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Home Other Building Blocks Ribavirin 5’-Triphosphate Trisodium Salt

Ribavirin 5’-Triphosphate Trisodium Salt

CAS No.:
63142-71-2
Catalog Number:
AG003U4R
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG003U4R
Chemical Name:
Ribavirin 5’-Triphosphate Trisodium Salt
CAS Number:
63142-71-2
MDL Number:
MFCD15071338
IUPAC Name:
[[(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
InChI:
InChI=1S/C8H15N4O14P3/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(24-8)1-23-28(19,20)26-29(21,22)25-27(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H,19,20)(H,21,22)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1
InChI Key:
MMJOCKKLRMRSEQ-AFCXAGJDSA-N
Properties
Complexity:
761  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
483.98g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
484.143g/mol
Monoisotopic Mass:
483.98g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
283A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-5.7  
Literature
Title Journal
Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites. Bioanalysis 20120801
Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. Journal of medicinal chemistry 20101125
HPLC-MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEM ss cells. Journal of pharmaceutical and biomedical analysis 20090712
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. Journal of medicinal chemistry 20080110
Control of hepatitis C: a medicinal chemistry perspective. Journal of medicinal chemistry 20050113
A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. The Journal of biological chemistry 20040820
Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase. The Journal of biological chemistry 20031226
Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets. Molecular pharmacology 20030301
Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy. Antiviral research 20020901
Mechanism of action of ribavirin in the combination treatment of chronic HCV infection. Hepatology (Baltimore, Md.) 20020501
Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase. Molecular pharmacology 19901201
Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses. Antimicrobial agents and chemotherapy 19860101
Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity. Antimicrobial agents and chemotherapy 19820101
Properties