2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide
| Title | Journal |
|---|---|
| Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model. | Disease models & mechanisms 20161101 |
| Merkel Cell Carcinoma with a Suppressor of Fused (SUFU) Mutation: Case Report and Potential Therapeutic Implications. | Dermatology and therapy 20150601 |
| The Hedgehog pathway: role in cell differentiation, polarity and proliferation. | Archives of toxicology 20150201 |
| Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. | Nature medicine 20140701 |
| Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro. | The Journal of thoracic and cardiovascular surgery 20140101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| The dawn of hedgehog inhibitors: Vismodegib. | Journal of pharmacology & pharmacotherapeutics 20130101 |
| Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. | Bioorganic & medicinal chemistry 20121115 |
| Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells. | Stem cells and development 20121101 |
| Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. | Cancer research 20121001 |
| Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma. | Clinical therapeutics 20121001 |
| In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines. | International journal of cancer 20120715 |
| Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations. | Clinical and experimental medicine 20120301 |
| Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. | Journal of medicinal chemistry 20120223 |
| Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened. | ACS medicinal chemistry letters 20120209 |
| The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. | Anticancer research 20120101 |
| Ivacaftor, vismodegib, and ingenol mebutate. | Journal of the American Pharmacists Association : JAPhA 20120101 |
| Emerging treatments and signaling pathway inhibitors. | Seminars in cutaneous medicine and surgery 20111201 |
| Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication. | Hepatology (Baltimore, Md.) 20111101 |
| A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry. | Drug metabolism and disposition: the biological fate of chemicals 20110801 |
| Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. | Cancer research 20110801 |
| Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening. | Drug metabolism and disposition: the biological fate of chemicals 20110601 |
| AACR highlights: promise for treating pancreatic cancer. | Journal of the National Cancer Institute 20110518 |
| Hedgehog signaling and therapeutics in pancreatic cancer. | Carcinogenesis 20110401 |
| New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. | Seminars in cutaneous medicine and surgery 20110301 |
| The role of targeted molecular inhibitors in the management of advanced nonmelanoma skin cancer. | Seminars in cutaneous medicine and surgery 20110301 |
| Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. | Cancer research 20110115 |
| Up-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cells. | PloS one 20110101 |
| Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. | PloS one 20110101 |
| Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. | PloS one 20110101 |
| Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway. | Bioorganic & medicinal chemistry letters 20101115 |
| Modulators of the hedgehog signaling pathway. | Bioorganic & medicinal chemistry 20100915 |
| Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling. | Drug metabolism and disposition: the biological fate of chemicals 20100701 |
| Small-molecule modulators of the Sonic Hedgehog signaling pathway. | Molecular bioSystems 20100101 |
| Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. | Xenobiotica; the fate of foreign compounds in biological systems 20091101 |
| Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. | Science (New York, N.Y.) 20091023 |
| GDC-0449-a potent inhibitor of the hedgehog pathway. | Bioorganic & medicinal chemistry letters 20091001 |
| Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. | The New England journal of medicine 20090917 |
| Evidence for allosteric interactions of antagonist binding to the smoothened receptor. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. | Neoplasia (New York, N.Y.) 20090101 |