One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.

Chemico-biological interactions 20140125

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Toxicology in vitro : an international journal published in association with BIBRA 20130901

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

Bioorganic & medicinal chemistry letters 20130401

Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.

Journal of applied toxicology : JAT 20130201

Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.

Xenobiotica; the fate of foreign compounds in biological systems 20120801

KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin.

The Journal of physiology 20120801

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Bioorganic & medicinal chemistry letters 20120715

Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).

Molecular biology reports 20120601

Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus.

Drug metabolism and disposition: the biological fate of chemicals 20120601

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.

Xenobiotica; the fate of foreign compounds in biological systems 20120501

Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise.

American journal of physiology. Heart and circulatory physiology 20120415

Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.

Drug metabolism and pharmacokinetics 20120101

Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa.

Journal of pharmacological sciences 20120101

Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats.

Biological & pharmaceutical bulletin 20120101

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

PLoS computational biology 20111201

A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.

Drug metabolism letters 20111201

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.

Journal of medicinal chemistry 20111027

Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015

Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes.

Journal of veterinary pharmacology and therapeutics 20111001

Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.

Chemico-biological interactions 20110905

Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.

Journal of pharmaceutical sciences 20110901

Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.

Journal of biomolecular screening 20110901

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

PLoS neglected tropical diseases 20110601

Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.

Drug metabolism and disposition: the biological fate of chemicals 20110501

Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.

Journal of medicinal chemistry 20110414

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.

European journal of drug metabolism and pharmacokinetics 20110301

New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.

Journal of medicinal chemistry 20110127

CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.

European journal of medicinal chemistry 20110101

In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone.

Biological & pharmaceutical bulletin 20110101

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.

Journal of translational medicine 20110101

Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

PloS one 20110101

Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women.

International journal of women's health 20110101

Endothelium-derived hyperpolarizing factor and vascular function.

Cardiology research and practice 20110101

Co-expression of recombinant human CYP2C9 with human cytochrome P450 reductase in protease deficient S. cerevisiae strain at a higher scale yields an enzyme of higher specific activity.

Drug metabolism letters 20101201

Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.

Journal of veterinary pharmacology and therapeutics 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Autophagy induced by ischemic preconditioning is essential for cardioprotection.

Journal of cardiovascular translational research 20100801

Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.

Chemical research in toxicology 20100517

In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine.

Cancer chemotherapy and pharmacology 20100401

7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver.

Analytical biochemistry 20100301

A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo.

Cardiovascular research 20100201

Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.

Toxicological sciences : an official journal of the Society of Toxicology 20100201

Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.

American journal of physiology. Heart and circulatory physiology 20100201

The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment.

The Journal of clinical endocrinology and metabolism 20100201

High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes.

Veterinary journal (London, England : 1997) 20100101

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.

Drug metabolism and disposition: the biological fate of chemicals 20100101

Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

Testosterone-metabolizing capacity and characteristics of adrenal microsomes in human fetus in vitro.

Journal of pediatric endocrinology & metabolism : JPEM 20100101

Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size.

Journal of pharmacological sciences 20100101

Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer.

Oxidative medicine and cellular longevity 20100101

Effects of CYP2C9*3 and CYP2C9*13 on Diclofenac Metabolism and Inhibition-based Drug-Drug Interactions.

Drug metabolism and pharmacokinetics 20100101

Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.

Biological & pharmaceutical bulletin 20100101

Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism.

PloS one 20100101

20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.

The Journal of pharmacology and experimental therapeutics 20091201

Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.

The Journal of pharmacy and pharmacology 20091201

Letter by Brown and Pretorius regarding article, 'effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients'.

Circulation 20091110

Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes.

Basic & clinical pharmacology & toxicology 20091101

[Metabolism of osthol in isolated hepatocytes of rat].

Yao xue xue bao = Acta pharmaceutica Sinica 20091001

Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.

Chemical research in toxicology 20090901

Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.

Drug metabolism and disposition: the biological fate of chemicals 20090801

The role of nitric oxide- and prostacyclin-independent vasodilatation in the human cutaneous microcirculation: effect of cytochrome P450 2C9 inhibition.

Clinical physiology and functional imaging 20090701

Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes.

Toxicology letters 20090622

Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats.

European journal of pharmacology 20090602

As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.

The Journal of pharmacology and experimental therapeutics 20090601

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.

Toxicology in vitro : an international journal published in association with BIBRA 20090601

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Journal of medicinal chemistry 20090423

Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.

Chemico-biological interactions 20090415

Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation.

Antioxidants & redox signaling 20090401

In vitro cytochrome p450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: possible occurrence of this metabolite in vivo.

International journal of molecular sciences 20090401

Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients.

Circulation 20090331

Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation.

Journal of lipid research 20090201

Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugs N-(1-phenyl cyclohexyl)-2-ethoxyethanamine and N-(1-phenylcyclohexyl)-2-methoxyethanamine.

Biochemical pharmacology 20090201

Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.

The Journal of pharmacy and pharmacology 20090101

Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety.

Arzneimittel-Forschung 20090101

In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

Journal of medicinal chemistry 20081225

CYP2C9-catalyzed metabolism of S-warfarin to 7-hydroxywarfarin in vivo and in vitro in chimeric mice with humanized liver.

Drug metabolism and disposition: the biological fate of chemicals 20081201

Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.

Drug metabolism and disposition: the biological fate of chemicals 20081201

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes.

Acta pharmacologica Sinica 20081201

Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.

Journal of medicinal chemistry 20081009

Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans.

Journal of applied physiology (Bethesda, Md. : 1985) 20081001

A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.

Drug metabolism and disposition: the biological fate of chemicals 20080901

Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells.

Journal of pharmacological sciences 20080901

[Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.

Interdisciplinary toxicology 20080901

Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.

Journal of medicinal chemistry 20080828

Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080801

Effects of cytochrome P450 (CYP) inducers and inhibitors on ondansetron pharmacokinetics in rats: involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism.

The Journal of pharmacy and pharmacology 20080701

Application of micellar electrokinetic capillary chromatography for evaluation of inhibitory effects on cytochrome P450 reaction.

Journal of chromatography. A 20080502

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.

The Journal of steroid biochemistry and molecular biology 20080501

Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

Journal of medicinal chemistry 20080410

Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry.

Journal of inorganic biochemistry 20080401

Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.

Acta pharmacologica Sinica 20080301

Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.

Investigative ophthalmology & visual science 20080301

Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

Investigational new drugs 20080201

Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.

Circulation research 20080104

Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.

Vascular pharmacology 20080101

Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

PloS one 20080101

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.

Journal of pharmacological and toxicological methods 20080101

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

Journal of medicinal chemistry 20071213

Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species.

The Journal of pharmacology and experimental therapeutics 20071201

Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination.

British journal of clinical pharmacology 20071001

In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

Journal of pharmaceutical sciences 20070901

Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.

Investigative ophthalmology & visual science 20070901

Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure.

European journal of heart failure 20070801

Chronic nitric oxide synthase inhibition blunts endothelium-dependent function of conduit coronary arteries, not arterioles.

American journal of physiology. Heart and circulatory physiology 20070601

[Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

Yao xue xue bao = Acta pharmaceutica Sinica 20070601

Visible spectra of type II cytochrome P450-drug complexes: evidence that 'incomplete' heme coordination is common.

Drug metabolism and disposition: the biological fate of chemicals 20070401

Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries.

Naunyn-Schmiedeberg's archives of pharmacology 20070401

Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.

Life sciences 20070320

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

Drug metabolism and disposition: the biological fate of chemicals 20070301

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.

Journal of medicinal chemistry 20070222

Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.

Investigative ophthalmology & visual science 20070201

CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.

Acta pharmacologica Sinica 20070101

In-vitro antifungal activities of sulfa drugs against clinical isolates of Aspergillus and Cryptococcus species.

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101

Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs.

Journal of vascular research 20070101

Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products.

Canadian journal of physiology and pharmacology 20070101

Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions.

Biochemical pharmacology 20061215

Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes.

Toxicology and applied pharmacology 20061215

Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.

Toxicological sciences : an official journal of the Society of Toxicology 20061201

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

PLoS medicine 20061101

Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.

British journal of pharmacology 20061001

[The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].

Yao xue xue bao = Acta pharmaceutica Sinica 20061001

Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.

Acta pharmacologica Sinica 20060901

Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode.

Drug metabolism and disposition: the biological fate of chemicals 20060801

Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060801

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone.

European journal of clinical pharmacology 20060801

Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients.

Journal of the American College of Cardiology 20060801

Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats.

Biopharmaceutics & drug disposition 20060701

Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats.

Life sciences 20060530

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies.

Acta pharmacologica Sinica 20060501

Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.

Biochemical pharmacology 20060428

Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.

Hypertension (Dallas, Tex. : 1979) 20060401

Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats.

The Journal of pharmacy and pharmacology 20060401

Role of vascular heme oxygenase in reduced myogenic reactivity following chronic hypoxia.

Microcirculation (New York, N.Y. : 1994) 20060301

Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.

Toxicology 20060201

Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

Chemical research in toxicology 20060101

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

Clinical pharmacokinetics 20060101

Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

Journal of cell science 20051201

Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20051101

Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation.

British journal of pharmacology 20051101

Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.

Circulation research 20051028

Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.

Vascular pharmacology 20051001

Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20050801

Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.

Drug metabolism and disposition: the biological fate of chemicals 20050801

Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats.

Peptides 20050801

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

Xenobiotica; the fate of foreign compounds in biological systems 20050801

Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats.

International journal of pharmaceutics 20050714

Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism.

Drug metabolism and disposition: the biological fate of chemicals 20050701

Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

Journal of medicinal chemistry 20050602

Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.

Drug metabolism and disposition: the biological fate of chemicals 20050601

The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

Journal of clinical pharmacology 20050601

Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.

Vascular pharmacology 20050601

Electrochemical characterisation of the human cytochrome P450 CYP2C9.

Biochemical pharmacology 20050515

Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9.

Kidney international 20050501

Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.

British journal of clinical pharmacology 20050501

Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.

The Journal of pharmacy and pharmacology 20050401

Role of human liver cytochrome P450 2C9 in the metabolism of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.

Drug metabolism and pharmacokinetics 20050401

Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium.

Vascular health and risk management 20050301

Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology 20050201

The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation.

Cardiovascular research 20050201

SuperLigands - a database of ligand structures derived from the Protein Data Bank.

BMC bioinformatics 20050101

Simultaneous determination of 16 sulfonamides in honey by liquid chromatography/tandem mass spectrometry.

Journal of AOAC International 20050101

Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.

Biochemistry 20041214

Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo.

Drug metabolism and disposition: the biological fate of chemicals 20041201

The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol.

Drug metabolism and disposition: the biological fate of chemicals 20041101

Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.

Expert opinion on therapeutic targets 20041001

Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways.

Journal of applied physiology (Bethesda, Md. : 1985) 20040901

Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.

European journal of pharmacology 20040823

Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.

Chemical research in toxicology 20040801

Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.

Drug metabolism and pharmacokinetics 20040801

The mechanism of EDHF-mediated responses in subcutaneous small arteries from healthy pregnant women.

American journal of physiology. Regulatory, integrative and comparative physiology 20040601

Validated assays for human cytochrome P450 activities.

Drug metabolism and disposition: the biological fate of chemicals 20040601

Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man.

Xenobiotica; the fate of foreign compounds in biological systems 20040501

Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.

Xenobiotica; the fate of foreign compounds in biological systems 20040401

In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily.

Drug metabolism and disposition: the biological fate of chemicals 20040301

Mediators of bradykinin-induced vasorelaxation in human coronary microarteries.

Hypertension (Dallas, Tex. : 1979) 20040201

Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors.

Drug metabolism and pharmacokinetics 20040201

Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease.

Circulation 20040120

Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.

Journal of vascular research 20040101

Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone.

Xenobiotica; the fate of foreign compounds in biological systems 20040101

Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells.

Journal of the American College of Nutrition 20031201

Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.

Xenobiotica; the fate of foreign compounds in biological systems 20031201

Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole.

Clinical science (London, England : 1979) 20031001

Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery.

Hypertension (Dallas, Tex. : 1979) 20031001

Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

European journal of biochemistry 20030901

Role of human hepatic cytochrome P-450s in territrem A metabolism.

Journal of toxicology and environmental health. Part A 20030711

Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia.

American journal of physiology. Heart and circulatory physiology 20030701

Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.

Arteriosclerosis, thrombosis, and vascular biology 20030701

Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.

Drug metabolism and disposition: the biological fate of chemicals 20030701

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

Drug metabolism and disposition: the biological fate of chemicals 20030701

Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.

Biochemistry 20030603

Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.

Journal of hepatology 20030601

EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs.

American journal of physiology. Heart and circulatory physiology 20030501

Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery.

Kidney international 20030501

Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.

Drug metabolism and disposition: the biological fate of chemicals 20030501

Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation.

Drug metabolism and disposition: the biological fate of chemicals 20030301

Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.

Acta pharmacologica Sinica 20030301

Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.

Hypertension research : official journal of the Japanese Society of Hypertension 20030301

Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

Archives of biochemistry and biophysics 20030101

Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.

Archives of biochemistry and biophysics 20030101

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20030101

Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans.

The Journal of physiology 20030101

Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.

Rapid communications in mass spectrometry : RCM 20030101

Identification of glutathione conjugates of troglitazone in human hepatocytes.

Chemico-biological interactions 20021110

Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries.

Naunyn-Schmiedeberg's archives of pharmacology 20021101

The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles.

American journal of physiology. Heart and circulatory physiology 20020901

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.

Life sciences 20020816

The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

Pharmaceutical research 20020701

Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.

The Journal of biological chemistry 20020503

Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20020501

In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes.

Acta pharmacologica Sinica 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid.

Circulation research 20020419

Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids.

Biochemical pharmacology 20020301

Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.

Pharmacology & toxicology 20020301

Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.

Drug metabolism and disposition: the biological fate of chemicals 20020201

Contribution of cytochrome P450 metabolites to bradykinin-induced vasodilation in endothelial NO synthase deficient mouse hearts.

British journal of pharmacology 20020201

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.

Biochemical and biophysical research communications 20020125

Design and application of fluorometric assays for human cytochrome P450 inhibition.

Methods in enzymology 20020101

Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.

Drug metabolism and pharmacokinetics 20020101

Quantitative determination of sulfonamide in meat by liquid chromatography-electrospray-mass spectrometry.

Talanta 20011224

Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.

Journal of medicinal chemistry 20011025

Interaction of new sulfaphenazole derivatives with human liver cytochrome p450 2Cs: structural determinants required for selective recognition by CYP 2C9 and for inhibition of human CYP 2Cs.

Archives of biochemistry and biophysics 20011015

Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.

Drug metabolism and disposition: the biological fate of chemicals 20010901

Role of CYP2C9 polymorphism in losartan oxidation.

Drug metabolism and disposition: the biological fate of chemicals 20010701

The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells.

Pflugers Archiv : European journal of physiology 20010701

Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20010601

Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.

Toxicology in vitro : an international journal published in association with BIBRA 20010601

Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.

Drug metabolism and disposition: the biological fate of chemicals 20010501

Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors.

Epilepsy research 20010401

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.

European journal of clinical pharmacology 20010401

Metabolic characterization of the major human small intestinal cytochrome p450s.

Drug metabolism and disposition: the biological fate of chemicals 20010301

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Drug metabolism and disposition: the biological fate of chemicals 20010201

Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline.

Pharmacogenetics 20010201

Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

Circulation research 20010119

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals 20010101

Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes.

Acta pharmacologica Sinica 20010101

Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect.

Antimicrobial agents and chemotherapy 20001001

Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.

Toxicological sciences : an official journal of the Society of Toxicology 20000601

Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

The Journal of pharmacology and experimental therapeutics 19980201

Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes.

Xenobiotica; the fate of foreign compounds in biological systems 19980201

Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.

Xenobiotica; the fate of foreign compounds in biological systems 19961201

Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

Annals of tropical medicine and parasitology 19961201

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.

Xenobiotica; the fate of foreign compounds in biological systems 19960701

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.

Biochemical and biophysical research communications 19910329