Oxiranecarboxylic acid, 2-(6-(4-chlorophenoxy)hexyl)-, ethyl ester
| Title | Journal |
|---|---|
| The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism. | Molecular endocrinology (Baltimore, Md.) 20120701 |
| Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. | Gastroenterology 20120401 |
| Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation. | Journal of vascular research 20120401 |
| Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. | PloS one 20120101 |
| Metabolic modulation: a new therapeutic target in treatment of heart failure. | American journal of therapeutics 20111101 |
| Altered HepG2 cell models using etomoxir versus tert-butylhydroperoxide. | Cell biology and toxicology 20111001 |
| Uterine contractility is strongly influenced by steroids and glucose metabolism: an in vitro study on bovine myometrium. | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110901 |
| Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. | Biochimica et biophysica acta 20110601 |
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. | Journal of medicinal chemistry 20110512 |
| Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. | The Biochemical journal 20110501 |
| Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death. | Endocrinology 20110301 |
| Fatty acid (FFA) transport in cardiomyocytes revealed by imaging unbound FFA is mediated by an FFA pump modulated by the CD36 protein. | The Journal of biological chemistry 20110211 |
| Radiochemical synthesis of etomoxir. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20110201 |
| Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells. | Lipids in health and disease 20110101 |
| Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. | Scientific reports 20110101 |
| Endocrine control of oleic acid and glucose metabolism in rainbow trout (Oncorhynchus mykiss) muscle cells in culture. | American journal of physiology. Regulatory, integrative and comparative physiology 20100801 |
| Synthesis and preliminary evaluation of 18-(18)F-fluoro-4-thia-oleate as a PET probe of fatty acid oxidation. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100801 |
| Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. | Diabetes 20100401 |
| Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. | Endocrinology 20100401 |
| Validation of (99m)Tc-labeled '4+1' fatty acids for myocardial metabolism and flow imaging: Part 2. Subcellular distribution. | Nuclear medicine and biology 20091001 |
| The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo. | Basic research in cardiology 20090901 |
| Fatty acid oxidation and meiotic resumption in mouse oocytes. | Molecular reproduction and development 20090901 |
| Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha. | Journal of molecular endocrinology 20090701 |
| Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. | The British journal of nutrition 20090601 |
| Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. | The Biochemical journal 20090415 |
| Influence of mitochondrial β-oxidation on early pea seedling development. | The New phytologist 20090301 |
| Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors. | Toxicologic pathology 20090101 |
| The metabolic treatment of coronary artery disease and heart failure. | Current pharmaceutical design 20090101 |
| Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species. | Acta biochimica Polonica 20090101 |
| AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. | The Journal of physiology 20081201 |
| Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. | Journal of biochemistry 20081101 |
| Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. | Journal of cellular physiology 20080801 |
| AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. | Bone 20080801 |
| Antiarrhythmic and arrhythmogenic effects of L-carnitine in ischemia and reperfusion. | Bulletin of experimental biology and medicine 20080801 |
| Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. | International journal of cancer 20080715 |
| Metabolic agents in the management of diabetic coronary patients: a new era. | International journal of cardiology 20080623 |
| Metabolic agents in the management of diabetic coronary patients: a new era. | International journal of cardiology 20080623 |
| Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. | Experimental cell research 20080610 |
| Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. | American journal of physiology. Regulatory, integrative and comparative physiology 20080201 |
| Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. | The FEBS journal 20071201 |
| Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. | The Journal of biological chemistry 20071130 |
| Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance. | American journal of physiology. Endocrinology and metabolism 20071001 |
| A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study. | Clinical science (London, England : 1979) 20070801 |
| Suppression of virus replication via down-modulation of mitochondrial short chain enoyl-CoA hydratase in human glioblastoma cells. | Antiviral research 20070801 |
| Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation. | Diabetes/metabolism research and reviews 20070301 |
| Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. | Toxicology in vitro : an international journal published in association with BIBRA 20061001 |
| 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. | The Journal of biological chemistry 20060908 |
| Modification of myocardial substrate use as a therapy for heart failure. | Nature clinical practice. Cardiovascular medicine 20060901 |
| Metabolic therapeutics in angina pectoris: history revisited with perhexiline. | European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601 |
| Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation. | Biochemistry 20060411 |
| Temperature dependence of O2 consumption; opposite effects of leptin and etomoxir on respiratory quotient in mice. | Obesity (Silver Spring, Md.) 20060401 |
| Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. | Diabetes 20051201 |
| A new therapeutic approach to treat psoriasis by inhibition of fatty acid oxidation by Etomoxir. | The British journal of dermatology 20051101 |
| Myocardial protection from ischemic preconditioning is not blocked by sub-chronic inhibition of carnitine palmitoyltransferase I. | Life sciences 20050902 |
| A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. | The Biochemical journal 20050715 |
| Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure? | Cardiovascular research 20050601 |
| [Metabolism and the hypertrophied heart of the elderly]. | Deutsche medizinische Wochenschrift (1946) 20050324 |
| Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G. | Cardiovascular diabetology 20050101 |
| Cardiac metabolism as a target for the treatment of heart failure. | Circulation 20040824 |
| Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. | European heart journal 20040401 |
| Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats. | Physiology & behavior 20040301 |
| Drug development based on functional genomics of overloaded cardiomyocytes: a novel approach for preventing progression of heart failure. | Journal of muscle research and cell motility 20040101 |
| Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201 |
| Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. | Cancer research 20031101 |
| Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2. | American journal of physiology. Endocrinology and metabolism 20030801 |
| Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph. | Journal of lipid research 20030701 |
| Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. | Journal of lipid research 20030201 |
| Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. | Journal of lipid research 20030201 |
| Impact of mitochondrial beta-oxidation in fatty acid-mediated inhibition of glioma cell proliferation. | Journal of lipid research 20030101 |
| The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. | Herz 20021101 |
| Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001 |
| Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically. | Toxicological sciences : an official journal of the Society of Toxicology 20020701 |
| Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta. | American journal of physiology. Endocrinology and metabolism 20020601 |
| PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. | Journal of lipid research 20020601 |
| Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. | The Biochemical journal 20020515 |
| Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. | Endocrinology 20020401 |
| Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. | The Journal of biological chemistry 20020322 |
| Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target. | Expert opinion on investigational drugs 20020301 |
| [Functional genomics of pressure-loaded cardiomyocytes: etomoxir in heart failure?]. | Herz 20020301 |
| Differential effects of etomoxir treatment on cardiac Na+-K+ ATPase subunits in diabetic rats. | Molecular and cellular biochemistry 20020301 |
| Co-administration of etomoxir and RU-486 mitigates insulin resistance in hepatic and muscular tissues of STZ-induced diabetic rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20011001 |
| Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. | Diabetes 20010801 |
| Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. | Biochemical and biophysical research communications 20010713 |
| Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. | Biochimica et biophysica acta 20010629 |
| Post-transcriptional regulation of rat carnitine octanoyltransferase. | Biochemical Society transactions 20010501 |
| Involvement of 1,2-diacylglycerol in improvement of heart function by etomoxir in diabetic rats. | Life sciences 20010216 |
| Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. | Diabetes 20010101 |
| Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. | Biochemical pharmacology 19911009 |
| Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes. | The Biochemical journal 19880701 |