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Neurokinin A

CAS No.:
86933-74-6
Catalog Number:
AG004I4X
Molecular Formula:
C28H46N6O5S
Molecular Weight:
578.7670
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
1 week
United States
$223
- +
5mg
1 week
United States
$723
- +
10mg
1 week
United States
$1257
- +
25mg
1 week
United States
$2640
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Product Description
Catalog Number:
AG004I4X
Chemical Name:
Neurokinin A
CAS Number:
86933-74-6
Molecular Formula:
C28H46N6O5S
Molecular Weight:
578.7670
MDL Number:
MFCD00167560
IUPAC Name:
(3S)-3-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
InChI:
InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1
InChI Key:
HEAUFJZALFKPBA-JPQUDPSNSA-N
SMILES:
CSCCC(C(=O)N)NC(=O)C(NC(=O)CNC(=O)C(C(C)C)NC(=O)C(Cc1ccccc1)NC)CC(C)C
UNII:
94168F9W1D
Properties
Complexity:
2030  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
0
Exact Mass:
1132.57g/mol
Formal Charge:
0
Heavy Atom Count:
79  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
16  
Isotope Atom Count:
0
Molecular Weight:
1133.334g/mol
Monoisotopic Mass:
1132.57g/mol
Rotatable Bond Count:
37  
Topological Polar Surface Area:
489A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-4.8  
Literature
Title Journal
The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry: towards a new function for the peptide in the brain. Neurochemistry international 20140501
In vitro pharmacological evaluation of the radiolabeled C-terminal substance P analogue Lys-Phe-Phe-Gly-Leu-Met-NH2: Does a specific binding site exist? Folia neuropathologica 20140101
Copper(II) complexes of neurokinin A with point mutation (S5A) and products of copper-catalyzed oxidation; role of serine residue in peptides containing neurokinin A sequence. Journal of inorganic biochemistry 20130401
Acid-base properties of the (1-4,18-36) fragments of neuropeptide K and their mono- and polynuclear copper(II) complexes products of metal-catalyzed oxidation. Inorganic chemistry 20130107
Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B. Hippocampus 20120501
Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120401
Tachykinins stimulate a subset of mouse taste cells. PloS one 20120101
Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells. Cardiovascular research 20111201
Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas. Pancreas 20110701
Novel expression of a functional glycine receptor chloride channel that attenuates contraction in airway smooth muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501
Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. British journal of pharmacology 20110301
Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis. Journal of investigational allergology & clinical immunology 20110101
Tachykinin receptors antagonism for asthma: a systematic review. BMC pulmonary medicine 20110101
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia. Journal of pharmacological sciences 20110101
The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism. Journal of neuroinflammation 20110101
Secretoneurin and the tachykinins substance P and neurokinin-A/B in NMDA-induced excitotoxicity in the rat retina. Regulatory peptides 20101130
Modulation of the CRH system by substance P/NKA in an animal model of depression. Behavioural brain research 20101112
Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit. Journal of applied physiology (Bethesda, Md. : 1985) 20101001
Coordination abilities of neurokinin A and its derivative and products of metal-catalyzed oxidation. Journal of inorganic biochemistry 20100801
Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene. British journal of pharmacology 20100701
Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201
Central administration of substance P inhibits feeding behavior in chicks. Hormones and behavior 20100201
Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity. Peptides 20100101
Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-). Advances in experimental medicine and biology 20100101
Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis. Journal of investigational allergology & clinical immunology 20100101
Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A. Journal of pharmacological sciences 20100101
Autocrine regulation of human sperm motility by tachykinins. Reproductive biology and endocrinology : RB&E 20100101
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. American journal of physiology. Gastrointestinal and liver physiology 20090801
Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression. Biochemical pharmacology 20090601
Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain research 20090519
Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation. The Journal of pharmacology and experimental therapeutics 20090401
An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats. Neurourology and urodynamics 20090101
NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries. Vascular pharmacology 20090101
Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation. American journal of physiology. Lung cellular and molecular physiology 20081201
Neurokinin-A inhibits cell cycle activators in K562 cells and activates Smad 4 through a non-canonical pathway: a novel method in neural-hematopoietic axis. Journal of neuroimmunology 20081115
Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. American journal of physiology. Regulatory, integrative and comparative physiology 20080701
Neurokinin receptor modulation of respiratory activity in the rabbit. The European journal of neuroscience 20080601
Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. The European journal of neuroscience 20080601
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. European journal of pharmacology 20080531
Estrogen determines sex differences in airway responsiveness after allergen exposure. American journal of respiratory cell and molecular biology 20080501
Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts? British journal of pharmacology 20080401
Changes in the control of gastric motor activity during metamorphosis in the amphibian Xenopus laevis, with special emphasis on purinergic mechanisms. The Journal of experimental biology 20080401
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology 20080301
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon. Digestive diseases and sciences 20080101
The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. Pulmonary pharmacology & therapeutics 20080101
Capsaicin-sensitive nerves and neurokinins modulate non-neuronal nNOS expression in lung. Respiratory physiology & neurobiology 20080101
Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. The Journal of pharmacology and experimental therapeutics 20080101
Nerve growth factor enhances neurokinin A-induced airway responses and exhaled nitric oxide via a histamine-dependent mechanism. Pulmonary pharmacology & therapeutics 20080101
Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder. Neurourology and urodynamics 20080101
Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum. Neuropeptides 20080101
Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists. European journal of pharmacology 20071222
Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201
Fluorometric immunoassay based on pH-sensitive dye-encapsulating liposomes and gramicidin channels. Analytical biochemistry 20071015
Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons. Gut 20071001
Distribution of neuroendocrine cells in the small and large intestines of the one-humped camel (Camelus dromedarius). Neuropeptides 20071001
Role for NK(1) and NK(2) receptors in the motor activity in mouse colon. European journal of pharmacology 20070910
Pelviureteric peristaltic contractions in diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20070801
A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701
A role for tachykinins in the regulation of human sperm motility. Human reproduction (Oxford, England) 20070601
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction. The Journal of allergy and clinical immunology 20070501
Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Experimental neurology 20070501
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. Journal of pharmacological sciences 20070501
The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus. Regulatory peptides 20070405
Distribution of neurokinin A-like and serotonin immunoreactivities within the vertical lobe complex in Sepia officinalis. Brain research 20070216
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain : a journal of neurology 20061201
MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist. European journal of pharmacology 20061107
Circulating markers of prognosis and response to treatment in patients with midgut carcinoid tumours. Gut 20061101
Ontogeny of excitatory and inhibitory control of gastrointestinal motility in the African clawed frog, Xenopus laevis. American journal of physiology. Regulatory, integrative and comparative physiology 20061001
Neurokinin3 receptor regulation of the airways. Vascular pharmacology 20061001
Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine. Biology of reproduction 20060901
The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye. Anesthesia and analgesia 20060901
Contribution of Rho-kinase in human gallbladder contractions. European journal of pharmacology 20060701
Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma. Respiratory medicine 20060601
NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. The Journal of pharmacology and experimental therapeutics 20060601
Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon. American journal of physiology. Gastrointestinal and liver physiology 20060501
Substance P initiates NFAT-dependent gene expression in spinal neurons. Journal of neurochemistry 20060401
Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle. European urology 20060301
Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders. Cephalalgia : an international journal of headache 20060301
Role of NK1 and NK2 receptors in mouse gastric mechanical activity. British journal of pharmacology 20060201
Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli. European journal of pharmacology 20051228
Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis. American journal of physiology. Cell physiology 20051201
Substance P, neurokinins A and B, and synthetic tachykinin peptides protect mesencephalic dopaminergic neurons in culture via an activity-dependent mechanism. Molecular pharmacology 20051101
Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway. The Journal of allergy and clinical immunology 20050801
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation. British journal of pharmacology 20050701
The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein. The Journal of biological chemistry 20050603
Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor. European journal of pharmacology 20050601
Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats. Alcohol (Fayetteville, N.Y.) 20050601
Impaired capsaicin and neurokinin-evoked colonic motility in inflammatory bowel disease. Journal of gastroenterology and hepatology 20050501
Tachykinins and tachykinin-receptors in the rat pineal gland. The European journal of neuroscience 20050501
Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation. American journal of physiology. Lung cellular and molecular physiology 20050401
Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle. European journal of pharmacology 20050221
Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye. Investigative ophthalmology & visual science 20050101
GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord. Neuroscience 20050101
Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulmonary pharmacology & therapeutics 20050101
Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study. European journal of histochemistry : EJH 20050101
Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea. Journal of biomedical science 20050101
[Effect of natural tachykinins on the bile production in rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101
[Structure-function organization of neurokinin A and neurokinin B molecules. III. A conformational study of glycine-monosubstituted analogues of neurokinins A and B]. Biofizika 20050101
Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. American journal of respiratory and critical care medicine 20041101
Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae. The Journal of experimental biology 20041101
Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. The Journal of pharmacology and experimental therapeutics 20041001
Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells. European journal of pharmacology 20040924
Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro. BJU international 20040901
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma. International archives of allergy and immunology 20040801
Functional role of the Na+/H+ exchanger in the regulation of cerebral arteriolar tone in rats. Journal of neurosurgery 20040801
Influence of maturation on constrictive response to stimulation of C-fiber afferents in isolated guinea pig airways. American journal of physiology. Lung cellular and molecular physiology 20040701
Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract. American journal of veterinary research 20040701
Seasonal changes of SP and NKA in frontal cortex, striatum and testes in the rat. Role of maternal pineal gland. Peptides 20040601
Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis. American journal of physiology. Gastrointestinal and liver physiology 20040501
Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Neuropharmacology 20040501
Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion. Toxicology and applied pharmacology 20040415
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors. Journal of pharmacological sciences 20040401
Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits. Pharmacology 20040301
Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. European journal of pharmacology 20040223
Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson's disease. Current drug targets 20040201
Role of sensory nerve peptides rather than mast cell histamine in paclitaxel hypersensitivity. American journal of respiratory and critical care medicine 20040101
Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients. The European respiratory journal 20040101
Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release. Neuroscience 20040101
Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord. British journal of pharmacology 20031201
Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles. Biophysical journal 20031201
Cholinergic transmission to colonic circular muscle of children with slow-transit constipation is unimpaired, but transmission via NK2 receptors is lacking. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20031201
Similarities of SP-, NKA- and NKB-induced currents in rat dorsal root ganglion neurons. Brain research 20031121
Inhibition of human detrusor contraction by a urothelium derived factor. The Journal of urology 20031101
Investigation of neurokinin-2 and -3 receptors in the human and pig bladder. BJU international 20031101
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors. American journal of physiology. Gastrointestinal and liver physiology 20031001
Characterization of tachykinin NK2 receptor in the anterior pituitary gland. Life sciences 20030926
A role for tachykinins in female mouse and rat reproductive function. Biology of reproduction 20030901
Human tachykinin NK2 receptor: a comparative study of the colon and urinary bladder. Clinical and experimental pharmacology & physiology 20030901
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors. Life sciences 20030829
Miniaturization of fluorescence polarization receptor-binding assays using CyDye-labeled ligands. Journal of biomolecular screening 20030801
[Effect of substance K on the contractility of cardiomyocytes]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20030801
Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration. Brain research 20030725
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission. The European journal of neuroscience 20030601
Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance P. European journal of pharmacology 20030516
Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation. The Journal of clinical investigation 20030401
Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. The Journal of allergy and clinical immunology 20030401
Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes. British journal of pharmacology 20030401
Biologic activity of the tachykinins on lamb and sheep gallbladder. Peptides 20030401
Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors. Pharmacology, biochemistry, and behavior 20030101
A tachykinin-like factor increases glutamate toxicity in rat cerebellar granule cells. Neuropharmacology 20030101
Mapping of neurokinin-like immunoreactivity in the human brainstem. BMC neuroscience 20030101
Effects of neurokinins on airway and alveolar eosinophil recruitment. Experimental lung research 20030101
SR 142801, a tachykinin NK(3) receptor antagonist, prevents beta(2)-adrenoceptor agonist-induced hyperresponsiveness to neurokinin A in guinea-pig isolated trachea. Life sciences 20021206
Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. Anesthesia and analgesia 20021201
Neurokinin A and the neurohypophysial response to melatonin: in vitro studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201
Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses. The Journal of biological chemistry 20021101
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum. British journal of pharmacology 20021101
Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses. The European journal of neuroscience 20021101
The primary structures and myotropic activities of two tachykinins isolated from the African clawed frog, Xenopus laevis. Regulatory peptides 20021015
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism. Brain research 20021011
Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease. The Journal of pharmacology and experimental therapeutics 20020801
Tachykinin-independent activity of capsaicin on in-vitro lamb detrusor. The Journal of pharmacy and pharmacology 20020801
Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. Autonomic & autacoid pharmacology 20020801
Effect of monensin on the levels of tachykinins and their processing enzyme activity in rat dorsal root ganglia. Neuroscience letters 20020628
Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma. The European respiratory journal 20020601
Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology 20020501
Age differences in neurokinin A and substance P from the hypothalamus, pituitary, pineal gland, and striatum of the rat. Effect of exogenous melatonin. Peptides 20020501
Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade. Regulatory peptides 20020415
Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Archives of surgery (Chicago, Ill. : 1960) 20020401
Effect of tachykinins on ascending and descending reflex pathway in rat small intestine. Acta pharmacologica Sinica 20020401
Role of tachykinins in sephadex-induced airway hyperreactivity and inflammation in guinea pigs. European journal of pharmacology 20020329
Enhancement of neurokinin A-induced smooth muscle contraction in human urinary bladder by mucosal removal and phosphoramidon: relationship to peptidase inhibition. European journal of pharmacology 20020308
Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect Beta-adrenoceptor-evoked response in the rat urinary bladder. Pharmacology 20020201
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. The Journal of pharmacology and experimental therapeutics 20020101
Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. British journal of pharmacology 20020101
In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum. Neuroscience 20020101
Role of cholinergic reflexes on the bronchoconstrictor reactivity to neurokinin a in allergic dogs. Pulmonary pharmacology & therapeutics 20020101
Activation of neurokinin-1 receptors promotes GABA release at synapses in the rat entorhinal cortex. Neuroscience 20020101
Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors. Neuroscience 20020101
2-Aryl indole NK(1) antagonists: optimisation of the amide substituent. Bioorganic & medicinal chemistry letters 20011203
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction. British journal of pharmacology 20011201
Presence of NK2 binding sites in the rat brain. Journal of neurochemistry 20011201
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction. Life sciences 20011121
Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene. Neuroscience letters 20011102
The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor. The Journal of investigative dermatology 20011101
Sources of calcium in neurokinin A-induced contractions of human colonic smooth muscle in vitro. The American journal of gastroenterology 20011101
Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats. Journal of studies on alcohol 20011101
Interaction of Met297 in the seventh transmembrane segment of the tachykinin NK2 receptor with neurokinin A. The Journal of biological chemistry 20011012
Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice. The Journal of pharmacology and experimental therapeutics 20011001
Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models. The Journal of pharmacology and experimental therapeutics 20011001
Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine. Naunyn-Schmiedeberg's archives of pharmacology 20011001
Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum. Regulatory peptides 20010915
The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states. The Journal of biological chemistry 20010914
The role of sensory neuropeptides in motor innervation of the hamster isolated urinary bladder. Naunyn-Schmiedeberg's archives of pharmacology 20010901
Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo. The Journal of pharmacology and experimental therapeutics 20010801
Tachykinin NK(2) receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. British journal of pharmacology 20010801
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease. British journal of pharmacology 20010801
Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin. Naunyn-Schmiedeberg's archives of pharmacology 20010801
Large veins in the Atlantic cod (Gadus morhua) and the rainbow trout (Oncorhynchus mykiss) are innervated by neuropeptide-containing nerves. Anatomy and embryology 20010801
Effect of calcitonin gene-related peptide (CGRP) on motility and on the release of substance P, neurokinin A, somatostatin and gastrin in the isolated perfused porcine antrum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010801
Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. European journal of pharmacology 20010706
Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons. Brain research bulletin 20010701
The roles of the N-terminal portions of various tachykinins in promoting salivation. Oral diseases 20010701
Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung. American journal of physiology. Lung cellular and molecular physiology 20010601
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. The Journal of clinical investigation 20010601
An animal model to assess aversion to intra-oral capsaicin: increased threshold in mice lacking substance p. Chemical senses 20010601
Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors. Microscopy research and technique 20010415
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation. American journal of physiology. Cell physiology 20010401
Tachykinin activation of human monocytes from patients with rheumatoid arthritis: in vitro and ex-vivo effects of cyclosporin A. Neuropeptides 20010401
Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. European journal of pharmacology 20010216
Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985) 20010201
The N-terminal domain of substance P is required for complete homologous desensitization but not phosphorylation of the rat neurokinin-1 receptor. Neuropeptides 20010201
Structure-activity relationships of neurokinin A (4-10) at the human tachykinin NK(2) receptor: the role of natural residues and their chirality. Biochemical pharmacology 20010101
Tachykinins contribute to nerve-mediated contractions in the human esophagus. Gastroenterology 20010101
Effect of tachykinins on airway function in cynomolgus monkeys. Pulmonary pharmacology & therapeutics 20010101
Bronchoconstrictor reactivity to NKA in allergic dogs: a comparison to histamine and methacholine. Pulmonary pharmacology & therapeutics 20010101
Involvement of spinal NK2 and NMDA receptors in aversive behavior induced by intra-arterial injection of capsaicin. Pharmacology, biochemistry, and behavior 20010101
NK2 tachykinin receptors mediate contraction of the pig intravesical ureter: tachykinin-induced enhancement of non-adrenergic non-cholinergic excitatory neurotransmission. Neurourology and urodynamics 20010101
Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway. Nitric oxide : biology and chemistry 20010101
Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks. Cephalalgia : an international journal of headache 20001201
Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors. Pancreas 20000401
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide. The Journal of pharmacology and experimental therapeutics 19981101
p38 mitogen-activated protein kinase expression and activation in smooth muscle. The American journal of physiology 19980801
Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat. The American journal of physiology 19980301
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. The Journal of pharmacology and experimental therapeutics 19970601
Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS letters 19961216
In vivo exposure to nitrogen dioxide (NO2) induces a decrease in calcitonin gene-related peptide (CGRP) and tachykinin immunoreactivity in guinea-pig peripheral airways. The European respiratory journal 19960901
The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. The Journal of biological chemistry 19960823
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats. The Journal of urology 19951001
New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists. Journal of medicinal chemistry 19950915
Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin. Journal of neurophysiology 19941001
Cyclic hexapeptide NK-2 antagonists. International journal of peptide and protein research 19940801
The non-peptide tachykinin NK2 receptor antagonist SR 48968 interacts with human, but not rat, cloned tachykinin NK3 receptors. Biochemical and biophysical research communications 19940215
Expression of rat NK-2 (neurokinin A) receptor in E. coli. Receptors & channels 19940101
Conformational study of cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 antagonist by NMR and molecular dynamics. Journal of pharmaceutical and biomedical analysis 19940101
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. British journal of pharmacology 19931101
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor. Biochemical and biophysical research communications 19930331
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. The Journal of biological chemistry 19921225
Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus. European journal of pharmacology 19921202
Structural characterization of tachykinins (neuropeptide gamma, neurokinin A, and substance P) from a reptile, Alligator mississipiensis. General and comparative endocrinology 19921101
Nonadrenergic, noncholinergic contractile responses of the guinea pig hilar bronchus involve the preferential activation of tachykinin neurokinin2 receptors. The Journal of pharmacology and experimental therapeutics 19920901
Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. Journal of medicinal chemistry 19920710
FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity. The Journal of pharmacology and experimental therapeutics 19920701
Molecular characterisation, expression and localisation of human neurokinin-3 receptor. FEBS letters 19920324
Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells. FEBS letters 19920127
A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life sciences 19920101
Studies of reflexogenic effects of capsaicin and neuropeptides on neural afferents in the dog parietal pericardium. Neuropeptides 19911101
Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea. British journal of pharmacology 19910601
Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems. Regulatory peptides 19901115
Competitive antagonists discriminate between NK2 tachykinin receptor subtypes. British journal of pharmacology 19900701
Structure-activity study of neurokinins: antagonists for the neurokinin-2 receptor. Pharmacology 19900101
[Arg3]substance P and neurokinin A from chicken small intestine. Regulatory peptides 19880201
Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins. European journal of pharmacology 19860605
A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. The Journal of biological chemistry 19850815
Neuromedin L: a novel mammalian tachykinin identified in porcine spinal cord. Neuropeptides 19840301
Synthesis and biological activities of neurokinin alpha and beta. Biochemical and biophysical research communications 19840130
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