TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Nature neuroscience 20120101

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

PloS one 20120101

γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.

PloS one 20120101

Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.

Frontiers in cellular neuroscience 20120101

A steered molecular dynamics study of binding and translocation processes in the GABA transporter.

PloS one 20120101

Simultaneous quantification of D- vs. L-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: differential modulation by N-methyl-D-aspartate (NMDA) and other pharmacological agents.

Journal of neuroscience methods 20111115

1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.

Bioorganic & medicinal chemistry letters 20110515

Methylone and monoamine transporters: correlation with toxicity.

Current neuropharmacology 20110301

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

Biochimica et biophysica acta 20110101

Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.

Bioorganic & medicinal chemistry letters 20110101

Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia.

Frontiers in systems neuroscience 20110101

Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats.

Neurotoxicology 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Bioorganic & medicinal chemistry 20101101

A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.

Neurochemical research 20100901

Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.

Journal of neurophysiology 20100801

Homology modelling of the GABA transporter and analysis of tiagabine binding.

ChemMedChem 20100705

An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets.

Experimental physiology 20100701

Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.

European journal of medicinal chemistry 20100601

Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.

Neuropharmacology 20100601

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Neuroscience 20100505

N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.

Journal of medicinal chemistry 20100325

Glutamatergic excitation and GABA release from a transplantable cell line.

Cell transplantation 20100101

Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cells.

Drug metabolism and pharmacokinetics 20100101

Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.

Epilepsy research 20091001

Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.

The Journal of physiology 20091001

Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia.

The journal of pain : official journal of the American Pain Society 20091001

Carnitine conjugate of nipecotic acid: a new example of dual prodrug.

Molecules (Basel, Switzerland) 20090831

Calibration of neurotransmitter release from neural cells for therapeutic implants.

International journal of neural systems 20090601

Stereoselective synthesis of nipecotic acid derivatives via palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with imines.

Organic letters 20090115

Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.

Molecular pain 20090101

Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.

Frontiers in neural circuits 20090101

Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.

Anesthesiology 20081201

Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.

European journal of medicinal chemistry 20081101

Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA.

Journal of neurochemistry 20081101

On the presence of 3H-GABA uptake mechanism in bovine spermatozoa.

Animal reproduction science 20081001

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.

Neurobiology of disease 20080601

Water-soluble calix[4]resorcinarenes with hydroxyproline groups as chiral NMR solvating agents.

The Journal of organic chemistry 20080404

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Nature chemical biology 20080401

Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness.

Sleep 20080401

Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.

Toxicology 20080203

Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.

PloS one 20080101

GABA uptake by purified avian Müller glia cells in culture.

Neurotoxicity research 20070901

Uptake and release of [(3)H]GABA in human dental pulp.

Archives of oral biology 20070701

Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.

Bioorganic & medicinal chemistry letters 20070701

Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter.

The Journal of biological chemistry 20070525

Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats.

Life sciences 20070116

Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine.

Neuroscience 20070105

[Tiagabine overdose--report of two cases].

Przeglad lekarski 20070101

Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).

Brain research 20061208

Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.

European journal of pharmacology 20061121

Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.

Neuroscience 20060901

GABAergic mechanisms in regulating the activity state of substantia nigra pars reticulata neurons.

Neuroscience 20060721

Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060701

GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.

Brain research 20060523

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.

Neuroscience letters 20060306

Improvement of metabolic competence of isolated nerve terminals by extracellular pyruvate.

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Journal of medicinal chemistry 20051103

Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.

European journal of pharmacology 20051003

Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.

Journal of neurophysiology 20050901

Anterior hypothalamic neurons respond to blood pressure changes via gamma-aminobutyric acid and angiotensins in rats.

Neuroscience letters 20050826

HPLC conditions are critical for the detection of GABA by microdialysis.

Journal of neurochemistry 20050801

Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.

Neuroreport 20050801

Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.

The Journal of biological chemistry 20050715

Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats.

Pharmaceutical research 20050401

Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.

The Journal of comparative neurology 20050314

Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050301

Thermodynamic study of N-trifluoroacetyl-O-alkyl nipecotic acid ester enantiomers on diluted permethylated beta-cyclodextrin stationary phase.

Journal of chromatography. A 20050204

Stimulated release of exogenous GABA and glutamate from cerebral cortical synaptosomes and brain slices by bis(acetato)tetrakis(imidazole) copper(II) complex.

Biological trace element research 20050101

Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.

Journal of inorganic biochemistry 20041201

Neuronal electrical high frequency stimulation modulates presynaptic GABAergic physiology.

Neuroscience letters 20041123

GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport.

Journal of neurobiology 20041101

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.

Bioorganic & medicinal chemistry 20041015

The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha.

Brain research 20041008

Effect of a high-salt diet on gamma-aminobutyric acid-mediated responses in the nucleus tractus solitarius of Sprague-Dawley rats.

Brain research bulletin 20040930

Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.

Journal of neurochemistry 20040601

Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040601

Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.

Farmaco (Societa chimica italiana : 1989) 20040501

Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.

Neurochemistry international 20040401

Role of taurine uptake on the induction of long-term synaptic potentiation.

The European journal of neuroscience 20040401

Assay for nipecotic acid in small blood samples by gas chromatography-mass spectroscopy.

Journal of pharmaceutical and biomedical analysis 20040310

Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.

Epilepsy research 20040201

Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.

Journal of pharmaceutical sciences 20040101

Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.

British journal of pharmacology 20040101

The 'Transport Specificity Ratio': a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis.

BMC biochemistry 20040101

Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.

The Biochemical journal 20031215

Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.

Brain research 20031212

Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells.

Epilepsy research 20031101

Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.

Archives of pharmacal research 20031001

Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells.

The European journal of neuroscience 20031001

Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030901

Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.

The Journal of physiology 20030801

Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes.

Neurochemistry international 20030601

De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers.

Chemical communications (Cambridge, England) 20030421

Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids.

Bioorganic & medicinal chemistry 20030403

Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

Science (New York, N.Y.) 20030321

Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats.

Journal of neural transmission (Vienna, Austria : 1996) 20030301

Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.

Neurochemistry international 20030101

GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.

American journal of physiology. Regulatory, integrative and comparative physiology 20021201

IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C.

Journal of neuroimmunology 20021201

Expression and functional characterization of GABA transporters in crayfish neurosecretory cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101

GAT-1 and reversible GABA transport in Bergmann glia in slices.

Journal of neurophysiology 20020901

Delta-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters.

British journal of cancer 20020812

Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.

Pain 20020801

GABA is toxic for mouse striatal neurones through a transporter-mediated process.

Journal of neurochemistry 20020801

Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition.

Journal of neuroscience research 20020701

AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.

The European journal of neuroscience 20020701

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus.

Journal of neurochemistry 20020601

Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent.

European journal of pharmacology 20020503

Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.

Pharmacology, biochemistry, and behavior 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.

The Journal of physiology 20020415

Does extracellular calcium determine what pool of GABA is the target for alpha-latrotoxin?

Neurochemistry international 20020401

Functional significance of nitric oxide in ionomycin-evoked [3H]GABA release from mouse cerebral cortical neurons.

Journal of neurochemistry 20020401

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

Journal of medicinal chemistry 20020131

Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.

Glia 20020101

Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.

British journal of pharmacology 20020101

[Effect of synaptosomal cytosolic [3H]GABA pool depletion on secretory ability of alpha-latrotoxin].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101

Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.

The Journal of biological chemistry 20011116

Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.

Bioorganic & medicinal chemistry 20011101

Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

Journal of neurophysiology 20011101

Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal of neurochemistry 20011101

Glutamate receptor desensitization block potentiates the stimulated GABA release through external Ca2+-independent mechanisms from granule cells of olfactory bulb.

Neurochemical research 20011101

Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters.

British journal of pharmacology 20011001

Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.

Journal of neurochemistry 20011001

GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011001

Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex.

Journal of the American Society of Nephrology : JASN 20010901

The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.

Neurochemical research 20010901

Nipecotic acid directly activates GABA(A)-like ion channels.

British journal of pharmacology 20010701

Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

Journal of medicinal chemistry 20010621

Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.

Journal of the American Society of Nephrology : JASN 20010601

GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010415

Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli.

FEBS letters 20010413

Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.

Journal of neuroscience research 20010401

Transport of L-carnitine in isolated cerebral cortex neurons.

European journal of biochemistry 20010401

GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.

Journal of neurophysiology 20010401

Tiagabine in clinical practice.

Epilepsia 20010101

GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

Current pharmaceutical design 20000801

1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.

British journal of pharmacology 19970301