Home Sulfos Omeprazole sulfone

Omeprazole sulfone

CAS No.:
88546-55-8
Catalog Number:
AG004DP5
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%(HPLC)powder
In Stock USA
United States
$151
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10mg
99%(HPLC)powder
In Stock USA
United States
$228
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25mg
99%(HPLC)powder
In Stock USA
United States
$540
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50mg
99%(HPLC)powder
In Stock USA
United States
$1026
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100mg
99%(HPLC)powder
In Stock USA
United States
$1686
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Product Description
Catalog Number:
AG004DP5
Chemical Name:
Omeprazole sulfone
CAS Number:
88546-55-8
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
MDL Number:
MFCD00869772
IUPAC Name:
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfonyl]-1H-benzimidazole
InChI:
InChI=1S/C17H19N3O4S/c1-10-8-18-15(11(2)16(10)24-4)9-25(21,22)17-19-13-6-5-12(23-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChI Key:
IXEQEYRTSRFZEO-UHFFFAOYSA-N
SMILES:
COc1ccc2c(c1)nc([nH]2)S(=O)(=O)Cc1ncc(c(c1C)OC)C
UNII:
76X040Z74O
Properties
Complexity:
553  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
361.11g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
361.416g/mol
Monoisotopic Mass:
361.11g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
103A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping. European journal of clinical pharmacology 20120401
Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers. Clinical pharmacology and therapeutics 20120301
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole. Drug metabolism and disposition: the biological fate of chemicals 20120101
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians. The pharmacogenomics journal 20110401
CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole. Journal of clinical pharmacy and therapeutics 20090801
Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs. European journal of clinical pharmacology 20080601
Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole. Acta pharmacologica Sinica 20071001
Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole. Journal of chromatography. A 20070713
Determination of esomeprazole and its two main metabolites in human, rat and dog plasma by liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205
Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography. Journal of pharmaceutical and biomedical analysis 20060911
Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. European journal of clinical pharmacology 20060801
Use of omeprazole as a CYP3A probe drug: effect of sex and menstrual cycle phase on CYP3A activity in healthy Caucasian adults. Journal of clinical pharmacology 20060301
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data. Clinical pharmacology and therapeutics 20051201
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clinical pharmacokinetics 20050101
Metabolism of omeprazole after two oral doses in children 1 to 9 months old. Proceedings of the Western Pharmacology Society 20050101
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics 20041201
Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes. Basic & clinical pharmacology & toxicology 20040901
Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability. Journal of clinical pharmacology 20040601
Assay of omeprazole and omeprazole sulfone by semi-microcolumn liquid chromatography with mixed-function precolumn. Journal of chromatography. B, Biomedical sciences and applications 20010425
Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. The Journal of pharmacology and experimental therapeutics 19940401
Properties