Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.

Neuroscience and biobehavioral reviews 20120401

A novel ALDH5A1 mutation in a patient with succinic semialdehyde dehydrogenase deficiency.

Pathology 20120401

Crystallization and preliminary X-ray crystallographic studies of succinic semialdehyde dehydrogenase from Streptococcus pyogenes.

Acta crystallographica. Section F, Structural biology and crystallization communications 20120301

A boy with a severe phenotype of succinic semialdehyde dehydrogenase deficiency.

Brain & development 20120201

Ethyl 2-[(2,4-difluoro-phen-yl)hydrazinyl-idene]-3-oxobutano-ate.

Acta crystallographica. Section E, Structure reports online 20120201

The diversity of cyanobacterial metabolism: genome analysis of multiple phototrophic microorganisms.

BMC genomics 20120101

Reconstruction and analysis of a genome-scale metabolic model for Scheffersomyces stipitis.

Microbial cell factories 20120101

Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders.

PloS one 20120101

ArgR of Streptomyces coelicolor is a versatile regulator.

PloS one 20120101

Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.

PloS one 20120101

Gain and loss of phototrophic genes revealed by comparison of two Citromicrobium bacterial genomes.

PloS one 20120101

The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected].

PloS one 20120101

The tricarboxylic acid cycle in cyanobacteria.

Science (New York, N.Y.) 20111216

Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi.

Journal of neuropathology and experimental neurology 20111201

A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.

The Journal of biological chemistry 20111111

Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development.

Journal of experimental botany 20111101

4-[(2,4-Difluoro-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Acta crystallographica. Section E, Structure reports online 20111101

Epilepsy in succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism.

Brain & development 20111001

4-[2-(4-Chloro-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Acta crystallographica. Section E, Structure reports online 20111001

4-[2-(4-Bromo-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Acta crystallographica. Section E, Structure reports online 20111001

Ethyl 2-[2-(3-meth-oxy-phen-yl)hydrazinyl-idene]-3-oxobutano-ate.

Acta crystallographica. Section E, Structure reports online 20111001

[Succinic semialdehyde dehydrogenase deficiency].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110901

Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance.

Antioxidants & redox signaling 20110801

Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.

Plant & cell physiology 20110801

Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.

Biochemical and biophysical research communications 20110715

The Agrobacterium tumefaciens transcription factor BlcR is regulated via oligomerization.

The Journal of biological chemistry 20110610

Familial 6p22.2 duplication associates with mild developmental delay and increased SSADH activity.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20110601

The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells.

Chemico-biological interactions 20110530

Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia.

Journal of proteome research 20110506

On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis.

Archives of biochemistry and biophysics 20110501

GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.

Biochemical and biophysical research communications 20110401

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20110301

4-Hydroxybutyric aciduria associated with catheter usage: a diagnostic pitfall in the identification of SSADH deficiency.

Molecular genetics and metabolism 20110201

The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae.

PLoS pathogens 20110201

Glutamate synthase, but not GABA shunt enzymes, contributes to nitrogen metabolism of the sheep abomasal nematode parasites Haemonchus contortus and Teladorsagia circumcincta.

Experimental parasitology 20110101

A modified rapid enzymatic microtiter plate assay for the quantification of intracellular γ-aminobutyric acid and succinate semialdehyde in bacterial cells.

Journal of microbiological methods 20110101

A Role for GAT-1 in Presynaptic GABA Homeostasis?

Frontiers in cellular neuroscience 20110101

Aberrant GABA(A) receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice.

PloS one 20110101

The impact of oxygen on the transcriptome of recombinant S. cerevisiae and P. pastoris - a comparative analysis.

BMC genomics 20110101

Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis.

BMC genomics 20110101

A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.

BMC systems biology 20110101

Network neighbors of drug targets contribute to drug side-effect similarity.

PloS one 20110101

Comparative analyses imply that the enigmatic Sigma factor 54 is a central controller of the bacterial exterior.

BMC genomics 20110101

Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors.

Advances in pharmacological sciences 20110101

Investigation of the adaptation of Lactococcus lactis to isoleucine starvation integrating dynamic transcriptome and proteome information.

Microbial cell factories 20110101

Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening.

BMC plant biology 20110101

Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation.

BMC genomics 20110101

Dynamic proteomic profiling of a unicellular cyanobacterium Cyanothece ATCC51142 across light-dark diurnal cycles.

BMC systems biology 20110101

Aldehyde Dehydrogenases in Arabidopsis thaliana: Biochemical Requirements, Metabolic Pathways, and Functional Analysis.

Frontiers in plant science 20110101

Cerebellar atrophy in human and murine succinic semialdehyde dehydrogenase deficiency.

Journal of child neurology 20101201

Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice.

Experimental neurology 20100901

Metabolic alterations in organic acids and gamma-aminobutyric acid in developing tomato (Solanum lycopersicum L.) fruits.

Plant & cell physiology 20100801

Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli.

Metabolic engineering 20100701

Head bobbing due to succinic semialdehyde dehydrogenase deficiency.

Neurology 20100615

Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).

Epilepsy research 20100601

Sleep disorders in succinic semialdehyde dehydrogenase deficiency: a family report.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20100501

Atlas of rice grain filling-related metabolism under high temperature: joint analysis of metabolome and transcriptome demonstrated inhibition of starch accumulation and induction of amino acid accumulation.

Plant & cell physiology 20100501

Neuropathology in succinic semialdehyde dehydrogenase deficiency.

Pediatric neurology 20100401

Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria.

Human mutation 20100301

Glycolysis and the tricarboxylic acid cycle are linked by alanine aminotransferase during hypoxia induced by waterlogging of Lotus japonicus.

Plant physiology 20100301

Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase.

Biochemistry 20100216

[Succinic semialdehyde dehydrogenase deficiency: decrease in 4-OH-butyric acid levels with low doses of vigabatrin].

Anales de pediatria (Barcelona, Spain : 2003) 20100201

A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy.

Journal of inherited metabolic disease 20100201

Crystal structure of non-redox regulated SSADH from Escherichia coli.

Biochemical and biophysical research communications 20100129

The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance.

BMC plant biology 20100101

Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion.

BMC genomics 20100101

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

PloS one 20100101

The complete genome sequence of Cupriavidus metallidurans strain CH34, a master survivalist in harsh and anthropogenic environments.

PloS one 20100101

Expression of GABAergic receptors in mouse taste receptor cells.

PloS one 20100101

Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis.

BMC systems biology 20100101

The arthrobacter arilaitensis Re117 genome sequence reveals its genetic adaptation to the surface of cheese.

PloS one 20100101

Interaction with diurnal and circadian regulation results in dynamic metabolic and transcriptional changes during cold acclimation in Arabidopsis.

PloS one 20100101

Targeting the OB-Folds of Replication Protein A with Small Molecules.

Journal of nucleic acids 20100101

Polysomnographic abnormalities in succinic semialdehyde dehydrogenase (SSADH) deficiency.

Sleep 20091201

Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL of Corynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases.

Molecular microbiology 20091101

Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.

Journal of the neurological sciences 20091015

Role of plant glyoxylate reductases during stress: a hypothesis.

The Biochemical journal 20091001

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency.

Neurology 20090811

Ethyl 2-[(2,6-dimethyl-phen-yl)hydrazono]-3-oxobutanoate.

Acta crystallographica. Section E, Structure reports online 20090701

The characteristics and mechanisms of pyridine biodegradation by Streptomyces sp.

Journal of hazardous materials 20090615

Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli.

The Journal of biological chemistry 20090612

Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men.

Journal of inherited metabolic disease 20090601

Sensory integration intervention: historical concepts, treatment strategies and clinical experiences in three patients with succinic semialdehyde dehydrogenase (SSADH) deficiency.

Journal of inherited metabolic disease 20090601

Neuroimaging findings in children with paediatric neurotransmitter diseases.

Journal of inherited metabolic disease 20090601

Ethyl 2-[(3-chloro-phen-yl)hydrazono]-3-oxobutanoate.

Acta crystallographica. Section E, Structure reports online 20090601

Ethyl 2-[(4-chloro-phen-yl)hydrazono]-3-oxobutanoate.

Acta crystallographica. Section E, Structure reports online 20090501

Redox-switch modulation of human SSADH by dynamic catalytic loop.

The EMBO journal 20090408

The conserved R166 residue of ALDH5A (succinic semialdehyde dehydrogenase) has multiple functional roles.

Chemico-biological interactions 20090316

The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1(-/-) mice.

Biochimica et biophysica acta 20090301

Detection of an L-amino acid dehydrogenase activity in Synechocystis sp. PCC 6803.

Journal of experimental botany 20090301

GrowMatch: an automated method for reconciling in silico/in vivo growth predictions.

PLoS computational biology 20090301

Gamma-hydroxybutyric acid and its relevance in neurology.

Neurology 20090120

Insight into the molecular requirements for pathogenicity of Fusarium oxysporum f. sp. lycopersici through large-scale insertional mutagenesis.

Genome biology 20090101

Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency.

Human genomics 20090101

Comparative proteomics analyses reveal the virB of B. melitensis affects expression of intracellular survival related proteins.

PloS one 20090101

An ATP and oxalate generating variant tricarboxylic acid cycle counters aluminum toxicity in Pseudomonas fluorescens.

PloS one 20090101

Polymorphism in the flanking regions of the PbGP43 gene from the human pathogen Paracoccidioides brasiliensis: search for protein binding sequences and poly(A) cleavage sites.

BMC microbiology 20090101

Deep RNA sequencing of L. monocytogenes reveals overlapping and extensive stationary phase and sigma B-dependent transcriptomes, including multiple highly transcribed noncoding RNAs.

BMC genomics 20090101

Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature.

Genome biology and evolution 20090101

SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex.

Journal of inherited metabolic disease 20081201

'Succinic semialdehyde dehydrogenase deficiency: phenotype evolution in an adolescent patient at 20-year follow-up'.

Developmental medicine and child neurology 20081101

Characterization and pharmacology of the GHB receptor.

Annals of the New York Academy of Sciences 20081001

Cognitive functioning and survival in the elderly: the SSADH C538T polymorphism.

Annals of human genetics 20080901

Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: gene identification, biochemical characterization and comparison with the mouse ortholog.

Molecular and biochemical parasitology 20080901

Inherited metabolic diseases in neurodevelopmental and neurobehavioral disorders.

Seminars in pediatric neurology 20080901

Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases.

Biochemical and biophysical research communications 20080801

Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism.

Epilepsy & behavior : E&B 20080801

Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients.

CNS spectrums 20080701

PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099.

Biochemistry 20080610

Molecular cloning, partial genomic structure and functional characterization of succinic semialdehyde dehydrogenase genes from the parasitic insects Lucilia cuprina and Ctenocephalides felis.

Insect molecular biology 20080601

Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification.

Journal of experimental botany 20080601

Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms.

Journal of experimental botany 20080601

Gene identification and characterization of the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid amidohydrolase from Mesorhizobium loti MAFF303099.

Journal of nutritional science and vitaminology 20080601

Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation.

Journal of neurochemistry 20080501

Ketogenic diet: stoking energy stores and still posing questions.

Experimental neurology 20080501

Physiological and molecular adaptations to drought in Andean potato genotypes.

Journal of experimental botany 20080501

Options for biochemical production of 4-hydroxybutyrate and its lactone as a substitute for petrochemical production.

Biotechnology and bioengineering 20080415

A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype.

Experimental neurology 20080401

Functional characterization of a Drosophila melanogaster succinic semialdehyde dehydrogenase and a non-specific aldehyde dehydrogenase.

Insect biochemistry and molecular biology 20080301

Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures.

BMC plant biology 20080101

Rapid acid treatment of Escherichia coli: transcriptomic response and recovery.

BMC microbiology 20080101

Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics.

BMC plant biology 20080101

The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress.

BMC plant biology 20080101

Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.

PloS one 20080101

Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development.

BMC developmental biology 20080101

Global transcriptional responses of Pseudomonas syringae DC3000 to changes in iron bioavailability in vitro.

BMC microbiology 20080101

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling.

Journal of neurochemistry 20071201

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.

The Lancet. Neurology 20071101

Exploration of intraclonal adaptation mechanisms of Pseudomonas brassicacearum facing cadmium toxicity.

Environmental microbiology 20071101

Diagnostic challenges in a severely delayed infant with hypersomnolence, failure to thrive and arteriopathy: a unique case of gamma-hydroxybutyric aciduria and Williams syndrome.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20071005

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice.

Journal of inherited metabolic disease 20071001

Identification of a novel glyoxylate reductase supports phylogeny-based enzymatic substrate specificity prediction.

Biochimica et biophysica acta 20070901

Pseudomonas putida 06909 genes expressed during colonization on mycelial surfaces and phenotypic characterization of mutants.

Journal of applied microbiology 20070701

Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology.

Journal of inherited metabolic disease 20070601

Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent.

Chemical research in toxicology 20070601

Lipid abnormalities in succinate semialdehyde dehydrogenase (Aldh5a1-/-) deficient mouse brain provide additional evidence for myelin alterations.

Biochimica et biophysica acta 20070501

Vigabatrin improves paroxysmal dystonia in succinic semialdehyde dehydrogenase deficiency.

Neurology 20070417

Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice).

Neurochemistry international 20070301

Inhibition of aldehyde detoxification in CNS mitochondria by fungicides.

Neurotoxicology 20070101

Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding.

BMC structural biology 20070101

The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family.

BMC structural biology 20070101

[Role of transamination in the mobilization of respiratory substrates in germinating seeds of castor oil plants].

Prikladnaia biokhimiia i mikrobiologiia 20070101

Comparative genomics of Bordetella pertussis reveals progressive gene loss in Finnish strains.

PloS one 20070101

Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.

BMC medical genetics 20070101

Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803.

BMC genomics 20070101

Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets.

The Biochemical journal 20061115

Global analysis of gene expression during development and ripening of citrus fruit flesh. A proposed mechanism for citric Acid utilization.

Plant molecular biology 20061101

Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens.

Molecular microbiology 20061001

Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100.

Archives of microbiology 20060901

Succinic semialdehyde dehydrogenase (SSADH) deficiency: Molecular analysis in a South American family.

Journal of inherited metabolic disease 20060801

Clinical, cytogenetic and molecular characterization of a patient with combined succinic semialdehyde dehydrogenase deficiency and incomplete WAGR syndrome with obesity.

Molecular genetics and metabolism 20060701

SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.

Journal of molecular evolution 20060701

Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function.

Brain research 20060523

Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain.

Molecular genetics and metabolism 20060501

D-2-hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon?

Molecular genetics and metabolism 20060501

Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity.

Neuroscience letters 20060424

Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency.

Biochimica et biophysica acta 20060401

Final steps in the catabolism of nicotine.

The FEBS journal 20060401

Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase.

Metabolism: clinical and experimental 20060301

Succinic semialdehyde dehydrogenase deficiency: clinical, biochemical and molecular characterization of a new patient with severe phenotype and a novel mutation.

Clinical genetics 20060301

Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.

Bioorganic & medicinal chemistry letters 20060201

Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency.

Journal of inherited metabolic disease 20060201

Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms.

Annals of neurology 20060101

Predicting genes for orphan metabolic activities using phylogenetic profiles.

Genome biology 20060101

The genome of Rhizobium leguminosarum has recognizable core and accessory components.

Genome biology 20060101

A human derived SSADH coding variant is replacing the ancestral allele shared with primates.

Annals of human biology 20060101

High-level expression and characterization of the recombinant enzyme, and tissue distribution of human succinic semialdehyde dehydrogenase.

Protein expression and purification 20051101

In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica.

Phytotherapy research : PTR 20051001

[Autism and metabolic disorders-a rational approach].

Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20051001

Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype.

IUBMB life 20050901

[Construction of recombinant Escherichia coli strains producing poly (4-hydroxybutyric acid) homopolyester from glucose].

Wei sheng wu xue bao = Acta microbiologica Sinica 20050601

Effect of genetically caused excess of brain gamma-hydroxybutyric acid and GABA on sleep.

Sleep 20050401

A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.

The Journal of biological chemistry 20050211

GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants.

FEBS letters 20050117

Gamma-hydroxybutyric aciduria: a biochemist's education from a heritable disorder of GABA metabolism.

Journal of inherited metabolic disease 20050101

[Chronic morphine intoxication and metabolism of neuroactive amino acids in the rat brain].

Biomeditsinskaia khimiia 20050101

[The role of succinate dehydrogenase in bacterial resistance to the delta endotoxins of Bacillus thuringiensis].

Mikrobiologiia 20050101

Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency.

Journal of inherited metabolic disease 20050101

Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops.

Journal of biomedicine & biotechnology 20050101

Brain succinic semialdehyde dehydrogenase. Reactions of sulfhydryl residues connected with catalytic activity.

European journal of biochemistry 20041201

Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy.

Pharmacology, biochemistry, and behavior 20041101

The assimilation of gamma-butyrolactone in Agrobacterium tumefaciens C58 interferes with the accumulation of the N-acyl-homoserine lactone signal.

Molecular plant-microbe interactions : MPMI 20040901

Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.

Molecular psychiatry 20040801

Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency.

Neurobiology of disease 20040801

Neurodevelopmental pattern of succinic semialdehyde dehydrogenase deficiency (gamma-hydroxybutyric aciduria).

Developmental medicine and child neurology 20040801

The ALDH gene superfamily of Arabidopsis.

Trends in plant science 20040801

A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.

Molecular psychiatry 20040601

Photosensitive absence epilepsy with myoclonias and heterozygosity for succinic semialdehyde dehydrogenase (SSADH) deficiency.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20040601

Clinical aspects of the disorders of GABA metabolism in children.

Current opinion in neurology 20040401

Monitoring gamma-hydroxybutyric acid levels in succinate-semialdehyde dehydrogenase deficiency.

Annals of neurology 20040401

The molecular basis of succinic semialdehyde dehydrogenase deficiency in one family.

Molecular genetics and metabolism 20040401

Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency.

Molecular therapy : the journal of the American Society of Gene Therapy 20040401

Proton MR spectroscopy in succinic semialdehyde dehydrogenase deficiency.

Neurology 20040323

Mental retardation and hypotonia seen in the knock out mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency.

Neuroscience letters 20040318

Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase.

Toxicology letters 20040314

GABA in plants: just a metabolite?

Trends in plant science 20040301

Reliable, sensitive, rapid and quantitative enzyme-based assay for gamma-hydroxybutyric acid (GHB).

Journal of forensic sciences 20040301

8-cyclopentadienyltricarbonyl 99mtc 8-oxooctanoic acid: a novel radiotracer for evaluation of medium chain fatty acid metabolism in the liver.

Bioconjugate chemistry 20040101

Sedation with 4-hydroxybutyric acid: a potential pitfall in the diagnosis of SSADH deficiency.

Journal of inherited metabolic disease 20040101

Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria).

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20040101

Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency.

Human mutation 20031201

Steady-state kinetics and molecular evolution of Escherichia coli MenD [(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase], an anomalous thiamin diphosphate-dependent decarboxylase-carboligase.

Biochemistry 20031125

Monitoring of 4-hydroxybutyric acid levels in body fluids during vigabatrin treatment in succinic semialdehyde dehydrogenase deficiency.

Annals of neurology 20031101

A novel gamma-hydroxybutyrate dehydrogenase: identification and expression of an Arabidopsis cDNA and potential role under oxygen deficiency.

The Journal of biological chemistry 20031017

Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria).

Biological psychiatry 20031001

[A case of succinic semialdehyde dehydrogenase deficiency].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20030901

Effect of valproic acid on the urinary metabolic profile of a patient with succinic semialdehyde dehydrogenase deficiency.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030715

Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).

Journal of neurochemistry 20030701

Clinical spectrum of succinic semialdehyde dehydrogenase deficiency.

Neurology 20030513

Cloning and characterization of a gene cluster involved in tetrahydrofuran degradation in Pseudonocardia sp. strain K1.

Archives of microbiology 20030401

The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation.

Neurochemistry international 20030201

Substrate specificity of mouse aldo-keto reductase AKR7A5.

Chemico-biological interactions 20030201

A relational database for the discovery of genes encoding amino acid biosynthetic enzymes in pathogenic fungi.

Comparative and functional genomics 20030201

Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.

Biochimica et biophysica acta 20030120

Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain.

BMC neuroscience 20030101

GABA, gamma-hydroxybutyric acid, and neurological disease.

Annals of neurology 20030101

Vigabatrin and newer interventions in succinic semialdehyde dehydrogenase deficiency.

Annals of neurology 20030101

Succinic semialdehyde dehydrogenase deficiency in children and adults.

Annals of neurology 20030101

Murine succinate semialdehyde dehydrogenase deficiency.

Annals of neurology 20030101

[Dynamics of local oxygen consumption an extraction under the condition of altered oxygen turnover in humans during head-down bed rest].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20030101

Phytol, SSADH inhibitory diterpenoid of Lactuca sativa.

Archives of pharmacal research 20021001

Prenatal diagnosis of succinate semialdehyde dehydrogenase deficiency in non-identical twins.

Journal of inherited metabolic disease 20021001

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.

The Biochemical journal 20020915

Rapid and sensitive detection of urinary 4-hydroxybutyric acid and its related compounds by gas chromatography-mass spectrometry in a patient with succinic semialdehyde dehydrogenase deficiency.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020825

Selective involvement of the globus pallidus and dentate nucleus in succinic semialdehyde dehydrogenase deficiency.

Pediatric radiology 20020801

Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.

Molecular genetics and metabolism 20020801

Spatial and temporal alterations in the GABA shunt in the gerbil hippocampus following transient ischemia.

Brain research 20020719

Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.

FEBS letters 20020717

Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).

The Journal of pharmacology and experimental therapeutics 20020701

GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.

Molecular microbiology 20020701

Purification and characterization of aminobutyraldehyde dehydrogenase from Arthrobacter Sp. TMP-1.

Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) 20020601

Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.

Journal of neurochemistry 20020401

Production of gamma-hydroxybutyric acid in postmortem liver increases with time after death.

Toxicology letters 20020328

Neuroleptic malignant syndrome in a patient with succinic semialdehyde dehydrogenase deficiency.

Pharmacopsychiatry 20020101

Evidence that gamma-aminobutyric acid is a major nitrogen source during Cladosporium fulvum infection of tomato.

Planta 20020101

Mutation analysis in a patient with succinic semialdehyde dehydrogenase deficiency: a compound heterozygote with 103-121del and 1460T > A of the ALDH5A1 gene.

Human heredity 20020101

A unique mouse model for succinic semialdehyde dehydrogenase deficiency with implications for gamma hydroxybutyrate intoxication.

The pharmacogenomics journal 20020101

[Changes in the level of short-chain volatile fatty acids and their aldehydes in oral air and fluid during inflammation of oral tissues].

Patologicheskaia fiziologiia i eksperimental'naia terapiia 20020101

Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.

Nature genetics 20011001

Prenatal diagnosis of succinic semialdehyde dehydrogenase deficiency: increased accuracy employing DNA, enzyme, and metabolite analyses.

Molecular genetics and metabolism 20010301

The first case of 4-hydroxybutyric aciduria in Japan.

Brain & development 20010301

Brain succinic semialdehyde dehydrogenase: identification of reactive lysyl residues labeled with pyridoxal-5'-phosphate.

Journal of neurochemistry 20010201

Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.

The Journal of biological chemistry 20010105

Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

The Biochemical journal 19991015