1-Oleoyl-2-acetyl-sn-glycerol (OAG)
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Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder. | Brain research 20130623 |
Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes. | Neurotoxicology 20130101 |
Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. | American journal of physiology. Renal physiology 20120201 |
Duodenal mucosal protein kinase C-δ regulates glucose production in rats. | Gastroenterology 20111101 |
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. | The Journal of biological chemistry 20100625 |
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes. | The Journal of physiology 20100501 |
Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. | The Journal of biological chemistry 20100423 |
Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. | Cellular signalling 20090901 |
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. | Cellular and molecular life sciences : CMLS 20090801 |
Knockdown of TRPC3 with siRNA coupled to carbon nanotubes results in decreased insulin-mediated glucose uptake in adult skeletal muscle cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601 |
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2+ entry. | Journal of leukocyte biology 20090401 |
Activation of neurokinin 3 receptor increases Na(v)1.9 current in enteric neurons. | The Journal of physiology 20090401 |
Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells. | Cell calcium 20090401 |
Modulation of transient and persistent inward currents by activation of protein kinase C in spinal ventral neurons of the neonatal rat. | Journal of neurophysiology 20090101 |
A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes. | European journal of pharmacology 20081203 |
Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells. | Investigative ophthalmology & visual science 20080701 |
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes. | The Journal of physiology 20080701 |
Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. | Cell calcium 20080501 |
High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway. | Arteriosclerosis, thrombosis, and vascular biology 20080401 |
Synergistic actions of diacylglycerol and inositol 1,4,5 trisphosphate for Ca2+-dependent inactivation of TRPC7 channel. | Acta pharmacologica Sinica 20080101 |
Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). | Molecular pain 20080101 |
Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels. | American journal of hypertension 20071001 |
The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. | Biochemical and biophysical research communications 20070914 |
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma. | Life sciences 20070726 |
Aquaporin-1 channel function is positively regulated by protein kinase C. | The Journal of biological chemistry 20070720 |
Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells. | The Biochemical journal 20070715 |
Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes. | The Journal of physiology 20070501 |
Characteristics of the ATP-induced Ca2+-entry pathway in the t-BBEC 117 cell line derived from bovine brain endothelial cells. | Journal of pharmacological sciences 20070501 |
C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. | The Journal of physiology 20070401 |
Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. | Journal of hypertension 20070401 |
Protein kinase signalling requirements for metabotropic action of kainate receptors in rat CA1 pyramidal neurones. | The Journal of physiology 20070301 |
Phosphorylation of sodium channels mediated by protein kinase-C modulates inhibition by topiramate of tetrodotoxin-sensitive transient sodium current. | British journal of pharmacology 20070301 |
Insulin potentiates TRPC3-mediated cation currents in normal but not in insulin-resistant mouse cardiomyocytes. | Cardiovascular research 20070115 |
Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells. | Pflugers Archiv : European journal of physiology 20070101 |
Characterization of the transient receptor potential channels mediating lysophosphatidic acid-stimulated calcium mobilization in B lymphoblasts. | Life sciences 20061214 |
Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes. | The Journal of physiology 20061201 |
Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. | The Journal of biological chemistry 20060901 |
Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8. | Molecular pharmacology 20060801 |
VEGF activates receptor-operated cation channels in human microvascular endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20060801 |
Roles of Ca2+ and protein kinase C in the excitatory response to serotonin in embryonic molluscan ciliary cells. | Canadian journal of physiology and pharmacology 20060601 |
Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G. | Journal of cellular physiology 20060501 |
Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C. | The Journal of biological chemistry 20060428 |
Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. | The Journal of physiology 20060415 |
Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301 |
Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. | Neuron 20060202 |
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression. | Pigment cell research 20060201 |
Association between myristoylated alanin-rich C kinase substrate (MARCKS) translocation and cortical granule exocytosis in rat eggs. | Reproduction (Cambridge, England) 20060201 |
Mechanism of non-capacitative Ca2+ influx in response to bradykinin in vascular endothelial cells. | Journal of vascular research 20060101 |
Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. | The Journal of biological chemistry 20051202 |
Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. | The Journal of biological chemistry 20051028 |
Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. | The Journal of biological chemistry 20050819 |
Diacylglycerols activate mitochondrial cationic channel(s) and release sequestered Ca(2+). | Journal of bioenergetics and biomembranes 20050801 |
1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain. | The Journal of biological chemistry 20050722 |
Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. | Journal of cellular physiology 20050701 |
Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3. | The Journal of biological chemistry 20050603 |
L-type calcium channel gating is modulated by bradykinin with a PKC-dependent mechanism in NG108-15 cells. | European biophysics journal : EBJ 20050501 |
Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112 |
Variants of TRP ion channel mRNA present in horseshoe crab ventral eye and brain. | Journal of neurochemistry 20041101 |
Inhibitory regulation of constitutive transient receptor potential-like cation channels in rabbit ear artery myocytes. | The Journal of physiology 20041001 |
Modulation by sphingosine of phosphorylation of substrate proteins by protein kinase C in nuclei from cow mammary gland. | The Journal of veterinary medical science 20041001 |
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. | Circulation research 20040903 |
Stimulation of intracellular Ca2+ oscillations by diacylglycerol in human myometrial cells. | Cell calcium 20040801 |
Inhibition by sulfatide of 21-kDa protein phosphorylation by protein kinase C in cow mammary gland and its reversal by phosphatidylserine. | The Journal of veterinary medical science 20040701 |
Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in Guinea pig ileal smooth muscle cells. | Journal of pharmacological sciences 20040601 |
Roles of curvature and hydrophobic interstice energy in fusion: studies of lipid perturbant effects. | Biochemistry 20040330 |
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. | Neuron 20040325 |
Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. | American journal of physiology. Heart and circulatory physiology 20040301 |
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. | Experimental cell research 20040115 |
Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. | British journal of pharmacology 20040101 |
Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents. | Neuroscience 20040101 |
Effects of protein kinase C on M-phase promoting factor in early development of fertilized mouse eggs. | Cell biochemistry and function 20040101 |
Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi. | The Biochemical journal 20031101 |
Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes. | The Journal of physiology 20031101 |
20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20030901 |
Capacitative cation entry in human myometrial cells and augmentation by hTrpC3 overexpression. | Biology of reproduction 20030801 |
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. | The Journal of biological chemistry 20030801 |
Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein. | Naunyn-Schmiedeberg's archives of pharmacology 20030801 |
Store-operated Ca2+ entry in first trimester and term human placenta. | The Journal of physiology 20030715 |
Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels. | Circulation 20030701 |
Transient receptor potential channel activation causes a novel form of [Ca 2+]I oscillations and is not involved in capacitative Ca 2+ entry in glial cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030601 |
Properties of a constitutively active Ca2+-permeable non-selective cation channel in rabbit ear artery myocytes. | The Journal of physiology 20030515 |
Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. | The Journal of biological chemistry 20030502 |
A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes. | Circulation research 20030418 |
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. | American journal of physiology. Gastrointestinal and liver physiology 20030401 |
Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels. | The Journal of biological chemistry 20030321 |
Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol. | Biochimica et biophysica acta 20030220 |
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115 |
Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn. | Neuroscience 20030101 |
Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. | The Journal of biological chemistry 20021227 |
Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells. | Toxicology letters 20020905 |
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. | The Biochemical journal 20020515 |
Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin. | Archives of insect biochemistry and physiology 20020501 |
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. | The Journal of biological chemistry 20020419 |
Mechanisms of modulation of neuronal nicotinic receptors by substance P and OAG. | American journal of physiology. Cell physiology 20011201 |
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages. | The Journal of parasitology 20011001 |
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein. | The Biochemical journal 20010915 |
Neurotrophin secretion from cultured microglia. | Journal of neuroscience research 20010815 |
Stimulation of C32 and G361 melanoma cells using oleoyl acetyl glycerol and its effect on sulphur mustard cytotoxicity. | Human & experimental toxicology 20010801 |
ANG II-mediated inhibition of neuronal delayed rectifier K+ current: role of protein kinase C-alpha. | American journal of physiology. Cell physiology 20010701 |
Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions. | American journal of physiology. Cell physiology 20010601 |
Phosphatidylcholine-specific phospholipase C regulates activation of RAW264.7 macrophage-like cells by lipopeptide JBT3002. | Journal of leukocyte biology 20010601 |
Low- and high-affinity phorbol ester and diglyceride interactions with protein kinase C: 1-O-alkyl-2-acyl-sn-glycerol enhances phorbol ester- and diacylglycerol-induced activity but alone does not induce activity. | Biochemistry 20010522 |
A store-operated nonselective cation channel in lymphocytes is activated directly by Ca(2+) influx factor and diacylglycerol. | American journal of physiology. Cell physiology 20010501 |
Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization. | The Journal of biological chemistry 20010420 |
Interaction between beta-adrenergic signaling and protein kinase C increases cytoplasmic Ca2+ in alveolar type II cells. | Life sciences 20010413 |
Kinetics of activation of a PKC-regulated epithelial calcium channel. | Cell calcium 20010401 |
Progesterone effect mediated by the voltage-dependent calcium channel and protein kinase C on noncapacitated cryopreserved bovine spermatozoa. | Andrologia 20010301 |
Evidence for platelet alphaIIb beta3 activation despite elevated cytosolic cAMP. | Thrombosis and haemostasis 20010201 |
Molecular characterization of rabbit renal epithelial calcium channel. | Biochemical and biophysical research communications 20010119 |
Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. | The Biochemical journal 20001101 |
Alveolar epithelial cells express and secrete parathyroid hormone-related protein. | American journal of respiratory cell and molecular biology 19941201 |
The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949. | The Journal of biological chemistry 19890225 |
Parathyroid hormone induction of creatine kinase activity and DNA synthesis is mimicked by phospholipase C, diacylglycerol and phorbol ester. | Biochimica et biophysica acta 19871112 |
Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters. | The Journal of biological chemistry 19870805 |