Home Sulfos 1-{4-[(3-methylphenyl)amino]pyridine-3-sulfonyl}-3-(propan-2-yl)urea

1-{4-[(3-methylphenyl)amino]pyridine-3-sulfonyl}-3-(propan-2-yl)urea

CAS No.:
56211-40-6
Catalog Number:
AG003UUA
Molecular Formula:
C16H20N4O3S
Molecular Weight:
348.4200
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$82
- +
5g
98%
In Stock USA
United States
$250
- +
10g
98%
In Stock USA
United States
$438
- +
25g
98%
In Stock USA
United States
$625
- +
Product Description
Catalog Number:
AG003UUA
Chemical Name:
1-{4-[(3-methylphenyl)amino]pyridine-3-sulfonyl}-3-(propan-2-yl)urea
CAS Number:
56211-40-6
Molecular Formula:
C16H20N4O3S
Molecular Weight:
348.4200
MDL Number:
MFCD00866166
IUPAC Name:
1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
InChI:
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
InChI Key:
NGBFQHCMQULJNZ-UHFFFAOYSA-N
SMILES:
CC(NC(=O)NS(=O)(=O)c1cnccc1Nc1cccc(c1)C)C
UNII:
W31X2H97FB
Properties
Complexity:
518  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
348.126g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
348.421g/mol
Monoisotopic Mass:
348.126g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
109A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chemical research in toxicology 20150518
In right or biventricular chronic heart failure addition of thiazides to loop diuretics to achieve a sequential blockade of the nephron is associated with increased risk of dilutional hyponatremia: results of a case-control study. Minerva cardioangiologica 20121001
[Use of neurostimulation in a patient with an implantable cardioverter defibrillator (ICD)]. Deutsche medizinische Wochenschrift (1946) 20121001
Should torsemide be the loop diuretic of choice in systolic heart failure? Future cardiology 20120901
Chemometrically assisted development and validation of LC-UV and LC-MS methods for simultaneous determination of torasemide and its impurities. Journal of chromatographic science 20120401
Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20120301
The genetics of loop diuretic effects. The pharmacogenomics journal 20120201
Potential drug-drug interactions and adverse drug reactions in patients with liver cirrhosis. European journal of clinical pharmacology 20120201
Adverse drug reactions in a complementary medicine hospital: a prospective, intensified surveillance study. Evidence-based complementary and alternative medicine : eCAM 20120101
Higher Blood Glucose within the Normal Range Is Associated with More Severe Strokes. Stroke research and treatment 20120101
In chronic heart failure with marked fluid retention, the i.v. high doses of loop diuretic are a predictor of aggravated renal dysfunction, especially in the set of heart failure with normal or only mildly impaired left ventricular systolic function. Minerva cardioangiologica 20111201
Use of the loop diuretic torsemide in three dogs with advanced heart failure. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Spinal epidural hematoma related to an epidural catheter in a cardiac surgery patient -A case report-. Korean journal of anesthesiology 20111201
Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. Journal of enzyme inhibition and medicinal chemistry 20111001
Study on the interaction between torasemide and 12-tungstophosphoric acid by resonance Rayleigh scattering and resonance nonlinear scattering spectra and its analytical applications. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901
Effects of prolonged-release torasemide versus furosemide on myocardial fibrosis in hypertensive patients with chronic heart failure: a randomized, blinded-end point, active-controlled study. Clinical therapeutics 20110901
Drug-induced photodermatitis in elderly nursing home residents. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20110801
Temporary bilateral sensorineural hearing loss following cardiopulmonary bypass -A case report-. Korean journal of anesthesiology 20110801
[Postpartum cardiomyopathy]. Deutsche medizinische Wochenschrift (1946) 20110601
[Treatment of nephritic edema by torasemide in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110601
Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy: criteria for weaning from ventricular assist devices. European heart journal 20110501
[Etiologies of nephrotic syndrome]. Praxis 20110427
A case of a false-positive anti-myeloperoxidase antibody ELISA in a patient with hypothyroidism. Chonnam medical journal 20110401
Nontarget analysis of polar contaminants in freshwater sediments influenced by pharmaceutical industry using ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. Environmental pollution (Barking, Essex : 1987) 20110201
Reversed-phase ultra-performance liquid chromatographic method development and validation for determination of impurities related to torsemide tablets. Journal of AOAC International 20110101
Sex differences in drug disposition. Journal of biomedicine & biotechnology 20110101
Role of the kidneys in resistant hypertension. International journal of hypertension 20110101
The causes, consequences, and treatment of left or right heart failure. Vascular health and risk management 20110101
[Torasemide is the effective loop diuretic for long-term therapy of arterial hypertension]. Kardiologiia 20110101
[Alternative therapy with ivabradine in patients with functional class III chronic heart failure]. Kardiologiia 20110101
Anti-albuminuric effects of the angiotensin AT1 receptor blocker telmisartan in hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101
Management of renal failure and ascites in patients with cirrhosis. International journal of hepatology 20110101
Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis. Indian journal of pharmacology 20110101
Targeting cardiac fibrosis: a new frontier in antiarrhythmic therapy? American journal of cardiovascular disease 20110101
Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet. International journal of emergency medicine 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Congestive heart failure in Indians: how do we improve diagnosis & management? The Indian journal of medical research 20101101
Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction. European journal of heart failure 20100901
[A new case of nevus oligemicus]. Dermatology online journal 20100815
The effects of adding torasemide to standard therapy on peak oxygen consumption, natriuretic peptides, and quality of life in patients with compensated left ventricular systolic dysfunction. European journal of heart failure 20100701
Mannitol is an independent risk factor of acute kidney injury after cerebral trauma: a case-control study. Renal failure 20100701
Loop diuretic therapy in left ventricular systolic dysfunction: has familiarity bred contempt for a critical but potentially nephrotoxic cardio renal therapy? European journal of heart failure 20100701
[Update: prolonged-release torasemide]. Drugs of today (Barcelona, Spain : 1998) 20100701
Hypertensive brainstem encephalopathy involving deep supratentorial regions: does only blood pressure matter? Neurology international 20100621
Multi-residue analysis of pharmaceutical compounds in wastewaters by dual solid-phase microextraction coupled to liquid chromatography electrospray ionization ion trap mass spectrometry. Journal of chromatography. A 20100514
Recurrent syncope and hypocalcaemic cardiomyopathy as manifestations of Fahr's syndrome. Archives of medical science : AMS 20100301
Gender is an important determinant of the disposition of the loop diuretic torasemide. Journal of clinical pharmacology 20100201
Agents with antialdosterone properties should be the preferred diuretics for reducing hypertension related atrial fibrillation. European journal of internal medicine 20100201
[Determination of brain natriuretic peptide levels and its N-terminal fragment for the evaluation of renal replacement therapies efficiency in patients with decompensated chronic heart failure]. Terapevticheskii arkhiv 20100101
Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases. PloS one 20100101
A comprehensive review of the loop diuretics: should furosemide be first line? The Annals of pharmacotherapy 20091101
[Frequent drug interactions in old age]. Praxis 20091021
The role of transporters in the pharmacokinetics of orally administered drugs. Pharmaceutical research 20090901
TORAFIC study protocol: torasemide prolonged release versus furosemide in patients with chronic heart failure. Expert review of cardiovascular therapy 20090801
Torasemide prolonged release. Drugs 20090709
Characterization of the binding of drugs to human intestinal fatty acid binding protein (IFABP): potential role of IFABP as an alternative to albumin for in vitro-in vivo extrapolation of drug kinetic parameters. Drug metabolism and disposition: the biological fate of chemicals 20090701
[Effects of various diuretics on cardiac function in rats with heart failure]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090701
[Intoxication with lithium]. Praxis 20090624
Loop diuretics in patients with heart failure: time to change to torsemide? Journal of cardiovascular pharmacology 20090601
Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide. Journal of cardiovascular pharmacology 20090601
Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis. European journal of clinical pharmacology 20090501
A bioavailability/bioequivalence and pharmacokinetic study of two oral doses of torasemide (5 and 10 mg): prolonged-release versus the conventional formulation. Clinical and experimental pharmacology & physiology 20090501
4-(3-Methyl-anilino)-N-[N-(1-methyl-ethyl)carbamo-yl]pyridinium-3-sulfon-amidate (torasemide) methanol 0.25-solvate 0.25-hydrate. Acta crystallographica. Section E, Structure reports online 20090501
4-(3-Methyl-anilino)-N-[N-(1-methyl-ethyl)carbamo-yl]pyridinium-3-sulfon-amidate (torasemide T-N): a low temperature redetermination. Acta crystallographica. Section E, Structure reports online 20090501
Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data. Pharmaceutical research 20090401
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure. Hypertension (Dallas, Tex. : 1979) 20090201
Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. Journal of neurotrauma 20090201
Comparison of repeated-dose pharmacokinetics of prolonged-release and immediate-release torasemide formulations in healthy young volunteers. Fundamental & clinical pharmacology 20090201
The management of acute heart failure and diuretic therapy. American journal of therapeutics 20090101
Effects of increased dose of diuretics on symptoms, weight, 6-minute walk distance, and echocardiographic measurements of left ventricular systolic and diastolic function in 51 patients with symptomatic heart failure caused by reduced left ventricular ejection fraction treated with beta blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. American journal of therapeutics 20090101
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Current medicinal chemistry 20090101
Management of ascites due to gastrointestinal malignancy. Annals of Saudi medicine 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report. Journal of medical case reports 20090101
Drugs impact on CYP-450 enzyme family: A pharmacogenetical study of response variation. Indian journal of human genetics 20090101
Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4. British journal of pharmacology 20081201
Probable interaction between warfarin and torsemide. The Annals of pharmacotherapy 20081201
Myocardial fibrosis in chronic kidney disease: potential benefits of torasemide. Kidney international. Supplement 20081201
[Hypertension, hypertensive heart disease and heart failure. Role of loop diuretics]. Medicina clinica 20081115
Comparison of the effects on ambulatory blood pressure of awakening versus bedtime administration of torasemide in essential hypertension. Chronobiology international 20081101
Efficacy and safety of torasemide in children with heart failure. Archives of disease in childhood 20080901
The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics 20080601
The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients. Journal of cardiac failure 20080601
Torasemide for the treatment of heart failure. Cardiovascular & hematological disorders drug targets 20080601
Torsemide-induced pseudoporphyria. Archives of dermatology 20080601
Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitation. The Annals of pharmacotherapy 20080301
The effects of amlodipine and enalapril on renal function in adults with hypertension and nondiabetic nephropathies: a 3-year, randomized, multicenter, double-blind, placebo-controlled study. Clinical therapeutics 20080301
Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. European journal of pharmacology 20080226
Comparative effects of torasemide and furosemide in rats with heart failure. Biochemical pharmacology 20080201
Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. European journal of clinical pharmacology 20080201
Pharmacologic approaches for volume excess in acute kidney injury (AKI). The International journal of artificial organs 20080201
Secondary pulmonary hypertension: haemodynamic effects of torasemide versus furosemide. Clinical drug investigation 20080101
Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers. Clinical pharmacokinetics 20080101
Clinical effects of torasemide prolonged release in mild-to-moderate hypertension: a randomized noninferiority trial versus torasemide immediate release. Cardiovascular therapeutics 20080101
NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy. PloS one 20080101
[Loop diuretics in the treatment of edema: torasemide potentials]. Terapevticheskii arkhiv 20080101
A simplified HPLC method for quantification of torsemide from human plasma and its application to a bioequivalence study. Indian journal of pharmaceutical sciences 20080101
Torasemide transport by organic anion transporters contributes to hyperuricemia. Journal of the American Society of Nephrology : JASN 20071201
[Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20071201
Effects of oral administration of furosemide and torsemide in healthy dogs. American journal of veterinary research 20071001
Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clinical pharmacology and therapeutics 20070901
Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure. Journal of the American College of Cardiology 20070828
Effect of torsemide on serum and urine electrolyte levels in dogs with congestive heart failure. The Veterinary record 20070616
Genetic variation at the CYP2C locus and its association with torsemide biotransformation. The pharmacogenomics journal 20070601
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharmaceutics & drug disposition 20070401
Hospital policies for treatment of acute decompensated heart failure. The Annals of pharmacotherapy 20070401
Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20070301
Vasodilatory action of loop diuretics: a plethysmography study of endothelial function in forearm arteries and dorsal hand veins in hypertensive patients and controls. Journal of cardiovascular pharmacology 20070201
[Chronotherapy with torasemide in hypertensive patients: increased efficacy and therapeutic coverage with bedtime administration]. Medicina clinica 20061118
Dose-dependent association between use of loop diuretics and mortality in advanced systolic heart failure. The American journal of cardiology 20061115
Classification of torasemide based on the Biopharmaceutics Classification System and evaluation of the FDA biowaiver provision for generic products of CLASS I drugs. The Journal of pharmacy and pharmacology 20061101
Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart (British Cardiac Society) 20061001
Efficacy and safety of a furosemide continuous infusion following cardiac surgery. The Annals of pharmacotherapy 20061001
Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. The Journal of pharmacology and experimental therapeutics 20060901
Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters. British journal of clinical pharmacology 20060901
Relation of loop diuretic dose to mortality in advanced heart failure. The American journal of cardiology 20060615
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Improved solid-phase extraction and HPLC measurement of torasemide and its important metabolites. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. The Annals of pharmacotherapy 20060101
[Diuretic therapy in heart failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20060101
[Clinical efficacy and safety of administration of loop diuretic torasemide]. Kardiologiia 20060101
Cardiomyopathy, familial dilated. Orphanet journal of rare diseases 20060101
Gemcitabine in combination with EGF-Receptor antibody (Cetuximab) as a treatment of cholangiocarcinoma: a case report. BMC cancer 20060101
[A case of severe hyponatremia in a patient suffering from epilepsy and using oxcarbazepine]. Medicina (Kaunas, Lithuania) 20060101
[Torasemide--new generation loop diuretic: clinical pharmacology and therapeutic application]. Kardiologiia 20060101
Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Drug metabolism and disposition: the biological fate of chemicals 20051201
Pharmacokinetics and pharmacodynamics of intravenous torasemide in diabetic rats induced by alloxan or streptozotocin. Biopharmaceutics & drug disposition 20051101
Comparison of the urine acidification tests of torsemide vs furosemide in healthy volunteers. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20051101
Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation. Therapeutic drug monitoring 20050801
Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats. International journal of pharmaceutics 20050714
Dose-independent pharmacokinetics of torasemide after intravenous and oral administration to rats. Biopharmaceutics & drug disposition 20050701
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Electrochemical characterisation of the human cytochrome P450 CYP2C9. Biochemical pharmacology 20050515
Embolic infarction associated with cardiac amyloidosis. Journal of clinical neurology (Seoul, Korea) 20050401
[Aldosterone antagonist therapy for chronic heart failure]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210
Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor. Cardiovascular drug reviews 20050101
Torsemide versus furosemide after continuous renal replacement therapy due to acute renal failure in cardiac surgery patients. Renal failure 20050101
[The place of diuretics in the treatment of chronic heart failure. Part I]. Kardiologiia 20050101
[Valsartan in patients with arterial hypertension and type 2 diabetes mellitus. The lapaval study]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20050101
High-Dose Torasemide is Equivalent to High-Dose Furosemide with Hypertonic Saline in the Treatment of Refractory Congestive Heart Failure. Clinical drug investigation 20050101
Torasemide inhibits transcardiac extraction of aldosterone in patients with congestive heart failure. Journal of the American College of Cardiology 20041207
Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro. The Journal of pharmacology and experimental therapeutics 20041201
CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide. Clinical pharmacology and therapeutics 20041201
Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors. Prostaglandins & other lipid mediators 20041001
A woman with infectious endocarditis caused by Abiotrophia defectiva. Internal medicine (Tokyo, Japan) 20041001
Effects of cysteine on the pharmacokinetics of intravenous torasemide in rats with protein-calorie malnutrition. Journal of pharmaceutical sciences 20040901
Effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of torasemide in rabbits. Biopharmaceutics & drug disposition 20040701
Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity. Biochemistry 20040622
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure. Journal of the American College of Cardiology 20040602
Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. The Journal of pharmacology and experimental therapeutics 20040501
Food: an unrecognized source of loop diuretic resistance. Pharmacotherapy 20040501
[Idiopathic hypereosinophilia with cardiac involvement]. Deutsche medizinische Wochenschrift (1946) 20040312
Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs). Advanced drug delivery reviews 20040223
Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9. Xenobiotica; the fate of foreign compounds in biological systems 20040101
Torasemide vs. furosemide in primary care patients with chronic heart failure NYHA II to IV--efficacy and quality of life. European journal of heart failure 20031201
Role of excess volume in the pathophysiology of hypertension in chronic kidney disease. Kidney international 20031101
Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous torasemide. The Journal of pharmacy and pharmacology 20031101
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry 20031009
[Heart failure therapy. Cheap can become expensive]. MMW Fortschritte der Medizin 20031009
The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats. The Journal of veterinary medical science 20031001
[Diuretics in heart failure. Fewer electrolyte disorders -- better prognosis]. MMW Fortschritte der Medizin 20030807
A double-blind randomized crossover trial of two loop diuretics in chronic kidney disease. Kidney international 20030801
[Favorable prognostic effect of heart failure therapy. Diuretic makes heart muscle more elastic]. MMW Fortschritte der Medizin 20030605
Effects of torasemide on left ventricular function and neurohumoral factors in patients with chronic heart failure. Circulation journal : official journal of the Japanese Circulation Society 20030501
[Hear failure. Indications for diuretic therapy in general practice]. MMW Fortschritte der Medizin 20030501
Multivariate optimisation of a cyclodextrin-assisted-capillary zone electrophoretic method for the separation of torasemide and its metabolites. Journal of chromatography. A 20030321
[Reducing hospital stay and costs in heart failure. The proper diuretic makes the difference]. MMW Fortschritte der Medizin 20030123
Ethacrynic acid and the sulfa-sensitive patient. Archives of internal medicine 20030113
Pharmacokinetics and pharmacodynamics of intravenous trasemide in mutant Nagase analbuminemic rats. Biopharmaceutics & drug disposition 20030101
Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. Prostaglandins, leukotrienes, and essential fatty acids 20030101
[Torasemide (Trifas) in clinical practice--own experience]. Przeglad lekarski 20030101
Calciphylaxis in chronic, non-dialysis-dependent renal disease. BMC nephrology 20030101
Pharmacotherapy in congestive heart failure: drug absorption in the management of congestive heart failure: loop diuretics. Congestive heart failure (Greenwich, Conn.) 20030101
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous torasemide in rats. Research communications in molecular pathology and pharmacology 20030101
[Which loop diuretic for heart failure? For prognosis the choices are not all the same]. MMW Fortschritte der Medizin 20021003
[Long-term diuretic treatment in heart failure: are there differences between furosemide and torasemide?]. Praxis 20020911
[A better diuretic for patients with heart failure. Better control of potassium loss]. MMW Fortschritte der Medizin 20020808
Torasemide in chronic heart failure: results of the TORIC study. European journal of heart failure 20020801
[Which diuretic in heart failure? For the prognosis, they are not all equal]. MMW Fortschritte der Medizin 20020328
Diuretics in the therapy of hypertension. Journal of human hypertension 20020301
Crystal forms of torasemide: new insights. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020101
Separation of the high-ceiling diuretic Torasemide and its metabolites by capillary zone electrophoresis with diode-array detection. Electrophoresis 20020101
[Aggression to the immature kidney]. La Pediatria medica e chirurgica : Medical and surgical pediatrics 20020101
[Diuretics in heart failure. Can they also prolong life?]. MMW Fortschritte der Medizin 20011206
Open-label randomized trial of torsemide compared with furosemide therapy for patients with heart failure. The American journal of medicine 20011101
Optimal diuretic therapy for heart failure. The American journal of medicine 20011101
Simultaneous determination of torasemide and its major metabolite M5 in human urine by high-performance liquid chromatography-electrochemical detection. Journal of chromatographic science 20011101
[Treatment of ascites in cirrhotic patients]. Anales del sistema sanitario de Navarra 20010901
[Torasemide (LUPRAC): a review of its pharmacological and clinical profile]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010801
Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles. Prostaglandins, leukotrienes, and essential fatty acids 20010801
Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor. The Journal of pharmacy and pharmacology 20010501
Intraplatelet calcium levels in patients with acute renal failure before and after the administration of loop diuretics. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010301
Long-term efficacy of torsemide compared with frusemide in cirrhotic patients with ascites. Scandinavian journal of gastroenterology 20010301
Effects of loop diuretics on angiotensin II-stimulated vascular smooth muscle cell growth. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101
The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101
Torasemide: a pharmacoeconomic review of its use in chronic heart failure. PharmacoEconomics 20010101
Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531. Cardiovascular drug reviews 20010101
Torasemide--a unique loop diuretic. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20010101
Allelic and functional variability of cytochrome P4502C9. Pharmacogenetics 19970201
Delayed progression of cytotoxic oedema in focal cerebral ischemia after treatment with a torasemide derivative: a diffusion-weighted magnetic resonance imaging study. Neuroscience letters 19960802
Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs 19950101
FDA approved new drug bulletin: torsemide (Demadex), trimetrexate glucuronate (neuTrexin). RN 19940501
Diuretic and vasodilating actions of torasemide. Cardiology 19940101
Comparative analysis of torasemide and furosemide in liver cirrhosis. Cardiology 19940101
Torasemide. A review of its pharmacological properties and therapeutic potential. Drugs 19910101
Properties