Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.

Chemico-biological interactions 20140525

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Archives of toxicology 20131101

Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism.

NMR in biomedicine 20121001

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

Cancer research 20121001

Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.

The Journal of biological chemistry 20120928

Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.

Journal of neuroscience methods 20120815

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.

Chemico-biological interactions 20120730

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

Journal of clinical pharmacology 20120601

Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.

Biomaterials 20120601

Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.

Hepato-gastroenterology 20120601

The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes.

Diabetes 20120501

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120501

Treatment for mitochondrial disorders.

The Cochrane database of systematic reviews 20120418

Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.

International journal of cancer 20120401

Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.

Molecular pharmaceutics 20120305

Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

Current protocols in nucleic acid chemistry 20120301

The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice.

Journal of biochemical and molecular toxicology 20120301

Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.

Brain & development 20120201

Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.

Drug metabolism and disposition: the biological fate of chemicals 20120201

The role of low-level lactate production in airway inflammation in asthma.

American journal of physiology. Lung cellular and molecular physiology 20120201

Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.

Biochemical pharmacology 20120201

Dichloroacetate induces different rates of cell death in cancer and noncancer cell lines in vitro.

Tumori 20120101

Synergistic effect of the combination of immobilized TiO2, UVA and ozone on the decomposition of dichloroacetic acid.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

PloS one 20120101

Mitochondrial metabolism - neglected link of cancer transformation and treatment.

Prague medical report 20120101

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage.

PloS one 20120101

Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.

Reproductive sciences (Thousand Oaks, Calif.) 20111201

In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells.

Cell proliferation 20111201

The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37.

Experimental oncology 20111201

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

Oncogene 20110922

Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products.

Journal of hazardous materials 20110915

Why are there no proven therapies for genetic mitochondrial diseases?

Mitochondrion 20110901

Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report.

Journal of palliative medicine 20110801

Removal of dichloroacetic acid from drinking water by using adsorptive ozonation.

Ecotoxicology (London, England) 20110701

Haloacetic acids in swimming pools: swimmer and worker exposure.

Environmental science & technology 20110701

[Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water].

Huan jing ke xue= Huanjing kexue 20110701

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

Circulation 20110607

The effect of dichloroacetate on health- and lifespan in C. elegans.

Biogerontology 20110601

Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.

Biotechnology and bioengineering 20110601

Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes.

Neurotoxicity research 20110501

Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs.

Cancer chemotherapy and pharmacology 20110301

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

International journal of cancer 20110301

High concentrations of dichloroacetate have minor effects on the vitality of the mammalian nerve fibers: an ex-vivo electrophysiological study.

Anti-cancer drugs 20110301

The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

Environmental health perspectives 20110201

Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.

International journal of oncology 20110201

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

The Journal of pharmacology and experimental therapeutics 20110101

Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

Developing new anti-cancer drugs.

Recent patents on anti-cancer drug discovery 20110101

In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110101

On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.

Neoplasia (New York, N.Y.) 20110101

Further optimization of detritylation in solid-phase oligodeoxyribonucleotide synthesis.

Nucleosides, nucleotides & nucleic acids 20110101

Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation.

Annals of nutrition & metabolism 20110101

Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer.

Journal of biomedicine & biotechnology 20110101

Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.

BMC cancer 20110101

Formation of disinfection byproducts in typical Chinese drinking water.

Journal of environmental sciences (China) 20110101

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.

Molecular cancer 20110101

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.

International journal of cancer 20101201

Severe encephalopathy and polyneuropathy induced by dichloroacetate.

Journal of neurology 20101201

Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.

Cancer letters 20101101

Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells.

Journal of biomolecular NMR 20101001

Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings.

Environmental pollution (Barking, Essex : 1987) 20100901

Electromigration diffusivity spectrometry: a way for simultaneous determination of diffusion coefficients from mixed samples.

Electrophoresis 20100901

Oncology's energetic pipeline.

Nature biotechnology 20100901

Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.

Human molecular genetics 20100815

A simple and effective treatment for ectopic sebaceous glands on the areola.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20100801

Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24.

Molecular and cellular biochemistry 20100701

Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.

Journal of applied toxicology : JAT 20100701

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.

British journal of cancer 20100608

Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis.

Lung 20100601

Change of purpose.

Nature 20100520

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

Cell cycle (Georgetown, Tex.) 20100515

Targeting cell metabolism in cancer patients.

Science translational medicine 20100512

Metabolic modulation of glioblastoma with dichloroacetate.

Science translational medicine 20100512

Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.

Circulation. Heart failure 20100501

Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats.

Toxicology and applied pharmacology 20100415

Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401

Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.

Molecular genetics and metabolism 20100301

The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.

Journal of biochemical and molecular toxicology 20100301

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.

Breast cancer research and treatment 20100201

[Cytotoxicity of dichloroacetic acid in lymphocyte and expression of chemokine receptor CXCR2 and chemokine receptor CXCR3 mRNA].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101

Degradation of a mixture of pollutants in water using the UV/H2O2 process.

Water science and technology : a journal of the International Association on Water Pollution Research 20100101

Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products.

Environmental and molecular mutagenesis 20100101

Enhanced ozonation of dichloroacetic acid in aqueous solution using nanometer ZnO powders.

Journal of environmental sciences (China) 20100101

Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.

The Journal of biological chemistry 20091204

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201

Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials.

Journal of hazardous materials 20091115

In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells.

Anticancer research 20091101

Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.

Journal of proteome research 20091001

Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans.

Respiratory physiology & neurobiology 20090930

Zero-valent aluminum for oxidative degradation of aqueous organic pollutants.

Environmental science & technology 20090915

Kinetics and effects of dichloroacetic acid in rainbow trout.

Aquatic toxicology (Amsterdam, Netherlands) 20090914

Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD.

Chest 20090901

Peripheral neuropathy in rats exposed to dichloroacetate.

Journal of neuropathology and experimental neurology 20090901

Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Toxicology 20090821

High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.

Journal of molecular and cellular cardiology 20090701

Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Toxicology and applied pharmacology 20090701

Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.

Biochemical pharmacology 20090415

Treatment for Leigh syndrome by monitoring dichloroacetate concentration.

Pediatrics international : official journal of the Japan Pediatric Society 20090401

Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.

Circulation research 20090327

Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.

Circulation research 20090327

Fate of THMs and HAAs in low TOC surface water.

Environmental research 20090201

The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution.

Organic & biomolecular chemistry 20090107

Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.

Toxicological sciences : an official journal of the Society of Toxicology 20090101

Therapeutic targets in pulmonary arterial hypertension.

Pharmacology & therapeutics 20090101

Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry.

Journal of chromatographic science 20090101

The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

Current pharmaceutical design 20090101

Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice.

Arthritis research & therapy 20090101

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

PloS one 20090101

Dichloroacetate-induced modulation of cellular antioxidant enzyme activities and glutathione level in the J774A.1 cells.

Journal of applied toxicology : JAT 20081101

Visible light photo-oxidations in the presence of alpha-Bi(2)O(3).

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20081101

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.

British journal of cancer 20081007

Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001

Theoretical studies of different tautomers of anti cancer drug: dichloroacetate.

Pakistan journal of pharmaceutical sciences 20081001

The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

Journal of neurochemistry 20080901

Comparison of H2O2/UV and heterogeneous photocatalytic processes for the degradation of dichloroacetic acid in water.

Environmental science & technology 20080815

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation.

The Prostate 20080801

Case: asymptomatic lesions on eyelids.

Geriatrics 20080801

Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080701

Metabolic agents in the management of diabetic coronary patients: a new era.

International journal of cardiology 20080623

Metabolic agents in the management of diabetic coronary patients: a new era.

International journal of cardiology 20080623

Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.

American journal of physiology. Heart and circulatory physiology 20080601

Dichloroacetate induces apoptosis in endometrial cancer cells.

Gynecologic oncology 20080601

Oxidoreductase regulation of Kv currents in rat ventricle.

Journal of molecular and cellular cardiology 20080601

Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine 20080515

Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

Pediatrics 20080501

A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.

Molecular genetics and metabolism 20080401

Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation.

Toxicology 20080312

Kinetics of chloral hydrate and its metabolites in male human volunteers.

Toxicology 20080312

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

The Journal of pharmacology and experimental therapeutics 20080301

Treatment of Fordyce spots with bichloracetic acid.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080301

Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.

Journal of biochemical and molecular toxicology 20080201

Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

Advanced drug delivery reviews 20080101

Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

Critical reviews in toxicology 20080101

Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101

MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.

Analytical chemistry 20071101

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Structure (London, England : 1993) 20070801

Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.

FEBS letters 20070626

Lactate interferes with ATP release from red blood cells.

American journal of physiology. Heart and circulatory physiology 20070601

The beneficial effects of dichloroacetate in acute limb ischemia.

Military medicine 20070601

Trials and tribulations.

Nature reviews. Drug discovery 20070501

Metabolic targeting as an anticancer strategy: dawn of a new era?

Science's STKE : signal transduction knowledge environment 20070410

NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies).

National Toxicology Program genetically modified model report 20070401

Cancer patients opt for unapproved drug.

Nature 20070329

Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts.

Fertility and sterility 20070301

Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes.

Archives of physiology and biochemistry 20070201

Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation.

Chemosphere 20070101

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Cancer cell 20070101

Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.

Journal of neurochemistry 20070101

Modelling the kinetics of UV/H2O2 oxidation of dichloroacetic acid.

Water science and technology : a journal of the International Association on Water Pollution Research 20070101

Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.

Journal of clinical pharmacology 20061201

[Study on rat's DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products].

Wei sheng yan jiu = Journal of hygiene research 20061101

Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.

Toxicology and applied pharmacology 20061015

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Neurology 20061010

Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro.

Reproductive toxicology (Elmsford, N.Y.) 20061001

Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Regulatory toxicology and pharmacology : RTP 20061001

Severe malaria: lessons learned from the management of critical illness in children.

Trends in parasitology 20061001

New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

Anesthesiology 20061001

Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake.

Pflugers Archiv : European journal of physiology 20060901

The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

Seminars in cardiothoracic and vascular anesthesia 20060901

Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

Environmental health perspectives 20060901

Modeling dichloroacetic acid formation from the reaction of monochloramine with natural organic matter.

Water research 20060801

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Neurology 20060711

Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.

Toxicological sciences : an official journal of the Society of Toxicology 20060701

An evidence-based approach to the management of pulmonary arterial hypertension.

Current opinion in cardiology 20060701

A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Circulation 20060606

Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

Mitochondrion 20060601

Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

Biochemical pharmacology 20060528

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.

Pediatrics 20060501

[Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction].

Se pu = Chinese journal of chromatography 20060501

Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model.

Annals of plastic surgery 20060301

Severe malaria: metabolic complications.

Current molecular medicine 20060301

Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit.

Neurology 20060214

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Neurology 20060214

Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.

The Journal of pharmacology and experimental therapeutics 20060201

Treatment for mitochondrial disorders.

The Cochrane database of systematic reviews 20060125

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

Biochemistry 20060117

Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

Drug metabolism and disposition: the biological fate of chemicals 20060101

The effects of cyanobacterial exudates on bacterial growth and biodegradation of organic contaminants.

Microbial ecology 20060101

Pulmonary arterial hypertension: new insights and new hope.

Respirology (Carlton, Vic.) 20060101

A case of Melas (A3243G) on chronic dichloroacetate treatment.

European neurology 20060101

Different net effect of TiO2 sintering temperature on the photocatalytic removal rates of 4-chlorophenol, 4-chlorobenzoic acid and dichloroacetic acid in water.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

Molecular genetics and metabolism 20060101

Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect eye development in the Sprague-Dawley rat?

International journal of toxicology 20060101

Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio).

Journal of biochemical and molecular toxicology 20060101

Malaria and fluids--balancing acts.

Trends in parasitology 20051201

Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.

Mitochondrion 20051201

Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres.

Environmental science & technology 20051115

Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.

Respiratory physiology & neurobiology 20051012

A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.

Biomedical chromatography : BMC 20051001

DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney.

Toxicological sciences : an official journal of the Society of Toxicology 20051001

The relevance of malaria pathophysiology to strategies of clinical management.

Current opinion in infectious diseases 20051001

Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901

Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

Toxicology 20050801

The impacts of cyanobacteria on pulp-and-paper wastewater toxicity and biodegradation of wastewater contaminants.

Canadian journal of microbiology 20050701

Determination of dichloroacetic acid and trichloroacetic acid in drinking water by acidic methanol esterification and headspace gas chromatography.

Water research 20050501

[Adsorption performance of haloacetic acids onto 5 GACs from water].

Huan jing ke xue= Huanjing kexue 20050501

Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.

Circulation 20050426

Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy.

Biochemistry 20050322

Redox regulation of Ito remodeling in diabetic rat heart.

American journal of physiology. Heart and circulatory physiology 20050301

Modulation of the expression of vascular endothelial growth factor in human fibroblasts.

Fertility and sterility 20050201

Chasing the 'ghost' of the acetyl group deficit.

Medicine and science in sports and exercise 20050101

Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos.

Journal of biochemical and molecular toxicology 20050101

Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM 20050101

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

The Journal of physiology 20041215

A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice.

Toxicological sciences : an official journal of the Society of Toxicology 20041201

Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.

Reproductive toxicology (Elmsford, N.Y.) 20041101

Muscle mechanoreceptor sensitivity in heart failure.

American journal of physiology. Heart and circulatory physiology 20041101

Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

Biochemistry 20041026

Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

Toxicology 20041015

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

Circulation research 20041015

Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.

Brain & development 20041001

Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.

Journal of contaminant hydrology 20041001

Binding and kinetic mechanisms of the Zeta class glutathione transferase.

The Journal of biological chemistry 20040806

Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.

Metabolism: clinical and experimental 20040801

Ischemic heart disease: metabolic approaches to management.

Clinical cardiology 20040801

Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.

Toxicology 20040701

Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise.

Medicine and science in sports and exercise 20040701

Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis.

The Journal of laboratory and clinical medicine 20040601

Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.

Chemical research in toxicology 20040501

Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.

The Journal of clinical endocrinology and metabolism 20040401

Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

American journal of obstetrics and gynecology 20040401

Dichloroacetate does not speed phase-II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise.

Pflugers Archiv : European journal of physiology 20040301

[Treatment for mitochondrial diseases].

No to hattatsu = Brain and development 20040301

Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.

Toxicology 20040301

Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice.

Toxicological sciences : an official journal of the Society of Toxicology 20040201

Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS.

Neurology 20040127

Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

Fertility and sterility 20040101

Mechanistic implications of the effect of TiO2 accessibility in TiO2-SiO2 coatings upon chlorinated organics photocatalytic removal in water.

Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Evaluation of the combined solar TiO2/photo-Fenton process using multivariate analysis.

Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats.

Nutrition and cancer 20040101

Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers.

Critical care (London, England) 20040101

Chronic treatment of mitochondrial disease patients with dichloroacetate.

Molecular genetics and metabolism 20040101

Some drinking-water disinfectants and contaminants, including arsenic.

IARC monographs on the evaluation of carcinogenic risks to humans 20040101

Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

IARC monographs on the evaluation of carcinogenic risks to humans 20040101

Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat.

Journal of toxicology and environmental health. Part A 20031212

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

Biochemical pharmacology 20031115

Lactate as a modulator of hypoxia-induced hyperventilation.

Respiratory physiology & neurobiology 20031016

Improvement of thermal hydrolysis rate of dichloroacetic acid using alcohol.

Chemosphere 20031001

Pyruvate and acetate metabolism in termite mitochondria.

Journal of insect physiology 20031001

The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.

Journal of the American College of Surgeons 20031001

Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans.

Journal of applied physiology (Bethesda, Md. : 1985) 20030901

Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy.

Biophysical journal 20030901

Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites.

Journal of molecular and cellular cardiology 20030901

Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation.

Biochimie 20030901

Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

Circulation research 20030808

Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.

Toxicological sciences : an official journal of the Society of Toxicology 20030701

Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.

American journal of physiology. Heart and circulatory physiology 20030701

Efficacy of dichloroacetate as a lactate-lowering drug.

Journal of clinical pharmacology 20030701

The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601

Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin.

Journal of chromatography. A 20030516

Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.

Pediatric research 20030501

Field level evaluation and risk assessment of the toxicity of dichloroacetic acid to the aquatic macrophytes Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum.

Ecotoxicology and environmental safety 20030501

Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

Fertility and sterility 20030501

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

Journal of clinical pharmacology 20030401

[Dichloroacetate treatment for adult patients with mitochondrial disease].

Rinsho shinkeigaku = Clinical neurology 20030401

Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes.

Electrophoresis 20030301

Altered gene expression in mouse livers after dichloroacetic acid exposure.

Mutation research 20030301

Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers.

American journal of physiology. Regulatory, integrative and comparative physiology 20030201

A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.

Environmental health perspectives 20030101

[Adverse effects of dichloroacetate in a girl with mitochondrial disorder].

No to hattatsu = Brain and development 20030101

Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia.

Vascular and endovascular surgery 20030101

The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.

Advances in experimental medicine and biology 20030101

Nephrotoxicity of chlorofluoroacetic acid in rats.

Toxicological sciences : an official journal of the Society of Toxicology 20021201

Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid.

American journal of obstetrics and gynecology 20021201

Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs.

Circulation 20021126

Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.

Chemical research in toxicology 20021101

[Acute complications due to diabetes mellitus: Lactic acidosis].

Nihon rinsho. Japanese journal of clinical medicine 20021001

Is lactate a mediator of hypoxia-induced anapyrexia?

Pflugers Archiv : European journal of physiology 20020901

Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.

Toxicological sciences : an official journal of the Society of Toxicology 20020801

Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.

Environmental health perspectives 20020801

Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.

American journal of physiology. Endocrinology and metabolism 20020701

Manipulations in glycogen metabolism and the failure to influence infarct size in the ischaemic rabbit heart.

European journal of anaesthesiology 20020701

Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).

Chemical research in toxicology 20020701

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Toxicology and applied pharmacology 20020701

Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enhanced photo-Fenton process.

Chemosphere 20020701

Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation.

Pediatric neurology 20020701

Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.

Drug metabolism and disposition: the biological fate of chemicals 20020601

Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.

Toxicology 20020501

[Drug therapy for mitochondrial diseases].

Nihon rinsho. Japanese journal of clinical medicine 20020401

Genetic polymorphisms in assessing interindividual variability in delivered dose.

Regulatory toxicology and pharmacology : RTP 20020401

Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.

Biochemical and biophysical research communications 20020308

Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.

The Journal of physiology 20020215

Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.

Circulation 20020115

Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans.

American journal of physiology. Regulatory, integrative and comparative physiology 20020101

Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.

The Journal of physiology 20020101

Renal manifestations of congenital lactic acidosis.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101

Mouse models of Huntington's disease.

Trends in pharmacological sciences 20020101

Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance.

American journal of respiratory and critical care medicine 20011101

Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.

Carcinogenesis 20010901

Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid.

Carcinogenesis 20010801

Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.

Muscle & nerve 20010701

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Annals of neurology 20010701

Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010601

Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.

American journal of physiology. Heart and circulatory physiology 20010401

Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP).

Biophysical journal 20010401

Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.

Journal of clinical pharmacology 20010301

Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis.

The Pediatric infectious disease journal 20010201

The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters.

Chemosphere 20010101

Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.

Toxicological sciences : an official journal of the Society of Toxicology 20010101

The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.

Journal of biochemical and molecular toxicology 20010101

Lack of IL-6 production during exercise in patients with mitochondrial myopathy.

European journal of applied physiology 20010101

[Benign infantile mitochondrial myopathy].

Ryoikibetsu shokogun shirizu 20010101

Solar detoxification of wastewater in a novel aerated cascade photoreactor (ACP).

Water science and technology : a journal of the International Association on Water Pollution Research 20010101

Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.

Advances in experimental medicine and biology 20010101

Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development?

International journal of toxicology 20010101

Role of metabolically active drugs in the management of ischemic heart disease.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine.

Toxicological sciences : an official journal of the Society of Toxicology 20000401

Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

Pharmacogenetics 20000201

The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.

Cell biology and toxicology 20000101

Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.

Research communications in molecular pathology and pharmacology 20000101

Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.

Biochemical and biophysical research communications 19990907

Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice.

Cancer letters 19961129

Effects of chemical pretreatment on posttraumatic cortical edema in the rat.

The American journal of emergency medicine 19960101

ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.

Carcinogenesis 19941001

The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.

Toxicology and applied pharmacology 19870915

Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases.

Applied and environmental microbiology 19850601