Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis.

Carcinogenesis 20120901

Exposure to secondhand smoke outside of a bar and a restaurant and tobacco exposure biomarkers in nonsmokers.

Environmental health perspectives 20120701

In vivo and in vitro metabolism of tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by the freshwater planarian, Dugesia japonica.

Chemosphere 20120601

Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120501

Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokers.

Chemical research in toxicology 20120416

Development of a method for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine of nonsmokers and smokers using liquid chromatography/tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20120407

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

The Journal of pharmacology and experimental therapeutics 20120401

Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

International journal of cancer 20120315

Environmental tobacco smoke and children's health.

Korean journal of pediatrics 20120201

European birth cohorts for environmental health research.

Environmental health perspectives 20120101

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke.

The Science of the total environment 20120101

Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.

Journal of biomedicine & biotechnology 20120101

Reduced exercise tolerance and pulmonary capillary recruitment with remote secondhand smoke exposure.

PloS one 20120101

Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure.

Regulatory toxicology and pharmacology : RTP 20111201

A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette.

Regulatory toxicology and pharmacology : RTP 20111201

Nicotine, carbon monoxide, and carcinogen exposure after a single use of a water pipe.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20111101

Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers.

Cancer research 20111101

Prevention of mouse lung tumors by combinations of chemopreventive agents using concurrent and sequential administration.

Anticancer research 20111001

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement.

PLoS medicine 20111001

Metabolic study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in vitro in human bronchial epithelial cells using chiral capillary electrophoresis.

Journal of chromatography. A 20110916

Mainstream smoke of the waterpipe: does this environmental matrix reveal as significant source of toxic compounds?

Toxicology letters 20110910

Racial differences in the relationship between number of cigarettes smoked and nicotine and carcinogen exposure.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110901

Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers.

Carcinogenesis 20110901

The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110901

The use of a novel tobacco-substitute sheet and smoke dilution to reduce toxicant yields in cigarette smoke.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

Relationship between biomarkers of cigarette smoke exposure and biomarkers of inflammation, oxidative stress, and platelet activation in adult cigarette smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110801

Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.

Chemical research in toxicology 20110620

Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110601

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

Toxicology and applied pharmacology 20110601

Effect of maternal tobacco smoking or exposure to second-hand smoke on the levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine of mother and the first urine of newborn.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601

Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines.

Tobacco control 20110501

Low ratio of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol-glucuronides (NNAL-Gluc)/free NNAL increases urothelial carcinoma risk.

The Science of the total environment 20110401

Environmental tobacco smoke exposure among casino dealers.

Journal of occupational and environmental medicine 20110401

Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110301

Is 24h nicotine equivalents a surrogate for smoke exposure based on its relationship with other biomarkers of exposure?

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110301

Comparison of urine cotinine and the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and their ratio to discriminate active from passive smoking.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110301

Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110201

Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.

Pharmacogenetics and genomics 20110201

Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110201

Microfluidic direct injection method for analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) using molecularly imprinted polymers coupled on-line with LC-MS/MS.

Journal of pharmaceutical and biomedical analysis 20110125

A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine.

Rapid communications in mass spectrometry : RCM 20110115

Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.

Critical care medicine 20110101

Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101

Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.

International journal of environmental research and public health 20110101

Paternal smoking and risk of childhood acute lymphoblastic leukemia: systematic review and meta-analysis.

Journal of oncology 20110101

The scientific foundation for tobacco harm reduction, 2006-2011.

Harm reduction journal 20110101

Urinary biomarkers for secondhand smoke.

Journal of clinical laboratory analysis 20110101

Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 20110101

Design and study protocol of the maternal smoking cessation during pregnancy study, (M-SCOPE).

BMC public health 20110101

Urine menthol as a biomarker of mentholated cigarette smoking.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101201

Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in passive compared with active smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101101

Urine concentrations of a tobacco-specific nitrosamine carcinogen in the U.S. population from secondhand smoke exposure.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101101

On-line concentration and determination of tobacco-specific N-nitrosamines by cation-selective exhaustive injection-sweeping-micellar electrokinetic chromatography.

Talanta 20101015

Chinese 'low-tar' cigarettes do not deliver lower levels of nicotine and carcinogens.

Tobacco control 20101001

Stability of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine samples stored at various temperatures.

Journal of analytical toxicology 20100901

Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20100601

Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100601

Formation and distribution of NNK metabolites in an isolated perfused rat lung.

Drug metabolism and disposition: the biological fate of chemicals 20100501

Tobacco smoke exposure in nonsmoking hospitality workers before and after a state smoking ban.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100401

UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility.

Drug metabolism and disposition: the biological fate of chemicals 20100301

Adaptive regression modeling of biomarkers of potential harm in a population of U.S. adult cigarette smokers and nonsmokers.

BMC medical research methodology 20100101

Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

PloS one 20100101

Role of glutathione in the regulation of Cisplatin resistance in cancer chemotherapy.

Metal-based drugs 20100101

Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20091201

Elimination kinetics of the tobacco-specific biomarker and lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20091201

Chinese 'herbal' cigarettes are as carcinogenic and addictive as regular cigarettes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20091201

Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.

International journal of cancer 20091115

Population estimates for biomarkers of exposure to cigarette smoke in adult U.S. cigarette smokers.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20091001

Longer term exposure to secondhand smoke and health outcomes in COPD: impact of urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20090801

A comparison of exposure to carcinogens among roll-your-own and factory-made cigarette smokers.

Addiction biology 20090701

Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.

Chemical research in toxicology 20090601

A modified method for the determination of tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine by solid phase extraction using a molecularly imprinted polymer and liquid chromatography tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515

Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Chemical research in toxicology 20090501

Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers.

Chemical research in toxicology 20090401

Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.

Cancer research 20090401

Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Chemical research in toxicology 20090201

A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090101

Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20090101

Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers.

Clinical chemistry and laboratory medicine 20090101

Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201

Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201

Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.

Cancer research 20081115

Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry.

Analytical chemistry 20081101

Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20081101

[Study advances on carcinogens and their metabolites in urine of smokers].

Wei sheng yan jiu = Journal of hygiene research 20081101

Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells.

International journal of chronic obstructive pulmonary disease 20080901

Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Chemical research in toxicology 20080701

Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080701

A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system.

Journal of clinical pharmacology 20080501

Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco.

Tobacco control 20080401

Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080401

Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).

Chemical research in toxicology 20080301

Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20080301

Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080301

Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats.

Carcinogenesis 20071201

Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20071101

Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20071101

The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070901

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

Cancer research 20070815

Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070801

Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070701

Urinary biomarkers to assess exposure of cats to environmental tobacco smoke.

American journal of veterinary research 20070401

The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401

An association of CYP2A6 genotype and smoking topography.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20070401

Smokeless tobacco brand switching: a means to reduce toxicant exposure?

Drug and alcohol dependence 20070316

Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany.

Regulatory toxicology and pharmacology : RTP 20070301

Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Chemical research in toxicology 20070201

Effects of high dose transdermal nicotine replacement in cigarette smokers.

Pharmacology, biochemistry, and behavior 20070101

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.

Respiratory research 20070101

Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas.

BMC cancer 20070101

Determination of tobacco specific hemoglobin adducts in smoking mothers and new born babies by mass spectrometry.

Biomarker insights 20070101

A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites.

Psychopharmacology 20061201

Study of the metabolism on tobacco-specific N-nitrosamines in the rabbit by solid-phase extraction and liquid chromatography-tandem mass spectrometry.

Analytical and bioanalytical chemistry 20061201

Toxicant exposure in cigarette reducers versus light smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201

Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201

A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer.

Preventive medicine 20061001

Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060801

[Detection of metabolites of tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung cancer smokers' urine].

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20060620

Determination of tobacco-specific N-nitrosamines in rabbit serum by capillary zone electrophoresis and capillary electrophoresis-electrospray ionization-mass spectrometry with solid-phase extraction.

Electrophoresis 20060601

Prevention of mouse lung tumors by targretin.

International journal of cancer 20060501

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060501

Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060101

Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants.

Breast cancer research : BCR 20060101

Analysis of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine by extraction on a molecularly imprinted polymer column and liquid chromatography/atmospheric pressure ionization tandem mass spectrometry.

Analytical chemistry 20051201

Relationships between cigarette consumption and biomarkers of tobacco toxin exposure.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051201

Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes.

Pharmacogenetics and genomics 20051101

Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' blood.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101

Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20051001

Carcinogen exposure during short-term switching from regular to 'light' cigarettes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050601

Smokeless tobacco topography and toxin exposure.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20050601

Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050501

Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Cancer 20050401

Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050301

Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

Chemical research in toxicology 20050201

ATP-binding cassette (ABC) transporters in normal and pathological lung.

Respiratory research 20050101

A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20041001

Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.

Drug metabolism and disposition: the biological fate of chemicals 20040901

Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Carcinogenesis 20040701

Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601

Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.

Chemical research in toxicology 20040501

Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke.

Tobacco control 20040301

Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences.

Environmental health perspectives 20040301

Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes.

Cancer research 20040201

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.

Journal of the National Cancer Institute 20040121

Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4.

Drug metabolism and disposition: the biological fate of chemicals 20040101

Development, validation and transfer of a hydrophilic interaction liquid chromatography/tandem mass spectrometric method for the analysis of the tobacco-specific nitrosamine metabolite NNAL in human plasma at low picogram per milliliter concentrations.

Rapid communications in mass spectrometry : RCM 20040101

Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20031101

Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.

Drug metabolism and disposition: the biological fate of chemicals 20031001

Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20030901

Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.

Chemical research in toxicology 20030601

Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages.

Clinical and experimental immunology 20030501

Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.

Carcinogenesis 20030301

The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.

Chemical research in toxicology 20030101

Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster.

Toxicology 20020930

Identification of tobacco-derived compounds in human pancreatic juice.

Chemical research in toxicology 20020501

Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.

Chemical research in toxicology 20020401

Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution.

Carcinogenesis 20020101

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.

Cancer research 20020101

The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.

Chemico-biological interactions 20011128

Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20011101

Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog.

The Journal of biological chemistry 20010727

The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

Mutation research 20010725

Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines.

Chemical research in toxicology 20010501

Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes.

Archives of physiology and biochemistry 20010401

Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke.

Journal of the National Cancer Institute 20010307

Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta.

Chemico-biological interactions 20010130

Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung.

Chemico-biological interactions 20010130

Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, via alpha-hydroxylation and carbonyl reduction pathways.

Carcinogenesis 20010101

Carcinogen biomarkers for lung or oral cancer chemoprevention trials.

IARC scientific publications 20010101

O-Glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanol (NNAL) by human UDP-glucuronosyltransferases 2B7 and 1A9.

Drug metabolism and disposition: the biological fate of chemicals 20001101

Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.

Drug metabolism and disposition: the biological fate of chemicals 19970201