Efaroxan hydrochloride
| Title | Journal |
|---|---|
| Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes? | Diabetologia 20121101 |
| Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120901 |
| Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence. | Addiction biology 20120301 |
| Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. | British journal of pharmacology 20100201 |
| Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat. | Acta pharmacologica Sinica 20091201 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors. | Current eye research 20090401 |
| Preventive mechanisms of agmatine against ischemic acute kidney injury in rats. | European journal of pharmacology 20090128 |
| Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. | European journal of pharmacology 20080728 |
| alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice. | British journal of pharmacology 20080701 |
| Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice. | The Journal of pharmacology and experimental therapeutics 20080601 |
| Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice. | Neuroscience letters 20080509 |
| The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase. | Cellular and molecular life sciences : CMLS 20080401 |
| Sympathoexcitation of moxonidine in the caudal ventrolateral medulla is dependent on I1-imidazoline receptors in anesthetized rats. | Neuroscience letters 20071016 |
| Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test. | European journal of pain (London, England) 20070701 |
| Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test. | European journal of pharmacology 20070622 |
| Quantification of very low enantiomeric impurity of efaroxan using a dual cyclodextrin system by capillary electrophoresis. | Analytica chimica acta 20070605 |
| Validation of a method using an achiral liquid chromatography sorbent and a circular dichroism detector. Analysis of the efaroxan enantiomers. | Journal of chromatography. A 20070209 |
| Sensitivity improvement of circular dichroism detection in HPLC by using a low-pass electronic noise filter: Application to the enantiomeric determination purity of a basic drug. | Chirality 20070201 |
| Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells. | Pharmacological reports : PR 20070101 |
| Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects. | European journal of pharmacology 20061228 |
| Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. | Biochemical and biophysical research communications 20061020 |
| RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines. | Biochemical and biophysical research communications 20060908 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. | Diabetologia 20051201 |
| Identification of the central imidazoline receptor subtype involved in modulation of halothane-epinephrine arrhythmias in rats. | Anesthesia and analgesia 20051201 |
| Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice. | European journal of pharmacology 20050905 |
| Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension. | The Journal of pharmacology and experimental therapeutics 20050901 |
| Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes. | Journal of pharmacological sciences 20050901 |
| Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. | Journal of neurophysiology 20050801 |
| Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs. | Journal of cardiovascular pharmacology 20050701 |
| Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension. | European journal of pharmacology 20050509 |
| Urinary responses to acute moxonidine are inhibited by natriuretic peptide receptor antagonist. | British journal of pharmacology 20050501 |
| Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection. | Journal of cellular physiology 20050401 |
| Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds. | Diabetes 20041201 |
| Desensitization of insulin secretion by depolarizing insulin secretagogues. | Diabetes 20041201 |
| Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. | American journal of physiology. Heart and circulatory physiology 20040701 |
| The effects of the alpha2-adrenergic receptor agonists clonidine and rilmenidine, and antagonists yohimbine and efaroxan, on the spinal cholinergic receptor system in the rat. | Basic & clinical pharmacology & toxicology 20040401 |
| Effect of moxonidine on contractile activity of isolated large intestine in mice: role of alpha2-adrenoceptors and Ii-imidazoline receptors. | Bulletin of experimental biology and medicine 20040301 |
| [Effect of rilmenidine on intraocular pressure in rabbits, interaction with efaroxan and rauwolscine]. | Klinika oczna 20040101 |
| Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells. | Annals of the New York Academy of Sciences 20031201 |
| The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. | Annals of the New York Academy of Sciences 20031201 |
| Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors. | Annals of the New York Academy of Sciences 20031201 |
| Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors. | Annals of the New York Academy of Sciences 20031201 |
| Tritium labelling and characterization of the potent imidazoline I1 receptor antagonist [5,7-3H] (+/-)-efaroxan at high specific activity. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20030601 |
| Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells. | JOP : Journal of the pancreas 20030501 |
| Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors. | The Journal of pharmacology and experimental therapeutics 20030301 |
| Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits. | Journal of hypertension 20030101 |
| Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. | European journal of pharmacology 20021101 |
| BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism. | The Journal of clinical endocrinology and metabolism 20021101 |
| Pharmacological evidence of a role for prejunctional imidazoline (I(1)) receptors in ocular function. | Current eye research 20021101 |
| Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. | British journal of pharmacology 20020501 |
| The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. | Pharmacological research 20011101 |
| Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats. | Journal of cardiovascular pharmacology 20010901 |
| Central imidazoline (I(1)) receptors modulate aqueous hydrodynamics. | Current eye research 20010501 |
| Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors. | European journal of pharmacology 20010406 |
| Role of I(1)-imidazoline receptors and alpha2-adrenoceptors in hemodynamic effects of moxonidine administration into the rostroventrolateral medulla. | Bulletin of experimental biology and medicine 20010401 |
| Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors. | Experimental eye research 20010301 |
| Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure. | Biochemical pharmacology 20010301 |
| Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells. | European journal of pharmacology 20010301 |
| Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. | Diabetes 20010201 |
| Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. | Diabetes 20010201 |
| [Imidazoline receptors-normal and pathological factors]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101 |
| [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. | Naunyn-Schmiedeberg's archives of pharmacology 19980101 |