Home Other Building Blocks JNJ-17203212

JNJ-17203212

CAS No.:
821768-06-3
Catalog Number:
AG004VS2
Molecular Formula:
C17H15F6N5O
Molecular Weight:
419.3243
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$190
- +
10mg
99%
1 week
United States
$290
- +
25mg
99%
1 week
United States
$557
- +
50mg
99%
1 week
United States
$923
- +
100mg
99%
1 week
United States
$1590
- +
Product Description
Catalog Number:
AG004VS2
Chemical Name:
JNJ-17203212
CAS Number:
821768-06-3
Molecular Formula:
C17H15F6N5O
Molecular Weight:
419.3243
MDL Number:
MFCD12828764
IUPAC Name:
4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
InChI:
InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChI Key:
JFRYYGVYCWYIDQ-UHFFFAOYSA-N
SMILES:
O=C(N1CCN(CC1)c1ncccc1C(F)(F)F)Nc1ccc(cn1)C(F)(F)F
UNII:
71JE0C439X
Properties
Complexity:
564  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
419.118g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
419.331g/mol
Monoisotopic Mass:
419.118g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
61.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin. Thorax 20121001
TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Molecular pain 20110101
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists. Bioorganic & medicinal chemistry letters 20101201
A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats. Methods and findings in experimental and clinical pharmacology 20101001
Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder. The Journal of urology 20090801
Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. The Journal of neuroscience : the official journal of the Society for Neuroscience 20081217
Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. The Journal of pharmacology and experimental therapeutics 20071101
The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. Journal of medicinal chemistry 20070531
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. Journal of medicinal chemistry 20050324
Properties