Home Nitriles 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile

6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile

CAS No.:
78415-72-2
Catalog Number:
AG003S4R
Molecular Formula:
C12H9N3O
Molecular Weight:
211.2194
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
98%(HPLC)
In Stock USA
United States
$128
- +
500mg
98%(HPLC)
In Stock USA
United States
$364
- +
1g
98%(HPLC)
In Stock USA
United States
$619
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5g
98%(HPLC)
In Stock USA
United States
$2419
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Product Description
Catalog Number:
AG003S4R
Chemical Name:
6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile
CAS Number:
78415-72-2
Molecular Formula:
C12H9N3O
Molecular Weight:
211.2194
MDL Number:
MFCD00133539
IUPAC Name:
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
InChI:
InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChI Key:
PZRHRDRVRGEVNW-UHFFFAOYSA-N
SMILES:
N#Cc1cc(c2ccncc2)c([nH]c1=O)C
EC Number:
278-903-6
UNII:
JU9YAX04C7
NSC Number:
760072
Properties
Complexity:
419  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
211.075g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
211.224g/mol
Monoisotopic Mass:
211.075g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
65.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0
Literature
Title Journal
A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition. Journal of applied toxicology : JAT 20121201
A comparison of the effects of digoxin, ouabain and milrinone on naloxone-precipitated withdrawal syndrome in mice. European journal of pharmacology 20121105
Pancreatic β-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes. Diabetes, obesity & metabolism 20121101
Synthesis of 2-(4-substitutedbenzylpiperazin-1-yl)-N-(2-oxo-2,3-dihydrobenzooxazol-6-yl)acetamides as inotropic agents. Medicinal chemistry (Shariqah (United Arab Emirates)) 20121101
Phosphodiesterase-III Inhibitors Amrinone and Milrinone on Epilepsy and Cardiovascular Activities. North American journal of medical sciences 20121001
Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): a target for heart failure and platelet aggregation. Bioorganic & medicinal chemistry letters 20120915
Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. European journal of pharmacology 20120905
Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20120901
Various phosphodiesterase activities in different regions of the heart alter the cardiac effects of nitric oxide. Journal of cardiovascular pharmacology 20120901
The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. Toxicology and applied pharmacology 20120901
Safe use of hemodialysis for dabigatran removal before cardiac surgery. The Annals of pharmacotherapy 20120901
Drug-induced atrial fibrillation. Drugs 20120820
Effects of milrinone on left ventricular cardiac function during cooling in an intact animal model. Cryobiology 20120801
Variation in the management of persistent pulmonary hypertension of the newborn: a survey of physicians in Canada, Australia, and New Zealand. American journal of perinatology 20120801
Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties. Bioorganic & medicinal chemistry letters 20120701
[Management of patients with pulmonary hypertension]. Der Anaesthesist 20120701
When the heart runs out of heartbeats: treatment options for refractory end-stage heart failure. Circulation 20120612
Milrinone and homeostasis to treat cerebral vasospasm associated with subarachnoid hemorrhage: the Montreal Neurological Hospital protocol. Neurocritical care 20120601
Seeking new approaches: milrinone in the treatment of cerebral vasospasm. Neurocritical care 20120601
A clinical assay for the measurement of milrinone in plasma by HPLC mass spectrometry. Biomedical chromatography : BMC 20120501
The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. Journal of molecular and cellular cardiology 20120501
[Pharmacotherapy of acute heart failure: update and perspectives]. Deutsche medizinische Wochenschrift (1946) 20120501
Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation. The Journal of pediatrics 20120401
Cardiovascular support in preterm infants: a survey of practices in Australia and New Zealand. Journal of paediatrics and child health 20120401
The 'missing' link between acute hemodynamic effect and clinical response. Journal of cardiovascular translational research 20120401
Global myocardial function is compromised in infants with pulmonary hypertension. Acta paediatrica (Oslo, Norway : 1992) 20120401
Current and novel renal biomarkers in heart failure. Heart failure reviews 20120301
Pre-operative risk factors and clinical outcomes associated with vasoplegia in recipients of orthotopic heart transplantation in the contemporary era. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120301
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. Journal of molecular and cellular cardiology 20120301
Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine. Pediatric research 20120301
Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents. Clinics in perinatology 20120301
Assessment of the heart failure pharmacotherapy of patients with continuous flow left-ventricular assist devices. The International journal of artificial organs 20120301
Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes. Innate immunity 20120201
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. Journal of molecular and cellular cardiology 20120201
Post-operative atrial fibrillation: a maze of mechanisms. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120201
Milrinone and mortality in adult cardiac surgery: a meta-analysis. Journal of cardiothoracic and vascular anesthesia 20120201
Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology 20120201
The use of milrinone in pediatric intensive care medicine. Paediatric anaesthesia 20120201
Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass. Korean journal of anesthesiology 20120201
Early recognition and management of septic shock in children. Pediatric reports 20120102
Cardiorenal syndrome. Heart & lung : the journal of critical care 20120101
Milrinone, a phosphodiesterase III inhibitor, prevents reduction of jugular bulb saturation during rewarming from hypothermic cardiopulmonary bypass. Perfusion 20120101
Preoperative inhalation of milrinone attenuates inflammation in patients undergoing cardiac surgery with cardiopulmonary bypass. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20120101
Preoperative management in patients with single-ventricle physiology. Congenital heart disease 20120101
Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity. Circulation journal : official journal of the Japanese Circulation Society 20120101
Advances in the management of meconium aspiration syndrome. International journal of pediatrics 20120101
Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. Cardiovascular diabetology 20120101
Editorial. Perfusion 20120101
Pharmacologic interventions to improve splanchnic oxygenation during ventilation with positive end-expiratory pressure. Advances in experimental medicine and biology 20120101
The methodology of Doppler-derived central blood flow measurements in newborn infants. International journal of pediatrics 20120101
The role of cilostazol, a phosphodiesterase 3 inhibitor, on oocyte maturation and subsequent pregnancy in mice. PloS one 20120101
Safety and efficacy of sildenafil citrate in reversal of cerebral vasospasm: A feasibility study. Surgical neurology international 20120101
A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat. PloS one 20120101
Heart failure treated with low-dose milrinone in a full-term newborn. Prague medical report 20120101
Left ventricular assist device implantation in high risk destination therapy patients: an alternative surgical approach. Journal of cardiothoracic surgery 20120101
Meningococcal disease serogroup C. Risk management and healthcare policy 20120101
A novel intravital method to evaluate cerebral vasospasm in rat models of subarachnoid hemorrhage: a study with synchrotron radiation angiography. PloS one 20120101
Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evidence-based complementary and alternative medicine : eCAM 20120101
Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure. Circulation journal : official journal of the Japanese Circulation Society 20120101
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PloS one 20120101
Fraud in anaesthetic research and publication. Indian journal of anaesthesia 20120101
Acute biventricular failure as a sequela of multiple autoimmune disorders. The Canadian journal of cardiology 20120101
Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling. PloS one 20120101
Inhaled epoprostenol therapy for pulmonary hypertension: Improves oxygenation index more consistently in neonates than in older children. Pulmonary circulation 20120101
Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy? Diabetes, metabolic syndrome and obesity : targets and therapy 20120101
Spectrophotometric Determination of Mycophenolate Mofetil as Its Charge-Transfer Complexes with Two π-Acceptors. Journal of analytical methods in chemistry 20120101
Milrinone treatment of bovine oocytes during in vitro maturation benefits production of nuclear transfer embryos by improving enucleation rate and developmental competence. The Journal of reproduction and development 20120101
Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibitors administered to mice. Pharmacological reports : PR 20120101
Venous air embolism leading to cardiac arrest in an infant with cyanotic congenital heart disease. Case reports in anesthesiology 20120101
Molecular diagnosis of generalized arterial calcification of infancy (GACI). Journal of cardiovascular disease research 20120101
Combination of β-blocker and milrinone for acute heart failure. Circulation journal : official journal of the Japanese Circulation Society 20120101
The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. PloS one 20120101
Use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients. Neonatology 20120101
Judgment often impossible without randomized trials. Commentary on N. Patel: use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients (Neonatology 2012;102:130-136). Neonatology 20120101
Inhibition of phosphodiesterase type 3 dilates the rat ductus arteriosus without inducing intimal thickening. Circulation journal : official journal of the Japanese Circulation Society 20120101
Vasoactive compounds in the neonatal period. Current medicinal chemistry 20120101
Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis. Clinical & developmental immunology 20120101
Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium. PloS one 20120101
Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia. Advances in experimental medicine and biology 20120101
Perioperative anesthesiological management of patients with pulmonary hypertension. Anesthesiology research and practice 20120101
Prevention for pediatric low cardiac output syndrome: results from the European survey EuLoCOS-Paed. Paediatric anaesthesia 20111201
Relation of milrinone after surgery for congenital heart disease to significant postoperative tachyarrhythmias. The American journal of cardiology 20111201
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's archives of pharmacology 20111201
Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey. Archives of disease in childhood 20111201
Theoretical estimation of cannulation methods for left ventricular assist device support as a bridge to recovery. Journal of Korean medical science 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Fatal pulmonary embolism and coincidental cerebral infarction after spinal anesthesia -A case report-. Korean journal of anesthesiology 20111201
cGMP Signaling, Phosphodiesterases and Major Depressive Disorder. Current neuropharmacology 20111201
Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care? Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20111128
Vassopressors and inotropes. The Medical letter on drugs and therapeutics 20111114
Dose-dependent hemodynamic and metabolic effects of vasoactive medications in normotensive, anesthetized neonatal piglets. Pediatric research 20111101
Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP. Neurochemistry international 20111101
How mechanical circulatory support helps not to need it--new strategies in pediatric heart failure. Artificial organs 20111101
Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. Clinical toxicology (Philadelphia, Pa.) 20111101
[Levosimendan treatment of severe acute congestive heart failure refractory to dobutamine/milrinone in children]. Vojnosanitetski pregled 20111101
[Combination therapy; dobutamine and milrinone]. Nihon rinsho. Japanese journal of clinical medicine 20111101
A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone. Biomedical chromatography : BMC 20111001
Haemodynamically unstable preterm infant: an unresolved management conundrum. European journal of pediatrics 20111001
Unmasking of neonatal renovascular hypertension by milrinone used for cardiac dysfunction. Pediatric cardiology 20111001
Age-dependent effects of milrinone and levosimendan on ventricular function and haemodynamics in newborn and mature pigs. Cardiology in the young 20111001
What's new in the treatment of neonatal shock. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20111001
Renal dysfunction in acute heart failure. Korean circulation journal 20111001
Factors associated with acute kidney injury or failure in children undergoing cardiopulmonary bypass: a case-controlled study. Paediatric anaesthesia 20110801
Newer inotropes in pediatric heart failure. Journal of cardiovascular pharmacology 20110801
Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. American journal of physiology. Regulatory, integrative and comparative physiology 20110801
Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe. Intensive care medicine 20110801
Role of cGMP and cAMP in the hemodynamic response to intrathecal sildenafil administration. Clinics (Sao Paulo, Brazil) 20110801
Pulmonary hypertension in a patient with subarachnoid hemorrhage. Journal of neurosurgical anesthesiology 20110701
Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. British journal of pharmacology 20110701
Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs. European journal of anaesthesiology 20110701
Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure: a report from the korean heart failure registry. Korean circulation journal 20110701
The increase in rat ventricular automaticity induced by salbutamol is mediated through β(1)- but not β(2)-adrenoceptors: role of phosphodiesterases. Life sciences 20110620
Is monitoring milrinone therapy useful in advanced heart failure? International journal of cardiology 20110616
Levosimendan in congenital cardiac surgery: a randomized, double-blind clinical trial. Journal of cardiothoracic and vascular anesthesia 20110601
Simultaneous delivery of inhaled prostacyclin and milrinone through a double nebulizer system. Journal of cardiothoracic and vascular anesthesia 20110601
Anesthetic considerations for the patient undergoing therapy for advanced heart failure. Current opinion in anaesthesiology 20110601
Management of septic shock. Indian journal of pediatrics 20110601
Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovascular drugs and therapy 20110601
Acute heart failure with dyspnoea: initial treatment. Furosemide and trinitrine, despite the lack of a proven survival benefit. Prescrire international 20110601
Effect of milrinone on ischemia-reperfusion injury in the rat kidney. Transplantation proceedings 20110601
Dexmedetomidine does not produce vasocontraction on human isolated gastroepiploic artery. Korean journal of anesthesiology 20110601
Anesthetic management of non-cardiac surgery with adult onset type of cor triatriatum sinister -A case report-. Korean journal of anesthesiology 20110601
[Effect of inhaling specific phosphodiesterase inhibitor on lung injury induced by cardiopulmonary bypass]. Zhonghua yi xue za zhi 20110531
Mechano-energetics of the asynchronous and resynchronized heart. Heart failure reviews 20110501
Electrical modalities beyond pacing for the treatment of heart failure. Heart failure reviews 20110501
New perspectives for the treatment of pulmonary hypertension. British journal of pharmacology 20110501
Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease. Current cardiology reviews 20110501
Immunologic considerations in heart transplantation for congenital heart disease. Current cardiology reviews 20110501
Heart transplantation in biventricular congenital heart disease: indications, techniques, and outcomes. Current cardiology reviews 20110501
Neonatal myocardial infarction or myocarditis? Pediatric cardiology 20110401
The role of milrinone in children with cardiovascular compromise: review of the literature. Wiener medizinische Wochenschrift (1946) 20110401
The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia. Intensive care medicine 20110401
Anesthetic management of aortocaval fistula repair associated with aortic valve replacement, severe aortic regurgitation, and bacterial endocarditis. Journal of anesthesia 20110401
The uncalibrated pulse contour cardiac output during off-pump coronary bypass surgery: performance in patients with a low cardiac output status and a reduced left ventricular function. Korean journal of anesthesiology 20110401
Hospital in the home. Australian family physician 20110401
Complete Repair of Coarctation of the Aorta and a Ventricular Septal Defect in a 1,480 g Low Birth Weight Neonate. The Korean journal of thoracic and cardiovascular surgery 20110401
UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110315
Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease. Intensive care medicine 20110301
Functional antagonism of β-adrenoceptor subtypes in the catecholamine-induced automatism in rat myocardium. British journal of pharmacology 20110301
Aortic atresia is associated with an inferior systemic, cerebral, and splanchnic oxygen-transport status in neonates after the Norwood procedure. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110301
Conserved expression and functions of PDE4 in rodent and human heart. Basic research in cardiology 20110301
Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro. The journal of sexual medicine 20110301
The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. Development (Cambridge, England) 20110301
The effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure. Korean journal of anesthesiology 20110301
Early ischemic lesions following subarachnoid hemorrhage: common cold remedy as precipitating factor? Acta neurologica Belgica 20110301
Mechanism of cardioprotective effect of adenocine and non-glycoside cardiotonic drugs during experimental chronic cardiac insufficiency. Bulletin of experimental biology and medicine 20110301
Angiographic evaluation of the effect of intra-arterial milrinone therapy in patients with vasospasm from aneurysmal subarachnoid hemorrhage. Neuroradiology 20110201
[Anesthetic management for mitral valve replacement in a patient with mitral stenosis and dilated cardiomyopathy]. Masui. The Japanese journal of anesthesiology 20110201
Predictors of low cardiac output in decompensated severe heart failure. Clinics (Sao Paulo, Brazil) 20110201
Determination of olprinone in human plasma utilizing liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20110105
S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evidence-based complementary and alternative medicine : eCAM 20110101
Rotating inotrope therapy in a pediatric population with decompensated heart failure. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20110101
Use of milrinone in the management of haemodynamic instability following duct ligation. European journal of pediatrics 20110101
Synthesis of 2-(4-substitutedbenzyl-[1,4]diazepan-1-yl)-n-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as inotropic agents. Chemical biology & drug design 20110101
The cardiorenal syndrome: making the connection. International journal of nephrology 20110101
Case report and mini literature review: anesthetic management for severe peripartum cardiomyopathy complicated with preeclampsia using sufetanil in combined spinal epidural anesthesia. Yonsei medical journal 20110101
Pharmacotherapy for acute heart failure syndromes. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110101
Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals. Intensive care medicine 20110101
Retraction: Urdaneta F, Willert JL, Beaver T, Naik B, Kirby DS, Lobato EB. Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. Ann Thorac Surg 2004;78:1433–7. The Annals of thoracic surgery 20110101
The cardiorenal syndrome: a review. International journal of nephrology 20110101
Experimental trauma models: an update. Journal of biomedicine & biotechnology 20110101
Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. PloS one 20110101
Acute and critically ill peripartum cardiomyopathy and 'bridge to' therapeutic options: a single center experience with intra-aortic balloon pump, extra corporeal membrane oxygenation and continuous-flow left ventricular assist devices. Critical care (London, England) 20110101
Cardiorenal syndrome in acute heart failure syndromes. International journal of nephrology 20110101
Variation in postoperative care following stage I palliation for single-ventricle patients: a report from the Joint Council on Congenital Heart Disease National Quality Improvement Collaborative. Congenital heart disease 20110101
The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes--a pilot study. Journal of cardiothoracic surgery 20110101
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. PloS one 20110101
Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PloS one 20110101
Hydrogen sulfide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells. PloS one 20110101
[Transesophageal echocardiography in Ross procedure]. Revista brasileira de anestesiologia 20110101
Hyponatremia and congestive heart failure: a marker of increased mortality and a target for therapy. International journal of nephrology 20110101
β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. PloS one 20110101
Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication. Trials 20110101
Prolonged Refractory Hypotension following Combined Amlodipine and Losartan Ingestion Responsive to Metaraminol. Case reports in medicine 20110101
Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials. Critical care (London, England) 20110101
Pulmonary hypertension related to left-sided cardiac pathology. Pulmonary medicine 20110101
Cardiorenal syndrome: an unsolved clinical problem. International journal of nephrology 20110101
Pharmacological management of cardiorenal syndromes. International journal of nephrology 20110101
Cor triatriatum presenting as heart failure with reduced ejection fraction: a case report. Journal of cardiothoracic surgery 20110101
Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications. Virology journal 20110101
High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery. Critical care (London, England) 20110101
Biopsy-Proven Acute Tubular Necrosis due to Vancomycin Toxicity. International journal of nephrology 20110101
Infrared assisted production of 3,4-dihydro-2(1H)-pyridones in solvent-free conditions. International journal of molecular sciences 20110101
Medical research: Is everything all right? Journal of anaesthesiology, clinical pharmacology 20110101
Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats. Evidence-based complementary and alternative medicine : eCAM 20110101
Mouse oocyte microinjection, maturation and ploidy assessment. Journal of visualized experiments : JoVE 20110101
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect. Respiratory research 20110101
Key role of congestion in natural history of heart failure. International journal of general medicine 20110101
Mouse versus rat: Profound differences in meiotic regulation at the level of the isolated oocyte. Molecular reproduction and development 20110101
Single-center experience with levosimendan in children undergoing cardiac surgery and in children with decompensated heart failure. BMC anesthesiology 20110101
Hypocalcemic cardiomyopathy presenting as cardiogenic shock. Annals of pediatric cardiology 20110101
Vitamin D deficiency presenting with cardiogenic shock in an infant. Annals of pediatric cardiology 20110101
Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PloS one 20110101
Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation. BMC systems biology 20110101
High-frequency oscillatory ventilation and short-term outcome in neonates and infants undergoing cardiac surgery: a propensity score analysis. Critical care (London, England) 20110101
Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. Journal of biomedical science 20110101
Myocardial recovery in peri-partum cardiomyopathy after continuous flow left ventricular assist device. Journal of cardiothoracic surgery 20110101
Diagnostic accuracy of pre-operative NT-proBNP level in predicting short-term outcomes in coronary surgery: a pilot study. Kardiologia polska 20110101
Low dose spinal anesthesia for peripartum cardiomyopathy. Journal of anaesthesiology, clinical pharmacology 20110101
A case report and brief review of the literature on bilateral retinal infarction following cardiopulmonary bypass for coronary artery bypass grafting. Journal of cardiothoracic surgery 20110101
Apelin and pulmonary hypertension. Pulmonary circulation 20110101
Dexmedetomidine as the primary anesthetic agent during cardiac surgery in an infant with a family history of malignant hyperthermia. Saudi journal of anaesthesia 20110101
Severe foetal hypertrophic cardiomyopathy evolving to left ventricular non-compaction. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20101201
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. Urology 20101201
Do high-risk infants have a poorer outcome from primary repair of coarctation? Analysis of 192 infants over 20 years. The Annals of thoracic surgery 20101201
Gene expression profiles in human HepG2 cells treated with extracts of the Tamarindus indica fruit pulp. Genes & nutrition 20101201
Amniotic fluid embolism that took place during an emergent Cesarean section -A case report-. Korean journal of anesthesiology 20101201
Hemodynamic support with TandemHeart in tako-tsubo cardiomyopathy - a case report. Archives of medical science : AMS 20101201
Milrinone for persistent pulmonary hypertension of the newborn. The Cochrane database of systematic reviews 20101110
Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3. American journal of hypertension 20101101
Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells. European journal of medicinal chemistry 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Clinical features, diagnosis, and management of enterovirus 71. The Lancet. Neurology 20101101
Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides. Archiv der Pharmazie 20101101
Congestive heart failure in Indians: how do we improve diagnosis & management? The Indian journal of medical research 20101101
Comparative therapeutic efficacy of adenocin and non-glycoside cardiotonic drugs in chronic heart failure at rest and under conditions of heart overload. Bulletin of experimental biology and medicine 20101101
Inhaled nitroglycerin versus inhaled milrinone in children with congenital heart disease suffering from pulmonary artery hypertension. Journal of cardiothoracic and vascular anesthesia 20101001
Early right ventriculo-arterial uncoupling in borderline pulmonary hypertension on experimental heart failure. Journal of applied physiology (Bethesda, Md. : 1985) 20101001
β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation. Anesthesia and analgesia 20101001
Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study. European journal of heart failure 20101001
Inotropic therapy for end-stage heart failure patients. Current treatment options in cardiovascular medicine 20101001
The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging. Clinical and translational science 20101001
The effects of selective and nonselective phosphodiesterase inhibitors on phagocytic cells in mice. Immunopharmacology and immunotoxicology 20100901
Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension. Journal of applied physiology (Bethesda, Md. : 1985) 20100901
Worsening heart failure in the setting of dronedarone initiation. The Annals of pharmacotherapy 20100901
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacological reviews 20100901
[A man with severe dilated cardiomyopathy with implantable cardioverter-defibrillator who underwent sigmoidectomy]. Masui. The Japanese journal of anesthesiology 20100901
Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS genetics 20100901
Combined usage of inhaled and intravenous milrinone in pulmonary hypertension after heart valve surgery. Collegium antropologicum 20100901
pH-Controlled twisted intramolecular charge transfer (TICT) excited state via changing the charge transfer direction. Physical chemistry chemical physics : PCCP 20100821
Use of a hybrid operating room to diagnose and treat delayed coronary spasm after mitral valve repair. The Journal of thoracic and cardiovascular surgery 20100801
Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. Bioorganic & medicinal chemistry letters 20100801
Suppressing apoptosis with milrinone simulating extracorporeal circulation: a pilot study. The Thoracic and cardiovascular surgeon 20100801
The effect of milrinone infusion on right ventricular function during coronary anastomosis and early outcomes in patients undergoing off-pump coronary artery bypass surgery. Korean journal of anesthesiology 20100801
Pharmacological preconditioning by milrinone: memory preserving and neuroprotective effect in ischemia-reperfusion injury in mice. Archives of pharmacal research 20100701
Use of conivaptan for the treatment of symptomatic hyponatremia in a patient with acute decompensated heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100615
Central leptin treatment modulates brain glucosensing function and peripheral energy metabolism of rainbow trout. Peptides 20100601
Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. Intensive care medicine 20100601
Urgent replacement of a mechanical mitral prosthesis in an anticoagulated patient with Bombay red blood cell phenotype. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20100601
Efficacy of milrinone versus nitroglycerin in controlling pulmonary arterial hypertension induced by intravenous injections of absolute ethanol in anesthetized dogs. Journal of vascular and interventional radiology : JVIR 20100601
Community-acquired oseltamivir-resistant pandemic (H1N1) 2009 in child, Israel. Emerging infectious diseases 20100601
Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium. Clinical research in cardiology : official journal of the German Cardiac Society 20100501
Update on anaesthetic approach to pulmonary hypertension. European journal of anaesthesiology 20100401
Milrinone improves diastolic function in coronary artery bypass surgery as assessed by acoustic quantification and peak filling rate: a prospective randomized study. Journal of cardiothoracic and vascular anesthesia 20100401
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management. Current opinion in critical care 20100401
Low central venous pressure with milrinone during living donor hepatectomy. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20100401
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. European heart journal 20100301
Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching. Intensive care medicine 20100301
Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone. Anesthesia and analgesia 20100301
Hybrid palliation for neonates with hypoplastic left heart syndrome: current strategies and outcomes. Korean circulation journal 20100301
[Mulibrey syndrome: anesthetic management]. Revista espanola de anestesiologia y reanimacion 20100301
Non-invasive and quantitative evaluation of peripheral vascular resistances in rats by combined NMR measurements of perfusion and blood pressure using ASL and dynamic angiography. NMR in biomedicine 20100201
Pediatric patients hospitalized with myocarditis: a multi-institutional analysis. Pediatric cardiology 20100201
Effect of arterial oxygen tension during reperfusion on myocardial recovery in patients undergoing valvular heart surgery. Korean journal of anesthesiology 20100201
Effect of preoperative statin therapy on myocardial protection and morbidity endpoints following off-pump coronary bypass surgery in patients with elevated C-reactive protein level. Korean journal of anesthesiology 20100201
Impact of the interval between coronary angiography and off-pump coronary bypass surgery on postoperative renal function. Korean journal of anesthesiology 20100201
Pulmonary hypertension in cardiac surgery. Current cardiology reviews 20100201
Cilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle. Circulation journal : official journal of the Japanese Circulation Society 20100101
Rapid assessment and safe management of severe pulmonary hypertension with milrinone during orthotopic liver transplantation. Clinical transplantation 20100101
Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone. Neurosurgery 20100101
Human cardiac tissue in a microperfusion chamber simulating extracorporeal circulation--ischemia and apoptosis studies. Journal of cardiothoracic surgery 20100101
Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial. Cardiology journal 20100101
Atrial natriuretic peptide regulates Ca channel in early developmental cardiomyocytes. PloS one 20100101
An obstetric emergency called peripartum cardiomyopathy! Journal of emergencies, trauma, and shock 20100101
[Right ventricular dysfunction after left ventricular assist device implantation]. Vnitrni lekarstvi 20100101
Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction. Journal of cardiothoracic surgery 20100101
Effect of levosimendan in experimental verapamil-induced myocardial depression. Scandinavian journal of trauma, resuscitation and emergency medicine 20100101
Metastatic breast cancer or multiple myeloma? Camouflage by lytic lesions. Journal of oncology 20100101
Draining Fluids through a Peritoneal Catheter in Newborns after Cardiac Surgery Helps to Control Fluid Balance. Case reports in medicine 20100101
Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101
Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide-treated with milrinone: a case report. The Turkish journal of pediatrics 20100101
Managing anemia in patients with chronic heart failure: what do we know? Vascular health and risk management 20100101
Quantitative assessment of cardiac load-responsiveness during extracorporeal life support: case and rationale. Journal of cardiothoracic surgery 20100101
Clinical review: practical recommendations on the management of perioperative heart failure in cardiac surgery. Critical care (London, England) 20100101
Nitric oxide and pulmonary hypertension. Korean journal of anesthesiology 20100101
Preoperative diastolic function predicts the onset of left ventricular dysfunction following aortic valve replacement in high-risk patients with aortic stenosis. Critical care (London, England) 20100101
Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry. Critical care (London, England) 20100101
Extravascular lung water index measurement in critically ill children does not correlate with a chest x-ray score of pulmonary edema. Critical care (London, England) 20100101
Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension. Drug design, development and therapy 20100101
MAPK-activated protein kinase 2 is required for mouse meiotic spindle assembly and kinetochore-microtubule attachment. PloS one 20100101
Pediatric Sepsis Guidelines: Summary for resource-limited countries. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20100101
Role of amino acid infusion in delayed recovery from neuromuscular blockers. Indian journal of anaesthesia 20100101
Comparison of the effects of dobutamine and milrinone on hemodynamic parameters and oxygen supply in patients undergoing cardiac surgery with low cardiac output after anesthetic induction. Revista brasileira de anestesiologia 20100101
Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PloS one 20100101
Effects of Dexmedetomidine-Fentanyl Infusion on Blood Pressure and Heart Rate during Cardiac Surgery in Children. Anesthesiology research and practice 20100101
Fulminant enterovirus 71 infection: case report. Annals of tropical paediatrics 20100101
Potential role for MATER in cytoplasmic lattice formation in murine oocytes. PloS one 20100101
Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. Critical care (London, England) 20100101
Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial infarction. Vascular health and risk management 20100101
Anaesthetic management of a child with 'cor-triatriatum' and multiple ventricular septal defects - A rare congenital anomaly. Indian journal of anaesthesia 20100101
Continuous glucose monitors prove highly accurate in critically ill children. Critical care (London, England) 20100101
ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. PloS one 20100101
Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PloS one 20100101
Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes. Journal of negative results in biomedicine 20100101
An investigation of patterns in hemodynamic data indicative of impending hypotension in intensive care. Biomedical engineering online 20100101
Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model. BMC systems biology 20100101
Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review. Journal of cardiothoracic surgery 20100101
Cerebral and somatic venous oximetry in adults and infants. Surgical neurology international 20100101
Baroreflex sensitivity might predict responders to milrinone in patients with heart failure. International heart journal 20100101
Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study. Critical care (London, England) 20100101
The critically ill obstetric patient - Recent concepts. Indian journal of anaesthesia 20100101
Management of perioperative low cardiac output state without extracorporeal life support: What is feasible? Annals of pediatric cardiology 20100101
The window ductus: Circulatory arrest as an option for surgical repair. Annals of pediatric cardiology 20100101
Modulating effects of nonselective and selective phosphodiesterase inhibitors on lymphocyte subsets and humoral immune response in mice. Pharmacological reports : PR 20100101
Model-based prediction of the patient-specific response to adrenaline. The open medical informatics journal 20100101
Clinical utility of tolvaptan in the management of hyponatremia in heart failure patients. International journal of nephrology and renovascular disease 20100101
Symptomatic giant left atrial aneurysm in a child: a rare entity. Images in paediatric cardiology 20100101
Use of milrinone in critically ill children. The Canadian journal of hospital pharmacy 20100101
[Inotropic agents for treatment of acute heart failure syndromes in intensive care]. Revue medicale suisse 20091209
Vasodilators in the treatment of acute heart failure: what we know, what we don't. Heart failure reviews 20091201
A novel approach to improve cardiac performance: cardiac myosin activators. Heart failure reviews 20091201
Postrenal biopsy AVM leading to severe hypertension and dilated cardiomyopathy. Pediatric nephrology (Berlin, Germany) 20091201
Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials. European heart journal 20091201
Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep. Pediatric research 20091201
Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. Heart failure reviews 20091201
Perioperative platelet activation and the inhibitory effect of milrinone. Anesthesiology 20091201
Phosphodiesterase 3 inhibition reduces platelet activation and monocyte tissue factor expression in knee arthroplasty patients. Anesthesiology 20091201
Influence of temperature on the positive inotropic effect of levosimendan, dobutamine and milrinone. European journal of anaesthesiology 20091101
Use of combination therapy with a beta-blocker and milrinone in patients with advanced heart failure. The Annals of pharmacotherapy 20091101
Effects of various selective phosphodiesterase inhibitors on relaxation and cyclic nucleotide contents in porcine iris sphincter. The Journal of veterinary medical science 20091101
Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review. Current cardiology reviews 20091101
Vasoactive drugs for vasodilatory shock in ICU. Current opinion in critical care 20091001
Hypothermic cardiopulmonary bypass as a determinant of late thrombocytopenia following cardiac operations in pediatric patients. Acta anaesthesiologica Scandinavica 20090901
Investigational positive inotropic agents for acute heart failure. Cardiovascular & hematological disorders drug targets 20090901
Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. American journal of physiology. Cell physiology 20090901
Can we improve outcome of congenital diaphragmatic hernia? Pediatric surgery international 20090901
Pulmonary arterial hypertension in human immunodeficiency virus infection. Postgraduate medicine 20090901
Milrinone inhibits hypoxia or hydrogen dioxide-induced persistent sodium current in ventricular myocytes. European journal of pharmacology 20090815
Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Bioorganic & medicinal chemistry 20090815
An 11-year, single-institution analysis of intra-aortic balloon pump use in cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20090801
Anti-ischemic effects of inotropic agents in experimental right ventricular infarction. Acta anaesthesiologica Scandinavica 20090801
Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20090801
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model. Lung 20090801
Enterovirus 71: epidemiology, pathogenesis and management. Expert review of anti-infective therapy 20090801
[Anesthetic management for emergency laparotomy in an adult patient with Eisenmenger syndrome: a case report]. Masui. The Japanese journal of anesthesiology 20090801
The efficacy of intravenous milrinone in left ventricular restoration. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20090801
Synthesis of 2-(4-substitutedmethylpiperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. European journal of medicinal chemistry 20090701
Implication of protein kinase A for a hepato-protective mechanism of milrinone pretreatment. The Journal of surgical research 20090701
The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass. Anesthesia and analgesia 20090701
Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090701
Prognosis on chronic dobutamine or milrinone infusions for stage D heart failure. Circulation. Heart failure 20090701
Should we use outpatient dobutamine or milrinone? Circulation. Heart failure 20090701
Current drugs and medical treatment algorithms in the management of acute decompensated heart failure. Expert opinion on investigational drugs 20090601
4-(4-Fluoro-phen-yl)-2-oxo-1,2,5,6-tetra-hydro-benzo[h]quinoline-3-carbonitrile. Acta crystallographica. Section E, Structure reports online 20090601
Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides. Bioorganic & medicinal chemistry letters 20090501
The effect of milrinone on platelet activation as determined by TEG platelet mapping. Anesthesia and analgesia 20090501
Therapy for acute heart failure syndromes. Current cardiology reports 20090501
Anaesthesia and right ventricular failure. Anaesthesia and intensive care 20090501
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. Journal of veterinary pharmacology and therapeutics 20090401
Comparison of inhaled and intravenous milrinone in patients with pulmonary hypertension undergoing mitral valve surgery. Advances in therapy 20090401
Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: a dose-response study. Shock (Augusta, Ga.) 20090301
High performance liquid chromatography using UV detection for the quantification of milrinone in plasma: improved sensitivity for inhalation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090301
Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20090201
Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. The Journal of pediatrics 20090201
Milrinone increases flow in coronary artery bypass grafts after cardiopulmonary bypass: a prospective, randomized, double-blind, placebo-controlled study. Journal of cardiothoracic and vascular anesthesia 20090201
Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation. Intensive care medicine 20090201
Total anomalous pulmonary venous connection: post operative problems and management. Indian journal of anaesthesia 20090201
Milrinone as a rescue therapy for symptomatic refractory cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Neurocritical care 20090101
Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats. Journal of vascular research 20090101
'Rapid two-stage' Norwood operation in a child with multiorgan failure. Pediatric cardiology 20090101
Intra-arterial milrinone for reversible cerebral vasoconstriction syndrome. Headache 20090101
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology 20090101
Inhaled milrinone attenuates experimental acute lung injury. Intensive care medicine 20090101
A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors. Molecular pharmaceutics 20090101
Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090101
[Extracorporeal membranous oxygenation in severe infant pertussis: a case report]. Annales francaises d'anesthesie et de reanimation 20090101
Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090101
Milrinone infusion: a therapeutic option in coronary vasospasm after primary percutaneous transluminal coronary angioplasty. Annals of cardiac anaesthesia 20090101
[Management of anesthesia with artificial pancreas STG-22 for pheochromocytoma resection]. Masui. The Japanese journal of anesthesiology 20090101
Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. Critical care (London, England) 20090101
A child presenting with acute renal failure secondary to a high dose of indomethacin: a case report. Journal of medical case reports 20090101
Successful cardiac transplantation in a patient with elevated pulmonary vascular resistance: a relative contraindication to transplantation. The heart surgery forum 20090101
Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study. Critical care (London, England) 20090101
Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism. PloS one 20090101
Imaging cytoplasmic cAMP in mouse brainstem neurons. BMC neuroscience 20090101
Effects of Astragaloside IV on heart failure in rats. Chinese medicine 20090101
To explant or not to explant: an invasive and noninvasive monitoring protocol to determine the need of continued ventricular assist device support. Congestive heart failure (Greenwich, Conn.) 20090101
Impact of emergency intubation on central venous oxygen saturation in critically ill patients: a multicenter observational study. Critical care (London, England) 20090101
The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target? Critical care (London, England) 20090101
Inhaled iloprost for the control of pulmonary hypertension. Vascular health and risk management 20090101
The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury. BMC infectious diseases 20090101
Predictors of inotrope use in patients undergoing concomitant coronary artery bypass graft (CABG) and aortic valve replacement (AVR) surgeries at separation from cardiopulmonary bypass (CPB). Journal of cardiothoracic surgery 20090101
Bench-to-bedside review: Inhaled nitric oxide therapy in adults. Critical care (London, England) 20090101
Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. Critical care (London, England) 20090101
Treatment of pediatric pulmonary hypertension. Vascular health and risk management 20090101
QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: model optimisation and evaluation. Journal of pharmacological and toxicological methods 20090101
Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure. Journal of translational medicine 20090101
Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study. Critical care (London, England) 20090101
Prophylactic application of levosimendan in cardiac surgical patients with severe left ventricle dysfunction. Experimental and clinical cardiology 20090101
Successful tricuspid valve replacement in a patient with severe pulmonary arterial hypertension and preserved right ventricular systolic function. Case reports in medicine 20090101
Estimated GFR reporting is not sufficient to allow detection of chronic kidney disease in an Italian regional hospital. BMC nephrology 20090101
Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Critical care (London, England) 20090101
Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Critical care (London, England) 20090101
Year in review 2008: Critical Care--cardiology. Critical care (London, England) 20090101
Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocrine research 20090101
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. PloS one 20090101
Newer treatments for decompensated heart failure: focus on levosimendan. Drug design, development and therapy 20090101
Amniotic fluid embolism. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20090101
Illustrative presentations of the failing heart in the acutely ill child: two case reports. Cases journal 20090101
The right ventricle: biologic insights and response to disease. Current cardiology reviews 20090101
When the heart kills the liver: acute liver failure in congestive heart failure. European journal of medical research 20090101
Modified single-patch technique: Repairing complete atrioventricular septal defect. Annals of pediatric cardiology 20090101
Vasopressin in the pediatric cardiac intensive care unit: Myth or reality. Annals of pediatric cardiology 20090101
Is there a role for carvedilol in the management of pediatric heart failure? A meta analysis and e-mail survey of expert opinion. Annals of pediatric cardiology 20090101
Diagnosis and management of vasospasm. F1000 medicine reports 20090101
Open pulmonary thromboembolectomy in patients with major pulmonary thromboembolism. Yonsei medical journal 20081231
Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)-acetamides. Archiv der Pharmazie 20081201
The use of continuous milrinone therapy as bridge to transplant is safe in patients with short waiting times. Journal of cardiac failure 20081201
Persistent pulmonary hypertension of the newborn: therapeutical approach. Mini reviews in medicinal chemistry 20081201
Potential for pulmonary protection by nebulized milrinone during warm ischemia. Transplantation proceedings 20081201
ABCD of the phosphodiesterase family: interaction and differential activity in COPD. International journal of chronic obstructive pulmonary disease 20081201
Tadalafil in the treatment of erectile dysfunction. Therapeutics and clinical risk management 20081201
Safety and efficacy of cilostazol in the management of intermittent claudication. Vascular health and risk management 20081201
catena-Poly[[[diaqua-bis(2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbo-nitrile)copper(II)]-μ-sulfato] tetra-hydrate]. Acta crystallographica. Section E, Structure reports online 20081201
In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats. Journal of neuroscience research 20081115
The base exchange reaction of NAD+ glycohydrolase: identification of novel heterocyclic alternative substrates. Archives of biochemistry and biophysics 20081115
A case of cardiogenic shock caused by capecitabine treatment. Nature clinical practice. Cardiovascular medicine 20081101
Nitric oxide in conjunction with milrinone better stabilized pulmonary hemodynamics after Fontan procedure. Artificial organs 20081101
[The effect of PDEIII inhibitors and colforsin daropate on hypoxic pulmonary vasoconstriction in rabbit lungs]. Masui. The Japanese journal of anesthesiology 20081101
Off-label use of cardiovascular medications in children hospitalized with congenital and acquired heart disease. Circulation. Cardiovascular quality and outcomes 20081101
Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery. Circulation 20081014
Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent. European journal of heart failure 20081001
A randomized trial evaluating different modalities of levosimendan administration in cardiac surgery patients with myocardial dysfunction. Journal of cardiothoracic and vascular anesthesia 20081001
Arterial pulmonary hypertension in noncardiac intensive care unit. Vascular health and risk management 20081001
Right heart dysfunction after left ventricular assist device implantation: a comparison of the pulsatile HeartMate I and axial-flow HeartMate II devices. The Annals of thoracic surgery 20080901
Nitric oxide and milrinone: combined effect on pulmonary circulation after Fontan-type procedure: a prospective, randomized study. The Annals of thoracic surgery 20080901
The case for milrinone. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20080901
Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives. Bioorganic & medicinal chemistry letters 20080815
Correlation between plasma milrinone concentration and renal function in patients with cardiac disease. Acta anaesthesiologica Scandinavica 20080801
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. American journal of physiology. Heart and circulatory physiology 20080801
Enterovirus 71, one virus and many stories. Pediatrics and neonatology 20080801
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. Journal of medicinal chemistry 20080724
Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation. Intensive care medicine 20080701
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2-(1H)quinolinone (cilostazol), a phosphodiesterase type 3 inhibitor, reduces infarct size via activation of mitochondrial Ca2+-activated K+ channels in rabbit hearts. The Journal of pharmacology and experimental therapeutics 20080701
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle. Therapeutic advances in respiratory disease 20080601
Tolvaptan: the evidence for its therapeutic value in acute heart failure syndrome. Core evidence 20080601
Mechanisms of the relaxant effect of vardenafil in rat penile arteries. European journal of pharmacology 20080531
Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circulation. Heart failure 20080501
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. Circulation research 20080411
Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure. The Journal of pharmacology and experimental therapeutics 20080401
Mitral valve replacement: a case report. AANA journal 20080401
Milrinone for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 20080301
Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs. Acta anaesthesiologica Scandinavica 20080301
New therapies in acute decompensated heart failure. Current opinion in cardiology 20080301
Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog. Perfusion 20080301
The effect of milrinone on metabolism after cardiopulmonary bypass. The Journal of cardiovascular surgery 20080201
Acute right ventricular failure in the setting of acute pulmonary embolism or chronic pulmonary hypertension: a detailed review of the pathophysiology, diagnosis, and management. Current cardiology reviews 20080201
YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity. European journal of pharmacology 20080128
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. The EMBO journal 20080123
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies. Bioorganic & medicinal chemistry letters 20080115
Prognostic value of B-type natriuretic peptide in surgical palliation of children with single-ventricle congenital heart disease. Pediatric cardiology 20080101
Pyridazinone derivatives: design, synthesis, and in vitro vasorelaxant activity. Bioorganic & medicinal chemistry 20080101
Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial. Acta anaesthesiologica Scandinavica 20080101
Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs. American journal of physiology. Heart and circulatory physiology 20080101
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive care medicine 20080101
Inotropes in the management of acute heart failure. Critical care medicine 20080101
Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study. Critical care (London, England) 20080101
Postpyloric enteral nutrition in the critically ill child with shock: a prospective observational study. Nutrition journal 20080101
Are platelets a 'forgotten' source of sepsis-induced myocardial depressing factor(s)? Critical care (London, England) 20080101
Complete mechanical circulatory support using ventricular assist devices for post-cardiotomy biventricular failure. The Ulster medical journal 20080101
[Extracorporeal membrane oxygenation treatment of a neonate with severe low cardiac output syndrome following open heart surgery]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20080101
Sensitivity of International Classification of Diseases codes for hyponatremia among commercially insured outpatients in the United States. BMC nephrology 20080101
Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression. Critical care (London, England) 20080101
Hyponatremia and hospital outcomes among patients with pneumonia: a retrospective cohort study. BMC pulmonary medicine 20080101
Understanding cardiac output. Critical care (London, England) 20080101
The effects of vasopressor and vasodilator on hemodynamic energy in terms of surplus hemodynamic energy. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20080101
Myocardial protection in sepsis. Critical care (London, England) 20080101
Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. PloS one 20080101
Shugoshin1 may play important roles in separation of homologous chromosomes and sister chromatids during mouse oocyte meiosis. PloS one 20080101
Higher cerebral oxygen saturation may provide higher urinary output during continuous regional cerebral perfusion. Journal of cardiothoracic surgery 20080101
Evaluation of the effects of sildenafil citrate (viagra) on vertebral artery blood flow in patients with vertebro-basilar insufficiency. Korean journal of radiology 20080101
Cardiac tamponade, an unusual and fatal complication of esophagus dilatation for benign stenosis: a case report. Cases journal 20080101
User's guide to the orthopaedic literature: how to use an article about a randomized trial? Indian journal of orthopaedics 20080101
Unidirectional valved patches for closure of septal defects in patients with severe pulmonary hypertension. Annals of pediatric cardiology 20080101
The first 1D twofold interpenetrating metal-organic network generated by 1D triple helical chains with nanosized cages. Dalton transactions (Cambridge, England : 2003) 20071228
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity. Journal of medicinal chemistry 20071227
Nebulized milrinone use in a pulmonary hypertensive crisis. Pharmacotherapy 20071201
Update on inotropic therapy in the management of acute heart failure. Current treatment options in cardiovascular medicine 20071201
[Rational use of catecholamines and inotropes]. Pneumologie (Stuttgart, Germany) 20071101
Peripartum cardiomyopathy: review of the literature. Yonsei medical journal 20071031
The effects of vasoactive agents, platelet agonists and anticoagulation on thrombelastography. Acta anaesthesiologica Scandinavica 20071001
Milrinone does not improve free flap survival in microvascular surgery. Anaesthesia and intensive care 20071001
[Anesthesia for repair of tetralogy of Fallot in an adult patient: case report.]. Revista brasileira de anestesiologia 20071001
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. Blood 20070901
Management strategies for patients with pulmonary hypertension in the intensive care unit. Critical care medicine 20070901
Anesthesia for repair of ventricular septal rupture after acute myocardial infarction. Journal of clinical anesthesia 20070901
Altered role of C-type natriuretic peptide-activated pGC-cGMP-PDE3-cAMP signaling in hyperthyroid beating rabbit atria. Regulatory peptides 20070816
[Unsuccessful anesthetic management for cesarean section in a patient with primary pulmonary hypertension]. Masui. The Japanese journal of anesthesiology 20070801
Effects of milrinone on contractility and cyclic adenosine monophosphate production induced by beta1- and beta2-adrenergic receptor activation in human myocardium. Clinical therapeutics 20070801
Comparison of relaxation responses to multiple vasodilators in TxA(2)-analog and endothelin-1-precontracted pulmonary arteries. Acta anaesthesiologica Scandinavica 20070701
Cardiac resynchronization therapy in patients with end-stage inotrope-dependent class IV heart failure. The American journal of cardiology 20070701
Milrinone enhances systolic, but not diastolic function during coronary artery bypass grafting surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070701
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site. Journal of medicinal chemistry 20070614
Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty. American journal of physiology. Heart and circulatory physiology 20070601
Preliminary experience with inhaled milrinone in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20070601
Classical inotropes and new cardiac enhancers. Heart failure reviews 20070601
Hemolytic-uremic syndrome and myocardial dysfunction in a 9-month-old boy. Paediatric anaesthesia 20070601
Arterial-wave reflections are increased in heart failure patients with a left-ventricular assist device. American journal of hypertension 20070601
Rationale, design, and methods for the Transplant-Eligible MAnagement of Congestive Heart Failure (TMAC) trial: a multicenter clinical outcomes trial using nesiritide for TMAC. American heart journal 20070601
The effects of vasoactive agents on flow through saphenous vein grafts during lower-extremity peripheral vascular surgery. Journal of cardiothoracic and vascular anesthesia 20070601
[Efficacy of continuous intraoperative administration of low-dose milrinone during the circumflex artery anastomosis of off-pump coronary artery bypass]. Masui. The Japanese journal of anesthesiology 20070601
NT-pro BNP secretion and clinical endpoints in cardiac surgery intensive care patients. Anaesthesia and intensive care 20070601
[Phosphodiesterase III inhibitor--characteristics, mechanisms of action, pharmacokinetics, indications, contraindications, clinical trials, and side effects]. Nihon rinsho. Japanese journal of clinical medicine 20070528
[How to use PDE III inhibitors]. Nihon rinsho. Japanese journal of clinical medicine 20070528
[Combination therapy with PDE III inhibitor for heart failure]. Nihon rinsho. Japanese journal of clinical medicine 20070528
Population pharmacokinetics and dosing regimen design of milrinone in preterm infants. Archives of disease in childhood. Fetal and neonatal edition 20070501
Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. The Biochemical journal 20070501
Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. Critical care medicine 20070501
Home inotropic therapy in children. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070501
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. Pharmacotherapy 20070501
Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials. Journal of the American College of Cardiology 20070403
Hospital policies for treatment of acute decompensated heart failure. The Annals of pharmacotherapy 20070401
Levosimendan in cardiac surgery: a unique drug for the treatment of perioperative left ventricular dysfunction or just another inodilator searching for a clinical application? Anesthesia and analgesia 20070401
The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesthesia and analgesia 20070401
[Case of epicardial left ventricular pacing lead implantation under general anesthesia in a patient with severe cardiac dysfunction]. Masui. The Japanese journal of anesthesiology 20070401
The cardiovascular effects of adrenaline, dobutamine and milrinone in rabbits using pressure-volume loops and guinea pig isolated atrial tissue. Anaesthesia and intensive care 20070401
Hydralazine and nitrates: beyond race and ethnicity. Journal of cardiac failure 20070401
The hemodynamic effects of insulin following overdosage with levobupivacaine or racemic bupivacaine in dogs. Journal of Korean medical science 20070401
Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner. Nitric oxide : biology and chemistry 20070301
Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post-operative cardiac surgery patients in Germany: results from a postal survey. Acta anaesthesiologica Scandinavica 20070301
Perioperative nesiritide versus milrinone in high-risk coronary artery bypass graft patients. The Annals of pharmacotherapy 20070301
Nesiritide compared with milrinone for cardiac surgery. The Annals of pharmacotherapy 20070301
Renal dysfunction in heart failure patients: what is the evidence? Heart failure reviews 20070301
Cardiovascular support in the preterm: treatments in search of indications. The Journal of pediatrics 20070201
Regulation of human internal mammary and radial artery contraction by extracellular and intracellular calcium channels and cyclic adenosine 3', 5' monophosphate. The Annals of thoracic surgery 20070201
Effects of low-dose milrinone on weaning from cardiopulmonary bypass and after in patients with mitral stenosis and pulmonary hypertension. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201
[Intravenous milrinone in the treatment of pediatric heart failure]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20070201
Review of current and investigational pharmacologic agents for acute heart failure syndromes. The American journal of cardiology 20070122
Hemodynamic properties of a new-generation positive luso-inotropic agent for the acute treatment of advanced heart failure. The American journal of cardiology 20070122
Arginine vasopressin in advanced cardiovascular failure during the post-resuscitation phase after cardiac arrest. Resuscitation 20070101
Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. Critical care medicine 20070101
Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity. Journal of applied toxicology : JAT 20070101
Use of levosimendan, a new inodilator, for postoperative myocardial stunning in a premature neonate. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070101
Effect of sildenafil on pulmonary artery pressure, systemic pressure, and nitric oxide utilization in patients with left ventricular assist devices. The Annals of thoracic surgery 20070101
Milrinone combined with vasopressin improves cardiac index after cardiopulmonary resuscitation in a pig model of myocardial infarction. Anesthesiology 20070101
Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology 20070101
Cardiovascular pharmacotherapy update for the intensive care unit. Critical care nursing quarterly 20070101
Revival of the side-to-side approach for distal coronary anastomosis. Journal of cardiothoracic surgery 20070101
Factors influencing the outcome of paediatric cardiac surgical patients during extracorporeal circulatory support. Journal of cardiothoracic surgery 20070101
Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone, administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs. Annals of cardiac anaesthesia 20070101
The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting. Critical care (London, England) 20070101
Long-term support with milrinone prior to cardiac transplantation in a neonate with left ventricular noncompaction cardiomyopathy. Pediatric cardiology 20070101
Effects of 4 classes of cardiovascular drugs on ventricular function in dogs with mitral regurgitation. Journal of veterinary internal medicine 20070101
Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use? Critical care (London, England) 20070101
Steroids in late ARDS? Critical care (London, England) 20070101
Safety and feasibility of inpatient exercise training in pediatric heart failure: a preliminary report. Journal of cardiopulmonary rehabilitation and prevention 20070101
Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage. Critical care (London, England) 20070101
Bench-to-bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis. Critical care (London, England) 20070101
Pulmonary hypertension due to unknown causes in liver resection. Journal of anesthesia 20070101
Outcomes of patients hospitalized for acute decompensated heart failure: does nesiritide make a difference? BMC cardiovascular disorders 20070101
The use of vasoactive therapy for acute decompensated heart failure: hemodynamic and renal considerations. Reviews in cardiovascular medicine 20070101
Effects of standard heart failure therapy and concomitant treatment with intravenous furosemide or inotropes (dobutamine, dopamine, and/or milrinone) on renal function and mortality in patients treated with nesiritide. The American journal of cardiology 20061215
Treatment of ischaemic left ventricular dysfunction with milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs. British journal of anaesthesia 20061201
Dynamic changes of post-ischemic hepatic microcirculation improved by a pre-treatment of phosphodiesterase-3 inhibitor, milrinone. The Journal of surgical research 20061201
Chronic inotropic therapy in end-stage heart failure. American heart journal 20061201
Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial. Journal of cardiac failure 20061201
Inhaled milrinone: a new alternative in cardiac surgery? Seminars in cardiothoracic and vascular anesthesia 20061201
A review of levosimendan in the treatment of heart failure. Vascular health and risk management 20061201
Sildenafil in the treatment of pulmonary hypertension. Vascular health and risk management 20061201
Evaluation of PDE4 inhibition for COPD. International journal of chronic obstructive pulmonary disease 20061201
Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation. Pediatric research 20061101
Outpatient continuous inotrope infusion as an adjunct to heart failure therapy in Duchenne muscular dystrophy. Neuromuscular disorders : NMD 20061101
The vasodilatory effects of levosimendan on the human internal mammary artery. Anesthesia and analgesia 20061101
Acute heart failure: inotropic agents and their clinical uses. Expert opinion on pharmacotherapy 20061101
European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts. European journal of pediatrics 20061101
Is vasopressin really superior to norepinephrine in reversing milrinone-induced vasodilation? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20061001
The effect of milrinone on the right ventricular function in patients with reduced right ventricular function undergoing off-pump coronary artery bypass graft surgery. Journal of Korean medical science 20061001
Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine. Cardiovascular drugs and therapy 20061001
Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurosurgical focus 20060915
Testing new drugs for heart failure in children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901
Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling. Endocrine, metabolic & immune disorders drug targets 20060901
Proper use of phosphodiesterase inhibitors according to the situations. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20060901
Abundant transcripts from retrotransposons are unstable in fully grown mouse oocytes. Biochemical and biophysical research communications 20060818
Effects of milrinone on blood flow of the Y-graft composed with the radial and the internal thoracic artery in patients with coronary artery disease. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801
Recent developments in the perioperative management of the paediatric cardiac patient. Current opinion in anaesthesiology 20060801
Outcomes associated with vasoactive therapy in patients with acute decompensated heart failure. Pharmacotherapy 20060801
Cardiovascular collapse due to massive pulmonary thromboembolism during orthotopic liver transplantation. Journal of clinical anesthesia 20060801
Effect of cyclodextrin nanocavity confinement on the photorelaxation of the cardiotonic drug milrinone. The journal of physical chemistry. B 20060727
Flexible versus nonflexible mitral valve rings for congestive heart failure: differential durability of repair. Circulation 20060704
cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3. American journal of physiology. Renal physiology 20060601
Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060601
A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. Anesthesia and analgesia 20060601
Fast relaxation dynamics of the cardiotonic drug milrinone in water solutions. Journal of medicinal chemistry 20060601
Critical management in patients with severe enterovirus 71 infection. Pediatrics international : official journal of the Japan Pediatric Society 20060601
Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 20060601
Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery. Journal of cardiothoracic and vascular anesthesia 20060601
Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. Journal of critical care 20060601
Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN) is in its infancy. Journal of critical care 20060601
Arterial baroreflex sensitivity is a good predictor of inotropic responses to a phosphodiesterase inhibitor in human heart failure. Clinical cardiology 20060601
Effect of combining phosphodiesterase III inhibitors with St Thomas Hospital's solution used as transplantation preservative solution in isolated rat hearts. Transplantation proceedings 20060601
Cardiovascular effects of a phosphodiesterase III inhibitor in the presence of carvedilol in dogs. The Journal of veterinary medical science 20060601
Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs. Journal of cardiovascular pharmacology and therapeutics 20060601
Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. Journal of ethnopharmacology 20060524
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Biventricular diastolic filling patterns after coronary artery bypass graft surgery. The Journal of thoracic and cardiovascular surgery 20060501
Activation of the adenylyl cyclase/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery. European journal of pharmacology 20060424
Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clinical science (London, England : 1979) 20060401
Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction. Anesthesia and analgesia 20060401
Levosimendan in cardiac surgery: current best available evidence. The Annals of thoracic surgery 20060401
Phosphodiesterase III inhibition affects platelet-monocyte aggregate formation depending on the axis of stimulation. Journal of cardiothoracic and vascular anesthesia 20060401
Tirofiban (Aggrastat) protects platelets and decreases platelet-granulocyte binding in an extracorporeal circulation model. The Thoracic and cardiovascular surgeon 20060401
Community-acquired bacterial meningitis. The New England journal of medicine 20060330
[Medical and ventilatory treatment of acute heart failure]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20060309
Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. British journal of anaesthesia 20060301
Optimizing outcomes in the patient with acute decompensated heart failure. American heart journal 20060301
Outpatient continuous parenteral inotropic therapy as bridge to transplantation in children with advanced heart failure. Journal of cardiac failure 20060301
Cardiovascular support in the preterm: treatments in search of indications. The Journal of pediatrics 20060301
Pilot study of milrinone for low systemic blood flow in very preterm infants. The Journal of pediatrics 20060301
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones. Bioorganic & medicinal chemistry letters 20060215
[Cesarean section in a patient with severe mitral stenosis after mitral valve replacement]. Masui. The Japanese journal of anesthesiology 20060201
[Anesthetic management of concomitant off-pump coronary artery bypass grafting, pulmonary resection, and mastectomy]. Masui. The Japanese journal of anesthesiology 20060201
Perioperative pulse contour cardiac output analysis in a patient with severe cardiac dysfunction. Anaesthesia and intensive care 20060201
NT-proBNP as a marker for persistent cardiac disease in children with history of dilated cardiomyopathy and myocarditis. Pediatric cardiology 20060101
Neonatal persistent pulmonary hypertension treated with milrinone: four case reports. Biology of the neonate 20060101
Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles. Journal of vascular research 20060101
In vivo dilatation of the fetal and postnatal ductus arteriosus by inhibition of phosphodiesterase 3 in rats. Biology of the neonate 20060101
Rescue treatment with terlipressin in children with refractory septic shock: a clinical study. Critical care (London, England) 20060101
The effects of olprinone, a phosphodiesterase 3 inhibitor, on systemic and cerebral circulation. Current vascular pharmacology 20060101
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo. Respiratory research 20060101
Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study. Critical care (London, England) 20060101
Cyclic nucleotide specific phosphodiesterases of Leishmania major. BMC microbiology 20060101
Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome. Critical care (London, England) 20060101
Effects of milrinone and butyrolactone-I on porcine oocyte meiotic progression and developmental competence. Reproduction, fertility, and development 20060101
Medical and ventilatory treatment of acute heart failure: new insights. Cardiology 20060101
Current status of anti-picornavirus therapies. Current pharmaceutical design 20060101
Clinical review: thyroid hormone replacement in children after cardiac surgery--is it worth a try? Critical care (London, England) 20060101
Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers. Critical care (London, England) 20060101
Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure. Journal of cardiothoracic surgery 20060101
Corticosteroids influence the mortality and morbidity of acute critical illness. Critical care (London, England) 20060101
An unusual case of cardiac dysfunction after left ventricular reconstruction. Journal of cardiothoracic surgery 20060101
Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia. Critical care (London, England) 20060101
New insight into the role of phosphodiesterase 3A in porcine oocyte maturation. BMC developmental biology 20060101
Bench-to-bedside review: thrombocytopenia-associated multiple organ failure--a newly appreciated syndrome in the critically ill. Critical care (London, England) 20060101
Predictors of clinical outcome in advanced heart failure patients on continuous intravenous milrinone therapy. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20060101
What role does the right side of the heart play in circulation? Critical care (London, England) 20060101
Effects of a phosphodiesterase 3 inhibitor, olprinone, on rhythmical change in tension of human gastroepiploic artery. European journal of pharmacology 20051228
Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents. European journal of medicinal chemistry 20051201
Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance. World journal of urology 20051201
Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20051201
[Anesthetic management of a patient undergoing PTA stent placement for right common carotid artery stenosis]. Masui. The Japanese journal of anesthesiology 20051201
3,4-trans-4-Aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates--new group of potential cardiotonic drugs. European journal of medicinal chemistry 20051101
Aortic smooth muscle relaxants KMUP-3 and KMUP-4, two nitrophenylpiperazine derivatives of xanthine, display cGMP-enhancing activity: roles of endothelium, phosphodiesterase, and K+ channel. Journal of cardiovascular pharmacology 20051101
Zaprinast attenuates hypoxic pulmonary artery injury and causes less aortic relaxation than milrinone. Shock (Augusta, Ga.) 20051101
Arginine vasopressin in 316 patients with advanced vasodilatory shock. Critical care medicine 20051101
Differential pharmacologic sensitivities of phosphodiesterase-3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries. Anesthesia and analgesia 20051001
Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium. European journal of pharmacology 20050920
Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. The American journal of cardiology 20050919
Overview of randomized clinical trials in acute heart failure syndromes. The American journal of cardiology 20050919
Pharmacological induction of CFTR function in patients with cystic fibrosis: mutation-specific therapy. Pediatric pulmonology 20050901
Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901
Reduction in interaction between cGMP and cAMP in dog ventricular myocytes with hypertrophic failure. American journal of physiology. Heart and circulatory physiology 20050901
Temporary left ventricular assist and levosimendan for coronary artery spasm. Interactive cardiovascular and thoracic surgery 20050801
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets. European journal of pharmacology 20050711
In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE). Journal of the American College of Cardiology 20050705
Acute decompensated heart failure: the shrinking role of inotropic therapy. Journal of the American College of Cardiology 20050705
Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. Journal of perinatology : official journal of the California Perinatal Association 20050701
Effects of phosphodiesterase-III inhibitors on sevoflurane-induced impairment of rat diaphragmatic function. Acta anaesthesiologica Scandinavica 20050701
Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisting mitral regurgitation: improvement with milrinone. Anesthesia and analgesia 20050701
Both milrinone and colforsin daropate attenuate the sustained pial arteriolar constriction seen after unclamping of an abdominal aortic cross-clamp in rabbits. Anesthesia and analgesia 20050701
Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery 20050701
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder. The Journal of veterinary medical science 20050701
A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a commercially available internal standard and low sample volume. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20050624
Restrictive left atrial outflow adversely affects outcome after the modified Norwood procedure. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050601
Impaired vasoreactivity in end-stage heart failure patients on intravenous inotropic support. Journal of cardiac failure 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Treating critical illness: the importance of first doing no harm. PLoS medicine 20050601
Effects of milrinone versus epinephrine on left ventricular relaxation after cardiopulmonary bypass following myocardial revascularization: assessment by color m-mode and tissue Doppler. Journal of cardiothoracic and vascular anesthesia 20050601
Levosimendan in cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20050601
Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation 20050517
Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. European journal of pharmacology 20050509
Diagnosis and treatment of neonatal hypotension outside the transitional period. Early human development 20050501
[Open heart operation for a pregnant patient with Marfan syndrome]. Masui. The Japanese journal of anesthesiology 20050501
Diagnosis and treatment of preterm transitional circulatory compromise. Early human development 20050501
Delayed cardiogenic shock and acute lung injury after aneurysmal subarachnoid hemorrhage. Anesthesia and analgesia 20050401
Nesiritide for secondary pulmonary hypertension in patients with end-stage heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050315
Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema. Pediatric pulmonology 20050301
Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart. Cardiovascular research 20050301
The effects of milrinone on hemodynamics in an experimental septic shock model. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050301
Left ventricular conditioning in the elderly patient to prevent congestive heart failure after transcatheter closure of atrial septal defect. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20050301
[Criss-cross heart: anesthetic considerations for total cavopulmonary shunt (Fontan procedure)]. Revista espanola de anestesiologia y reanimacion 20050301
Effect of milrinone on echocardiographic parameters after single dose in Beagle dogs and relationship with drug-induced cardiotoxicity. Toxicology letters 20050215
Concomitant use of nesiritide and milrinone in decompensated congestive heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050201
Milrinone for pulmonary hypertension: additional benefits, concerns, and caution. Journal of cardiothoracic and vascular anesthesia 20050201
[A case of continuous infusion of milrinone during continuous venovenous hemofiltration causing high plasma concentration of milrinone]. Masui. The Japanese journal of anesthesiology 20050201
Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050201
Nesiritide in cardiovascular anesthesia. Current opinion in anaesthesiology 20050201
Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism. American journal of physiology. Gastrointestinal and liver physiology 20050101
Dobutamine versus milrinone after subarachnoid hemorrhage. Neurosurgery 20050101
Oral sildenafil reduces pulmonary hypertension after cardiac surgery. The Annals of thoracic surgery 20050101
Application of papillary muscle sling concept in an infant as a biological bridge to transplantation. The Annals of thoracic surgery 20050101
Greater vasopressin-induced vasoconstriction and inferior effects of nitrovasodilators and milrinone in the radial artery than in the internal thoracic artery. The Journal of thoracic and cardiovascular surgery 20050101
Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Critical care medicine 20050101
Levosimendan and gut mucosal blood flow--not all inotropes are created equal. Critical care medicine 20050101
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulmonary pharmacology & therapeutics 20050101
Look-alike, sound-alike drugs review: include look-alike packaging as an additional safety check. Joint Commission journal on quality and patient safety 20050101
Clinical review: Vasopressin and terlipressin in septic shock patients. Critical care (London, England) 20050101
Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review. Critical care (London, England) 20050101
Intravenous milrinone infusion improves congestive heart failure caused by diastolic dysfunction: a brief case series. Texas Heart Institute journal 20050101
A comparative study of discriminating human heart failure etiology using gene expression profiles. BMC bioinformatics 20050101
Renal blood flow in sepsis. Critical care (London, England) 20050101
[Myocardial depression in a patient with celiac disease. A clinical case report and literature review]. Revista de gastroenterologia de Mexico 20050101
Milrinone and low cardiac output following cardiac surgery in infants: is there a direct myocardial effect? Pediatric cardiology 20050101
Drugs to facilitate recovery of neuromuscular blockade and muscle strength. Journal of anesthesia 20050101
Increased cost effectiveness with nesiritide vs. milrinone or dobutamine in the treatment of acute decompensated heart failure. Congestive heart failure (Greenwich, Conn.) 20050101
Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovascular toxicology 20050101
[Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan]. Medizinische Klinik (Munich, Germany : 1983) 20041215
Multiple endocrine neoplasia 2A syndrome presenting as peripartum cardiomyopathy due to catecholamine excess. European journal of endocrinology 20041201
Risk stratification after hospitalization for decompensated heart failure. Journal of cardiac failure 20041201
Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness. Planta medica 20041201
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochemical pharmacology 20041115
Compatibility of argatroban with selected cardiovascular agents. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20041115
Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery. British journal of anaesthesia 20041101
Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. Biology of reproduction 20041001
Efficacy of pre-emptive milrinone in off-pump coronary artery bypass surgery: comparison between patients with a low and normal pre-graft cardiac index. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041001
Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. The Annals of thoracic surgery 20041001
Prevention of early sudden circulatory collapse after the Norwood operation. Circulation 20040914
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice. European journal of pharmacology 20040913
A prospective study of continuous intravenous milrinone therapy for status IB patients awaiting heart transplant at home. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040901
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli. The Journal of veterinary medical science 20040901
Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs. The Journal of veterinary medical science 20040901
Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor. Life sciences 20040806
KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. British journal of pharmacology 20040801
Off-pump epicardial tissue sealing--a novel method for atrioventricular disruption complicating mitral valve procedures. The Annals of thoracic surgery 20040801
Solid-phase synthesis and evaluation of libraries of substituted 4,5-dihydropyridazinones as vasodilator agents. The Journal of pharmacy and pharmacology 20040801
The impact of arrhythmias in acute heart failure. Journal of cardiac failure 20040801
Platelet cyclic adenosine monophosphate phosphodiesterases: targets for regulating platelet-related thrombosis. Seminars in thrombosis and hemostasis 20040801
Predictors of inotrope use during separation from cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia 20040801
In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. Clinical therapeutics 20040801
Milrinone reduces cerebral vasospasm after subarachnoid hemorrhage of WFNS grade IV or V. Neurologia medico-chirurgica 20040801
Effect of aerosolized milrinone during drug-induced pulmonary hypertension in lambs. Pharmacological research 20040701
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bioorganic & medicinal chemistry letters 20040607
Enhanced vasodilatory responses to milrinone in catecholamine-precontracted small pulmonary arteries. Anesthesia and analgesia 20040601
New positive inotropic agents in the treatment of left ventricular dysfunction. Italian heart journal : official journal of the Italian Federation of Cardiology 20040601
Pharmacological assessment of composite arterial conduits using angiography early in the postoperative period. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20040601
[Differences in outcome in patients with poor grade subarachnoid hemorrhage (WFNS grade IV and V): according to the perioperative management against vasospasm]. No shinkei geka. Neurological surgery 20040601
Pharmacokinetics and pharmacodynamics of olprinone after cardiac surgery. Osaka city medical journal 20040601
High-dosage continuous amiodarone therapy to treat new-onset supraventricular tachyarrhythmias in surgical intensive care patients: an observational study. Wiener klinische Wochenschrift 20040531
A rational approach for the treatment of acute heart failure: current strategies and future options. Current opinion in cardiology 20040501
Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040501
Models of dilated cardiomyopathy in small animals and novel positive inotropic therapies. Annals of the New York Academy of Sciences 20040501
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria. Circulation research 20040416
Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries. European journal of pharmacology 20040405
Guidelines for acute decompensated heart failure treatment. The Annals of pharmacotherapy 20040401
Infant pertussis deaths and the management of cardiovascular compromise. Journal of paediatrics and child health 20040401
Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off-pump coronary artery bypass graft surgery. Anaesthesia 20040401
Milrinone improves lung compliance. Acta anaesthesiologica Scandinavica 20040401
Inotropes improve right heart function in patients undergoing aortic valve replacement for aortic stenosis. Anesthesia and analgesia 20040401
Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040401
Milrinone and nitric oxide: combined effect on pulmonary artery pressures after cardiopulmonary bypass in children. Journal of cardiothoracic and vascular anesthesia 20040401
Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart. Journal of cardiovascular pharmacology 20040401
Bovine cumulus cell-oocyte gap junctional communication during in vitro maturation in response to manipulation of cell-specific cyclic adenosine 3',5'-monophosophate levels. Biology of reproduction 20040301
Terlipressin as rescue therapy for intractable hypotension during neonatal septic shock. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040301
[Inotropic therapy in heart failure: general aspects and clinical results]. Medicina clinica 20040227
Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12. Hypertension (Dallas, Tex. : 1979) 20040201
Mechanisms of prostaglandin E1-induced relaxation in penile resistance arteries. The Journal of urology 20040201
Dobutamine-related asthma in a patient awaiting cardiac transplantation: the eosinophilic dilemma. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040201
Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors. Chest 20040201
[Atrial natriuretic factor stimulates the frog urinary bladder osmotic permeability in presence of a cyclic nucleotide phosphodiesterase inhibitor]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040201
A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery. Journal of pharmacokinetics and pharmacodynamics 20040201
Inhaled milrinone for the improvement of contractility of fatigued diaphragm in dogs: a dose-ranging study. Pulmonary pharmacology & therapeutics 20040101
Need for hospice and palliative care services in patients with end-stage heart failure treated with intermittent infusion of inotropes. Clinical cardiology 20040101
Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clinical pharmacokinetics 20040101
Acute cholecystitis and severe ischemic cardiac disease: is laparoscopy indicated? JSLS : Journal of the Society of Laparoendoscopic Surgeons 20040101
Science Review: Vasopressin and the cardiovascular system part 2 - clinical physiology. Critical care (London, England) 20040101
The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respiratory research 20040101
Inhibition by reproterol of cAMP PDE in intact mastocytoma P-815 cells. Pulmonary pharmacology & therapeutics 20040101
Beneficial effects of early initiation of vasoactive agents in patients with acute decompensated heart failure. Reviews in cardiovascular medicine 20040101
Surgical ventricular restoration in end-stage ischemic cardiomyopathy patients. The heart surgery forum 20040101
Role of pharmacotherapy in Brugada syndrome. Indian pacing and electrophysiology journal 20040101
Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction. Circulation 20031216
The role of B-type natriuretic peptide in heart failure. Critical care nursing clinics of North America 20031201
Case studies in heart failure. Critical care nursing clinics of North America 20031201
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors. Bioorganic & medicinal chemistry letters 20031117
Negative functional effects of cyclic GMP are altered by cyclic AMP phosphodiesterases in rabbit cardiac myocytes. European journal of pharmacology 20031114
Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone. Bioorganic & medicinal chemistry 20031103
Prophylactic milrinone during OPCAB of posterior vessels: implication in angina patients taking beta-blockers. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20031101
Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. Metabolism: clinical and experimental 20031101
Anesthetic management for implantation of the Jarvik 2000 left ventricular assist system. Anesthesia and analgesia 20031001
Critical care in cardiovascular medicine. Current opinion in pediatrics 20031001
Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031001
B-type natriuretic peptide: spectrum of application. Nesiritide (recombinant BNP) for heart failure. Heart failure reviews 20031001
Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Molecular and cellular biochemistry 20031001
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. American journal of respiratory cell and molecular biology 20030901
Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. The American journal of cardiology 20030901
Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. The Journal of physiology 20030815
Effect of nesiritide versus milrinone in the treatment of acute decompensated heart failure. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030815
Effects of preemptive therapy with milrinone or amrinone on perioperative platelet function and haemostasis in patients undergoing coronary bypass grafting. Platelets 20030801
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. Biochemical and biophysical research communications 20030718
Effect of milrinone on vecuronium-induced neuromuscular block. Anaesthesia 20030701
Milrinone improves lung compliance in patients receiving mechanical ventilation for cardiogenic pulmonary edema. Acta anaesthesiologica Scandinavica 20030701
Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium. Pharmacology & toxicology 20030701
Milrinone in meningococcal sepsis. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030701
[The use of milrinone in a patient with mitral regurgitation and severe pulmonary hypertension: a case report]. Masui. The Japanese journal of anesthesiology 20030701
Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupole-linear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030605
[Sex, erectile dysfunction, and the heart: a growing problem]. Herz 20030601
New therapies for the management of acute heart failure. Current cardiology reports 20030501
Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins. Journal of cardiovascular pharmacology 20030501
Sustained use of nesiritide to aid in bridging to heart transplant. Clinical cardiology 20030501
Vasospasm-induced stroke in a varsity athlete secondary to ephedrine ingestion. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 20030501
Morbidity and mortality of UNOS status 1B cardiac transplant candidates at home. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20030401
3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3. Planta medica 20030401
Possible contribution of the sarcoplasmic reticulum Ca(2+) pump function to electrical and mechanical alternans. Journal of electrocardiology 20030401
In vivo effects of phosphodiesterase III inhibitors on glucose metabolism and insulin sensitivity. Journal of the Chinese Medical Association : JCMA 20030401
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries. Autonomic & autacoid pharmacology 20030401
Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. Journal of the American College of Cardiology 20030319
Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells. Journal of pharmacological sciences 20030301
Role of nonglycosidic inotropic agents: indications, ethics, and limitations. The Medical clinics of North America 20030301
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 20030225
Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. American heart journal 20030201
A bridge for the 21st century in heart transplantation? American heart journal 20030201
Comparison of dobutamine versus milrinone therapy in hospitalized patients awaiting cardiac transplantation: a prospective, randomized trial. American heart journal 20030201
New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase. Naunyn-Schmiedeberg's archives of pharmacology 20030201
Dopamine stabilizes milrinone-induced changes in heart rate and arterial pressure during anaesthesia with isoflurane. European journal of anaesthesiology 20030201
Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes. Biochemical pharmacology 20030115
Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure. The American journal of cardiology 20030115
Effects of epinephrine and phosphodiesterase III inhibitors on bupivacaine-induced myocardial depression in guinea-pig papillary muscle. British journal of anaesthesia 20030101
Anti-thrombotic effect of milrinone is caused by inhibition of calcium release from the dense tubular system in human platelets. Acta anaesthesiologica Scandinavica 20030101
Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein. Cardiovascular research 20030101
OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. European journal of heart failure 20030101
[Levosimendan: a new option in the pharmacologic management of cardiac insufficiency]. Gaceta medica de Mexico 20030101
Intravenous vasodilator therapy in congestive heart failure. Drugs & aging 20030101
Intravenous milrinone in treatment of advanced congestive heart failure. Texas Heart Institute journal 20030101
Milrinone. Neonatal network : NN 20030101
Reversibility of medically unresponsive pulmonary hypertension with nesiritide in a cardiac transplant recipient. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20030101
Cilostazol as a unique antithrombotic agent. Current pharmaceutical design 20030101
AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. American journal of physiology. Renal physiology 20021201
Inhaled prostacyclin for the treatment of pulmonary hypertension after cardiac surgery. Critical care medicine 20021201
Effects of cAMP modulators on long-chain fatty-acid uptake and utilization by electrically stimulated rat cardiac myocytes. The Biochemical journal 20021101
Interaction of sildenafil with cAMP-mediated vasodilation in vivo. Hypertension (Dallas, Tex. : 1979) 20021101
Dopamine may preserve the myocardial oxygen balance better than dobutamine when administered with milrinone. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20021101
Continuous milrinone infusion during preoperative anti-inflammatory therapy in inflammatory aortic aneurysm complicating severe congestive heart failure. Heart and vessels 20021101
Severe ischemic early liver injury after cardiac surgery. The Annals of thoracic surgery 20021101
Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment. The Annals of thoracic surgery 20021101
Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin. European journal of anaesthesiology 20021101
Successful treatment of chronic pulmonary thromboembolism by long-term intermittent administration of milrinone, a phosphodiesterase-ill inhibitor. Internal medicine (Tokyo, Japan) 20021101
Comparison of the cardiovascular effects of intracellular cyclic adenosine 3',5'-monophosphate (cAMP)-modulating agents in isoflurane-anesthetized cats. The Journal of veterinary medical science 20021101
Lipopolysaccharide-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition. The Journal of pharmacology and experimental therapeutics 20021001
New mechanism of action for cilostazol: interplay between adenosine and cilostazol in inhibiting platelet activation. Journal of cardiovascular pharmacology 20021001
Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation 20020924
Subtype-specific roles of cAMP phosphodiesterases in regulation of atrial natriuretic peptide release. European journal of pharmacology 20020920
Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure. Journal of the American College of Cardiology 20020918
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorganic & medicinal chemistry letters 20020902
Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis. Molecular pharmacology 20020901
Potentiation of slow component of delayed rectifier K(+) current by cGMP via two distinct mechanisms: inhibition of phosphodiesterase 3 and activation of protein kinase G. British journal of pharmacology 20020901
Megadose of milrinone as an alternative to extracorporeal membrane oxygenation for treatment of graft failure early after cardiac transplantation. The Journal of thoracic and cardiovascular surgery 20020901
Anesthesia for arterial switch operation in simple transposition of the great arteries: experience at Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020901
Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. Cardiovascular drugs and therapy 20020901
Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. Biology of reproduction 20020801
Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation 20020801
Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. Human reproduction (Oxford, England) 20020801
Nitric oxide signalling by selective beta(2)-adrenoceptor stimulation prevents ACh-induced inhibition of beta(2)-stimulated Ca(2+) current in cat atrial myocytes. The Journal of physiology 20020801
The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis. European journal of heart failure 20020801
Mechanisms of leptin secretion from white adipocytes. American journal of physiology. Cell physiology 20020701
[Effects of recombinant human brain natriuretic peptide and milrinone on cardiac hemodynamics and renal function in anesthetized dog]. Yao xue xue bao = Acta pharmaceutica Sinica 20020701
Cardiac performance during vasopressin infusion in postcardiotomy shock. Intensive care medicine 20020601
Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. The Journal of veterinary medical science 20020601
Effects of phosphodiesterase III inhibition on length-dependent regulation of myocardial function in coronary surgery patients. British journal of anaesthesia 20020601
Relaxation induced by milrinone and rolipram in human penile arteries and veins. European journal of pharmacology 20020524
Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases. Circulation research 20020517
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Developmental biology 20020501
Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure. Clinical cardiology 20020501
Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases. Thrombosis and haemostasis 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Differential effects of specific phosphodiesterase isoenzyme inhibitors on bovine oocyte meiotic maturation. Developmental biology 20020415
Positive inotropic drug infusions for patients with heart failure: current controversies and best practice. Home healthcare nurse 20020401
Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 20020327
Treatment of acute heart failure: out with the old, in with the new. JAMA 20020327
Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020301
Involvement of phosphodiesterase isozymes in osteoblastic differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020201
Milrinone increases middle cerebral artery blood flow velocity after cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia 20020201
[Reversible cardiomyopathy secondary to interferon-alpha in chronic myelogenous leukemia]. Gan to kagaku ryoho. Cancer & chemotherapy 20020201
Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. Neuroscience letters 20020118
Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells. The Journal of membrane biology 20020115
Effect of type 3 and type 4 phosphodiesterase inhibitors on the maintenance of bovine oocytes in meiotic arrest. Biology of reproduction 20020101
The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting. Anesthesia and analgesia 20020101
Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics. American heart journal 20020101
Assessing the emetic potential of PDE4 inhibitors in rats. British journal of pharmacology 20020101
Effects of milrinone for right ventricular failure after left ventricular assist device implantation. Heart and vessels 20020101
Intravenous milrinone in cardiac surgery. The Annals of thoracic surgery 20020101
Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids. Pulmonary pharmacology & therapeutics 20020101
[Pharmacology of inotropic agents]. Archivos de cardiologia de Mexico 20020101
Recently published papers: topical issues in pharmacology. Critical care (London, England) 20020101
22nd International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, 19-22 March 2002. Critical care (London, England) 20020101
Levosimendan: a unique approach to the treatment of heart failure. Heart disease (Hagerstown, Md.) 20020101
Symptomatic improvement in patients treated with intermittent infusion of inotropes: a double-blind placebo controled pilot study. Journal of medicine 20020101
A review of mechanical ventilation strategies in children following the Fontan procedure. Images in paediatric cardiology 20020101
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. American journal of physiology. Heart and circulatory physiology 20011201
Comparison of dobutamine-based and milrinone-based therapy for advanced decompensated congestive heart failure: Hemodynamic efficacy, clinical outcome, and economic impact. American heart journal 20011201
The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension. Anesthesia and analgesia 20011201
Inhibition of cyclic-3',5'-nucleotide phosphodiesterase abrogates the synergism of hypoxia with lipopolysaccharide in the induction of macrophage TNF-alpha production. The Journal of surgical research 20011201
Milrinone versus dobutamine in heart failure subjects treated chronically with carvedilol. International journal of cardiology 20011201
Comparison of milrinone versus nitroglycerin, alone and in combination, on grafted internal mammary artery flow after cardiopulmonary bypass: effects of alpha-adrenergic stimulation. Journal of cardiothoracic and vascular anesthesia 20011201
Mouse oocyte mitogenic activity is developmentally coordinated throughout folliculogenesis and meiotic maturation. Developmental biology 20011201
[The pulmonary vasodilatory effect of inhaled prostacyclin and milrinone in heart]. Revista espanola de anestesiologia y reanimacion 20011201
Identification and functional study of phosphodiesterases in rat urinary bladder. Urological research 20011201
Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. American journal of physiology. Cell physiology 20011101
Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication. Journal of cardiovascular pharmacology 20011101
Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats. Psychopharmacology 20011101
Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings. European journal of pharmacology 20011005
The evolving management of acute right-sided heart failure in cardiac transplant recipients. Journal of the American College of Cardiology 20011001
Carvedilol titration in patients with congestive heart failure receiving inotropic therapy. American heart journal 20010901
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. The Journal of physiology 20010901
Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease. The Journal of thoracic and cardiovascular surgery 20010901
Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clinical and experimental pharmacology & physiology 20010901
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. Circulation 20010807
A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. International journal of impotence research 20010801
Possible involvement of cyclic adenosine monophosphate-independent mechanism in the positive chronotropic effect of norepinephrine in the isolated guinea pig right atrium. Anesthesiology 20010801
The effects of alpha-human atrial natriuretic peptide and milrinone on pial vessels during blood-brain barrier disruption in rabbits. Anesthesia and analgesia 20010701
Milrinone echocardiographic viability test: a pilot study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20010701
Inhibition of phosphodiesterase type III before aortic cross-clamping preserves intramyocardial cyclic adenosine monophosphate during cardiopulmonary bypass. Anesthesia and analgesia 20010601
Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89. Cellular signalling 20010601
A randomized multicenter study comparing the efficacy and safety of intravenous milrinone and intravenous nitroglycerin in patients with advanced heart failure. Journal of cardiac failure 20010601
Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20010601
Dose response to nitric oxide in adult cardiac surgery patients. Journal of clinical anesthesia 20010601
Inotropes and beta-blockers: is there a need for new guidelines? Journal of cardiac failure 20010601
Surgical issues in heart failure: what's new? Journal of cardiac failure 20010601
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation. European journal of pharmacology 20010518
Improved survival with simendan after experimental myocardial infarction in rats. European journal of pharmacology 20010511
Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide (LPS)-induced microvascular permeability change in mouse skin. British journal of pharmacology 20010501
Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device. Journal of clinical anesthesia 20010501
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501
Local anesthetic toxicity and milrinone. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501
Effect of low-dose milrinone on gastric intramucosal pH and systemic inflammation after hypothermic cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia 20010401
Milrinone for the treatment of cerebral vasospasm after subarachnoid hemorrhage: report of seven cases. Neurosurgery 20010401
[The effects of milrinone on hemodynamics in patients undergoing cardiac surgery]. Masui. The Japanese journal of anesthesiology 20010401
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochimica et biophysica acta 20010319
Pharmacodynamic effects of milrinone with and without a bolus loading infusion. American heart journal 20010201
Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 20010201
Slow induction of milrinone after coronary artery bypass grafting. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20010201
'cAMP-specific' phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide. Molecular pharmacology 20010101
Iloprost inhibits inositol-1,4,5-trisphosphate-mediated calcium mobilization stimulated by angiotensin II in cultured preglomerular vascular smooth muscle cells. Journal of the American Society of Nephrology : JASN 20010101
Experimental study of a type 3 phosphodiesterase inhibitor on liver graft function. The British journal of surgery 20010101
[Effect of colforsin daropate hydrochloride after cardiopulmonary bypass]. Masui. The Japanese journal of anesthesiology 20010101
Comparison of systemic vasodilators: effects on flow in internal mammary and radial arteries. The Annals of thoracic surgery 20010101
Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin. Intensive care medicine 20010101
High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition. BMC physiology 20010101
Vascular relaxant effects of toborinone on the isolated canine internal mammary artery. Surgery today 20010101
Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake. Cardiovascular drug reviews 20010101
New therapeutic choices in the management of acute congestive heart failure. Reviews in cardiovascular medicine 20010101
Drug treatment of patients with decompensated heart failure. American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101
A comparison of the inotropic effects of milrinone and piroximone. Annals of cardiac anaesthesia 20010101
Hemodynamic effects of milrinone during weaning from cardiopulmonary bypass: comparison of patients with a low and high prebypass cardiac index. Journal of cardiothoracic and vascular anesthesia 20000801
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochemical pharmacology 20000215
Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. The American journal of cardiology 20000215
[The effects of intravenous milrinone for the patient undergoing CABG]. Kyobu geka. The Japanese journal of thoracic surgery 20000201
Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. Critical care medicine 20000101
The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 19990401
Milrinone, a phosphodiesterase inhibitor, suppresses intimal thickening after photochemically induced endothelial injury in the mouse femoral artery. Atherosclerosis 19990101
A multicenter, randomized, blind comparison of amrinone with milrinone after elective cardiac surgery. Anesthesia and analgesia 19980401
Treatment of milrinone-associated tachycardia with beta-blockers. Canadian journal of anaesthesia = Journal canadien d'anesthesie 19980101
The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti-asthma drugs on inflammatory cell activation. British journal of pharmacology 19961101
[Differential therapy of cardiogenic shock with dopamine/milrinone in comparison with dopamine/dobutamine]. Zeitschrift fur Kardiologie 19961101
Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. Chest 19960501
Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. Critical care medicine 19951101
Comparative cardiac effects of milrinone and sodium nitroprusside in conscious rats. Drug and chemical toxicology 19950201
Electrophysiologic and proarrhythmic effects of intravenous inotropic agents. Progress in cardiovascular diseases 19950101
Combined use of glucagon and milrinone may not be preferable for severe propranolol poisoning in the canine model. Journal of toxicology. Clinical toxicology 19950101
Milrinone versus glucagon: comparative hemodynamic effects in canine propranolol poisoning. Journal of toxicology. Clinical toxicology 19940101
Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. Journal of cardiovascular pharmacology 19930601
The influence of clinical intervention on pressure-volume relationships--the conductance (volume) technique. European heart journal 19921101
3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. Journal of medicinal chemistry 19920221
Effects of milrinone on left ventricular remodeling after acute myocardial infarction. Circulation 19910801
Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP. Journal of cardiovascular pharmacology 19910701
Phosphodiesterase III inhibition or adrenoreceptor stimulation: milrinone as an alternative to dobutamine in the treatment of severe heart failure. American heart journal 19910601
Beneficial hemodynamic effects of two weeks' milrinone treatment in conscious rats with heart failure. European journal of pharmacology 19900717
Positive inotropy contributes to the hemodynamic mechanism of action of flosequinan (BTS 49465) in the intact dog. Journal of cardiovascular pharmacology 19900601
Cardiac and hemodynamic profile of the new cardiotonic agent, DPI 201-106, in the conscious dog. European journal of pharmacology 19890608
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure. Journal of medicinal chemistry 19890201
Acute effects of milrinone on the electrocardiogram and the cardiac hemodynamics of rats with pressure overload-induced congestive heart failure. Archives internationales de pharmacodynamie et de therapie 19890101
Differential effects of milrinone and dobutamine on right ventricular preload, afterload and systolic performance in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. The American journal of cardiology 19871201
[Central and regional vascular hemodynamics of milrinone in experimental heart failure: comparison with captopril and dobutamine]. Zeitschrift fur Kardiologie 19870801
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856). Journal of medicinal chemistry 19870201
Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside. The Journal of clinical investigation 19850201
The new inotropic phosphodiesterase inhibitors. Archives internationales de physiologie et de biochimie 19841101
The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog. Life sciences 19831031
Cardiotonic activity of milrinone, a new and potent cardiac bipyridine, on the normal and failing heart of experimental animals. Journal of cardiovascular pharmacology 19830101
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