |
| Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. | American journal of physiology. Cell physiology 20010901 |
| Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair. | Journal of clinical pharmacology 20010901 |
| Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer. | Cellular and molecular biology (Noisy-le-Grand, France) 20010901 |
| Pneumocystis carinii pneumonia in pregnancy. | Chest 20010801 |
| Measurement of chemopreventive efficacy in skin biopsies. | Analytical and quantitative cytology and histology 20010801 |
| [Effect of inhibition of polyamine biosynthesis on the growth and telomerase activity of human laryngeal carcinoma cells Hep-2]. | Zhonghua er bi yan hou ke za zhi 20010801 |
| Polyamines regulate gap junction communication in connexin 43-expressing cells. | The Biochemical journal 20010715 |
| Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms. | American journal of physiology. Gastrointestinal and liver physiology 20010701 |
| Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model. | Tree physiology 20010701 |
| Thank God for rich women with mustaches. | Medicine and health, Rhode Island 20010701 |
| Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture. | Breast cancer research and treatment 20010701 |
| A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia. | Archives of internal medicine 20010625 |
| Increases in ornithine decarboxylase activity in the positive inotropism induced by androgens in isolated left atrium of the rat. | European journal of pharmacology 20010622 |
| A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line. | Biochemical pharmacology 20010601 |
| Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010601 |
| NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20010501 |
| Transporters in African trypanosomes: role in drug action and resistance. | International journal for parasitology 20010501 |
| Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501 |
| Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions. | Archives of otolaryngology--head & neck surgery 20010501 |
| Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda. | Tropical medicine & international health : TM & IH 20010501 |
| Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO). | The Laryngoscope 20010501 |
| Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi. | Biochemical and biophysical research communications 20010420 |
| Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration. | American journal of physiology. Cell physiology 20010401 |
| Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells. | The Biochemical journal 20010401 |
| Prostate cancer prevention strategies using antiproliferative or differentiating agents. | Urology 20010401 |
| Vaniqa--eflornithine 13.9% cream. | Skin therapy letter 20010401 |
| Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity. | Journal of neuroscience research 20010301 |
| Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301 |
| Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity. | Cellular and molecular biology (Noisy-le-Grand, France) 20010301 |
| Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta. | European journal of pharmacology 20010209 |
| Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes. | Cardiovascular research 20010201 |
| [Eflornithine for hair removal. Topical application for hirsutism]. | Medizinische Monatsschrift fur Pharmazeuten 20010201 |
| p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine. | Biochemical and biophysical research communications 20010126 |
| Hypertrophy and hyperfunction of the diabetic kidney. | The Journal of clinical investigation 20010115 |
| Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. | The Journal of clinical investigation 20010115 |
| Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. | The Journal of biological chemistry 20010112 |
| Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. | Journal of the National Cancer Institute 20010103 |
| Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. | Journal of the National Cancer Institute 20010103 |
| Uptake and mode of action of drugs used against sleeping sickness. | Biochemical pharmacology 20010101 |
| Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice. | Carcinogenesis 20010101 |
| Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme. | International journal of radiation oncology, biology, physics 20010101 |
| Development of difluoromethyl-ornithine and Bowman-Birk inhibitor as chemopreventive agents by assessment of relevant biomarker modulation: some lessons learned. | IARC scientific publications 20010101 |
| Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa), a novel treatment for excessive facial hair. | Current medical research and opinion 20010101 |
| Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. | Anticancer research 20010101 |
| Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi. | The Journal of eukaryotic microbiology 20010101 |
| Induction of gastric ornithine decarboxylase in early weaning rats. | Digestion 20010101 |
| Hirsutism: diagnosis and management. | The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101 |
| Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor. | In vivo (Athens, Greece) 20010101 |
| Topical eflornithine. | American journal of clinical dermatology 20010101 |
| Characterization of spermine uptake by Ehrlich tumour cells in culture. | Amino acids 20010101 |
| Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice. | Experimental lung research 20001201 |
| Attenuation of isoproterenol-mediated myocardial injury in rat by an inhibitor of polyamine synthesis. | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20000101 |
| Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart. | Life sciences 19990101 |
| Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells. | Biochemical pharmacology 19980415 |
| Rapid induction of apoptosis by deregulated uptake of polyamine analogues. | The Biochemical journal 19971115 |
| Inhibition by 1alpha,25-dihydroxyvitamin D3 of activin A-induced differentiation of murine erythroleukemic F5-5 cells. | Archives of biochemistry and biophysics 19970715 |
| Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney. | Biochimica et biophysica acta 19970527 |
| Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine. | Antimicrobial agents and chemotherapy 19960401 |
| Effect of diethyldithiocarbamate on Cryptosporidium parvum infection in immunosuppressed rats. | The Journal of parasitology 19960201 |
| In vitro model to assess effect of antimicrobial agents on Encephalitozoon cuniculi. | Antimicrobial agents and chemotherapy 19941001 |
| Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model. | The Journal of infectious diseases 19930301 |
| Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | Antimicrobial agents and chemotherapy 19920901 |
| Anti-cryptosporidial drug activity screened with an immunosuppressed rat model. | The Journal of protozoology 19910101 |
| Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine. | Mycopathologia 19901001 |
| Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia. | Antimicrobial agents and chemotherapy 19900901 |
| American Society for Biochemistry and Molecular Biology, the American Association of Immunologists, joint meeting. New Orleans, Louisiana, June 4-7, 1990. Abstracts 1-3659, TU1-TU35, indexes. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19900426 |
| Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia. | Antimicrobial agents and chemotherapy 19880801 |
| Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. | Antimicrobial agents and chemotherapy 19880601 |
| Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness. | Lancet (London, England) 19871219 |
| Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine. | Journal of neuroscience research 19850101 |
| Factors which may be significant regarding regulation of the clofibrate-dependent induction of hepatic peroxisomal beta-oxidation and hepatomegaly. | Biochemical pharmacology 19840401 |
| Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19840201 |
| Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. | Journal of molecular and cellular cardiology 19820801 |