Home Other Building Blocks Trimipramine Maleate, BP

Trimipramine Maleate, BP

CAS No.:
521-78-8
Catalog Number:
AG003V4U
Molecular Formula:
C24H30N2O4
Molecular Weight:
410.5060
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
≥95%
1 week
United States
$94
- +
5g
≥95%
1 week
United States
$151
- +
Product Description
Catalog Number:
AG003V4U
Chemical Name:
Trimipramine Maleate, BP
CAS Number:
521-78-8
Molecular Formula:
C24H30N2O4
Molecular Weight:
410.5060
MDL Number:
MFCD00082376
IUPAC Name:
(Z)-but-2-enedioic acid;3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine
InChI:
InChI=1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key:
YDGHCKHAXOUQOS-BTJKTKAUSA-N
SMILES:
CN(CC(CN1c2ccccc2CCc2c1cccc2)C)C.OC(=O)/C=C\C(=O)O
EC Number:
208-318-3
NSC Number:
758386
Properties
Complexity:
436  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
410.221g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
410.514g/mol
Monoisotopic Mass:
410.221g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
81.1A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Antidepressants for patients with tinnitus. The Cochrane database of systematic reviews 20120912
Electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the quantification of trimipramine enantiomers. Electrophoresis 20120201
Two polymorphs and the diethylammonium salt of the barbiturate eldoral. Acta crystallographica. Section C, Crystal structure communications 20120201
Venlafaxine in somatopsychic and autopsychic depersonalization. Progress in neuro-psychopharmacology & biological psychiatry 20111201
FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression. American family physician 20111101
Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology 20110901
Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Analytical and bioanalytical chemistry 20110401
Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection. Talanta 20110215
The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model. Aquatic toxicology (Amsterdam, Netherlands) 20110117
Styryl-based and tricyclic compounds as potential anti-prion agents. PloS one 20110101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Persistent tinnitus induced by tricyclic antidepressants. Journal of psychopharmacology (Oxford, England) 20100801
Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine. Drug metabolism and disposition: the biological fate of chemicals 20100501
Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases. Journal of forensic and legal medicine 20100401
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
The effect of trimipramine on dream recall and dream emotions in depressive outpatients. Psychiatry research 20090530
Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial. Journal of psychiatric research 20090401
Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study. Journal of psychiatric research 20080601
Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman. Forensic science international 20071220
Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Psychopharmacology 20071101
Heart rate variability reveals risk of arrhythmias after intoxication with antidepressants. Intensive care medicine 20070101
Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance? The Journal of pharmacy and pharmacology 20070101
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine. Pharmacology, biochemistry, and behavior 20060401
Trimipramine for refractory panic attacks. The American journal of psychiatry 20060301
Galactorrhea during treatment with trimipramine. A case report. Pharmacopsychiatry 20051101
[Multiple fibromas in systemic mastocytosis]. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050501
Protonation of trimipramine salts of maleate, mesylate and hydrochloride observed by 1H, 13C and 15N NMR spectroscopy. Magnetic resonance in chemistry : MRC 20050201
Fluoxetine versus trimipramine in the treatment of depression in geriatric patients. Pharmacopsychiatry 20050101
Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG. Psychoneuroendocrinology 20041001
[Hypotensive cardio-circulatory failure and metabolic acidosis after suicidal intoxication with trimipramine and quetiapine. Case report and background]. Der Anaesthesist 20040101
Trimipramine determination in pharmaceutical preparations with an automated multicommutated reversed-flow system. Journal of pharmaceutical and biomedical analysis 20031204
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity. Pharmacogenetics 20031201
Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics. Journal of clinical psychopharmacology 20031001
Clinical outcome after trimipramine in patients with delusional depression - a pilot study. Pharmacopsychiatry 20030101
abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice. Journal of psychiatric research 20030101
Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine. Pharmacopsychiatry 20030101
Prescribing cyclic antidepressants for vitiligo patients: which agents are superior, which are not? Psychotherapy and psychosomatics 20030101
Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001
Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Pharmacopsychiatry 20020901
Hydrophobia as a rare presentation of Cotard's syndrome: a case report. Acta psychiatrica Scandinavica 20020801
[Delusional depression as differential dementia of the Alzheimer type diagnosis]. Der Nervenarzt 20020501
Effects of the atypical antidepressant trimipramine on neuronal excitability and long-term potentiation in guinea pig hippocampal slices. Progress in neuro-psychopharmacology & biological psychiatry 20020201
Effects of REM sleep awakenings and related wakening paradigms on the ultradian sleep cycle and the symptoms in depression. Journal of psychiatric research 20020101
[Chronic sleep disorders. Masked depression]. MMW Fortschritte der Medizin 20011018
Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein. Electrophoresis 20010901
Seizure during combination of trimipramine and bupropion. The Journal of clinical psychiatry 20010601
Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsychiatry 20010301
Differential effects of trimipramine and fluoxetine on sleep in geriatric depression. Pharmacopsychiatry 20010301
[Instead of benzodiazepines. An antidepressant as sleep aid]. MMW Fortschritte der Medizin 20010118
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochemistry international 20010101
Seizures associated with therapeutic doses of venlafaxine and trimipramine. The Annals of pharmacotherapy 20001201
[Tourette's syndrome and antidepressant therapy: exacerbation of nervous tics with paroxetine]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20000501
Clomipramine and related structures as inhibitors of the skeletal sarcoplasmic reticulum Ca2+ pump. Journal of bioenergetics and biomembranes 20000401
Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation. Journal of neural transmission (Vienna, Austria : 1996) 19980101
Rapid cycling following antidepressant in an adolescent. Biological psychiatry 19900515
Trimipramine-induced neuroleptic malignant syndrome after transient psychogenic polydipsia in one patient. The Journal of clinical psychiatry 19890401
Intractable manic-depressive psychosis with rapid cycling in an 18-year-old woman successfully treated with electroconvulsive therapy. The Journal of nervous and mental disease 19870401
Trimipramine-induced acute renal failure. The New Zealand medical journal 19860409
A comparative trial of the antidepressant, anxiolytic, and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients. The Journal of clinical psychiatry 19850301
Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics. Journal of the Royal Society of Medicine 19840401
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