Home Carboxys (2S)-2-Amino-4-((2-amino-2-carboxyethyl)thio)butanoic acid

(2S)-2-Amino-4-((2-amino-2-carboxyethyl)thio)butanoic acid

CAS No.:
535-34-2
Catalog Number:
AG003U60
Molecular Formula:
C7H14N2O4S
Molecular Weight:
222.2621
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Purity
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Product Description
Catalog Number:
AG003U60
Chemical Name:
(2S)-2-Amino-4-((2-amino-2-carboxyethyl)thio)butanoic acid
CAS Number:
535-34-2
Molecular Formula:
C7H14N2O4S
Molecular Weight:
222.2621
MDL Number:
MFCD28334245
IUPAC Name:
2-amino-4-(2-amino-2-carboxyethyl)sulfanylbutanoic acid
InChI:
InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
InChI Key:
ILRYLPWNYFXEMH-UHFFFAOYSA-N
SMILES:
N[C@H](C(=O)O)CCSCC(C(=O)O)N
NSC Number:
118379
Properties
Complexity:
212  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
222.067g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
222.259g/mol
Monoisotopic Mass:
222.067g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
152A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
-6  
Literature
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Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency. Journal of inherited metabolic disease 20110201
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Foreword to special issue on homocysteine disorders. Journal of inherited metabolic disease 20110201
Hydrogen sulfide inhibits macrophage-derived foam cell formation. Experimental biology and medicine (Maywood, N.J.) 20110201
Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine β-synthase-catalyzed H(2)S generation. Biochemistry 20110125
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Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms. Environmental health perspectives 20110101
Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. Journal of lipid research 20110101
Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. The Journal of pharmacology and experimental therapeutics 20110101
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Nucleotide-induced conformational transitions in the CBS domain protein MJ0729 of Methanocaldococcus jannaschii. Protein engineering, design & selection : PEDS 20110101
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Mechanisms of action of the gasotransmitter hydrogen sulfide in modulating contractile activity of longitudinal muscle of rat ileum. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20110101
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Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase. Journal of clinical biochemistry and nutrition 20110101
Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis. PloS one 20110101
Middle cerebral artery occlusion model in rodents: methods and potential pitfalls. Journal of biomedicine & biotechnology 20110101
Hyperhomocysteinemia decreases bone blood flow. Vascular health and risk management 20110101
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences 20110101
Comparative genomics reveals diversity among xanthomonads infecting tomato and pepper. BMC genomics 20110101
Regulation of vascular tone by adipocytes. BMC medicine 20110101
Genomic heterogeneity within conservedmetabolic pathways of Arthrobacter species - a bioinformatic approach. Bioinformation 20110101
Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients. Cancer cell international 20110101
Of mice and men (and sheep, swine etc.): the intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S). Critical care (London, England) 20110101
High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway. Lipids in health and disease 20110101
Significance of hydrogen sulfide production in the pancreatic β-cell. Journal of pharmacological sciences 20110101
Revealing the beneficial effect of protease supplementation to high gravity beer fermentations using '-omics' techniques. Microbial cell factories 20110101
More than 200 genes required for methane formation from H₂ and CO₂ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus. Archaea (Vancouver, B.C.) 20110101
Cystathionine β-synthase in the central nervous system of the shore crab Hemigrapsus sanguineus. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20110101
Hydrogen sulfide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells. PloS one 20110101
Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae. Microbial cell factories 20110101
New methods to measure residues coevolution in proteins. BMC bioinformatics 20110101
Analysis of common bean expressed sequence tags identifies sulfur metabolic pathways active in seed and sulfur-rich proteins highly expressed in the absence of phaseolin and major lectins. BMC genomics 20110101
Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica. BMC genomics 20110101
Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & metabolism 20110101
Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies. PloS one 20110101
Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review. International journal of molecular sciences 20110101
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PloS one 20110101
Increased fat-free body mass and no adverse effects on blood lipid concentrations 4 weeks after additional meat consumption in comparison with an exclusion of meat in the diet of young healthy women. Journal of nutrition and metabolism 20110101
Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway. PloS one 20110101
Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism? Journal of lipids 20110101
Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors. Molecular vision 20110101
Vitamin E modulates cigarette smoke extract-induced cell apoptosis in mouse embryonic cells. International journal of biological sciences 20110101
Serum methionine metabolites are risk factors for metastatic prostate cancer progression. PloS one 20110101
Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation. BMC genomics 20110101
Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. Journal of toxicology 20110101
Bacterial Catabolism of Dimethylsulfoniopropionate (DMSP). Frontiers in microbiology 20110101
Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PloS one 20110101
Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C. Genetics and molecular biology 20110101
Hydrogen Sulfide in the RVLM and PVN has No Effect on Cardiovascular Regulation. Frontiers in physiology 20110101
Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. PloS one 20110101
Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. PloS one 20110101
Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk. PloS one 20110101
S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling. PloS one 20110101
Protective role of hydrogen sulfide against noise-induced cochlear damage: a chronic intracochlear infusion model. PloS one 20110101
Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects. PloS one 20110101
Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation. BMC genomics 20110101
The MetJ regulon in gammaproteobacteria determined by comparative genomics methods. BMC genomics 20110101
Cystathionine beta-synthase deficiency causes fat loss in mice. PloS one 20110101
Cord blood glutathione depletion in preterm infants: correlation with maternal cysteine depletion. PloS one 20110101
Hydrogen sulfide and the metabolic syndrome. Expert review of clinical pharmacology 20110101
Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential. Expert review of clinical pharmacology 20110101
Therapeutic applications of organosulfur compounds as novel hydrogen sulfide donors and/or mediators. Expert review of clinical pharmacology 20110101
Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Journal of toxicology 20110101
T2DM: Why Epigenetics? Journal of nutrition and metabolism 20110101
Emergent role of gasotransmitters in ischemia-reperfusion injury. Medical gas research 20110101
Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. Journal of biomedicine & biotechnology 20110101
Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice. PloS one 20110101
Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. PloS one 20110101
The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. ISRN neurology 20110101
Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of medicinal chemistry 20101223
Cross-talk between the catalytic core and the regulatory domain in cystathionine β-synthase: study by differential covalent labeling and computational modeling. Biochemistry 20101214
The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction. Age (Dordrecht, Netherlands) 20101201
Preliminary report: hyperhomocysteinemia in patients with acute intermittent porphyria. Metabolism: clinical and experimental 20101201
Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. British journal of pharmacology 20101201
Identification of evolutionarily conserved genetic regulators of cellular aging. Aging cell 20101201
Association of methylenetetrahydrofolate reductase C677T and cystathionine β-synthase polymorphisms in cardiovascular disease in the algerian population. Genetic testing and molecular biomarkers 20101201
Novel alleles of 31-bp VNTR polymorphism in the human cystathionine β-synthase (CBS) gene were detected in healthy Asians. Journal of genetics 20101201
Identification and origin of Nε-homocysteinyl-lysine isopeptide in humans and mice. Amino acids 20101101
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. American journal of physiology. Heart and circulatory physiology 20101101
Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress. American journal of physiology. Heart and circulatory physiology 20101101
Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochemical and biophysical research communications 20101015
Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis. Cardiovascular & hematological agents in medicinal chemistry 20101001
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Molecular genetics and metabolism 20101001
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment. Molecular genetics and metabolism 20101001
Frequency of prothrombotic risk factors in patients with deep venous thrombosis and controls: their implications for thrombophilia screening in Chilean subjects. Genetic testing and molecular biomarkers 20101001
Stacking multiple transgenes at a selected genomic site via repeated recombinase-mediated DNA cassette exchanges. Plant physiology 20101001
The association between CBS 844ins68 polymorphism and head and neck squamous cell carcinoma risk - a case-control analysis. Archives of medical science : AMS 20101001
Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. Journal of hepatology 20100901
Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. Journal of hypertension 20100901
Genomic and epigenomic instability, fragile sites, schizophrenia and autism. Current genomics 20100901
Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli. Analytical biochemistry 20100801
Transcriptional profiles of drought-responsive genes in modulating transcription signal transduction, and biochemical pathways in tomato. Journal of experimental botany 20100801
Residue N84 of yeast cystathionine beta-synthase is a determinant of reaction specificity. Biochimica et biophysica acta 20100701
Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato. Plant physiology 20100701
Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins 20100701
Contribution of dietary intakes of antioxidants to homocysteine-induced low density lipoprotein (LDL) oxidation in atherosclerotic patients. Yonsei medical journal 20100701
Cystathionine beta-synthase mutations: effect of mutation topology on folding and activity. Human mutation 20100701
Artificial tripartite symbiosis involving a green alga (Chlamydomonas), a bacterium (Azotobacter) and a fungus (Alternaria): morphological and physiological characterization. Folia microbiologica 20100701
One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Current genomics 20100601
The pleiotropic CymR regulator of Staphylococcus aureus plays an important role in virulence and stress response. PLoS pathogens 20100501
Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng. Journal of clinical biochemistry and nutrition 20100501
Modulation of Ca(2+) signalling in human vascular endothelial cells by hydrogen sulfide. Atherosclerosis 20100401
Hydrogen sulfide as a gasotransmitter. Journal of neurochemistry 20100401
Major determinants of serum homocysteine concentrations in a Korean population. Journal of Korean medical science 20100401
Investigations of low-frequency vibrational dynamics and ligand binding kinetics of cystathionine beta-synthase. The journal of physical chemistry. B 20100311
Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume. Journal of experimental botany 20100301
Characterization of site-directed mutants of residues R58, R59, D116, W340 and R372 in the active site of E. coli cystathionine beta-lyase. Protein science : a publication of the Protein Society 20100301
Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study. Clinica chimica acta; international journal of clinical chemistry 20100301
Reconstruction of metabolic pathways, protein expression, and homeostasis machineries across maize bundle sheath and mesophyll chloroplasts: large-scale quantitative proteomics using the first maize genome assembly. Plant physiology 20100301
Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver. Journal of clinical biochemistry and nutrition 20100301
Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production. Journal of molecular biology 20100226
Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases. British journal of cancer 20100216
Vitamin B6 metabolism in chronic kidney disease--relation to transsulfuration, advanced glycation and cardiovascular disease. Nephron. Clinical practice 20100101
Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice. Neurochemistry international 20100101
Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase. Nutrition (Burbank, Los Angeles County, Calif.) 20100101
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. PLoS genetics 20100101
Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. BMC medical genetics 20100101
Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition (Burbank, Los Angeles County, Calif.) 20100101
Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status. PloS one 20100101
Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PloS one 20100101
Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects. Journal of biomedicine & biotechnology 20100101
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans. PloS one 20100101
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.). BMC genomics 20100101
Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics. Journal of biomedicine & biotechnology 20100101
A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis. Arthritis research & therapy 20100101
Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans. BMC developmental biology 20100101
Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment 20100101
Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation. BMC microbiology 20100101
alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PloS one 20100101
Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Molecular pain 20100101
Cysteinyl-glycine in the control of glutathione homeostasis in bovine lenses. Molecular vision 20100101
Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance. Diabetology & metabolic syndrome 20100101
Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role? PPAR research 20100101
Mobile genetic element proliferation and gene inactivation impact over the genome structure and metabolic capabilities of Sodalis glossinidius, the secondary endosymbiont of tsetse flies. BMC genomics 20100101
The ascorbic acid content of tomato fruits is associated with the expression of genes involved in pectin degradation. BMC plant biology 20100101
Integrative inference of gene-regulatory networks in Escherichia coli using information theoretic concepts and sequence analysis. BMC systems biology 20100101
Animal models of ischemic stroke. Part one: modeling risk factors. The open neurology journal 20100101
Global regulation of gene expression in response to cysteine availability in Clostridium perfringens. BMC microbiology 20100101
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PloS one 20100101
Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks. BMC medical genomics 20100101
Hydrogen sulfide protects amyloid-β induced cell toxicity in microglia. Journal of Alzheimer's disease : JAD 20100101
The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile. Annals of nutrition & metabolism 20100101
cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PloS one 20100101
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models. PloS one 20100101
The allele frequencies of three polymorphisms in genes involved in homocysteine metabolism in a group of unrelated healthy Singaporeans. Disease markers 20100101
Characteristic metabolism of free amino acids in cetacean plasma: cluster analysis and comparison with mice. PloS one 20100101
Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. PloS one 20100101
Atherogenic factors and their epigenetic relationships. International journal of vascular medicine 20100101
The gasotransmitter hydrogen sulfide in hemodialysis patients. Journal of nephrology 20100101
Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India. Journal of cardiovascular disease research 20100101
Homocysteine is a risk factor in predialysis patients when associated with malnutrition and inflammation. International journal of nephrology 20100101
Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. PloS one 20100101
Possible role of hydrogen sulfide in insulin secretion and in development of insulin resistance. Journal of young pharmacists : JYP 20100101
Homocystinuria: A rare condition presenting as stroke and megaloblastic anemia. Journal of pediatric neurosciences 20100101
Potential for development of an Escherichia coli-based biosensor for assessing bioavailable methionine: a review. Sensors (Basel, Switzerland) 20100101
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Human molecular genetics 20091215
Characterisation of a human liver cystathionine beta synthase mRNA sequence corresponding to the c.[833T>C;844_845ins68] mutation in CBS gene. Molecular and cellular biochemistry 20091201
The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS genetics 20091201
Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate. Pediatric research 20091101
Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. Free radical biology & medicine 20091015
Genetics of human neural tube defects. Human molecular genetics 20091015
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Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications. Assay and drug development technologies 20091001
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Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. American journal of physiology. Gastrointestinal and liver physiology 20090901
Choline and risk of neural tube defects in a folate-fortified population. Epidemiology (Cambridge, Mass.) 20090901
Hydrogen sulphide is involved in testosterone vascular effect. European urology 20090801
Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock. Journal of cellular and molecular medicine 20090801
Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. Molecular genetics and metabolism 20090801
Cystathionine gamma-lyase expression during avian embryogenesis. Journal of anatomy 20090801
The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. Journal of proteome research 20090701
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Molecular characterization of Mycobacterium tuberculosis cystathionine gamma synthase--apo- and holoforms. International journal of biological macromolecules 20090601
Identification and characterization of a strain-dependent cystathionine beta/gamma-lyase in Lactobacillus casei potentially involved in cysteine biosynthesis. FEMS microbiology letters 20090601
Two pathways for cysteine biosynthesis in Leishmania major. The Biochemical journal 20090527
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20090501
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Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery. European heart journal 20090401
Alpha-ketoglutarate protects the liver of piglets exposed during prenatal life to chronic excess of dexamethasone from metabolic and structural changes. Journal of animal physiology and animal nutrition 20090401
Multiple strokes in a newborn. Ophthalmology 20090401
Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutation research 20090331
Birth prevalence of homocystinuria in Central Europe: frequency and pathogenicity of mutation c.1105C>T (p.R369C) in the cystathionine beta-synthase gene. The Journal of pediatrics 20090301
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Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? Journal of cellular and molecular medicine 20090301
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HPLC-electrospray tandem mass spectrometry for simultaneous quantitation of eight plasma aminothiols: application to studies of diabetic nephropathy. Talanta 20090215
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A pathway-specific microarray analysis highlights the complex and co-ordinated transcriptional networks of the developing grain of field-grown barley. Journal of experimental botany 20090101
Population pharmacokinetic/pharmacodynamic analyses of pemetrexed and neutropenia: effect of vitamin supplementation and differences between Japanese and Western patients. Clinical cancer research : an official journal of the American Association for Cancer Research 20090101
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Therapeutic antioxidant medical gas. Journal of clinical biochemistry and nutrition 20090101
The endogenous production of hydrogen sulphide in intrauterine tissues. Reproductive biology and endocrinology : RB&E 20090101
Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids. International journal of biological sciences 20090101
Genome wide expression analysis of CBS domain containing proteins in Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their developmental and stress regulation. BMC genomics 20090101
Predicting metabolic biomarkers of human inborn errors of metabolism. Molecular systems biology 20090101
Differential expression of Gs in a murine model of homocysteinemic heart failure. Vascular health and risk management 20090101
Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters. Molecular systems biology 20090101
The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens. BMC microbiology 20090101
Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. Journal of translational medicine 20090101
Multiple horizontal gene transfer events and domain fusions have created novel regulatory and metabolic networks in the oomycete genome. PloS one 20090101
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Time-resolved transcriptome analysis of Bacillus subtilis responding to valine, glutamate, and glutamine. PloS one 20090101
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Edgetic perturbation models of human inherited disorders. Molecular systems biology 20090101
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Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response, oxidative stress, iron homeostasis and methionine synthesis. BMC genomics 20090101
Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of inflammation (London, England) 20090101
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Inherited trombophilic states and pulmonary embolism. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20090101
Coronary artery dissection in adult-onset homocystinuria. BMJ case reports 20090101
Aspartate-Derived Amino Acid Biosynthesis in Arabidopsis thaliana. The arabidopsis book 20090101
Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: diagnosis in an expanded neonatal screening programme. Journal of inherited metabolic disease 20081201
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. Journal of nutritional science and vitaminology 20081201
Identification and molecular analysis of betaC-S lyase producing hydrogen sulfide in Streptococcus intermedius. Journal of medical microbiology 20081101
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The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance. British journal of cancer 20080805
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Gas chromatographic-mass spectrometric analysis of biomarkers related to folate and cobalamin status in human serum after dimercaptopropanesulfonate reduction and heptafluorobutyl chloroformate derivatization. Analytical chemistry 20080801
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Transcription factors relevant to auxin signalling coordinate broad-spectrum metabolic shifts including sulphur metabolism. Journal of experimental botany 20080701
Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice. PLoS genetics 20080701
Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase. Biochemistry 20080610
Molecular and enzymatic characterization of betaC-S lyase in Streptococcus constellatus. Oral microbiology and immunology 20080601
Application of the Phenomenex EZ:faasttrade mark amino acid analysis kit for rapid gas-chromatographic determination of concentrations of plasma tryptophan and its brain uptake competitors. Amino acids 20080501
Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino acids 20080501
Markers of B-vitamin deficiency and frailty in older women. The journal of nutrition, health & aging 20080501
An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. PLoS computational biology 20080501
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Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase. Biochemistry 20080311
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Patterns of correlation of plasma ceruloplasmin in sepsis. The Journal of surgical research 20080101
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A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1. Molecular systems biology 20080101
H2r: identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments. BMC bioinformatics 20080101
Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. BMC plant biology 20080101
Environmental influences on familial discordance of phenotype in people with homocystinuria: a case report. Journal of medical case reports 20080101
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A flax fibre proteome: identification of proteins enriched in bast fibres. BMC plant biology 20080101
Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae. Genome biology 20080101
The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution. Genome biology 20080101
The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers. BMC plant biology 20080101
An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes, with emphasis on prediction of substrate specificity of transporters. BMC genomics 20080101
Fluctuating Hemiparesis Secondary to Moyamoya Phenomenon in a Child with Down Syndrome: a case report. Cases journal 20080101
Changes induced by dietary energy intake and divergent selection for muscle fat content in rainbow trout (Oncorhynchus mykiss), assessed by transcriptome and proteome analysis of the liver. BMC genomics 20080101
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC biochemistry 20080101
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Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells. American journal of physiology. Cell physiology 20071201
Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process. Biochemistry 20071113
AMPK and SNF1: Snuffing Out Stress. Cell metabolism 20071107
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A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders. Hormone research 20060101
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The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity. Archives of biochemistry and biophysics 20050101
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Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status. Clinical chemistry and laboratory medicine 20050101
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Failure to confirm influence of methyltetrahydrofolate reductase (MTHFR) polymorphisms on age at onset of Huntington disease. Journal of negative results in biomedicine 20050101
Cystathionine beta-synthase T833C/844INS68 polymorphism: a family-based study on mentally retarded children. Behavioral and brain functions : BBF 20050101
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Screening for serum total homocysteine in newborn children. Clinical chemistry 20041001
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Thioether side chain cyclization for helical peptide formation: inhibitors of estrogen receptor-coactivator interactions. The journal of peptide research : official journal of the American Peptide Society 20040301
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Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications. Reproductive biology and endocrinology : RB&E 20040101
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The biosynthesis of cysteine and homocysteine in Methanococcus jannaschii. Biochimica et biophysica acta 20031205
A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana. European journal of biochemistry 20031201
Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. Annals of the New York Academy of Sciences 20031201
Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways. The Journal of biological chemistry 20031024
Cystine uptake prevents production of hydrogen peroxide by Lactobacillus fermentum BR11. FEMS microbiology letters 20031010
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Anaplerotic reactions in tumour proliferation and apoptosis. Biochemical pharmacology 20030801
Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Human molecular genetics 20030715
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Reaction mechanism and regulation of cystathionine beta-synthase. Biochimica et biophysica acta 20030411
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Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects. Molecular genetics and metabolism 20030301
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Differences in the betaC-S lyase activities of viridans group streptococci. Biochemical and biophysical research communications 20030103
Hyperhomocysteinemia and vitamin B-12 deficiency are more striking in Syrians than in Germans--causes and implications. Atherosclerosis 20030101
Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level. Genome biology 20030101
Genetics of hyperhomocysteinaemia in cardiovascular disease. Annals of clinical biochemistry 20030101
Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model. BMC musculoskeletal disorders 20030101
Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress. Cardiovascular diabetology 20030101
Redox regulation of homocysteine-dependent glutathione synthesis. Redox report : communications in free radical research 20030101
Maternal methionine adenosyltransferase I/III deficiency: reproductive outcomes in a woman with four pregnancies. Journal of inherited metabolic disease 20030101
Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides. Biopolymers 20030101
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Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation. The Journal of biological chemistry 20021213
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lcd from Streptococcus anginosus encodes a C-S lyase with alpha,beta-elimination activity that degrades L-cysteine. Microbiology (Reading, England) 20021201
Methionine adenosyltransferase I/III deficiency: two Korean compound heterozygous siblings with a novel mutation. Journal of inherited metabolic disease 20021201
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Beta-replacement reaction of serine-O-carbonate derivatives with thiols catalyzed by a pyridoxal model having an ionophore side-chain. Chemical communications (Cambridge, England) 20020907
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Synthesis of optically active homocysteine from methionine and its use in preparing four stereoisomers of cystathionine. Chemical & pharmaceutical bulletin 20020801
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Peptidolytic, esterolytic and amino acid catabolic activities of selected bacterial strains from the surface of smear cheese. International journal of food microbiology 20020625
Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase. The Journal of biological chemistry 20020621
The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats. Metabolism: clinical and experimental 20020601
Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochemical and biophysical research communications 20020524
Lactobacillus reuteri DSM 20016: purification and characterization of a cystathionine gamma-lyase and use as adjunct starter in cheesemaking. The Journal of dairy research 20020501
Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase. Biochemistry 20020409
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Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake. Journal of the American Geriatrics Society 20020401
Molecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea. Eukaryotic cell 20020401
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Cystathionine pathway-dependent cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived cell cultures. Alternatives to laboratory animals : ATLA 20020101
Subclinical protein malnutrition is a determinant of hyperhomocysteinemia. Nutrition (Burbank, Los Angeles County, Calif.) 20020101
Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme. Journal of inorganic biochemistry 20011215
Metabolism of amino acids in cats with severe cobalamin deficiency. American journal of veterinary research 20011201
Enhanced cystathionine beta-lyase activity in transgenic potato plants does not force metabolite flow towards methionine. Planta 20011201
Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter. The Journal of biological chemistry 20011123
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Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect. American journal of medical genetics 20011001
Nutritional regulation of homocysteine: effects of drugs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20011001
A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum. Journal of industrial microbiology & biotechnology 20011001
The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine. Biochemistry 20010911
Homocysteine levels in patients treated with lipid apheresis: effect of a vitamin therapy. European journal of clinical investigation 20010801
Amino acid catabolism in cheese-related bacteria: selection and study of the effects of pH, temperature and NaCl by quadratic response surface methodology. Journal of applied microbiology 20010801
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein. The EMBO journal 20010801
Total plasma homocysteine and related amino acids in end-stage renal disease (ESRD) patients measured by gas chromatography-mass spectrometry--comparison with the Abbott IMx homocysteine assay and the HPLC method. Clinical chemistry and laboratory medicine 20010801
Genetic defects as important factors for moderate hyperhomocysteinemia. Clinical chemistry and laboratory medicine 20010801
Homocysteine, cystathionine, methylmalonic acid and B-vitamins in patients with renal disease. Clinical chemistry and laboratory medicine 20010801
Does a single vitamin B-supplementation induce functional vitamin B-deficiency? Clinical chemistry and laboratory medicine 20010801
Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circulation research 20010720
Chromatographic method for diaminopimelic acid detection in calcareous rocks. Presence of a bacterial biomarker in stromatolites. Journal of chromatography. A 20010713
Homocysteine metabolism in children with Down syndrome: in vitro modulation. American journal of human genetics 20010701
Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3. The Biochemical journal 20010701
The role of amino acids in the regulation of hydrogen sulfide production during ultradian respiratory oscillation of Saccharomyces cerevisiae. Archives of microbiology 20010701
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme. The Journal of biological chemistry 20010601
Measurement of intracellular sulfur amino acid metabolism in humans. American journal of physiology. Endocrinology and metabolism 20010601
Biosynthesis of methionine from homocysteine, cystathionine and homoserine plus cysteine by mixed rumen microorganisms in vitro. Applied microbiology and biotechnology 20010601
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. American journal of physiology. Endocrinology and metabolism 20010501
Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype. American journal of medical genetics 20010501
Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. European journal of pediatrics 20010501
MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public health nutrition 20010401
[Homocysteine and hyperhomocysteinemia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010301
Homocyst(e)ine metabolism in hemodialysis patients treated with vitamins B6, B12 and folate. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 20010301
Homocysteine, its metabolites, and B-group vitamins in renal transplant patients. Kidney international. Supplement 20010201
Crystallization and preliminary X-ray diffraction analysis of the active core of human recombinant cystathionine beta-synthase: an enzyme involved in vascular disease. Acta crystallographica. Section D, Biological crystallography 20010201
Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-gamma-lyase. Molecular & general genetics : MGG 20010201
Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme. Biochemistry 20010116
Functional properties of the active core of human cystathionine beta-synthase crystals. The Journal of biological chemistry 20010105
ClC chloride channels. Genome biology 20010101
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. Thrombosis and haemostasis 20010101
[Homocysteine, endothelial dysfunction and cardiovascular risk: pathomechanisms and therapeutic options]. Zeitschrift fur Kardiologie 20010101
Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. Gerontology 20010101
Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro. Reproductive toxicology (Elmsford, N.Y.) 20010101
Suicide inactivation of bacterial cystathionine gamma-synthase and methionine gamma-lyase during processing of L-propargylglycine. Biochemistry 19791016
Effects of glutamate and sulphur containing amino acids on ammonia toxicity and methionine sulphoximine convulsions in mice. Brain research 19760618
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